Janet M. Shaw, PhD

Research Interests

  • Mitochondria
  • Mitochondrial Fusion
  • Mitochondrial Fission
  • Dynamics of Mitochondrial Membranes
  • Mitochondrial Diseases

Labs

Lab Website

Languages

  • English

Academic Information

  • Departments: Biochemistry - Professor

Academic Office Information

  • 801-585-6205
  • Emma Eccles Jones Research Building
    Department of Biochemistry
    15 North Medical Drive East, Room: 5800K
    Salt Lake City, UT 84112

Education History

Type School Degree
Postdoctoral Fellowship University of California, Molecular Biology Institute
Postdoctoral Fellow
Doctoral Training University of California
Molecular Biology
Ph.D.
Undergraduate University of California
Genetics
B.A.

Selected Publications

Journal Article

  1. Nguyen TT, Oh SS, Weaver D, Lewandowska A, Maxfield D, Schuler MH, Smith NK, Macfarlane J, Saunders G, Palmer CA, Debattisti V, Koshiba T, Pulst S, Feldman EL, Hajnoczky G, Shaw JM (2014). Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease. Proc Natl Acad Sci U S A, 111(35), E3631-40.
  2. Lewandowska A, Macfarlane J, Shaw JM (2013). Mitochondrial association, protein phosphorylation, and degradation regulate the availability of the active Rab GTPase Ypt11 for mitochondrial inheritance. Mol Biol Cell, 24(8), 1185-95.
  3. Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw JM (2013). Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proc Natl Acad Sci U S A, 110(15), E1342-51.
  4. Guo Q, Koirala S, Perkins EM, McCaffery JM, Shaw JM (2012). The mitochondrial fission adaptors Caf4 and Mdv1 are not functionally equivalent. PLoS One, 7(12), e53523.
  5. Bui HT, Karren MA, Bhar D, Shaw JM (2012). A novel motif in the yeast mitochondrial dynamin Dnm1 is essential for adaptor binding and membrane recruitment. J Cell Biol, 199(4), 613-22.
  6. Nguyen TT, Lewandowska A, Choi JY, Markgraf DF, Junker M, Bilgin M, Ejsing CS, Voelker DR, Rapoport TA, Shaw JM (2012). Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance. Traffic, 13(6), 880-90.
  7. Cohen MM, Amiott EA, Day AR, Leboucher GP, Pryce EN, Glickman MH, McCaffery JM, Shaw JM, Weissman AM (2011). Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion. J Cell Sci, 124(Pt 9), 1403-10.
  8. Koshiba T, Holman HA, Kubara K, Yasukawa K, Kawabata S, Okamoto K, MacFarlane J, Shaw JM (2011). Structure-function analysis of the yeast mitochondrial Rho GTPase, Gem1p: implications for mitochondrial inheritance. J Biol Chem, 286(1), 354-62.
  9. Koirala S, Bui HT, Schubert HL, Eckert DM, Hill CP, Kay MS, Shaw JM (2010). Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes. J Cell Biol, 191(6), 1127-39.
  10. Amiott EA, Cohen MM, Saint-Georges Y, Weissman AM, Shaw JM (2009). A mutation associated with CMT2A neuropathy causes defects in Fzo1 GTP hydrolysis, ubiquitylation, and protein turnover. Mol Biol Cell, 20(23), 5026-35.
  11. Kondo-Okamoto N, Shaw JM, Okamoto K (2008). Tetratricopeptide repeat proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis. EMBO Rep, 9(1), 63-9.
  12. Frederick RL, Okamoto K, Shaw JM (2008). Multiple pathways influence mitochondrial inheritance in budding yeast. Genetics, 178(2), 825-37.
  13. Amiott EA, Lott P, Soto J, Kang PB, McCaffery JM, DiMauro S, Abel ED, Flanigan KM, Lawson VH, Shaw JM (2008). Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations. Exp Neurol, 211(1), 115-27.
  14. Coonrod EM, Karren MA, Shaw JM (2007). Ugo1p is a multipass transmembrane protein with a single carrier domain required for mitochondrial fusion. Traffic, 8(5), 500-11.
  15. Bhar D, Karren MA, Babst M, Shaw JM (2006). Dimeric Dnm1-G385D interacts with Mdv1 on mitochondria and can be stimulated to assemble into fission complexes containing Mdv1 and Fis1. J Biol Chem, 281(25), 17312-20.
  16. Kondo-Okamoto N, Ohkuni K, Kitagawa K, McCaffery JM, Shaw JM, Okamoto K (2006). The novel F-box protein Mfb1p regulates mitochondrial connectivity and exhibits asymmetric localization in yeast. Mol Biol Cell, 17(9), 3756-67.
  17. Karren MA, Coonrod EM, Anderson TK, Shaw JM (2005). The role of Fis1p-Mdv1p interactions in mitochondrial fission complex assembly. J Cell Biol, 171(2), 291-301.
  18. Gorsich SW, Shaw JM (2004). Importance of mitochondrial dynamics during meiosis and sporulation. Mol Biol Cell, 15(10), 4369-81.
  19. Frederick RL, McCaffery JM, Cunningham KW, Okamoto K, Shaw JM (2004). Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway. J Cell Biol, 167(1), 87-98.
  20. Singer JM, Shaw JM (2003). Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast. Proc Natl Acad Sci U S A, 100(13), 7644-9.
  21. Kondo-Okamoto N, Shaw JM, Okamoto K (2003). Mmm1p spans both the outer and inner mitochondrial membranes and contains distinct domains for targeting and foci formation. J Biol Chem, 278(49), 48997-9005.
  22. Christensen CA, Gorsich SW, Brown RH, Jones LG, Brown J, Shaw JM, Drews GN (2002). Mitochondrial GFA2 is required for synergid cell death in Arabidopsis. Plant Cell, 14(9), 2215-32.
  23. Voth WP, Richards JD, Shaw JM, Stillman DJ (2001). Yeast vectors for integration at the HO locus. Nucleic Acids Res, 29(12), E59-9.
  24. Fukushima NH, Brisch E, Keegan BR, Bleazard W, Shaw JM (2001). The GTPase effector domain sequence of the Dnm1p GTPase regulates self-assembly and controls a rate-limiting step in mitochondrial fission. Mol Biol Cell, 12(9), 2756-66.
  25. Singer JM, Hermann GJ, Shaw JM (2000). Suppressors of mdm20 in yeast identify new alleles of ACT1 and TPM1 predicted to enhance actin-tropomyosin interactions. Genetics, 156(2), 523-34.
  26. Wong ED, Wagner JA, Gorsich SW, McCaffery JM, Shaw JM, Nunnari J (2000). The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria. J Cell Biol, 151(2), 341-52.
  27. Mozdy AD, McCaffery JM, Shaw JM (2000). Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J Cell Biol, 151(2), 367-80.

Review

  1. Bui HT, Shaw JM (2013). Dynamin assembly strategies and adaptor proteins in mitochondrial fission. [Review]. Curr Biol, 23(19), R891-9.
  2. Shaw JM, Winge DR (2009). Shaping the mitochondrion: mitochondrial biogenesis, dynamics and dysfunction. Conference on Mitochondrial Assembly and Dynamics in Health and Disease. [Review]. EMBO Rep, 10(12), 1301-5.
  3. Frederick RL, Shaw JM (2007). Moving mitochondria: establishing distribution of an essential organelle. [Review]. Traffic, 8(12), 1668-75.
  4. Okamoto K, Shaw JM (2005). Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes. [Review]. Annu Rev Genet, 39, 503-36.
  5. Mozdy AD, Shaw JM (2003). A fuzzy mitochondrial fusion apparatus comes into focus. [Review]. Nat Rev Mol Cell Biol, 4(6), 468-78.
  6. Shaw JM, Nunnari J (2002). Mitochondrial dynamics and division in budding yeast. [Review]. Trends Cell Biol, 12(4), 178-84.