Janet M. Shaw

Janet M. Shaw, PhD

Academic Information

Departments Emeritus - Biochemistry

Academic Office Information

shaw@biochem.utah.edu

Lab

Research Interests

  • Mitochondria
  • Mitochondrial Fusion
  • Mitochondrial Fission
  • Dynamics of Mitochondrial Membranes
  • Mitochondrial Diseases

Education History

Postdoctoral Fellowship University of California, Molecular Biology Institute
 Postdoctoral Fellow
University of California
 PhD
Undergraduate University of California
 BA

Selected Publications

Journal Article

  1. Schuler MH, Lewandowska A, Caprio GD, Skillern W, Upadhyayula S, Kirchhausen T, Shaw JM, Cunniff B (2017). Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration. Mol Biol Cell, 28(16), 2159-2169. (Read full article)
  2. Nguyen TT, Oh SS, Weaver D, Lewandowska A, Maxfield D, Schuler MH, Smith NK, Macfarlane J, Saunders G, Palmer CA, Debattisti V, Koshiba T, Pulst S, Feldman EL, Hajnoczky G, Shaw JM (2014). Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease. Proc Natl Acad Sci U S A, 111(35), E3631-40. (Read full article)
  3. Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw JM (2013). Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proc Natl Acad Sci U S A, 110(15), E1342-51. (Read full article)
  4. Lewandowska A, Macfarlane J, Shaw JM (2013). Mitochondrial association, protein phosphorylation, and degradation regulate the availability of the active Rab GTPase Ypt11 for mitochondrial inheritance. Mol Biol Cell, 24(8), 1185-95. (Read full article)
  5. Bui HT, Karren MA, Bhar D, Shaw JM (2012). A novel motif in the yeast mitochondrial dynamin Dnm1 is essential for adaptor binding and membrane recruitment. J Cell Biol, 199(4), 613-22. (Read full article)
  6. Nguyen TT, Lewandowska A, Choi JY, Markgraf DF, Junker M, Bilgin M, Ejsing CS, Voelker DR, Rapoport TA, Shaw JM (2012). Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance. Traffic, 13(6), 880-90. (Read full article)
  7. Guo Q, Koirala S, Perkins EM, McCaffery JM, Shaw JM (2012). The mitochondrial fission adaptors Caf4 and Mdv1 are not functionally equivalent. PLoS One, 7(12), e53523. (Read full article)
  8. Cohen MM, Amiott EA, Day AR, Leboucher GP, Pryce EN, Glickman MH, McCaffery JM, Shaw JM, Weissman AM (2011). Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion. J Cell Sci, 124(Pt 9), 1403-10. (Read full article)
  9. Koshiba T, Holman HA, Kubara K, Yasukawa K, Kawabata S, Okamoto K, MacFarlane J, Shaw JM (2011). Structure-function analysis of the yeast mitochondrial Rho GTPase, Gem1p: implications for mitochondrial inheritance. J Biol Chem, 286(1), 354-62. (Read full article)
  10. Koirala S, Bui HT, Schubert HL, Eckert DM, Hill CP, Kay MS, Shaw JM (2010). Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes. J Cell Biol, 191(6), 1127-39. (Read full article)
  11. Amiott EA, Cohen MM, Saint-Georges Y, Weissman AM, Shaw JM (2009). A mutation associated with CMT2A neuropathy causes defects in Fzo1 GTP hydrolysis, ubiquitylation, and protein turnover. Mol Biol Cell, 20(23), 5026-35. (Read full article)
  12. Amiott EA, Lott P, Soto J, Kang PB, McCaffery JM, DiMauro S, Abel ED, Flanigan KM, Lawson VH, Shaw JM (2008). Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations. Exp Neurol, 211(1), 115-27. (Read full article)
  13. Frederick RL, Okamoto K, Shaw JM (2008). Multiple pathways influence mitochondrial inheritance in budding yeast. Genetics, 178(2), 825-37. (Read full article)
  14. Kondo-Okamoto N, Shaw JM, Okamoto K (2008). Tetratricopeptide repeat proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis. EMBO Rep, 9(1), 63-9. (Read full article)
  15. Coonrod EM, Karren MA, Shaw JM (2007). Ugo1p is a multipass transmembrane protein with a single carrier domain required for mitochondrial fusion. Traffic, 8(5), 500-11. (Read full article)
  16. Kondo-Okamoto N, Ohkuni K, Kitagawa K, McCaffery JM, Shaw JM, Okamoto K (2006). The novel F-box protein Mfb1p regulates mitochondrial connectivity and exhibits asymmetric localization in yeast. Mol Biol Cell, 17(9), 3756-67. (Read full article)
  17. Bhar D, Karren MA, Babst M, Shaw JM (2006). Dimeric Dnm1-G385D interacts with Mdv1 on mitochondria and can be stimulated to assemble into fission complexes containing Mdv1 and Fis1. J Biol Chem, 281(25), 17312-20. (Read full article)
  18. Karren MA, Coonrod EM, Anderson TK, Shaw JM (2005). The role of Fis1p-Mdv1p interactions in mitochondrial fission complex assembly. J Cell Biol, 171(2), 291-301. (Read full article)
  19. Frederick RL, McCaffery JM, Cunningham KW, Okamoto K, Shaw JM (2004). Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway. J Cell Biol, 167(1), 87-98. (Read full article)
  20. Gorsich SW, Shaw JM (2004). Importance of mitochondrial dynamics during meiosis and sporulation. Mol Biol Cell, 15(10), 4369-81. (Read full article)
  21. Kondo-Okamoto N, Shaw JM, Okamoto K (2003). Mmm1p spans both the outer and inner mitochondrial membranes and contains distinct domains for targeting and foci formation. J Biol Chem, 278(49), 48997-9005. (Read full article)
  22. Singer JM, Shaw JM (2003). Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast. Proc Natl Acad Sci U S A, 100(13), 7644-9. (Read full article)
  23. Christensen CA, Gorsich SW, Brown RH, Jones LG, Brown J, Shaw JM, Drews GN (2002). Mitochondrial GFA2 is required for synergid cell death in Arabidopsis. Plant Cell, 14(9), 2215-32. (Read full article)
  24. Fukushima NH, Brisch E, Keegan BR, Bleazard W, Shaw JM (2001). The GTPase effector domain sequence of the Dnm1p GTPase regulates self-assembly and controls a rate-limiting step in mitochondrial fission. Mol Biol Cell, 12(9), 2756-66. (Read full article)
  25. Voth WP, Richards JD, Shaw JM, Stillman DJ (2001). Yeast vectors for integration at the HO locus. Nucleic Acids Res, 29(12), E59-9. (Read full article)
  26. Mozdy AD, McCaffery JM, Shaw JM (2000). Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J Cell Biol, 151(2), 367-80. (Read full article)
  27. Wong ED, Wagner JA, Gorsich SW, McCaffery JM, Shaw JM, Nunnari J (2000). The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria. J Cell Biol, 151(2), 341-52. (Read full article)
  28. Singer JM, Hermann GJ, Shaw JM (2000). Suppressors of mdm20 in yeast identify new alleles of ACT1 and TPM1 predicted to enhance actin-tropomyosin interactions. Genetics, 156(2), 523-34. (Read full article)

Review

  1. Bui HT, Shaw JM (2013). Dynamin assembly strategies and adaptor proteins in mitochondrial fission. [Review]. Curr Biol, 23(19), R891-9. (Read full article)
  2. Shaw JM, Winge DR (2009). Shaping the mitochondrion: mitochondrial biogenesis, dynamics and dysfunction. Conference on Mitochondrial Assembly and Dynamics in Health and Disease. [Review]. EMBO Rep, 10(12), 1301-5. (Read full article)
  3. Frederick RL, Shaw JM (2007). Moving mitochondria: establishing distribution of an essential organelle. [Review]. Traffic, 8(12), 1668-75. (Read full article)
  4. Okamoto K, Shaw JM (2005). Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes. [Review]. Annu Rev Genet, 39, 503-36. (Read full article)
  5. Mozdy AD, Shaw JM (2003). A fuzzy mitochondrial fusion apparatus comes into focus. [Review]. Nat Rev Mol Cell Biol, 4(6), 468-78. (Read full article)
  6. Shaw JM, Nunnari J (2002). Mitochondrial dynamics and division in budding yeast. [Review]. Trends Cell Biol, 12(4), 178-84. (Read full article)