About Us

'Accelerating Discoveries Toward Better Health'
- CTSA program motto 

The University of Utah Center for Clinical and Translational Science builds on the University's strengths in genetics and bioinformatics to translate promising bench science into practices that improve human health. The Center serves as an academic home for clinical and translational research, developing innovative health services for the community and health researchers, and training a new generation of clinical and translational investigators.  The Center and its partners will increase the visibility, volume, and quality of participatory research by connecting investigators at the University with other health care institutions, clinical practitioners, public health personnel, patients, and research participants.  The Center also will formally link research activities across systems that together provide health care coverage to 80 percent of Utah's population as well as patients in surrounding states.

The CCTS is composed of the Integrated Home, Tracking & Evaluation Core and the following services cores:

BioMedical Informatics     Clinical Services
 
Community Outreach & Collaboration     Patient-Centered Outcomes Research Methods
 
Recruitment, Retention & Safety     Research Education, Training & Career Development
 
Study Design & Biostatistics     Translational Technologies & Resources

 

CCTS Model

What is Translational Research?

The NIH Common Fund defines Translational Research as the following:

"To improve human health, scientific discoveries must be translated into practical applications. Such discoveries typically begin at “the bench” with basic research in which scientists study disease at a molecular or cellular level then progress to the clinical level, or the patient's “bedside.”

Scientists are increasingly aware that this bench-to-bedside approach to translational research is really a two-way street. Basic scientists provide clinicians with new tools for use in patients and for assessment of their impact, and clinical researchers make novel observations about the nature and progression of disease that often stimulate basic investigations.

Translational research has proven to be a powerful process that drives the clinical research engine. However, a stronger research infrastructure could strengthen and accelerate this critical part of the clinical research enterprise. The NIH Roadmap attempts to catalyze translational research in various ways."

The levels of translational research are often represented by the symbols T1 through T4.

T1 represents the translation of a discovery in the basic sciences (biochemistry, for example) into a clinical application (a new drug).

T2 represents the translation from a clinical application (a new drug) into accepted practice or clinical guideling by physicians.

T3 represents the translation of an accepted practice for clinicians into better health for a community or population.

T4 represents the translation of a practice for the better health of a population into better health on a global scale.

 

translational research diagram

Leadership

Contact Program Director

Donald McClain, M.D., Ph.D.

Translational Focus: T1

University of Utah:
Associate Vice President for Clinical Trials
Bettilyon Chair in Diabetes Research
Professor, Internal Medicine & Biochemistry

edu image 1

Program Co-Director 

Carrie Byington, M.D.

Translational Focus: T2 & T3

University of Utah:
H.A. and Edna Benning Presidential Professor of Pediatrics
Vice Dean for Academic Affairs and Faculty Development
Vice Chair for the Research Enterprise, Department of Pediatrics

Intermountain Healthcare:

edu image 2

Program Associate Director, Intermountain Health Care 

Michael Varner, M.D.

Translational Focus: T2

University of Utah:
Professor & Vice Chair for Research, Department of Obstetrics & Gynecology
Interim Director, Program for Personalized Healthcare

Intermountain Healthcare:
Director of Perinatal Research

edu image 2

 Program Associate Director, Salt Lake Veterans Administration Medical Center

Matthew Samore, M.D.

Translational Focus: T3

Veteran's Administration Health Center:
PI, Salt Lake VA Informatics Decision Enhancement and Surveillance (IDEAS) Center
PI, VA Consortium for Healthcare Informatics Research

University of Utah:
Professor, Medicine
Adjunct Professor, Biomedical Informatics
Chief, Division of Epidemiology

edu image 2

 Program Associate Director, Utah Deptartment of Health

Wu Xu, Ph.D.

Translational Focus: T4

Utah Department of Health:

edu image 2

 

 

Core Directors

BioMedical Informatics

Julio Facelli, Ph.D.

Dr. Facelli is a Professor and Chair of the University of Utah Department of Biomedical Informatics.

Facelli image 1
Clinical Services

J. Robinson Singleton, M.D.

Dr. Singleton, Professor in the Department of Neurology, is a neuromuscular disease clinical specialist and experienced researcher in the areas of metabolic neuropathy and peripheral nerve surrogate measures. He also serves as the Director of the Neurophysiology Laboratory at the Salt Lake City Veterans Administration Medical Center.

 

Singleton image 1
Clinical Services

Stephen Guthrey, M.D., M.S.

Dr. Guthery is an Associate Professor in the Department of Pediatrics and an Adjunct Associate Professor in the Department of Human Genetics.

Singleton image 1
Community Outreach & Collaboration

Louisa Stark, Ph.D.

Dr. Stark is Director of the Genetics Scieince Learning Center and faculty in the University of Utah Department of Human Genetics.

edu image 1
Research Education, Training and Career Development

Dean Li, M.D., Ph.D.

Dr. Li serves the University of Utah Health Sciences as the inaugural Vice Dean for Research. He is also the Chief Scientific Officer for University of Utah Health Care. 

edu image 1
Research Education, Training and Career Development

Carol Sweeney, Ph.D.

Dr. Sweeney serves as a faculty member in the University of Utah Department of Internal Medicine, Epidemiology Division.

edu image 1
Patient-Centered Research Methods

Lucy Savitz, Ph.D., MBA

Dr. Savitz is a highly-regarded health services researcher with a wealth of experience and expertise in health care quality and outcomes.

edu image 1
Patient-Centered Research Methods

Steven Adler, Ph.D.

Dr. Alder is an Associate Professor in the Department of Family and Preventive Medicine, Division of Public Health.

edu image 1
Recruitment, Retention and Safety

Jeff Botkin, M.D., MPH

Dr. Botkin serves as the University of Utah Associate Vice President for Research Integrity, as well as serving as a Professor in the Department of Pediatrics. Dr. Botkin was also recently named Chair of HHS Secretary Sebelius's Advisory Panel on Human Research Protections.

edu image 1
Study Design & Biostatistics

Tom Greene, Ph.D.

Dr. Greene is an expert biostatistician and Professor in the University of Utah Department of Internal Medicine, Epidemiolgy Division. He serves as the Director of the University of Utah Study Design and Biostatistics Center.

edu image 1
Study Design & Biostatistics

Richard Holubkov, Ph.D.

Dr. Holubkov is an expert biostatistician with over 25 years of experience as an applied biostatistician, focusing on the design, execution, and analysis of prospective interventional studies, with a focus on pediatrics and cardiology. He has authored or co-authored more than 100 publications in the areas of pediatrics, cardiology, and statistical methodology. He serves on several Data Safety Monitoring Boards and protocol review committees.

edu image 1

What is the Internal Advisory Committee (IAC)?

The Internal Advisory Committee has the responsibility for the review, approval, and oversight of all research projects requesting CCTS support. The chairman of the committee is J. Robinson Singleton, M.D. The committee meets monthly to evaluate proposals based upon scientific merit and need for center resources. Approved research projects are prioritized using these two factors. The committee is responsible for the designation of the category of inpatient days and outpatient visits for each research project proposed to the center as category A, B, or D, including the classification of research sponsored by industry.

What is the IAC process?

The Clinical Services Center (CSC) Director assigns a primary reviewer to each protocol submitted. The reviewer critiques the study verbally and in a written report on the qualifications of the principal investigator, proposed science, suitability of study design, strengths and weaknesses, and need for center resources.

If the Committee approves the protocol with no changes, the investigator can begin to use CCTS resources immediately (assuming IRB approval has been granted). If the study is not approved as submitted, the protocol will be returned to the investigator with specific suggestions for revision. Consideration following resubmission is usually expedited.

After each meeting, the principal investigator of each study reviewed is sent a written notice indicating the action taken by the committee at the meeting.

No studies requiring center support can take place without Internal Advisory Committee approval, except when temporary approval is given by the chairman for urgent studies created by an unexpected opportunity to study unusual patients.

A protocol can be reviewed simultaneously by the IRB and the Internal Advisory Committee, but the study cannot be activated on the GCRC until a copy of the IRB letter of approval is received at the CCTS office.

Internal Advisory Committee

Name: Department: Affiliation(s):
J. Robinson Singleton, M.D.
Chair - IAC
CSC Director
Neurology University of Utah edu image 1
D. Ware Branch, M.D. Obstetrics & Gynelcology University of Utah edu image 1
Kristina Callis Duffin, M.D. Dermatology University of Utah edu image 1
Hillary Coon, Ph.D. Psychiatry University of Utah edu image 1
Sadie Gabler CCTS University of Utah edu image 1
Launce Gouw, M.D. Oncology University of Utah edu image 1
Tom Greene, Ph.D. Clinical Epidemiology University of Utah edu image 1
Stephen Guthery, M.D. Pediatrics University of Utah
Intermountain Healthcare
edu image 1
Kimberly Hanson, M.D., M.M.S. Infectious Disease

University of Utah

edu image 1
Marta E. Heilbrun, MD, MS Radiology University of Utah edu image 1
John Hoidal, M.D. Medicine - Pulmonology University of Utah edu image 1
Richard Holubkov, Ph.D. Pediatrics - Biostatistics University of Utah edu image 1

Richard Kanner, M.D.

Data Safety Monitor

Medicine - Pulmonology & IRB University of Utah edu image 1
Jennifer P. Katz, B.S., C.C.R.P. Clinical Trials Administrative Director University of Utah edu image 1
Robin Marcus, Ph.D. Physical Therapy University of Utah edu image 1
Donald McClain, M.D., Ph.D. Endocrinology/CCTS Program Director University of Utah edu image 1
Mark Munger, Pharm.D., F.C.C.P., F.A.C.C. Pharmacotherapy and Internal Medicine University of Utah edu image 1
Ginny Pepper, R.N., Ph.D. Nursing University of Utah edu image 1
John Phillips, Ph.D. Medicine - Hematology University of Utah edu image 1
Matthew Rondina, M.D. Internal Medicine University of Utah edu image 1
Hillarie Slater BS RPT CBDT CCRC Pediatrics

University of Utah
Intermountain Healthcare

edu image 1
Mark Supiano, M.D. Geriatrics University of Utah edu image 1
David Viskochil, M.D., Ph.D. Pediatrics - Human Genetics University of Utah edu image 1


Internal Advisory Committee (Ad Hoc)

Name: Department: Affiliation(s):
Lorenzo
CCTS University of Utah
Chris Chambreau CCTS University of Utah edu image 1
Lynette Holman CCTS University of Utah edu image 1
Bernie LaSalle, B.S. Biomedical Informatics/CCTS University of Utah edu image 1
Deanna Palma, R.N. CCTS University of Utah edu image 1
Kitiya Suvannasankha CCTS University of Utah edu image 1
Laurene Vickers, B.S.N. CCTS University of Utah edu image 1

External Advisory Committee

Name: Department: Affiliation(s):
Gordon H. Williams, M.D. Medicine Harvard Medical School edu image 1
Eric Topol, M.D. Human Genetics Scripps Translational Science Institute edu image 1
Peter Tarczy-Hornoch, M.D. Bioinformatics University of Washington edu image 1
William W. Hay, Jr., M.D. Pediatrics University of Colorado edu image 1

Steering Committee

Name: Role & Department: Affiliation(s):
Donald McClain, M.D., Ph.D. Co-Director, CCTS University of Utah edu image 1
Carrie Byington, M.D. Co-Director, CCTS University of Utah
Intermountain Healthcare
edu image 1
Michael Varner, M.D. Associate Director, Intermountain University of Utah
Intermountain Healthcare
edu image 1
Wu Xu, Ph.D. Associate Director, Utah Department of Health Utah Department of Health edu image 1
Matthew Samore, M.D. Associate Director, VA Medical Center Salt Lake VA Medical Center edu image 1
Keely Coffrin Allen, Ph.D. Director, Office of Healthcare Statistics Utah Department of Health edu image 1
Vivian Lee, M.D., Ph.D., M.B.A. Senior Vice President, Health Sciences University of Utah edu image 1
John Zone, M.D.

Professor and Chair, Department of Dermatology
Chair, University of Utah Medical Group

University of Utah edu image 1
Rose Marie Hunter, Ph.D., L.C.S.W. Director, University Neighborhood Partners University of Utah edu image 1
Edward B. Clark, M.D. Professor and Chair, Department of Pediatric
Chief Medical Officer, Primary Children's Medical Center

University of Utah
Intermountain Healthcare

edu image 1
Debra Scammon, Ph.D. Emma Eccles Jones Professor, Department of Marketing
Chair, Utah Partnership for Value Driven Healthcare
University of Utah edu image 1
Lynne Jorde, Ph.D. Professor and Chair, Department of Genetics University of Utah edu image 1
Brent Wllace, M.D. Chief Medical Office and Director of Research Intermountain Healthcare edu image 1
Elizabeth Joy, M.D. Medical Director, Outcomes Research Intermountain Healthcare edu image 1
Peter Haug, M.D. Director, Homer Warner Center for Informatics Research Intermountain Healthcare edu image 1
Laurence Meyer, M.D., Ph.D. Professor Salt Lake VA Medical Center edu image 1
Charlene Weir, Ph.D. R.N. Director, Tracking and Evaluation - CCTS Salt Lake VA Medical Center edu image 1
Daniel Clegg, M.D. Professor, Department of Rheumatology Salt Lake VA Medical Center edu image 1
Dean Li, M.D., Ph.D. Vice Dean for Research
Chief Scientific Officer
University of Utah edu image 1
Jeff Botkin, M.D. Associate Vice President for Research Integrity University of Utah edu image 1
Jean Shipman, M.S.L.S. Director, Spencer S. Eccles Health Sciences Library University of Utah edu image 1
Cynthia Furse, Ph.D. Associate Vice President for Research
Professor, Department of Electrical Engineering
University of Utah edu image 1

Administrative Staff

Name: Role:

Chris Chambreau

Administrative Director edu image 1
Lynette Holman Administrative Program Coordinator
Translational Pilot Project Funding Program Coordinator
edu image 2
OfficeContactLocation

Administrative Offices

801-581-6736

 

Spencer S. Eccles Health Sciences Library
Garden Level, Rm 22
10 North 1900 East
Salt Lake City, UT 84112

Clinical Services

801-581-2224
801-585-3629 (fax)

 

University of Utah Medical Center
Level 5
50 North Medical Drive
Salt Lake City, UT 84132

Translational Technologies

801-581-5889

 

University of Utah School of Medicine
Level 4, Rm. 4R151
30 North 1900 East
Salt Lake City, UT 84132
myra icon