Department of Biochemistry
A vigorous group of scientists and trainees dedicated to the expansion and transmission of knowledge about the biological world. Our particular focus is the characterization of macromolecules and biological processes at the molecular level. Research groups in the department address the structure of biological macromolecules, the mechanisms by which they function, and the possible applications to research technology and to medicine. more
Danny Hung-Chieh Chou, Ph.D.
We focus on using synthetic protein engineering to create peptide or protein therapeutics to understand their biological effects in human disease and improve clinical treatment. We are tackling type 1 diabetes (T1D), an autoimmune disease in which the pancreas stops producing insulin, a hormone that enables glucose uptake from blood. By developing novel insulin and glucagon (a hormone that elevates glucose levels) analogues, we hope to maintain normal blood glucose levels in type 1 diabetic patients.
Currently, we are focusing on the following research programs:
*New insulin and glucagon analogues for use in the artificial pancreas
*Glucose-responsive insulin or “smart insulin
*Synthetic methodologies for creating peptide and protein analogues