Evan Dale Abel, M.B.B.S., D.Phil.

Languages

  • English

Academic Information

  • Departments: Human Genetics - Adjunct Professor, Internal Medicine - Adjunct Professor
  • Divisions: Endocrinology and Metabolism

Board Certification

  • American Board of Internal Medicine (Internal Medicine)
  • American Board of Internal Medicine (Sub: Endocrinology, Diabetes & Metabolism)

Academic Office Information

  • (801) 585-0727
  • George and Dolores Eccles Institute of Human Genetics
    15 N 2030 E, Room: 3110B
    Salt Lake City, UT 84112

Academic Bio

E. Dale Abel, M.D., Ph.D. is Chief of the Division of Endocrinology, Metabolism & Diabetes at the University of Utah School of Medicine. He is also Medical Director of the Utah Diabetes & Endocrinology Center, Professor of Medicine, Biochemistry and Human Genetics and Investigator of the University of Utah Molecular Medicine Program.

Dr. Abel was recruited to the University of Utah in 2000 as an Assistant Professor and was promoted to Associate Professor of Medicine and Biochemistry in 2004, and Professor of Medicine and Biochemistry in 2008. Before that Dr. Abel was on the faculty at Harvard Medical School and co-Director of the Endocrinology Fellowship Program at the Beth Israel Deaconess Medical Center in Boston.

Dr. Abel received his Medical Degree with Distinction from the University of the West Indies. He then attended Oxford University as a Rhodes Scholar, where he obtained his D.Phil in the Nuffield Department of Medicine. After his doctoral studies, Dr. Abel completed internal medicine residency training at Northwestern University in Chicago where he served as Chief Medical Resident. He then moved to the Beth Israel Deaconess Medical Center, Harvard Medical School for training in Endocrinology. He is board certified in Internal Medicine and Endocrinology.

Dr. Abel’s current research interests focus on elucidating the molecular mechanisms leading to cardiac dysfunction in diabetes and the regulation of myocardial growth and metabolism by insulin signaling. Dr. Abel has been the recipient of numerous prestigious scholastic honors, including:

• 2012 Gerald D. Aurbach Award Lecture. International Laureate Award from The Endocrine Society for “outstanding” contributions to endocrinology research
• James A. Pulliam Memorial Lectureship Award 2012 from Meharry Medical College

This year, Dr. Abel was elected Chair of the Board of Scientific Counsellors NIDDK, Chair of the Sarnoff Cardiovascular Research Foundation’s Scientific Committee 2012 – 2013, Fellow of the American Heart Association and Fellow of The College of Physicians.

Education History

Type School Degree
Fellowship Harvard Medical School, Beth Israel Deaconess Medical Center
Endocrinology/Metabolism
Fellow
Chief Resident Northwestern University Medical School
Internal Medicine
Chief Resident
Residency Northwestern University
Internal Medicine
Resident
Doctoral Training University of Oxford
Physiology
D.Phil.
Internship University of the West Indies
Surgery, Medicine, OBGYN, Peds, ER
Intern
Professional Medical University of the West Indies
Medicine
M.B.B.S.
Undergraduate Wolmers Boys School
Pre-Medicine
Pre Med

Global Impact

Education History

Type School Degree Country
Doctoral Training University of Oxford
Physiology
D.Phil. United Kingdom
Internship University of the West Indies
Surgery, Medicine, OBGYN, Peds, ER
Intern Jamaica
Professional Medical University of the West Indies
Medicine
M.B.B.S. Jamaica
Undergraduate Wolmers Boys School
Pre-Medicine
Pre Med Jamaica

Selected Publications

Journal Article

  1. Chen JX, Krane M, Deutsch MA, Wang L, Rav-Acha M, Gregoire S, Engels M, Rajarajan K, Karra R, Abel ED, Wu JC, Milan D, Wu SM (2012). Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c,Tbx5. In Press. Circulation Research.
  2. Boudina S, Sena S, Sloan C, Tebbi A, Han YH, ONeill BT, Cooksey RC, Jones D, McClain DA, Abel ED (2012). Early Mitochondrial Adaptations in Skeletal Muscle to Diet-Induced Obesity are Strain Dependent and Determine Oxidative Stress and Energy Expenditure but not Insulin Sensitivity. Endocrinology.
  3. Zhang QJ, Holland WL, Wilson L, Tanner JM, Kearns D, Cahoon JM, Dix P, Losee J, Duncan B, Gale D, Kowalski CA, Deeter N, Nichols A, Michole Deesing M, Arrant C, Ruan T, Boehme C, McCamey DR, Rou J, Ambal K, Narra KK, Summers SA, Abel ED, Symons JD (2012). Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex. Diabetes.
  4. Marcus RL, Addison O, LaStayo PC, Hungerford R, Wende AR, Hoffman JM, Abel ED, McClain DA (2012). Regional muscle glucose uptake remains elevated 1 week after cessation of resistance training independent of altered insulin sensitivity response in older adults with type 2 diabetes. Journal of Endocrinological Investigation. Journal of Endocrinological Investigation.
  5. Bugger H, Riehle C, Jaishy B, Wende AR, Tuinei J, Chen D, Soto J, Pires KM, Boudina S, Theobald HA, Luptak I, Wayment B, Wang X, Sheldon E Litwin SE, Weimer BC, Abel ED (2012). Genetic Loss of Insulin Receptors Worsens Cardiac Efficiency in Diabetes. Journal of Molecular and Cellular Cardiology.
  6. Ock S, Ahn J, Lee SH, Park H, Son JW, Oh JG, Yang DK, Lee WS, Kim H-S, Rho J, Oh GT, Abel ED, Park WJ, Min J-K, Kim J (2012). Receptor activator of nuclear factor-κB ligand (RANKL) is a novel inducer of myocardial inflammation. Cardiovascular Research.
  7. Han CY, Umemoto T, Omer M, Den Hartigh LJ, Chiba T, LeBoeuf R, Buller CL, Sweet IR, Pennathur S, Abel ED, Chait A (2012). NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes. Journal of Biological Chemistry.
  8. Li Y, Wende AR, Nunthakungwan O, Huang, Y, Hu E, Jin H, Boudina S, Abel ED, Jalili T (2012). Cytosolic, but not mitochondrial, oxidative stress likely contributes to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice. 2012. The FEBS Journal.
  9. Troncoso R, Vicencio JM, Parra V, Nemchenko A, Kawashima Y, del Campo A, Toro B, Battiprolu PK, Aranguiz P, Chiong M, Yakar S, Gillette TG, Hill JA, Abel ED, LeRoith D, Lavandero S (2012). Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy. Cardiovascular Research, 93, 320-9.
  10. Ock S Lee SH, Ahn J, Lee TJ, Cho C-H, Abel ED, Kimura S, Kim J (2011). Conditional deletion of insulin receptor in thyrocytes does not affect thyroid structure and function. Endocrine Journal, 58, 1013-9.
  11. The maximal downstroke of epicardial potentials as an index of electrical activity in mouse hearts.Sohn K, Sachse FB, Moreno AP, Ershler PR, Wende AR, Abel ED, Punske BB (2011). The maximal downstroke of epicardial potentials as an index of electrical activity in mouse hearts. IEEE Trans Biomed Eng, 58(11), 3175-83.
  12. Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes.Li Y, Ma J, Zhu H, Singh M, Hill D, Greer PA, Arnold JM, Abel ED, Peng T (2011). Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes. Diabetes, 60(11), 2985-94.
  13. Oxidative phosphorylation flexibility in the liver of mice resistant to high-fat diet-induced hepatic steatosis.Poussin C, Ibberson M, Hall D, Ding J, Soto J, Abel ED, Thorens B (2011). Oxidative phosphorylation flexibility in the liver of mice resistant to high-fat diet-induced hepatic steatosis. Diabetes, 60(9), 2216-24.
  14. PGC-1beta deficiency accelerates the transition to heart failure in pressure overload hypertrophy.Riehle C, Wende AR, Zaha VG, Pires KM, Wayment B, Olsen C, Bugger H, Buchanan J, Wang X, Moreira AB, Doenst T, Medina-Gomez G, Litwin SE, Lelliott CJ, Vidal-Puig A, Abel ED (2011). PGC-1beta deficiency accelerates the transition to heart failure in pressure overload hypertrophy. Circ Res, 109(7), 783-93.
  15. Modulation of Glucose Transporter 1 (GLUT1) Expression Levels Alters Mouse Mammary Tumor Cell Growth In Vitro and In Vivo.Young CD, Lewis AS, Rudolph MC, Ruehle MD, Jackman MR, Yun UJ, Ilkun O, Pereira R, Abel ED, Anderson SM (2011). Modulation of Glucose Transporter 1 (GLUT1) Expression Levels Alters Mouse Mammary Tumor Cell Growth In Vitro and In Vivo. PLoS ONE, 6(8), e23205.
  16. Sloan C, Tuinei J, Nemetz K, Frandsen J, Soto J, Wride N, Sempokuya T, Alegria L, Bugger H, Abel ED (2011). Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric restricted ob/ob mice. Diabetes, 60, 1424-3.
  17. Expression of slow skeletal TnI in adult mouse hearts confers metabolic protection to ischemia.Pound KM, Arteaga GM, Fasano M, Wilder T, Fischer SK, Warren CM, Wende AR, Farjah M, Abel ED, Solaro RJ, Lewandowski ED (2011). Expression of slow skeletal TnI in adult mouse hearts confers metabolic protection to ischemia. Journal of Molecular and Cellular Cardiology, 51(2), 236-43.
  18. Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload.Symons JD, Hu P, Yang Y, Wang X, Zhang QJ, Wende AR, Sloan CL, Sena S, Abel ED, Litwin SE (2011). Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload. American Journal of Physiology: Heart and Circulatory Physiology, 300(1), H374-81.
  19. Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis.Huang J, Jones D, Luo B, Sanderson M, Soto J, Abel ED, Cooksey RC, McClain DA (2011). Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. Diabetes, 60(1), 80-7.
  20. 74 Fang X, Palanivel R, Cresser J, Schram K, Ganguly R, Thong FS, Tuinei J, Xu A, Abel ED, Sweeney G (2010). An APPL1-AMPK Signaling Axis Mediates Beneficial Metabolic Effects of Adiponectin in the Heart. American Journal of Physiology: Endocrinology and Metabolism, 299(5), E721-9.
  21. Fasting-induced reductions in cardiovascular and metabolic variables occur sooner in obese versus lean mice.Tanner JM, Kearns DT, Kim BJ, Sloan C, Jia Z, Yang T, Abel ED, Symons JD (2010). Fasting-induced reductions in cardiovascular and metabolic variables occur sooner in obese versus lean mice. Exp Biol Med (Maywood), 235(12), 1489-97.
  22. PPARgamma-induced cardiolipotoxicity in mice is ameliorated by PPARalpha deficiency despite increases in fatty acid oxidation.Son NH, Yu S, Tuinei J, Arai K, Hamai H, Homma S, Shulman GI, Abel ED, Goldberg IJ (2010). PPARgamma-induced cardiolipotoxicity in mice is ameliorated by PPARalpha deficiency despite increases in fatty acid oxidation. J Clin Invest, 120(10), 3443-54.
  23. Aberrant water homeostasis detected by stable isotope analysis.OGrady SP, Wende AR, Remien CH, Valenzuela LO, Enright LE, Chesson LA, Abel ED, Cerling TE, Ehleringer JR (2010). Aberrant water homeostasis detected by stable isotope analysis. PLoS One, 5(7), e11699.
  24. Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARalpha.Banke NH, Wende AR, Leone TC, ODonnell JM, Abel ED, Kelly DP, Lewandowski ED (2010). Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARalpha. Circ Res, 107(2), 233-41.
  25. Wende AR, Soto J, Olsen CD, Pires KM, Schell JC, Larrieu-Lahargue F, Litwin SE, Kakoki M, Takahashi N, Smithies O, Abel ED (2010). Loss of Bradykinin Signaling Does Not Accelerate the Development of Cardiac Dysfunction in Type 1 Diabetic Akita Mice. Endocrinology. 2010: In Press. Endocrinology.
  26. Cooksey RC, Jones D, Gabrielsen S, Huang J, Simcox JA, Luo B, Soesanto YA, Rienhoff H, Abel ED, McClain DA (2010). Dietary iron restriction or iron chelation protect from diabetes and loss of beta cell function in the obese (ob/ob lep-/-) mouse. Am J Physiol Endocrinol Metab. 2010: In Press. American Journal of Physiology: Endocrinology and Metabolism.
  27. Shimizu I, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M 1, Nojima A, Koh GY, Akazawa H, Shiojima I, Kahn CR, Abel ED, Komuro I (2010). Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload. Journal of Clinical Investigation, (120), 1506-14.
  28. Griesel BA, Weems J, Russell RA, Abel ED, Humphries K, Olson AL (2010). Acute inhibition of fatty acid import inhibits GLUT4 transcription in adipose tissue, but not skeletal or cardiac muscle tissue, partly through LXR signaling. Diabetes.
  29. Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth.Zhang Y, Soto J, Park K, Viswanath G, Kuwada S, Abel ED, Wang L (2010). Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol Cell Biol, 30(6), 1341-56.
  30. Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats.Soesanto W, Lin HY, Hu E, Lefler S, Litwin SE, Sena S, Abel ED, Symons JD, Jalili T (2009). Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats. Hypertension, 54(6), 1321-7.
  31. Insulin signaling regulates mitochondrial function in pancreatic beta-cells.Liu S, Okada T, Assmann A, Soto J, Liew CW, Bugger H, Shirihai OS, Abel ED, Kulkarni RN (2009). Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One, 4(11), e7983.
  32. Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy.Ikeda H, Shiojima I, Ozasa Y, Yoshida M, Holzenberger M, Kahn CR, Walsh K, Igarashi T, Abel ED, Komuro I (2009). Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy. J Mol Cell Cardiol, 47(5), 664-75.
  33. Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice.Bugger H, Chen D, Riehle C, Soto J, Theobald HA, Hu XX, Ganesan B, Weimer BC, Abel ED (2009). Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice. Diabetes, 58(9), 1986-97.
  34. Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases.Zhang QJ, McMillin SL, Tanner JM, Palionyte M, Abel ED, Symons JD (2009). Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases. J Physiol, 587(Pt 15), 3911-20.
  35. Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues.Bakirtzi K, Belfort G, Lopez-Coviella I, Kuruppu D, Cao L, Abel ED, Brownell AL, Kandror KV (2009). Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues. J Neurosci, 29(16), 5193-201.
  36. Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure.Symons JD, McMillin SL, Riehle C, Tanner J, Palionyte M, Hillas E, Jones D, Cooksey RC, Birnbaum MJ, McClain DA, Zhang QJ, Gale D, Wilson LJ, Abel ED (2009). Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure. Circ Res, 104(9), 1085-94.
  37. Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.Boudina S, Bugger H, Sena S, ONeill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel ED (2009). Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. Circulation (online), 119(9), 1272-83.
  38. Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction.Sena S, Hu P, Zhang D, Wang X, Wayment B, Olsen C, Avelar E, Abel ED, Litwin SE (2009). Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction. J Mol Cell Cardiol, 46(6), 910-8.
  39. The role of mPer2 clock gene in glucocorticoid and feeding rhythms.Yang S, Liu A, Weidenhammer A, Cooksey RC, McClain D, Kim MK, Aguilera G, Abel ED, Chung JH (2009). The role of mPer2 clock gene in glucocorticoid and feeding rhythms. Endocrinology, 150(5), 2153-60.
  40. Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding.Wright JJ, Kim J, Buchanan J, Boudina S, Sena S, Bakirtzi K, Ilkun O, Theobald HA, Cooksey RC, Kandror KV, Abel ED (2009). Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding. Cardiovasc Res, 82(2), 351-60.
  41. Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy.Kim J, Wende AR, Sena S, Theobald HA, Soto J, Sloan C, Wayment BE, Litwin SE, Holzenberger M, LeRoith D, Abel ED (2008). Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. Mol Endocrinol, 22(11), 2531-43.
  42. Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.Bugger H, Boudina S, Hu XX, Tuinei J, Zaha VG, Theobald HA, Yun UJ, McQueen AP, Wayment B, Litwin SE, Abel ED (2008). Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3. Diabetes, 57(11), 2924-32.
  43. Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism.Augustus AS, Buchanan J, Gutman E, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP (2008). Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism. Cell Cycle, 7(16).
  44. Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts.Augustus AS, Buchanan J, Addya S, Rengo G, Pestell RG, Fortina P, Koch WJ, Bensadoun A, Abel ED, Lisanti MP (2008). Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts. Am J Physiol Heart Circ Physiol, 295(2), H657-66.
  45. Reversal of oxidative stress in endothelial cells by controlled release of adiponectin.Mossalam M, Jeong JH, Abel ED, Kim SW, Kim YH (2008). Reversal of oxidative stress in endothelial cells by controlled release of adiponectin. J Control Release, 130(3), 234-7.
  46. Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations.Amiott EA, Lott P, Soto J, Kang PB, McCaffery JM, Dimauro S, Abel ED, Flanigan KM, Lawson VH, Shaw JM (2008). Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations. Exp Neurol, 211(1), 115-27.
  47. Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.Yin Z, Jones GN, Towns WH, Zhang X, Abel ED, Binkley PF, Jarjoura D, Kirschner LS (2008). Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis. Circulation, 117(11), 1414-22.
  48. Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts.Tabbi-Anneni I, Buchanan J, Cooksey RC, Abel ED (2008). Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts. Endocrinology, 149(8), 4043-50.
  49. Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity.Fang C, Gu J, Xie F, Behr M, Yang W, Abel ED, Ding X (2008). Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity. Drug Metab Dispos, 36(8), 1722-8.
  50. The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP (2008). The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis. Am J Physiol Heart Circ Physiol, 295(1), H185-96.
  51. Ceramide is a cardiotoxin in lipotoxic cardiomyopathy.Park TS, Hu Y, Noh HL, Drosatos K, Okajima K, Buchanan J, Tuinei J, Homma S, Jiang XC, Abel ED, Goldberg IJ (2008). Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. J Lipid Res, 49(10), 2101-12.
  52. Jouihan HA, Cobine PA, Cooksey RC, Hoagland EA, Boudina S, Abel ED, Winge DR, McClain DA (2008). Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis. Molecular Medicine, 14(3-4), 98-108.
  53. Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression.Bray MS, Shaw CA, Moore MW, Garcia RA, Zanquetta MM, Durgan DJ, Jeong WJ, Tsai JY, Bugger H, Zhang D, Rohrwasser A, Rennison JH, Dyck JR, Litwin SE, Hardin PE, Chow CW, Chandler MP, Abel ED, Young ME (2008). Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. American Journal of Physiology: Heart and Circulatory Physiology, 294(2), H1036-47.
  54. Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins.Boudina S, Sena S, Theobald H, Sheng X, Wright JJ, Hu XX, Aziz S, Johnson JI, Bugger H, Zaha VG, Abel ED (2007). Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes, 56(10), 2457-66.
  55. Cardiac hypertrophy caused by peroxisome proliferator- activated receptor-gamma agonist treatment occurs independently of changes in myocardial insulin signaling.Sena S, Rasmussen IR, Wende AR, McQueen AP, Theobald HA, Wilde N, Pereira RO, Litwin SE, Berger JP, Abel ED (2007). Cardiac hypertrophy caused by peroxisome proliferator- activated receptor-gamma agonist treatment occurs independently of changes in myocardial insulin signaling. Endocrinology, 148(12), 6047-53.
  56. CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice.Benjamin IJ, Guo Y, Srinivasan S, Boudina S, Taylor RP, Rajasekaran NS, Gottlieb R, Wawrousek EF, Abel ED, Bolli R (2007). CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice. Am J Physiol Heart Circ Physiol, 293(5), H3201-9.
  57. PAS kinase is required for normal cellular energy balance.Hao HX, Cardon CM, Swiatek W, Cooksey RC, Smith TL, Wilde J, Boudina S, Abel ED, McClain DA, Rutter J (2007). PAS kinase is required for normal cellular energy balance. Proc Natl Acad Sci U S A, 104(39), 15466-71.
  58. A Conserved Role for Phosphatidylinositol 3-Kinase but Not Akt Signaling in Mitochondrial Adaptations that Accompany Physiological Cardiac Hypertrophy.ONeill BT, Kim J, Wende AR, Theobald HA, Tuinei J, Buchanan J, Guo A, Zaha VG, Davis DK, Schell JC, Boudina S, Wayment B, Litwin SE, Shioi T, Izumo S, Birnbaum MJ, Abel ED (2007). A Conserved Role for Phosphatidylinositol 3-Kinase but Not Akt Signaling in Mitochondrial Adaptations that Accompany Physiological Cardiac Hypertrophy. Cell Metabolism, 6(4), 294-306.
  59. Menage-a-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Makela TP, Schneider MD (2007). Menage-a-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. Cell Metab, 5(2), 129-42.
  60. Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Bloun M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Stromstedt M, Snaith M, Ore M, Abel ED, Cannon B, Vidal-Puig A (2006). Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. P L o S Biology Online, 4(11), e369.
  61. Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction.Augustus AS, Buchanan J, Park TS, Hirata K, Noh HL, Sun J, Homma S, Darmiento J, Abel ED, Goldberg IJ (2006). Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction. Journal of Biological Chemistry, 281(13), 8716-23.
  62. Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin.Durgan DJ, Smith JK, Hotze MA, Egbejimi O, Cuthbert KD, Zaha VG, Dyck JR, Abel ED, Young ME (2006). Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin. Am J Physiol Heart Circ Physiol, 290(6), H2480-97.
  63. Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase.Buerger A, Rozhitskaya O, Sherwood MC, Dorfman AL, Bisping E, Abel ED, Pu WT, Izumo S, Jay PY (2006). Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. J Card Fail, 12(5), 392-8.
  64. Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1.Rui T, Feng Q, Lei M, Peng T, Zhang J, Xu M, Abel ED, Xenocostas A, Kvietys PR (2005). Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1. Cardiovasc Res, 65(3), 719-27.
  65. PGC-1a deficient mice exhibit multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP (2005). PGC-1a deficient mice exhibit multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PL o S Biology, 3(4), e101.
  66. The intrinsic circadian clock within the cardiomyocyte.Durgan DJ, Hotze MA, Tomlin TM, Egbejimi O, Graveleau C, Abel ED, Shaw CA, Bray MS, Hardin PE, Young ME (2005). The intrinsic circadian clock within the cardiomyocyte. Am J Physiol Heart Circ Physiol, 289(4), H1530-41.
  67. Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action.Graveleau C, Zaha VG, Mohajer A, Banerjee RR, Dudley-Rucker N, Steppan CM, Rajala MW, Scherer PE, Ahima RS, Lazar MA, Abel ED (2005). Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action. J Biol Chem, 280(36), 31679-85.
  68. Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.Buchanan J, Mazumder PK, Hu P, Chakrabarti G, Roberts MW, Yun UJ, Cooksey RC, Litwin SE, Abel ED (2005). Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity. Endocrinology, 146(12), 5341-9.
  69. Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density.McQueen AP, Zhang D, Hu P, Swenson L, Yang Y, Zaha VG, Hoffman JL, Yun UJ, Chakrabarti G, Wang Z, Albertine KH, Abel ED, Litwin SE (2005). Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density. J Mol Cell Cardiol, 39(6), 882-92.
  70. Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity.Boudina S, Sena S, ONeill BT, Tathireddy P, Young ME, Abel ED (2005). Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. Circulation, 112(17), 2686-95.
  71. Gender-dependent attenuation of cardiac potassium currents in type 2 diabetic db/db mice.Shimoni Y, Chuang M, Abel ED, Severson DL (2004). Gender-dependent attenuation of cardiac potassium currents in type 2 diabetic db/db mice. J Physiol, 555(Pt 2), 345-54.
  72. Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure.Hayashi M, Kim SW, Imanaka-Yoshida K, Yoshida T, Abel ED, Eliceiri B, Yang Y, Ulevitch RJ, Lee JD (2004). Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J Clin Invest, 113(8), 1138-48.
  73. Regulation of insulin-responsive aminopeptidase expression and targeting in the insulin-responsive vesicle compartment of glucose transporter isoform 4-deficient cardiomyocytes.Abel ED, Graveleau C, Betuing S, Pham M, Reay PA, Kandror V, Kupriyanova T, Xu Z, Kandror KV (2004). Regulation of insulin-responsive aminopeptidase expression and targeting in the insulin-responsive vesicle compartment of glucose transporter isoform 4-deficient cardiomyocytes. Mol Endocrinol, 18(10), 2491-501.
  74. Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle.Stavinoha MA, RaySpellicy JW, Essop MF, Graveleau C, Abel ED, Hart-Sailors ML, Mersmann HJ, Bray MS, Young ME (2004). Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle. Am J Physiol Endocrinol Metab, 287(5), E888-95.
  75. Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts.Mazumder PK, ONeill BT, Roberts MW, Buchanan J, Yun UJ, Cooksey RC, Boudina S, Abel ED (2004). Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. Diabetes, 53(9), 2366-74.
  76. Optical mapping of propagation changes induced by elevated extracellular potassium ion concentration in genetically altered mouse hearts.Punske BB, Rossi S, Ershler P, Rasmussen I, Abel ED (2004). Optical mapping of propagation changes induced by elevated extracellular potassium ion concentration in genetically altered mouse hearts. J Electrocardiol, 37 Suppl, 128-34.
  77. Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload.Hu P, Zhang D, Swenson L, Chakrabarti G, Abel ED, Litwin SE (2003). Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload. Am J Physiol Heart Circ Physiol, 285(3), H1261-9.
  78. Dominant inhibition of thyroid hormone action selectively in the pituitary of thyroid hormone receptor-beta null mice abolishes the regulation of thyrotropin by thyroid hormone.Abel ED, Moura EG, Ahima RS, Campos-Barros A, Pazos-Moura CC, Boers ME, Kaulbach HC, Forrest D, Wondisford FE (2003). Dominant inhibition of thyroid hormone action selectively in the pituitary of thyroid hormone receptor-beta null mice abolishes the regulation of thyrotropin by thyroid hormone. Mol Endocrinol, 17(9), 1767-76.
  79. Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression.Belke DD, Betuing S, Tuttle MJ, Graveleau C, Young ME, Pham M, Zhang D, Cooksey RC, McClain DA, Litwin SE, Taegtmeyer H, Severson D, Kahn CR, Abel ED (2002). Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. Journal of Clinical Investigation, 109(5), 629-39.
  80. Akt signaling mediates postnatal heart growth in response to insulin and nutritional status.Shiojima I, Yefremashvili M, Luo Z, Kureishi Y, Takahashi A, Tao J, Rosenzweig A, Kahn CR, Abel ED, Walsh K (2002). Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem, 277(40), 37670-7.
  81. Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis.Pachucki J, Hopkins J, Peeters R, Tu H, Carvalho SD, Kaulbach H, Abel ED, Wondisford FE, Ingwall JS, Larsen PR (2001). Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis. Endocrinology, 142(1), 13-20.
  82. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver.Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, Minnemann T, Shulman GI, Kahn BB (2001). Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature, 409(6821), 729-33.
  83. An unliganded thyroid hormone receptor causes severe neurological dysfunction.Hashimoto K, Curty FH, Borges PP, Lee CE, Abel ED, Elmquist JK, Cohen RN, Wondisford FE (2001). An unliganded thyroid hormone receptor causes severe neurological dysfunction. Proc Natl Acad Sci U S A, 98(7), 3998-4003.
  84. Critical role for thyroid hormone receptor beta2 in the regulation of TRH neurons in the paraventricular hypothalamus.Abel ED, Ahima RS, Boers ME, Elmquist JK, Wondisford FE (2001). Critical role for thyroid hormone receptor beta2 in the regulation of TRH neurons in the paraventricular hypothalamus. Journal of Clinical Investigation, 107(8), 1017-23.
  85. Responses of GLUT4-deficient hearts to ischemia underscore the importance of glycolysis.Tian R, Abel ED (2001). Responses of GLUT4-deficient hearts to ischemia underscore the importance of glycolysis. Circulation, 103(24), 2961-6.
  86. Cardiac dysfunction caused by myocardium-specific expression of a mutant thyroid hormone receptor.Pazos-Moura C, Abel ED, Boers ME, Moura E, Hampton TG, Wang J, Morgan JP, Wondisford FE (2000). Cardiac dysfunction caused by myocardium-specific expression of a mutant thyroid hormone receptor. Circ Res, 86(6), 700-6.
  87. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JF, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR, Kahn BB (2000). Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med, 6(8), 924-8.
  88. Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart.Abel ED, Kaulbach HC, Tian R, Hopkins JC, Duffy J, Doetschman T, Minnemann T, Boers ME, Hadro E, Oberste-Berghaus C, Quist W, Lowell BB, Ingwall JS, Kahn BB (1999). Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J Clin Invest, 104(12), 1703-14.
  89. Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin.Abel ED, Kaulbach HC, Campos-Barros A, Ahima RS, Boers ME, Hashimoto K, Forrest D, Wondisford FE (1999). Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin. J Clin Invest, 103(2), 271-9.
  90. Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system.Abel ED, Boers ME, Pazos-Moura C, Moura E, Kaulbach H, Zakaria M, Lowell B, Radovick S, Liberman MC, Wondisford F (1999). Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system. J Clin Invest, 104(3), 291-300.
  91. Mice expressing human but not murine beta3-adrenergic receptors under the control of human gene regulatory elements.Ito M, Grujic D, Abel ED, Vidal-Puig A, Susulic VS, Lawitts J, Harper ME, Himms-Hagen J, Strosberg AD, Flier JS, Lowell BB (1998). Mice expressing human but not murine beta3-adrenergic receptors under the control of human gene regulatory elements. Diabetes, 47(9), 1464-71.
  92. Impaired glucose tolerance in hypertension is associated with impaired insulin release independently of changes in insulin sensitivity.Abel ED, Ledingham JG (1994). Impaired glucose tolerance in hypertension is associated with impaired insulin release independently of changes in insulin sensitivity. Journal of Hypertension, 12(11), 1265-1273.
  93. Leukocyte sodium content and sodium pump activity in overweight and lean hypertensives.Ng LL, Harker M, Abel ED (1989). Leukocyte sodium content and sodium pump activity in overweight and lean hypertensives. Clinical Endocrinology, 30(2), 191-200.
  94. Mechanisms of leukocyte sodium influx in essential hypertension.Ng LL, Harker M, Abel ED (1988). Mechanisms of leukocyte sodium influx in essential hypertension. Clinical Science, 75(5), 521-6.

Review

  1. Abel ED, Sweeny G (2012). Modulation of the cardiovascular system by leptin. [Review]. Biochimie.
  2. Ardehali H, Sabbah HN, Burke MA, Sarma S, Liu PP, Cleland JGF, Maggioni A, Gregg C Fonarow GC, Abel ED, Campia U, Gheorghiade M (2012). Targeting myocardial substrate metabolism in heart failure: Potential for new therapies. [Review]. European Journal of Heart Failure, 14, 120-9.
  3. Abel ED, Doenst T (2011). Mitochondrial adaptations to physiological versus pathological cardiac hypertrophy. [Review]. Cardiovascular Research, 90(2), 234-42.
  4. Abel ED (2010). Free fatty acid oxidation in insulin resistance and obesity. [Review]. Heart and Metabolism: Management of the Coronary Patient, 48, 1-6.
  5. Bugger H, Abel ED (2010). Mitochondria in the diabetic heart. [Review]. Cardiovascular Research, 88(2), 229-40.
  6. Boudina S, Abel ED (2010). Diabetic cardiomyopathy, causes and effects. [Review]. Reviews in Endocrine & Metabolic Disorders, 11, 31-9.
  7. Lipotoxicity in the heart.Wende AR, Abel ED (2010). Lipotoxicity in the heart. [Review]. Biochimica et Biophysica Acta, 1801(3), 311-9.
  8. Rodent models of diabetic cardiomyopathy.Bugger H, Abel ED (2009). Rodent models of diabetic cardiomyopathy. [Review]. Disease Models and Mechanisms, 2(9-10), 454-66.
  9. Bugger H, Abel ED (2008). Molecular basis of cardiac efficiency. [Review]. Heart and Metabolism: Management of the Coronary Patient, 39, 1-5.
  10. Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome.Bugger H, Abel ED (2008). Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome. [Review]. Clin Sci (Lond), 114(3), 195-210.
  11. Abel ED, Litwin SE, Sweeney GD (2008). Cardiac remodeling in obesity. [Review]. Physiological Reviews, 88(2), 389-419.
  12. Recipes for creating animal models of diabetic cardiovascular disease.Hsueh W, Abel ED, Breslow JL, Maeda N, Davis RC, Fisher EA, Dansky H, McClain DA, McIndoe R, Wassef MK, Rabadan-Diehl C, Goldberg IJ (2007). Recipes for creating animal models of diabetic cardiovascular disease. [Review]. Circ Res, 100(10), 1415-27.
  13. Diabetic cardiomyopathy revisited.Boudina S, Abel ED (2007). Diabetic cardiomyopathy revisited. [Review]. Circulation, 115(25), 3213-23.
  14. Abel ED (2007). Glucose for the aging heart? [Review]. Circulation, 116(8), 884-887.
  15. Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.Boudina S, Abel ED (2006). Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes. [Review]. Physiology (Bethesda), 21, 250-8.
  16. ONeill BT, Abel ED (2005). Akt1 in the cardiovascular system: friend or foe? [Review]. Journal of Clinical Investigation, 115, 2059-64.
  17. Abel ED (2005). Metabolic perturbations in the diabetic heart: Mechanisms and molecular targets. [Review]. Drug Discovery Today: Disease Mechanisms, 2, 115-122.
  18. Myocardial insulin resistance and cardiac complications of diabetes.Abel ED (2005). Myocardial insulin resistance and cardiac complications of diabetes. [Review]. Current Drug Targets. Immune, Endocrine & Metabolic Disorders, 5(2), 219-26.
  19. Vidal-Puig AJ, Abel ED Volume Cardiovascular Pharmacogenetics Edited by Martin R Wilkins Heidelberg Springer-Verlag (2004). Insulin resistance and cardiovascular disease - New insights from genetics. [Review]. Handbook of Experimental Pharmacology, 243-279.
  20. Glucose transport in the heart.Abel ED (2004). Glucose transport in the heart. [Review]. Front Biosci, 9, 201-15.
  21. Insulin signaling in heart muscle: lessons from genetically engineered mouse models.Abel ED (2004). Insulin signaling in heart muscle: lessons from genetically engineered mouse models. [Review]. Current Hypertension Reports, 6(6), 416-23.
  22. McCowen KC, Abel ED (2000). The contribution of defects in insulin signaling in skeletal muscle to insulin resistance and Type 2 diabetes: Cellular and molecular aspects. Editor. JAI Press. [Review]. Advances in Structural Biology, 6, 41-64.
  23. Abel ED, Houseknecht KL, Kahn BB (1995). Recent advances in understanding the molecular basis for insulin stimulated glucose transport. [Review]. Current Opinion in Endocrinology & Diabetes, 2(4), 313-324.

Book Chapter

  1. Sweeney GD, Litwin SE, Abel ED Edited by Rexford A Ahima Publisher Springer-Verlag, NY (2010). Obesity and cardiac dysfunction. In Rexford A. Ahima (Ed.), Metabolic Basis of Obesity (pp. 257-292). New York: Springer-Verlag.
  2. Abel ED (2002). Glucose transporters and cardiac function. Insights from heart selective GLUT4 knockout mice. Editors G. Grunberger and Y. Zick. In G. Grunberger and Y. Zick (Eds.), Frontiers in animal diabetes research. Insulin signaling: From cultured cells to animal models (3, pp. 397-408).
  3. Abel ED, Shepherd PR, Kahn BB (1996). Glucose transporters and pathophysiologic states. In Leroith D, Olefsky JM and Taylor S (Eds.), Diabetes Mellitus a Fundamental and Clinical Text (pp. 530-543). Philadelphia: JB Lippincott.

Editorial

  1. Bugger H, Abel ED (2012). Endonuclease G: the link between mitochondria and cardiac hypertrophy? Circulation Research, 110, 378-80.
  2. A new twist in the function of the cardiac lipid droplet.Abel ED (2011). A new twist in the function of the cardiac lipid droplet. Nat Med, 17(9), 1045-6.
  3. Obesity stresses cardiac mitochondria even when you are young.Abel ED (2011). Obesity stresses cardiac mitochondria even when you are young. J Am Coll Cardiol, 57(5), 586-9.

Abstract

  1. Bharat Jaishy, Adam R Wende, Curtis Olsen, E Dale Abel (2011). Fat Feeding or Palmitate Exposure Induces Autophagy in Cardiomyocytes Independently of Changes in Insulin Signaling to Akt and F0X01 [Abstract]. Diabetes, 1557.
  2. Renata O Pereira, Adam R Wende, Jamie Soto, E Dale Abel (2011). Short-Term Increase in Glut1-Mediated Myocardial Glucose Uptake Preserves Mitochondrial Function but Does Not Prevent Cardiac Dysfunction Following Pressure Overload Hypertrophy [Abstract]. Diabetes, 1491.
  3. Quan-Jiang Zhang, Nicholas B Deeter, Alexandrea Nichols, Michole Deesing, Chris Kowalski, William L Holland, Scott A Summers, E Dale Abel, J David Symons (2011). Ceramide-Induced Vascular Dysfunction Results from PP2A Association with ENOS [Abstract]. Diabetes, 576.
  4. Donald A McClain, Robert C Cooksey, Scott Gabrielsen, JingYu Huang, Judith A Simcox, Deborah Jones, E Dale Abel, Hugh Rienhoff (2010). Dietary Iron Restriction or Iron Chelation Protect from Diabetes and Loss of Beta Cell Function in the Obese (Ob/Ob Lep) Mouse [Abstract]. Diabetes, 1525.
  5. Yi Zhu, Brian T Oneill, Olesya Ilkun, E Dale Abel (2010). Constitutive Activation of Phosphatidylinositol 3-Kinase (PI3K) p110 Impairs Insulin [Abstract]. Diabetes, 1364.
  6. Crystal L Sloan, Joseph Tuinei, and E Dale Abel (2010). Hypothalamic Leptin Resistance Contributes to Increased Myocardial Fatty Acid Oxidation Rates in Obesity [Abstract]. Circulation, (122), A17402.
  7. Ariel Contreras-Ferrat, Adam R Wende, Amira Klip, Sergio Lavandero, and E Dale Abel (2010). Insulin-Mediated GLUT4 Translocation Requires Intracellular and Extracellular Calcium and is Impaired by Short-Term High Fat Feeding [Abstract]. Circulation, (122), A17501.
  8. Quan-Jiang Zhang, Adam R Wende, Yi Zhu, and E Dale Abel (2010). Phopshoinositide-Dependent Protein Kinase-1 Mediates Fasting Induced Autophagy in the Heart [Abstract]. Circulation, (122), A18652.
  9. Heiko Bugger, Chintan K Kikani, William L Holland, Garrett Locketz, Genevieve Sparagna, Scott A Summers, Jared Rutter, Jean E Schaffer, and E Dale Abel (2009). Impaired Mitochondrial Dynamics: A Novel Mechanism for Lipotoxic Heart Disease [Abstract]. Circulation, (120), S744.
  10. Olesya Ilkun, Joseph Tuinei, Karla M Pires, Heiko Bugger, Benjamin Wayment, Curtis Olsen, Sheldon E Litwin, and E Dale Abel (2009). Cardiac-specific Overexpression of Mitochondrial Superoxide Dismutase Leads to Myocardial Insulin Resistance [Abstract]. Circulation, (120), S856.
  11. Adam R Wende, Karla M Pires, Benjamin Wayment, Joseph Tuinei, Nam H Jeoung, Sheldon E Litwin, Robert A Harris, and E Dale Abel (2009). Pyruvate Dehydrogenase Kinase 4 (PDK4) Deficiency Does Not Impair the Cardiac Metabolic or Contractile Response to Pressure Overload Hypertrophy [Abstract]. Circulation, (120), S880.
  12. Olesya Ilkun, Joseph Tuinei, Karla M Pires, Heiko Bugger, Sheldon E Litwin, and E Dale Abel (2009). Oxidative Stress Mediates Cardiac Hypertrophy and Myocardial Insulin Resistance in the UCP-DTA Mouse Model of the Metabolic Syndrome [Abstract]. Circulation, (120), S892.
  13. Christian Riehle, Heiko Bugger, Sandra Sena, Karla M Pires, Heather A Theobald, Cynthia N Perry-Garza, Deborah Frank, Xiaocheng Dong, Anne Moon, Roberta Gottlieb, Morris F White, and E Dale Abel (2009). Insulin Receptor Substrates (IRS) are Critical Regulators of Autophagy and Cardiomyocyte Survival [Abstract]. Circulation, (120), S901.
  14. Sihem Boudina, Heiko Bugger, Sandra Sena, Brian T ONeill, Vlad G Zaha, Olesya Ilkun, Jordan J Wright, Pradip K Mazumder, Eric Palfreyman, Timothy J Tidwell, Heather Theobald, Oleh Khalimonchuk, Benjamin Wayment, Xiaoming Sheng, Kenneth J Rodnick, Ryan Centini, Dong Chen, Sheldon E Litwin, Bart E Weimer, and E Dale Abel (02/23/2009). Contribution of Impaired Myocardial Insulin Signaling to Mitochondrial Dysfunction and Oxidative Stress in the Heart [Abstract]. Molecular Cardiology, (119), 1272-1283.
  15. Symons JD, Holland W, Gale D, Tanner J, Cahoon J, Wilson L, Losee J, Pettey D, Narra K, Wang L, Abel ED, Summers S (2009). Endogenous Ceramide Biosynthesis Impairs Vascular Function in a Tissue Autonomous Manner [Abstract]. Diabetes. 69th Scientific Session of the American Diabetes Association, 58, A361.
  16. Sloan CL, Tuinei J, Soto J, Bugger H, Abel ED (2009). Persistent Metabolic Dysfunction in Hearts of Pair-Fed ob/ob and db/db Mice Despite Normalization of Body Weight and Glucose Tolerance [Abstract]. Diabetes. 69th Scientific Session of the American Diabetes Association, 58, A340.
  17. Wende AR, Soto J, Schell JC, Olsen CD, Litwin SE, Kakoki M, Takahashi N, Smithies O, Abel ED (2009). Impact of Bradykinin Receptor Deficiency on Cardiac Contractility and Mitochondrial Function in Type 1 Diabetic Akita Mice [Abstract]. Diabetes. 69th Scientific Session of the American Diabetes Association, 58, A338.
  18. Pereira R, Sena S, Bray MS, Moura AS, Abel ED (2009). Parental High-Fat Diet Programs Insulin Sensitivity and Susceptibility to Diet-Induced Obesity in the Offspring [Abstract]. Diabetes. 69th Scientific Session of the American Diabetes Association, 58, A93-94.
  19. Wende AR, Schell JC, Tuinei J, Yun UJ, Abel ED (2009). Enhanced Myocardial Glucose Delivery Accelerates Development of Diabetic Contractile and Mitochondrial Dysfunction [Abstract]. Diabetes. 69th Scientific Session of the American Diabetes Association, 58, A28.
  20. Bugger H, Riehle C, Wende AR, Wayment B, Chen D, Weimer BC, Litwin SE, Abel ED (2009). Insulin Resistance and Hyperglycemia Synergistically Impair Mitochondrial Function without Further Impairing Myocardial Function [Abstract]. Diabetes. 69th Scientific Session of the American Diabetes Association, 58, A28.
  21. Zhu Y, Pires KM, Wayment B, Thomas G, Kozma SC, Abel ED (2008). Mammalian Target of Rapamyacin (mTOR) is Essential for Murine Heart Development [Abstract]. Circulation. American Heart Association 62nd Scientific Sessions, 118.
  22. Wende AR, Schell JC, Tuinei J, Yun UJ, Abel ED (2008). Short-term, Cardiac Specific Overexpression of GLUT4 Does Not Rescue Metabolic and Contractile Dysfunction in the Diabetic Heart [Abstract]. Circulation. American Heart Association 62nd Scientific Sessions, 118.
  23. Bugger H, Hu XX, Tuinei J, Theobald H, Hollan WL, Sparagna G, Summer SA, Schaffer JE, Abel ED (2008). Increased Myocardial Fatty Acid Uptake by Acyl-CoA Synthesase 1 Impairs Mytochondrial Function and Dynamics [Abstract]. Circulation. American Heart Association 62nd Scientific Sessions, 118.
  24. Riehle C, Wayment B, Pires KM, Moreira AB, Theobald H, Dong X, White MF, Litwin SE, Abel ED (2008). Insulin Receptor Substrates (IRS) Signaling are Essential Regulators of Mitochondrial Function and Cardiomyocyte Survival [Abstract]. Circulation. American Heart Association 62nd Scientific Sessions, 118.
  25. Riehle C, Zaha VG, Wende AR, Hu P, Gomez GM, Lelliot C, Vidal-Puig A, Abel ED (2008). Role of PGC-1β in the Regulation of Myocardial Mitochondrial Function [Abstract]. Diabetes. 68th Scientific Sessions of the American Diabetes Association, 57, A430.
  26. Kim J, Wende AR, Sena S, Wayment BE, Litwin SE, Abel ED (2008). Insulin Receptor Deficient Hearts Exhibit a Normal Hypertrophic Response to Exercise Training Despite Reduced Baseline Cardiac Size: Potential Compensatory Role for Cardiac IGF-1 Receptor Signaling [Abstract]. Diabetes.68th Scientific Sessions of the American Diabetes Association, 57, A379.
  27. Ilkun O, Tuinei J, Soto J, Abel ED (2008). Role of Oxidative Stress in Myocardial Insulin Resistance [Abstract]. Diabetes.68th Scientific Sessions of the American Diabetes Association, 57, A373.
  28. Heiko Bugger, Xia Xuan Hu, Joseph Tuinei, Vlad G Zaha, Sihem Boudina, Ui Jeong Yun, Sheldon E Litwin, E Dale Abel (2008). Preserved Mitochondrial Coupling Despite Increased Uncoupling Protein 3 Abundance in Type 1 Diabetic Akita Mouse Hearts [Abstract]. Diabetes.68th Scientific Sessions of the American Diabetes Association, 57, A372.
  29. Wilde N, Tuinei J, Abel ED (2007). Treatment of db/db Mice with the Catalytic Antioxidant MnTBAP Restores Mitochondrial Energetics and Normalizes Fatty Acid Oxidation [Abstract]. Circulation. American Heart Association 61st Scientific Sessions, 116(16 Suppl).
  30. Tabbi-Anneni I, Buchanan J, Cooksey RC, Abel ED (2007). Captopril Restores Insulin Sensitivity in ob/ob Mouse Hearts [Abstract]. Circulation. American Heart Association 61st Scientific Sessions, 116(16 Suppl).
  31. Sloan C, Tuinei J, Abel ED (2007). Myocardial Fatty Acid Oxidation Rates Remain Elevated in ob/ob Mice Despite Reversal of Obesity and Diabetes by Caloric Restriction [Abstract]. Circulation. American Heart Association 61st Scientific Sesssion, 116(16 Suppl.).
  32. Park T, Hu Y, Okajima K, Buchanan J, Homma S, Davidson MM, Abel ED, Jiang X, Goldberg IJ (2007). Inhibition Of Ceramide Biosynthesis Decreases Cardiomyopathy In Lipoprotein Lipase (LpL) Lipotoxicity [Abstract]. Circulation. American Heart Association 61st Scientific Session, 116(16 Suppl.).
  33. Stringham J, Jerman JD, Abel ED, Christensen M, Ericksen A, Evans T, Stringham TR (2007). Prevalence of Type 2 Diabetes Mellitus in Cambodia vs. the Prevalence of Type 2 Diabetes Mellitus in Cambodian Emigrants Living in Long Beach, California: An Urbanization Effect Analysis [Abstract]. Diabetes.67th Scientific Sessions of the American Diabetes Association, 56.
  34. Kim JT, Wende AR, Sloan CL, Wayment BE, Litwin SE, LeRoith D, Abel ED (2007). Mice with Cardiomyocyte-Restricted IGF-1 Receptor Deletion Exhibit Diminished Cardiomyocyte Size and Resistance to Exercise-Induced Cardiac Hypertrophy [Abstract]. Circulation. American Heart Association 61st Scientific Sessions.
  35. Boudina S, Tuinei J, Thebald H, Sena S, Abel ED (2007). Uncoupling Protein 3 Does Not Regulate Myocardial Fatty Acid Oxidation Rates but Regulates ROS Production and Cardiac Efficiency [Abstract]. Circulation. American Heart Association 61st Scientific Sessions.
  36. Tabbi-Ameni I, Theobald H, Hu P, Litwin SE, Abel (2007). The Role of P13 Kinase Signaling in Obesity Related Cardiac Hypertrophy [Abstract]. Diabetes.67th Scientific Sessions of the American Diabetes Association, 56, Suppl..
  37. Wende, AR, Wayment B, Litwin SE, Abel ED (2007). GLUT4 is Required for Akt Activation and the Maintenance of Cardiac Function in Response to Exercise Training [Abstract]. Diabetes.67th Scientific Sessions of the American Diabetes Association, 56, Suppl..
  38. Fountain KT, Boudina S, Soto J, Sena S, Theobald H, Accili D, Abel ED (2007). Differential Effects of Postmatal Versus Germline Deletion of Insulin Receptors in Cardiac Mitochondrial Function [Abstract]. Diabetes.67th Scientific Sessions of the American Diabetes Association, 56, Suppl..
  39. Fountain KT, Boudina S, Soto J, Sena S, Theobald H, Accili D, Abel ED (2007). Impact of insulin Receptor Deletion on Skeletal Muscle Mitochondrial Function [Abstract]. Diabetes.67th Scientific Sessions of the American Diabetes Association, 56 ,Suppl.
  40. Zaha VG, Hungerford PR, Li Y, Nuthakungwan O, Safaee M, Jalili T, Abel ED (2006). Hypertrophy in GLUT4 Deficient Hearts Results from Increased Sensitivity to mTOR Signaling [Abstract]. Circulation. American Heart Association 60th Scientific Sessions, 112(II), 54.
  41. Boudina S, Sena S, ONeill BT, Aziz S, Abel ED (2006). Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) [Abstract]. Circulation. American Heart Association 60th Scientific Sessions, 112(II), 244.
  42. Mazumder PK, Sloan C, Rasmussen I, Abel ED (2006). Vascular Endothelial KO of Insulin Receptors Confirm a Critical Role of Endothelial Signaling in Regulating Myocardial Glucose Utilization [Abstract]. Circulation. American Heart Association 60th Scientific Sessions, 112(II), 135.
  43. Zaha VG, Buchanan J, Lelliot CJ, Hu P, McQueen AP, Medina-Gomez G, Kiss A, Litwin SE, Vidal-Puig A, Abel ED (2006). Impact of PGC-1 beta Deletion on Contractile, Metabolic and Transcriptional Responses of the Heart to Pressure Overload Hypertrophy [Abstract]. Circulation. American Heart Association 60th Scientific Sessions, 112(II), 134.
  44. Wright J, Buchanan J, Boudina S, Abel ED (2006). Differential Effects of High-Fat Feeding on the Ability of Insulin to Modulate Glucose versus FA Utilization in the Heart [Abstract]. Circulation. American Heart Association 60th Scientific Sessions, 112(II), 209.
  45. Bugger H, Schaffer JE, Abel ED (2006). Insulin Resistance and Increased Fatty Acid Delivery Independently Impair Mitochondrial Function in the Heart [Abstract]. Circulation, American Heart Association 60th Scientific Sessions, 112(II), 210.
  46. ONeill BT, Izumo S, Abel ED (2006). PI3-Kinase Regulates Myocardial Mitochondrial Mass and Oxidative Capacity via Akt-Independent Signaling Pathways [Abstract]. Circulation. American Heart Association 60th Scientific Sessions, 112(II), 245.
  47. Bugger H, Buchanan J, McQueen AP, Litwin SE, Schaffer JE, Abel ED (2006). Increased Myocardial Fatty Acid Delivery Precipitates Mitochondrial Dysfunction [Abstract]. Diabetes. 66th Scientific Sessions of the American Diabetes Association, 55(Supp 1), A290.
  48. Boudina S, Zaha VG, Mazumder PK, ONeill BT, Theobald H, Abel ED (2006). Mitochondrial Adaptations to Chronic Myocardial GLUT4 Deficiency [Abstract]. Diabetes. 66th Scientific Sessions of the American Diabetes Association, 55(Supp 1), A290.
  49. Sena S, Mazumder PK, Hu P, Litwin SE, Abel ED (2006). Insulin Signaling Regulates Cardiac GLUT1 Expression in Response to Pressure Overload Hypertrophy via Sp Factors [Abstract]. Diabetes. 66th Scientific Sessions of the American Diabetes Association, 55(Supp 1), A302.
  50. Tabbi-Anneni I, Hu P, Zaha VG, ONeill BT, Litwin SE, Abel ED (2006). Partial Cardiac Insulin and IGF1 Resistance Impairs Cardiac Adaptation to Pressure Overload [Abstract]. Diabetes. 66th Scientific Sessions of the American Diabetes Association, 55(Supp 1), A303.
  51. 54 Wright J, Buchanan J, McKnight RA, Lane RH, Abel ED (2006). Intrauterine Growth Retardation Delays Myocardial Metabolic Maturation in the Rat Heart [Abstract]. Diabetes. 66th Scientific Sessions of the American Diabetes Association, 55(Supp 1), A342.
  52. ONeill BT, Buchanan J, Zaha VG, Theobald H, Izumo S, Abel ED (2006). Chronic Akt Activation in the Heart Induces Insulin Resistance Mitochondrial Dysfunction [Abstract]. Diabetes. 66th Scientific Sessions of the American Diabetes Association, 55, A301.
  53. Symons DJ, McMillin S, Lloyd J, Miller N, Snedeger B, Accili D Abel ED (2006). Differential Effects of Selective Versus Total Loss of Vascular Insulin Signaling on Blood Pressure Regulation [Abstract]. Diabetes. 66th Scientific Sessions of the American Diabetes Association, 55, A303.
  54. ONeill BT, Buchanan J, Mazumder PK, Birnbaum MJ, Abel ED (2005). Insulin-mediated stimulation of myocardial glucose transport and glycolysis is mediated by Akt2 but the regulation of oxidative metabolism by insulin is mediated by Akt1 [Abstract]. Circulation. American Heart Association Scientific Sessions, 112(II), 180.
  55. ONeill BT, Davis DK, Boudina S, Mazumder PK, Izumo S, Abel ED (2005). Kinase regulates myocardial fatty acid utilization via modulation of PGC-1 expression [Abstract]. Circulation. American Heart Association Scientific Sessions, 112(II), 35.
  56. Lehman JJ, Boudina S, Young DM, Leone TC, Abel ED, Kelly DP (2005). The transcriptional coactivator PGC1-a is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and ATP synthesis [Abstract]. Circulation. American Heart Association Scientific Sessions, 112(II), 157.
  57. Buchanan J, ONeill BT, Sloan C, Shiojima I, Walsh K, Abel ED (2005). Impact of acute activation of Akt in the adult heart on mitochondrial metabolism and myocardial substrate utilization [Abstract]. Circulation. American Heart Association Scientific Sessions, 112(II), 157.
  58. Tabbi-Anneni I, Hu P, McQueen AP, Rasmussen I, ONeill BT, Litwin SE, Abel ED (2005). Myocardial overexpression of a dominant negative IGF1 receptor induces partial cardiac insulin resistance and leads to impaired adaptation to pressure overload hypertrophy [Abstract]. Circulation. American Heart Association Scientific Sessions, 112.
  59. McQueen A, Zhang D, Hu P, Zaha V, Hoffman J, Wang Z, Albertine K, Abel ED, Litwin SE (2005). Insulin receptor signaling in cardiomyocytes protects against myocardial injury during cardiac hypertrophy by regulating capillary density [Abstract]. Circulation. American Heart Association Scientific Sessions, 112.
  60. Mazumder PK, Abel ED (2005). The nitric oxide/cyclic GMP pathway mediates insulin-stimulated glucose utilization in the heart. (42-44) Presented at the Society for Heart and Vascular Metabolism annual meeting, Oxford UK, 2005) [Abstract]. Circulation. American Heart Association Scientific Sessions.
  61. Mazumder PK, Rasmussen I, Kahn CR, Accili D, Abel ED (2005). Paracrine regulation of cardiac metabolism by endothelial insulin signaling – Potential role of the nitric oxide/cyclic GMP pathway [Abstract]. Circulation. American Heart Association Scientific Sessions, 112(II), 59.
  62. Mazumder PK, Abel ED (2005). The nitric oxide/cyclic GMP pathway mediates insulin-stimulated glucose utilization in the heart.  (40-41 Presented at the International Society for Heart Research European Section Meeting, Tromso, Norway, 2005) [Abstract]. J Mol and Cell Cardiol, 38:999.
  63. ONeill BT, Davis DK, Boudina S, Mazumder PK, Abel ED (2005). PI-3 Kinase regulates myocardial mitochondrial fatty acid utilization via modulation of PGC-1-beta expression [Abstract]. J Mol and Cell Cardiol, 38:999.
  64. Mazumder PK, Abel ED (2005). Insulin stimulated glucose utilization is mediated via the nitric oxide/cyclic GMP pathway in the heart.  (35-39 Presented at the 65th Annual Meeting and Scientific Session of the American Diabetes Association, San Diego, CA, 2005) [Abstract]. Diabetes. 65th Scientific Sessions of the American Diabetes Association, 54.
  65. ONeill BT, Birnbaum MJ, Abel ED (2005). Isoform specific regulation of glucose transport in the heart by Akt [Abstract]. Diabetes. 65th Scientific Sessions of the American Diabetes Association, 54.
  66. ONeill BT, Davis DK, Boudina S, Izumo S, Abel ED (2005). PI-3 Kinase regulates myocardial mitochondrial fatty acid utilization by modulating the expression of PGC-1-beta [Abstract]. Diabetes. 65th Scientific Sessions of the American Diabetes Association, 54.
  67. Tabbi-Anneni I, Buchanan J, Abel ED (2005). The effect of angiotensin converting enzyme inhibition on insulin signaling and substrate metabolism in the ob/ob mouse heart [Abstract]. Diabetes. 65th Scientific Sessions of the American Diabetes Association, 54.
  68. Tabbi-Anneni I, ONeill BT, Rasmussen I, McQueen AP, Litwin SE (2005). Myocardial overexpression of the K159R mutant IGF-1 receptor impairs myocardial insulin and IGF-1 signaling [Abstract]. Diabetes. 65th Scientific Sessions of the American Diabetes Association, 54.
  69. Boudina S, Sena S, Wright J, ONeill BT, Mazumder PK, Abel ED (2004). Postnatal deletion of insulin receptors augments myocardial fatty acid utilization and enhances mitochondrial biogenesis.  (26-30 Presented at the American Heart Association Scientific Sessions 2004) [Abstract]. Circulation. American Heart Association Scientific Sessions, 110(324).
  70. Litwin SE, Wang W, Hu P, Mazumder PK, Buchanan J, Yang Y, Ross RS, Hsueh WA, Abel ED (2004). Myocardial deficiency of PPARg leads to increased fibrosis in response to pressure overload hypertrophy [Abstract]. Circulation. American Heart Association Scientific Sessions, 110(320).
  71. ONeill BT, Buchanan J, Izumo S, Walsh K, Shiojima I, Abel ED (2004). Impact of short-term and long-term activation of Akt on myocardial glucose utilization [Abstract]. Circulation. American Heart Association Scientific Sessions, 110(278).
  72. Punske BB, Rossi S, Pappas AL, Ershler PR, Rasmussen I, Abel ED (2004). Diminished propagation of electrical conductance in insulin receptor deficient mouse hearts under normoxic and ischemic conditions [Abstract]. Circulation. American Heart Association Scientific Sessions, 110(164).
  73. Buchanan J, Mazumder PK, Chakrabarti G, Roberts MW, Cooksey RC, Abel ED (2004). Decreased myocardial efficiency and increased fatty acid oxidation characterize ob/ob and db/db mouse hearts prior to the onset of hyperglycemia. Presented at the American Heart Association Scientific Sessions [Abstract]. Circulation. American Heart Association Scientific Sessions, 110, III-323.
  74. Rasmussen I, McQueen AP, Zaha VG, Litwin SE, Berger JP, Abel ED (2004). Cardiac hypertrophy induced by PPARy agonist treatment occurs independently of changes in myocardial insulin signaling. Presented at the American Heart Association Scientific Sessions [Abstract]. Circulation. American Heart Association Scientific Sessions, 110, III-321.
  75. Litwin SE, Wang W, Hu P, Mazumder PK (2004). Myocardial deficiency of PPARy leads to increased fibrosis in response to pressure overload hypertrophy. Presented at the American Heart Association Scientific Sessions [Abstract]. Circulation. American Heart Association Scientific Sessions, 110, III-320.
  76. ONeill BT, Buchanan J, Izumo S, Walsh K, Shiojima I, Abel ED (2004). Impact of short-term and long-term activation of Akt on myocardial glucose utilization. Presented at the American Heart Association Scientific Sessions [Abstract]. Circulation. American Heart Association Scientific Sessions, 110, III-278.
  77. ONeill BT, Yun UJ, Graveleau C, Shioi T, Izumo S, Walsh K, Shiojima I, Abel ED (2004). Short-term activation of Akt impairs insulin-stimulated glucose uptake in the heart. Presented at the 64th Scientific sessions of the American Diabetes Association [Abstract]. Diabetes. 65th Scientific Sessions of the American Diabetes Association, 53, A333.
  78. Boudina S, ONeill BT, Abel ED (2004). Mitochondrial uncoupling and decreased oxidative capacity contributes to cardiac dysfunction in db/db mice. Presented at the 64th Scientific sessions of the American Diabetes Association [Abstract]. Diabetes. 64th Scientific Sessions of the American Diabetes Association, 53, A335.
  79. Zaha VG, Dunn DM, Weiss RB, Abel ED (2004). Transcriptional profiling reveals mechanisms responsible for the impaired contractile response of GLUT4 deficient hearts to fasting. Presented at the 64th Scientific sessions of the American Diabetes Association [Abstract]. Diabetes. 64th Scientific Sessions of the American Diabetes Association, 53, A5.
  80. Hu P, Zhang D, Chakrabarti G, Zhang D, Avelar E, Abel ED (2003). Insulin resistance in the heart without systemic diabetes increases the mortality and contractile dysfunction after myocardial infarction [Abstract]. Presented at the American Heart Association Scientific Conference on the Molecular Mechanisms of Growth, Death, and Regeneration in the Myocardium: Basic Biology and Insights into Ischemic Heart Disease and Heart failure, Snowbird UT.
  81. Boudina S, Cooksey RC, Jones D, McClain DA, Abel ED (2003). Insulin resistance, mitochondrial dysfunction and energy expenditure following high fat feeding Diabetes [Abstract]. Diabetes. 63rd Scientific Sessions of the American Diabetes Association, 108(IV), 1404.
  82. Hu P, Zhang D, Avelar E, Abel ED, Litwin SE (2003). Insulin resistance in the heart increases the mortality and contractile dysfunction after myocardial infarction. Presented at the American Heart Association Scientific Sessions [Abstract]. Circulation. American Heart Association Scientific Sessions, 108, 894.
  83. Boudina S, ONeill B, Belke DD, Rodnick KJ, Abel ED (2003). Insulin resistance leads to progressive mitochondrial dysfunction in the mouse heart. Presented at the American Heart Association Scientific Sessions [Abstract]. Circulation. American Heart Association Scientific Sessions, 108, IV-1404.
  84. Mazumder PK, Tuttle MJ, Accili D, Abel ED (2003). Insulin signaling regulates cardiac substrate metabolism via cross-talk between non-myocytes and cardiomyocytes. Presented at the American Heart Association Scientific Sessions [Abstract]. Circulation. American Heart Association Scientific Sessions, 108, IV-1411.
  85. Boudina S, Mazumder PK, Cooksey RC, McClain DA, Abel ED (2003). Mitochondrial impairment contributes to cardiac dysfunction in obese leptin-deficient (ob/ob) mice. Presented at the American Heart Association Scientific Sessions [Abstract]. Circulation. American Heart Association Scientific Sessions, 108, IV-75.
  86. Chakrabarti G, Abel ED (2003). Differential contributions of insulin resistance versus hyperglycemia to the transcriptional changes that characterize the diabetic heart. Presented at the 63rd annual scientific session of the American Diabetes Association [Abstract]. Diabetes. 63rd Scientific Sessions of the American Diabetes Association, 52, A285.
  87. Litwin SE, Hu P, Cooksey RC, Zhang D, Swenson L, McClain DA, Abel ED (2003). Diastolic abnormalities in db/db mice precede the development of hyperglycemia. Presented at the 63rd annual scientific session of the American Diabetes Association [Abstract]. Diabetes. 63rd Scientific Sessions of the American Diabetes Association, 52, A389.
  88. Zaha V, Tuttle MJ, Izumo S, Patti ME, Abel ED (2003). GLUT4 deficient hearts exhibit a unique and distinct transcriptional profile. Presented at the 63rd annual scientific session of the American Diabetes Association [Abstract]. Diabetes. 63rd Scientific Sessions of the American Diabetes Association, 52, A283.
  89. Mazumder PK, Graveleau C, Boudina S, Belke DD, Abel ED (2003). Metabolic characterization of the insulin resistant mouse heart. Presented at the 63rd annual scientific session of the American Diabetes Association [Abstract]. Diabetes. 63rd Scientific Sessions of the American Diabetes Association, 52, A300.
  90. Boudina S, ONeil B, Belke DD, Rodnick KJ, Abel ED (2003). Resistance leads to multiple mitochondrial defects in the mouse. Presented at the 63rd annual scientific session of the American Diabetes Association [Abstract]. Diabetes. 63rd Scientific Sessions of the American Diabetes Association, 52, A284.
  91. Swenson L, Zhang D, Hu P, Abel ED, Litwin SE (2002). Protective role of insulin signaling in isoproterenol-induced cardiac injury. Presented at the American Heart Association Scientific Sessions [Abstract]. Circulation.American Heart Association Scientific Sessions, 106, II-307.
  92. Mazumder PK, Graveleau C, Tuttle MJ, Betuing S, Belke DD, Shioi T, Izumo S, Abel ED (2002). Regulation of cardiac substrate metabolism by PI3 Kinase. Presented at the American Heart Association Scientific Sessions [Abstract]. Circulation.American Heart Association Scientific Sessions, 106, II-157.
  93. Tuttle MJ, Mazumder PK, Litwin SE, Belke DD, Winder WW, Abel ED (2002). GLUT4 deficient hearts - a model of compensated cardiac hypertrophy with elevated fatty acid oxidation rates. Presented at the American Heart Association Scientific Sessions [Abstract]. Circulation.American Heart Association Scientific Sessions, 106, II-263.
  94. Mazumder PK, Graveleau C, Belke DD, Abel ED (2002). Glucose oxidation rates and contractile function are reduced in the hearts of insulin resistant mice prior to the onset of diabetes [Abstract]. Diabetes. 62nd Scientific Sessions of the American Diabetes Association, 51, A317.
  95. Belke DD, Litwin SE, Zhang D, Mazumder PK, Kahn CR, Abel ED (2002). Contribution of impaired insulin signaling or reduced glucose utilization to the metabolic abnormalities of the diabetic heart [Abstract]. Diabetes. 62nd Scientific Sessions of the American Diabetes Association, 51, A326.
  96. Graveleau C, Mohajer A, Banerjee R, Dudley-Rucker N, Steppan C, Ahima RS, Lazar MA, Abel ED (2002). Effects of mouse and human resistins on cardiomyocyte glucose transport [Abstract]. Diabetes. 62nd Scientific Sessions of the American Diabetes Association, 51, A308.
  97. Litwin SE, Zhang D, Graveleau C, Abel ED (2001). Impact of cardiac selective ablation of the insulin receptor on myocyte mechanics and in vivo cardiac contractility. Presented at the American Heart Association scientific sessions [Abstract]. Circulation. American Heart Association Scientific Sessions, 17, II-569.
  98. Graveleau C, Banerjee RR, Dudley-Rucker N, Ahima RS, Lazar MA, Abel ED (2001). Insulin Resistance in cardiac muscle-potential role of resistin. Presented at the American Heart Association Scientific Sessions [Abstract]. Circulation. American Heart Association Scientific Sessions, 17, II-119.
  99. Betuing S, Graveleau C, Shioi T, Izumo S, Abel ED (2001). Cardiac selective overexpression of a constitutively active phosphoinositide 3-kinase in transgenic mice leads to insulin resistance in cardiac myocytes. Presented at the 61st annual scientific session of the American Diabetes Association [Abstract]. Diabetes. 61st Scientific Sessions of the American Diabetes Association, 50, A294.
  100. Graveleau C, Shiojima I, Mantzoros C, Walsh K, Abel ED (2001). Downregulation of glucose transport and insulin-mediated phosphorylation of glycogen synthase kinase -3 are early defects in the cardiac muscle of insulin resistant mice [Abstract]. Diabetes. 61st Scientific Sessions of the American Diabetes Association, 50, A271.
  101. Peroni O, Zisman A, Wojtaszewski J, Hirschman M, Abel ED, Goodyear JL, Kahn BB (2000). Exercise Capacity is Impaired in Mice with Muscle-Specific GLUT4 Knock Out but is Normal with Cardiac-Specific GLUT4 Knock Out. Presented at the 60th annual scientific session of the American Diabetes Association [Abstract]. Diabetes. 60th Scientific Sessions of the American Diabetes Association, 49, A271.
  102. Hampton T, Wang J-F, DeAngelis J, Abel ED (1999). Preserved basal contractility but impaired responses to isoproterenol in vivo in mice with cardiac selective GLUT4 ablation. Presented at the 72nd annual Scientific Conference of the American Heart Association [Abstract]. Circulation. American Heart Association Scientific Sessions, 100, 118.