Katharine S. Ullman, PhD

Research Interests

  • Cell Division
  • Cancer Biomarkers
  • Breast Cancer
  • Nuclear Pore Complex
  • Cytokinesis

Labs

Lab Website

Languages

  • English

Academic Information

  • Departments: Biochemistry - Adjunct Professor, Oncological Sciences - Professor
  • Cancer Center Programs: Cell Response & Regulation

Academic Office Information

  • 801-585-7123
  • Huntsman Cancer Institute
    2000 Circle of Hope, Room: 3262
    Salt Lake City, UT 84112

Academic Bio

Huntsman Cancer Institute (HCI) investigator Katharine Ullman, PhD, is a professor in the Department of Oncological Sciences at the University of Utah School of Medicine, an adjunct professor in the Department of Biochemistry at the University of Utah, and a member of the Cell Response and Regulation Program. She began serving as the Associate Dean of the Graduate School at the University of Utah in 2016.

Ullman and her research team focus on the coordination of cell division, with a particular interest in how disassembly and assembly of nuclear architecture is integrated with other events of cell division. The nucleus harbors a specialized environment, optimized to protect and regulate the cell's DNA. Mis-coordination of cellular remodeling during division leaves the DNA vulnerable to damage and mis-regulation. Elucidating this aspect of cell cycle control opens a new avenue to understanding cell function and how mistakes in division may contribute to tumorigenesis.

Ullman earned a PhD from Stanford University before going to the University of California at San Diego for her postdoctoral studies, which were funded in part by the American Cancer Society. She is a recipient of a Burroughs Wellcome Career Award in the Biomedical Sciences and a Scholar award from the Leukemia and Lymphoma Society.

Education History

Type School Degree
Postdoctoral Training University of California at San Diego
In the Laboratory of Dr. Douglass Forbes
Postdoctoral Training
Doctoral Training Stanford University
Microbiology & Immunology
Ph.D.
Undergraduate Northwestern University
Biochemistry, Molecular Biology & Cell Biology
B.A.

Selected Publications

Journal Article

  1. Enhanced arginine methylation of programmed cell death 4 protein during nutrient deprivation promotes tumor cell viability.Fay MM, Clegg JM, Uchida KA, Powers MA, Ullman KS (2014). Enhanced arginine methylation of programmed cell death 4 protein during nutrient deprivation promotes tumor cell viability. J Biol Chem, 289(25), 17541-52.
  2. The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function.Chow KH, Elgort S, Dasso M, Powers MA, Ullman KS (2014). The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function. Mol Biol Cell, 25(1), 160-8.
  3. The Nup153-Nup50 protein interface and its role in nuclear import.Makise M, Mackay DR, Elgort S, Shankaran SS, Adam SA, Ullman KS (2012). The Nup153-Nup50 protein interface and its role in nuclear import. J Biol Chem, 287(46), 38515-22.
  4. The nuclear envelope environment and its cancer connections.Chow KH, Factor RE, Ullman KS (2012). The nuclear envelope environment and its cancer connections. Nat Rev Cancer, 12(3), 196-209.
  5. Coordinating postmitotic nuclear pore complex assembly with abscission timing.Mackay DR, Ullman KS (2011). Coordinating postmitotic nuclear pore complex assembly with abscission timing. Nucleus, 2(4).
  6. Protein arginine methyltransferase 5 accelerates tumor growth by arginine methylation of the tumor suppressor programmed cell death 4.Powers MA, Fay MM, Factor RE, Welm AL, Ullman KS (2011). Protein arginine methyltransferase 5 accelerates tumor growth by arginine methylation of the tumor suppressor programmed cell death 4. Cancer Res, 71(16), 5579-87.
  7. Defects in nuclear pore assembly lead to activation of an Aurora B-mediated abscission checkpoint.Mackay DR, Makise M, Ullman KS (2010). Defects in nuclear pore assembly lead to activation of an Aurora B-mediated abscission checkpoint. J Cell Biol, 191(5), 923-31.
  8. The nucleoporin Nup153 has separable roles in both early mitotic progression and the resolution of mitosis.Mackay DR, Elgort SW, Ullman KS (2009). The nucleoporin Nup153 has separable roles in both early mitotic progression and the resolution of mitosis. Mol Biol Cell, 20(6), 1652-60.
  9. The COPI complex functions in nuclear envelope breakdown and is recruited by the nucleoporin Nup153.Liu J, Prunuske AJ, Fager AM, Ullman KS (2003). The COPI complex functions in nuclear envelope breakdown and is recruited by the nucleoporin Nup153. Dev Cell, 5(3), 487-98.

Other

  1. Time-lapse imaging of mitosis after siRNA transfection.LID - 10.3791/1878 [doi]LID - 1878 [pii]Mackay DR, Ullman KS, Rodesch CK (2010). Time-lapse imaging of mitosis after siRNA transfection.LID - 10.3791/1878 [doi]LID - 1878 [pii]. J Vis Exp ((40)). United States.