About Us
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'Accelerating Discoveries Toward Better Health' The University of Utah Center for Clinical and Translational Science builds on the University's strengths in genetics and bioinformatics to translate promising bench science into practices that improve human health. The Center serves as an academic home for clinical and translational research, developing innovative health services for the community and health researchers, and training a new generation of clinical and translational investigators. The Center and its partners will increase the visibility, volume, and quality of participatory research by connecting investigators at the University with other health care institutions, clinical practitioners, public health personnel, patients, and research participants. The Center also will formally link research activities across systems that together provide health care coverage to 80 percent of Utah's population as well as patients in surrounding states. The CCTS is composed of the Integrated Home, Tracking & Evaluation Core and the following services cores: |
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What is Translational Research?The NIH Common Fund defines Translational Research as the following: "To improve human health, scientific discoveries must be translated into practical applications. Such discoveries typically begin at “the bench” with basic research in which scientists study disease at a molecular or cellular level then progress to the clinical level, or the patient's “bedside.” Scientists are increasingly aware that this bench-to-bedside approach to translational research is really a two-way street. Basic scientists provide clinicians with new tools for use in patients and for assessment of their impact, and clinical researchers make novel observations about the nature and progression of disease that often stimulate basic investigations. Translational research has proven to be a powerful process that drives the clinical research engine. However, a stronger research infrastructure could strengthen and accelerate this critical part of the clinical research enterprise. The NIH Roadmap attempts to catalyze translational research in various ways." The levels of translational research are often represented by the symbols T1 through T4. T1 represents the translation of a discovery in the basic sciences (biochemistry, for example) into a clinical application (a new drug). T2 represents the translation from a clinical application (a new drug) into accepted practice or clinical guideling by physicians. T3 represents the translation of an accepted practice for clinicians into better health for a community or population. T4 represents the translation of a practice for the better health of a population into better health on a global scale. |
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Leadership | |||
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Contact Program Director |
Donald McClain, M.D., Ph.D. Translational Focus: T1 University of Utah: |
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Program Co-Director |
Carrie Byington, M.D. Translational Focus: T2 & T3 University of Utah: Intermountain Healthcare: |
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Program Associate Director, Intermountain Health Care |
Michael Varner, M.D. Translational Focus: T2 University of Utah: Intermountain Healthcare: |
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Program Associate Director, Salt Lake Veterans Administration Medical Center |
Matthew Samore, M.D. Translational Focus: T3 Veteran's Administration Health Center: University of Utah: |
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Program Associate Director, Utah Deptartment of Health |
Wu Xu, Ph.D. Translational Focus: T4 Utah Department of Health: |
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Core Directors | |||
| Bioinformatics |
Julio Facelli, Ph.D. Dr. Facelli is a Professor and Chair of the University of Utah Department of Biomedical Informatics. |
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| Clinical Services |
J. Robinson Singleton, M.D. Dr. Singleton, Professor in the Department of Neurology, is a neuromuscular disease clinical specialist and experienced researcher in the areas of metabolic neuropathy and peripheral nerve surrogate measures. He also serves as the Director of the Neurophysiology Laboratory at the Salt Lake City Veterans Administration Medical Center.
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| Clinical Services |
Stephen Guthrey, M.D., M.S. Dr. Guthery is an Associate Professor in the Department of Pediatrics and an Adjunct Associate Professor in the Department of Human Genetics. |
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| Community Outreach & Collaboration |
Louisa Stark, Ph.D. Dr. Stark is Director of the Genetics Scieince Learning Center and faculty in the University of Utah Department of Human Genetics. |
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| Research Education, Training and Career Development |
Dean Li, M.D., Ph.D. Dr. Li serves the University of Utah Health Sciences as the inaugural Vice Dean for Research. He is also the Chief Scientific Officer for University of Utah Health Care. |
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| Research Education, Training and Career Development |
Carol Sweeney, Ph.D. Dr. Sweeney serves as a faculty member in the University of Utah Department of Internal Medicine, Epidemiology Division. |
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| Patient-Centered Research Methods |
Lucy Savitz, Ph.D., MBA Dr. Savitz is a highly-regarded health services researcher with a wealth of experience and expertise in health care quality and outcomes. |
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| Patient-Centered Research Methods |
Steven Adler, Ph.D. Dr. Alder is an Associate Professor in the Department of Family and Preventive Medicine, Division of Public Health. |
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| Recruitment, Retention and Safety |
Jeff Botkin, M.D., MPH Dr. Botkin serves as the University of Utah Associate Vice President for Research Integrity, as well as serving as a Professor in the Department of Pediatrics. Dr. Botkin was also recently named Chair of HHS Secretary Sebelius's Advisory Panel on Human Research Protections. |
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| Study Design & Biostatistics |
Tom Greene, Ph.D. Dr. Greene is an expert biostatistician and Professor in the University of Utah Department of Internal Medicine, Epidemiolgy Division. He serves as the Director of the University of Utah Study Design and Biostatistics Center. |
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| Study Design & Biostatistics |
Richard Holubkov, Ph.D. Dr. Holubkov is an expert biostatistician with over 25 years of experience as an applied biostatistician, focusing on the design, execution, and analysis of prospective interventional studies, with a focus on pediatrics and cardiology. He has authored or co-authored more than 100 publications in the areas of pediatrics, cardiology, and statistical methodology. He serves on several Data Safety Monitoring Boards and protocol review committees. |
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| Translational Technologies & Resources |
Elsayed Ahmed, DVM Dr. Ahmed serves as the Director of the Translation Technology Core Laboratory for the University of Utah Health Sciences. |
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What is the Internal Advisory Committee (IAC)?
The Internal Advisory Committee has the responsibility for the review, approval, and oversight of all research projects requesting CCTS support. The chairman of the committee is J. Robinson Singleton, M.D. The committee meets monthly to evaluate proposals based upon scientific merit and need for center resources. Approved research projects are prioritized using these two factors. The committee is responsible for the designation of the category of inpatient days and outpatient visits for each research project proposed to the center as category A, B, or D, including the classification of research sponsored by industry.
What is the IAC process?
The Clinical Services Center (CSC) Director assigns a primary reviewer to each protocol submitted. The reviewer critiques the study verbally and in a written report on the qualifications of the principal investigator, proposed science, suitability of study design, strengths and weaknesses, and need for center resources.
If the Committee approves the protocol with no changes, the investigator can begin to use CCTS resources immediately (assuming IRB approval has been granted). If the study is not approved as submitted, the protocol will be returned to the investigator with specific suggestions for revision. Consideration following resubmission is usually expedited.
After each meeting, the principal investigator of each study reviewed is sent a written notice indicating the action taken by the committee at the meeting.
No studies requiring center support can take place without Internal Advisory Committee approval, except when temporary approval is given by the chairman for urgent studies created by an unexpected opportunity to study unusual patients.
A protocol can be reviewed simultaneously by the IRB and the Internal Advisory Committee, but the study cannot be activated on the GCRC until a copy of the IRB letter of approval is received at the CCTS office.
Internal Advisory Committee | ||||
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| Name: | Department: | Affiliation(s): | ||
| J. Robinson Singleton, M.D. Chair - IAC CSC Director |
Neurology | University of Utah | ||
| D. Ware Branch, M.D. | Obstetrics & Gynelcology | University of Utah | ||
| Kristina Callis Duffin, M.D. | Dermatology | University of Utah | ||
| Hillary Coon, Ph.D. | Psychiatry | University of Utah | |
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| Sadie Gabler | CCTS | University of Utah |  |
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| Launce Gouw, M.D. | Oncology | University of Utah | ||
| Tom Greene, Ph.D. | Clinical Epidemiology | University of Utah | ||
| Douglas Grossman, M.D., Ph.D. |
Dermatology |
University of Utah | ||
| Stephen Guthery, M.D. | Pediatrics | University of Utah Intermountain Healthcare |
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| Kimberly Hanson, M.D., M.M.S. | Infectious Disease |
University of Utah |
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| Marta E. Heilbrun, MD, MS | Radiology | University of Utah | ||
| John Hoidal, M.D. | Medicine - Pulmonology | University of Utah | ||
| Richard Holubkov, Ph.D. | Pediatrics - Biostatistics | University of Utah | |
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| Richard Kanner, M.D. | Medicine - Pulmonology & IRB | University of Utah | ||
| Jennifer P. Katz, B.S., C.C.R.P. | Clinical Trials Administrative Director | University of Utah |  |
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| Robin Marcus, Ph.D. | Physical Therapy | University of Utah | ||
| Donald McClain, M.D., Ph.D. | Endocrinology/CCTS Program Director | University of Utah | ||
| Mark Munger, Pharm.D., F.C.C.P., F.A.C.C. | Pharmacotherapy and Internal Medicine | University of Utah | |
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| Ginny Pepper, R.N., Ph.D. | Nursing | University of Utah | |
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| John Phillips, Ph.D. | Medicine - Hematology | University of Utah | ||
| Matthew Rondina, M.D. | Internal Medicine | University of Utah | ||
| Hillarie Slater BS RPT CBDT CCRC | Pediatrics |
University of Utah |
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| Mark Supiano, M.D. | Geriatrics | University of Utah | ||
| David Viskochil, M.D., Ph.D. | Pediatrics - Human Genetics | University of Utah | ||
Internal Advisory Committee (Ad Hoc) | ||||
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| Name: | Department: | Affiliation(s): | ||
| Sayed Ahmed | CCTS | University of Utah | |
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| Chris Chambreau | CCTS | University of Utah |  |
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| Lynette Holman | CCTS | University of Utah |  |
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| Bernie LaSalle, B.S. | Biomedical Informatics/CCTS | University of Utah | ||
| Deanna Palma, R.N. | CCTS | University of Utah |  |
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| Kitiya Suvannasankha | CCTS | University of Utah | |
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| Laurene Vickers, B.S.N. | CCTS | University of Utah | |
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External Advisory Committee | ||||
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| Name: | Department: | Affiliation(s): | ||
| Gordon H. Williams, M.D. | Medicine | Harvard Medical School |  |
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| Eric Topol, M.D. | Human Genetics | Scripps Translational Science Institute |  |
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| Peter Tarczy-Hornoch, M.D. | Bioinformatics | University of Washington |  |
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| William W. Hay, Jr., M.D. | Pediatrics | University of Colorado |  |
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Steering Committee | ||||
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| Name: | Role & Department: | Affiliation(s): | ||
| Donald McClain, M.D., Ph.D. | Co-Director, CCTS | University of Utah | ||
| Carrie Byington, M.D. | Co-Director, CCTS | University of Utah Intermountain Healthcare |
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| Michael Varner, M.D. | Associate Director, Intermountain | University of Utah Intermountain Healthcare |
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| Wu Xu, Ph.D. | Associate Director, Utah Department of Health | Utah Department of Health | |
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| Matthew Samore, M.D. | Associate Director, VA Medical Center | Salt Lake VA Medical Center | ||
| Keely Coffrin Allen, Ph.D. | Director, Office of Healthcare Statistics | Utah Department of Health | |
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| Vivian Lee, M.D., Ph.D., M.B.A. | Senior Vice President, Health Sciences | University of Utah | ||
| John Zone, M.D. |
Professor and Chair, Department of Dermatology |
University of Utah | ||
| Rose Marie Hunter, Ph.D., L.C.S.W. | Director, University Neighborhood Partners | University of Utah | |
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| Edward B. Clark, M.D. | Professor and Chair, Department of Pediatric Chief Medical Officer, Primary Children's Medical Center |
University of Utah |
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| Debra Scammon, Ph.D. | Emma Eccles Jones Professor, Department of Marketing Chair, Utah Partnership for Value Driven Healthcare |
University of Utah | |
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| Lynne Jorde, Ph.D. | Professor and Chair, Department of Genetics | University of Utah |  |
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| Brent Wllace, M.D. | Chief Medical Office and Director of Research | Intermountain Healthcare | |
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| Elizabeth Joy, M.D. | Medical Director, Outcomes Research | Intermountain Healthcare | ||
| Peter Haug, M.D. | Director, Homer Warner Center for Informatics Research | Intermountain Healthcare | ||
| Laurence Meyer, M.D., Ph.D. | Professor | Salt Lake VA Medical Center | ||
| Charlene Weir, Ph.D. R.N. | Director, Tracking and Evaluation - CCTS | Salt Lake VA Medical Center | ||
| Daniel Clegg, M.D. | Professor, Department of Rheumatology | Salt Lake VA Medical Center | ||
| Dean Li, M.D., Ph.D. | Vice Dean for Research Chief Scientific Officer |
University of Utah | ||
| Jeff Botkin, M.D. | Associate Vice President for Research Integrity | University of Utah | ||
| Jean Shipman, M.S.L.S. | Director, Spencer S. Eccles Health Sciences Library | University of Utah |  |
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| Cynthia Furse, Ph.D. | Associate Vice President for Research Professor, Department of Electrical Engineering |
University of Utah | ||
Administrative Staff | |||
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Chris Chambreau |
Administrative Director | |
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| Lynette Holman | Administrative Program Coordinator Translational Pilot Project Funding Program Coordinator |
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| Carrie Roberts | Program Coordinator |  |
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| Peter Jones | Research Concierge |  |
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Core Staff | |||
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| Sadie Gabler | Research Participant Advocate | |
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| Dylan Turner | Research Participant Assistant | |
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| Deanna Palma | Nurse Administrator | |
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| Office | Contact | Location |
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Administrative Offices |
801-581-6736
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Spencer S. Eccles Health Sciences Library Garden Level, Rm 22 10 North 1900 East Salt Lake City, UT 84112 |
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Clinical Services |
801-581-2224 801-585-3629 (fax)
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University of Utah Medical Center Level 5 50 North Medical Drive Salt Lake City, UT 84132 |
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Translational Technologies |
801-581-5889
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University of Utah School of Medicine Level 4, Rm. 4R151 30 North 1900 East Salt Lake City, UT 84132 |
