Department of Biochemistry
A vigorous group of scientists and trainees dedicated to the expansion and transmission of knowledge about the biological world. Our particular focus is the characterization of macromolecules and biological processes at the molecular level. Research groups in the department address the structure of biological macromolecules, the mechanisms by which they function, and the possible applications to research technology and to medicine. more
Tim Formosa, Ph.D.
We use yeast to study a highly conserved complex called yFACT. yFACT binds to nucleosomes and reorganizes them into an alternative structure whose nature remains poorly understood. This reorganization of the basic subunits of chromatin changes the properties of chromatin, and the ability to make this change in the structure of nucleosomes is essential for the viability of eukaryotic cells.