Mitochondrial Dynamics in Eukaryotic Cells

Eukaryotic cells contain many membrane-bound organelles, each with a characteristic shape and distribution. Our lab is interested in how organelles establish and maintain these features. We use yeast and mammalian cells to study how mitochondrial fission, fusion, and transport regulate mitochondrial function and inheritance during cell division. Our studies are directly relevant to human heath and disease, as defects in these processes cause embryonic lethality in multicellular organisms and are linked to neurological disorders in humans.