Andrew E. Anderson, PhD

Research Interests

  • Biomechanics
  • Computational Modeling and Visualization Techniques for Biomechanical Analysis
  • Biomedical Engineering
  • Imaging, Three-Dimensional
  • Computed Tomography - CT
  • Magnetic Resonance Imaging - MRI
  • Muscles
  • Orthopaedic Biomechanics
  • Hip
  • Dynamic Imaging
  • Fluoroscopy
  • Musculoskeletal Imaging
  • Musculoskeletal Modeling
  • Statistical Shape Modeling
  • Gait Analysis
  • Dual Fluoroscopy
  • Ankle

Languages

  • English

Academic Information

  • Departments: Bioengineering - Adjunct Assistant Professor, Orthopaedics - Research Associate Professor, Physical Therapy and Athletic Training - Adjunct Assistant Professor

Academic Office Information

  • University Orthopaedic Center
    590 Wakara Way
    Salt Lake City, UT 84108

Research Statement

Combine principles of experimental and computational and experimental engineering mechanics, motion analysis, and imaging to solve unique problems in biomedical engineering and orthopaedics. Mentor students across multiple sub-disciplines of Bioengineering and Physical Therapy.

Academic Bio

I was born in Kalamazoo, Michigan and grew up in Brighton, Michigan. I went to Michigan Tech University and graduated with a BS in Biomedical Engineering in 2001. I did a research internship in the Orthopaedic Research Lab at the Mayo Clinic in 1999. I earned my PhD in Bioengineering at the University of Utah in 2007.

My primary goal is to improve the clinical diagnosis and treatment of patients suffering from hip and ankle pathology using volumetric imaging (CT, MRI), dynamic imaging (dual fluoroscopy), motion analysis, and computational modeling (musculoskeletal/FE/statistical shape modeling). My research group has expertise in femoroacetabular impingement, hip dysplasia, and ankle arthritis. We analyze how abnormal anatomy influences human biomechanics at multiple levels of the physiome for these conditions – from analysis of whole-body kinematics to quantification of cartilage contact mechanics.

One of my team’s specialties is incorporating patient-specific variables, such as anatomy, muscle geometry, and motion profiles, to better-understand how these features (unique to the individual) pre-dispose the ankle and hip joints to early degeneration. In doing so, we hope to illuminate novel strategies to diagnose and treat joints early in the stages of osteoarthritis such that we can prevent or delay the need for joint replacement.

My group is also leading the development and deployment of 3D methods that objectively diagnose conditions such as femoroacetabular impingement and dysplasia. With NIH funding, we are using statistical shape modeling to characterize anatomical variation among groups and sub-groups of patients with abnormally shaped hips. These models should reduce misdiagnosis rates and assist clinicians with selecting the most appropriate treatment.

Finally, with NIH funding, my lab quantifies motion of human joints using a combination of high-speed dual fluoroscopy and skin marker motion analysis. Here, we seek to establish the relationship between form (i.e. anatomy) and function (i.e. joint motion). We are currently extending this protocol to image patients before and after surgery to quantify the extent in which treatment restores joint function.

My group maintains active collaborations with surgeons and researchers in the Department of Orthopaedics, as well as Bioengineering and Physical Therapy. We also collaborate with computer scientists at the Scientific Computing and Imaging Institute and School of Computing

Education History

Type School Degree
Other Training Stanford University
Neuromuscular Biomechanics
Visiting Scholar
Postdoctoral Fellowship University of Utah Department of Orthopaedics, Orthopaedic Research Laboratory
Biomechanics of the Hip
Postdoctoral Fellow
Doctoral Training University Of Utah
Bioengineering- Orthopaedic Biomechanics
Ph.D.
Undergraduate Michigan Technological University
Engineering, Biomedical Engineering
B.S.
Research Fellow Mayo Clinic, Orthopaedic Biomechanical Laboratory
Optimization of a Dynamic Knee Brace System
Research Fellow

Selected Publications

Journal Article

  1. Roach KE, Wang B, Kapron AL, Fiorentino NM, Saltzman CL, Bo Foreman K, Anderson AE (2016). In Vivo Kinematics of the Tibiotalar and Subtalar Joints in Asymptomatic Subjects: A High-Speed Dual Fluoroscopy Study.LID - 10.1115/1.4034263 [doi]. J Biomech Eng, 138(9).
  2. Wiewiorski M, Werner L, Paul J, Anderson AE, Barg A, Valderrabano V (2016). Sports Activity After Reconstruction of Osteochondral Lesions of the Talus With Autologous Spongiosa Grafts and Autologous Matrix-Induced Chondrogenesis.LID - 0363546516659643 [pii]. (Epub ahead of print) Am J Sports Med.
  3. Anderson AE (2016). CORR Insights(R): Head-Neck Osteoplasty has Minor Effect on the Strength of an Ovine Cam-FAI Model: In Vitro and Finite Element Analyses. (Epub ahead of print) Clin Orthop Relat Res.
  4. Nichols JA, Roach KE, Fiorentino NM, Anderson AE (2016). Predicting tibiotalar and subtalar joint angles from skin-marker data with dual-fluoroscopy as a reference standard. Gait Posture, 49, 136-143.
  5. Fiorentino NM, Kutschke MJ, Atkins PR, Foreman KB, Kapron AL, Anderson AE (2016). Accuracy of Functional and Predictive Methods to Calculate the Hip Joint Center in Young Non-pathologic Asymptomatic Adults with Dual Fluoroscopy as a Reference Standard. Ann Biomed Eng, 44(7), 2168-80.
  6. Wiewiorski M, Hoechel S, Anderson AE, Nowakowski AM, DeOrio JK, Easley ME, Nunley JA, Valderrabano V, Barg A (2016). Computed Tomographic Evaluation of Joint Geometry in Patients With End-Stage Ankle Osteoarthritis. Foot Ankle Int, 37(6), 644-51.
  7. Barg K, Wiewiorski M, Anderson AE, Schneider SW, Wimmer MD, Wirtz DC, Valderrabano V, Barg A, Pagenstert G (2015). Total ankle replacement in patients with von Willebrand disease: mid-term results of 18 procedures. Haemophilia, 21(5), e389-401.
  8. Wang B, Roach KE, Kapron AL, Fiorentino NM, Saltzman CL, Singer M, Anderson AE (2015). Accuracy and feasibility of high-speed dual fluoroscopy and model-based tracking to measure in vivo ankle arthrokinematics. Gait Posture, 41(4), 888-93.
  9. Barg A, Amendola RL, Henninger HB, Kapron AL, Saltzman CL, Anderson AE (2015). Influence of Ankle Position and Radiographic Projection Angle on Measurement of Supramalleolar Alignment on the Anteroposterior and Hindfoot Alignment Views. Foot Ankle Int, 36(11), 1352-61.
  10. Kapron AL, Aoki SK, Peters CL, Anderson AE (2015). In-vivo hip arthrokinematics during supine clinical exams: Application to the study of femoroacetabular impingement. J Biomech, 48(11), 2879-86.
  11. Abraham CL, Bangerter NK, McGavin LS, Peters CL, Drew AJ, Hanrahan CJ, Anderson AE (2015). Accuracy of 3D dual echo steady state (DESS) MR arthrography to quantify acetabular cartilage thickness. J Magn Reson Imaging, 42(5), 1329-38.
  12. Henak CR, Kapron AL, Anderson AE, Ellis BJ, Maas SA, Weiss JA (2014). Specimen-specific predictions of contact stress under physiological loading in the human hip: validation and sensitivity studies. Biomech Model Mechanobiol, 13(2), 387-400.
  13. Henak CR, Abraham CL, Peters CL, Sanders RK, Weiss JA, Anderson AE (2014). Computed tomography arthrography with traction in the human hip for three-dimensional reconstruction of cartilage and the acetabular labrum. Clin Radiol, 69(10), e381-91.
  14. Kapron AL, Aoki SK, Peters CL, Anderson AE (2014). Subject-specific patterns of femur-labrum contact are complex and vary in asymptomatic hips and hips with femoroacetabular impingement. Clin Orthop Relat Res, 472(12), 3912-22.
  15. Henak CR, Abraham CL, Anderson AE, Maas SA, Ellis BJ, Peters CL, Weiss JA (2014). Patient-specific analysis of cartilage and labrum mechanics in human hips with acetabular dysplasia. Osteoarthritis Cartilage, 22(2), 210-7.
  16. Kapron AL, Aoki SK, Peters CL, Maas SA, Bey MJ, Zauel R, Anderson AE (2014). Accuracy and feasibility of dual fluoroscopy and model-based tracking to quantify in vivo hip kinematics during clinical exams. J Appl Biomech, 30(3), 461-70.
  17. Harris MD, Kapron AL, Peters CL, Anderson AE (2014). Correlations between the alpha angle and femoral head asphericity: Implications and recommendations for the diagnosis of cam femoroacetabular impingement. Eur J Radiol, 83(5), 788-96.
  18. Harris MD, Reese SP, Peters CL, Weiss JA, Anderson AE (2013). Three-dimensional quantification of femoral head shape in controls and patients with cam-type femoroacetabular impingement. Ann Biomed Eng, 41(6), 1162-71.
  19. Abraham CL, Maas SA, Weiss JA, Ellis BJ, Peters CL, Anderson AE (2013). A new discrete element analysis method for predicting hip joint contact stresses. J Biomech, 46(6), 1121-7.
  20. Henak CR, Carruth ED, Anderson AE, Harris MD, Ellis BJ, Peters CL, Weiss JA (2013). Finite element predictions of cartilage contact mechanics in hips with retroverted acetabula. Osteoarthritis Cartilage, 21(10), 1522-9.
  21. Harris MD, Datar M, Whitaker RT, Jurrus ER, Peters CL, Anderson AE (2013). Statistical shape modeling of cam femoroacetabular impingement. J Orthop Res, 31(10), 1620-6.
  22. Kapron AL, Anderson AE, Peters CL, Phillips LG, Stoddard GJ, Petron DJ, Toth R, Aoki SK (2012). Hip internal rotation is correlated to radiographic findings of cam femoroacetabular impingement in collegiate football players. Arthroscopy, 28(11), 1661-70.
  23. Hansen BJ, Harris MD, Anderson LA, Peters CL, Weiss JA, Anderson AE (2012). Correlation between radiographic measures of acetabular morphology with 3D femoral head coverage in patients with acetabular retroversion. Acta Orthop, 83(3), 233-9.
  24. Peters CL, Aoki SK, Erickson JA, Anderson LA, Anderson AE (2012). Early experience with a comprehensive hip preservation service intended to improve clinical care, education, and academic productivity. Clin Orthop Relat Res, 470(12), 3446-52.
  25. Barg A, Harris MD, Henninger HB, Amendola RL, Saltzman CL, Hintermann B, Anderson AE (2012). Medial distal tibial angle: comparison between weightbearing mortise view and hindfoot alignment view. Foot Ankle Int, 33(8), 655-61.
  26. Henninger HB, Barg A, Anderson AE, Bachus KN, Tashjian RZ, Burks RT (2012). Effect of deltoid tension and humeral version in reverse total shoulder arthroplasty: a biomechanical study. J Shoulder Elbow Surg, 21(4), 483-90.
  27. Henninger HB, Barg A, Anderson AE, Bachus KN, Burks RT, Tashjian RZ (2012). Effect of lateral offset center of rotation in reverse total shoulder arthroplasty: a biomechanical study. J Shoulder Elbow Surg, 21(9), 1128-35.
  28. Harris MD, Anderson AE, Henak CR, Ellis BJ, Peters CL, Weiss JA (2012). Finite element prediction of cartilage contact stresses in normal human hips. J Orthop Res, 30(7), 1133-9.
  29. Peters CL, Anderson LA, Erickson JA, Anderson AE, Weiss JA (2011). An algorithmic approach to surgical decision making in acetabular retroversion. Orthopedics, 34(1), 10.
  30. Henak CR, Ellis BJ, Harris MD, Anderson AE, Peters CL, Weiss JA (2011). Role of the acetabular labrum in load support across the hip joint. J Biomech, 44(12), 2201-6.
  31. Kapron AL, Anderson AE, Aoki SK, Phillips LG, Petron DJ, Toth R, Peters CL (2011). Radiographic prevalence of femoroacetabular impingement in collegiate football players: AAOS Exhibit Selection. J Bone Joint Surg Am, 93(19), e111(1-10).
  32. Barg A, Elsner A, Anderson AE, Hintermann B (2011). The effect of three-component total ankle replacement malalignment on clinical outcome: pain relief and functional outcome in 317 consecutive patients. J Bone Joint Surg Am, 93(21), 1969-78.
  33. Barg A, Knupp M, Anderson AE, Hintermann B (2011). Total ankle replacement in obese patients: component stability, weight change, and functional outcome in 118 consecutive patients. Foot Ankle Int, 32(10), 925-32.
  34. Anderson AE, Ellis BJ, Maas SA, Weiss JA (2010). Effects of idealized joint geometry on finite element predictions of cartilage contact stresses in the hip. J Biomech, 43(7), 1351-7.
  35. Allen BC, Peters CL, Brown NA, Anderson AE (2010). Acetabular cartilage thickness: accuracy of three-dimensional reconstructions from multidetector CT arthrograms in a cadaver study. Radiology, 255(2), 544-52.
  36. Peters CL, Erickson JA, Anderson L, Anderson AA, Weiss J (2009). Hip-preserving surgery: understanding complex pathomorphology. J Bone Joint Surg Am, 91 Suppl 6, 42-58.
  37. Anderson AE, Ellis BJ, Maas SA, Peters CL, Weiss JA (2008). Validation of finite element predictions of cartilage contact pressure in the human hip joint. J Biomech Eng, 130(5), 051008.
  38. Anderson AE, Ellis BJ, Peters CL, Weiss JA (2008). Cartilage thickness: factors influencing multidetector CT measurements in a phantom study. Radiology, 246(1), 133-41.
  39. Anderson AE, Peters CL, Tuttle BD, Weiss JA (2005). Subject-specific finite element model of the pelvis: development, validation and sensitivity studies. J Biomech Eng, 127(3), 364-73.

Review

  1. Henak CR, Anderson AE, Weiss JA (2013). Subject-specific analysis of joint contact mechanics: application to the study of osteoarthritis and surgical planning. [Review]. J Biomech Eng, 135(2), 021003.
  2. Henninger HB, Reese SP, Anderson AE, Weiss JA (2010). Validation of computational models in biomechanics. [Review]. Proc Inst Mech Eng H, 224(7), 801-12.
  3. Anderson AE, Ellis BJ, Weiss JA (2007). Verification, validation and sensitivity studies in computational biomechanics. [Review]. Computer Methods in Biomechanics and Biomedical Engineering, 10(3), 171-84.

Video