Jody Rosenblatt, Ph.D.

Research Interests

  • Homeostasis
  • Carcinoma
  • Epithelial Cells
  • Cell Biology
  • Apoptosis
  • Extrusion

Labs

Lab Website

Languages

  • English

Academic Information

  • Departments: Oncological Sciences - Associate Professor
  • Cancer Center Programs: Cell Response & Regulation

Academic Office Information

  • (801) 587-4073
  • Huntsman Cancer Institute
    2000 Circle of Hope, Room: 5344
    Salt Lake City, UT 84112

Academic Bio

Jody Rosenblatt, PhD, is an Associate Professor in the Department of Oncological Sciences at the University of Utah School of Medicine, an investigator at Huntsman Cancer Institute, and a member of the Cell Response and Regulation Program.The Rosenblatt Lab at Huntsman Cancer Institute studies cell death and division in epithelia. Cell turnover occurs at a high rate throughout the body, particularly in epithelia. In order to maintain constant cell numbers, the number of cells that die must match those that divide. If they do not, epithelia could lose their primary function as a barrier, as in asthma and colitis, or amass into carcinomas. We have found that both cell death and division are controlled by mechanical tensions--if epithelial cells become too dense, they extrude some cells that later die. If they become too sparse, stretch causes some cells to rapidly divide. Because these processes are critical for cell turnover, not surprisingly, we have found that their misregulation leads to tumor formation and initiation or barrier function diseases.Rosenblatt received her BA with honors from the University of California, Berkeley, and her PhD from the University of California, San Francisco. She then completed postdoctoral fellowships at the University College London. Rosenblatt presents and publishes widely and has received numerous research fellowships and grants in the United States and the United Kingdom.

Education History

Type School Degree
Postdoctoral Fellowship University College London, MRC-LMCB
Postdoctoral Fellow
Postdoctoral Fellowship University College London, American Cancer Society
Cell Biology
Postdoctoral Fellow
Postdoctoral Fellowship University College London, Department of Anatomy
Postdoctoral Fellow
Postdoctoral Fellowship University College London, EMBO
Cell Biology
Postdoctoral Fellow
Doctoral Training University of California
Biophysics & Biochemistry
Ph.D.
Fellowship University of California San Francisco, National Science Foundation
Cell Biology
Fellow
Fellowship University of California Berkeley, Genetics Society of America
Genetics
Fellow
Undergraduate University of California
Molecular Biology
B.A.

Global Impact

Education History

Type School Degree Country
Postdoctoral Fellowship University College London, MRC-LMCB
Postdoctoral Fellow United Kingdom
Postdoctoral Fellowship University College London, American Cancer Society
Cell Biology
Postdoctoral Fellow United Kingdom
Postdoctoral Fellowship University College London, Department of Anatomy
Postdoctoral Fellow United Kingdom
Postdoctoral Fellowship University College London, EMBO
Cell Biology
Postdoctoral Fellow United Kingdom

Presentations

Description Country
Young Investigator Meeting, Goa, India India
Tata Institute of Fundamental Research, Mumbai, India India

Selected Publications

Journal Article

  1. A toolbox to study epidermal cell types in zebrafish.LID - jcs.184341 [pii]Eisenhoffer GT, Slattum G, Ruiz OE, Otsuna H, Bryan CD, Lopez J, Wagner DS, Bonkowsky JL, Chien CB, Dorsky RI, Rosenblatt J (2016). A toolbox to study epidermal cell types in zebrafish.LID - jcs.184341 [pii]. (Epub ahead of print) J Cell Sci.
  2. Defective apical extrusion signaling contributes to aggressive tumor hallmarks.Gu Y, Shea J, Slattum G, Firpo MA, Alexander M, Mulvihill SJ, Golubovskaya VM, Rosenblatt J (2015). Defective apical extrusion signaling contributes to aggressive tumor hallmarks. Elife, 4, e04069.
  3. Tumour cell invasion: an emerging role for basal epithelial cell extrusion.Slattum GM, Rosenblatt J (2014). Tumour cell invasion: an emerging role for basal epithelial cell extrusion. Nat Rev Cancer, 14(7), 495-501.
  4. Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P.Slattum G, Gu Y, Sabbadini R, Rosenblatt J (2014). Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P. Curr Biol, 24(1), 19-28.
  5. Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia.Eisenhoffer GT, Loftus PD, Yoshigi M, Otsuna H, Chien CB, Morcos PA, Rosenblatt J (2012). Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. Nature, 484(7395), 546-9.
  6. The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium.Marshall TW, Lloyd IE, Delalande JM, Nathke I, Rosenblatt J (2011). The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium. Mol Biol Cell, 22(21), 3962-70.
  7. Live imaging of cell extrusion from the epidermis of developing zebrafish.LID - 10.3791/2689 [doi]LID - 2689 [pii]Eisenhoffer GT, Rosenblatt J (2011). Live imaging of cell extrusion from the epidermis of developing zebrafish.LID - 10.3791/2689 [doi]LID - 2689 [pii]. J Vis Exp, (52).
  8. Rosenblatt J (2011). Explaining extrusion. International Innovation, 1, 111-113.
  9. Apoptotic regulation of epithelial cellular extrusion.Andrade D, Rosenblatt J (2011). Apoptotic regulation of epithelial cellular extrusion. Apoptosis, 16(5), 491-501.
  10. Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway.Gu Y, Forostyan T, Sabbadini R, Rosenblatt J (2011). Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway. J Cell Biol, 193(4), 667-76.
  11. P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium.Slattum G, McGee KM, Rosenblatt J (2009). P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium. J Cell Biol, 186(5), 693-702.
  12. Mitosis: moesin and the importance of being round.Rosenblatt J (2008). Mitosis: moesin and the importance of being round. Curr Biol, 18(7), R292-3.
  13. Rosenblatt J, Cramer LP, Baum B, McGee KM (2004). Myosin II-dependent cortical movement is required for centrosome separation and positioning during mitotic spindle assembly. Cell, 117(3), 361-72.
  14. Rosenblatt J, Raff MC, Cramer LP (2001). An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism. Curr Biol, 11(23), 1847-57.
  15. Welch MD, Rosenblatt J, Skoble J, Portnoy DA, Mitchison TJ (07/03/1998). Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation. Science, 281(5373), 105-8.
  16. Rosenblatt J, Agnew BJ, Abe H, Bamburg JR, Mitchison TJ (03/24/1997). Xenopus actin depolymerizing factor/cofilin (XAC) is responsible for the turnover of actin filaments in Listeria monocytogenes tails. J Cell Biol, 136(6), 1323-32.
  17. A purified Drosophila septin complex forms filaments and exhibits GTPase activity.Field CM, al-Awar O, Rosenblatt J, Wong ML, Alberts B, Mitchison TJ (1996). A purified Drosophila septin complex forms filaments and exhibits GTPase activity. J Cell Biol, 133(3), 605-16.
  18. The bulk of unpolymerized actin in Xenopus egg extracts is ATP-bound.Rosenblatt J, Peluso P, Mitchison TJ (1995). The bulk of unpolymerized actin in Xenopus egg extracts is ATP-bound. Mol Biol Cell, 6(2), 227-36.
  19. Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts.Theriot JA, Rosenblatt J, Portnoy DA, Goldschmidt-Clermont PJ, Mitchison TJ (1994). Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts. Cell, 76(3), 505-17.
  20. Crystal structure of cyclin-dependent kinase 2.De Bondt HL, Rosenblatt J, Jancarik J, Jones HD, Morgan DO, Kim SH (1993). Crystal structure of cyclin-dependent kinase 2. Nature, 363(6430), 595-602.
  21. A transcriptional switch between the Pig-1 and Sgs-4 genes of Drosophila melanogaster.Mougneau E, von Seggern D, Fowler T, Rosenblatt J, Jongens T, Rogers B, Gietzen D, Beckendorf SK (1993). A transcriptional switch between the Pig-1 and Sgs-4 genes of Drosophila melanogaster. Mol Cell Biol, 13(1), 184-95.
  22. Purification and crystallization of human cyclin-dependent kinase 2.Rosenblatt J, De Bondt H, Jancarik J, Morgan DO, Kim SH (1993). Purification and crystallization of human cyclin-dependent kinase 2. J Mol Biol, 230(4), 1317-9.
  23. Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.Rosenblatt J, Gu Y, Morgan DO (1992). Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A. Proc Natl Acad Sci U S A, 89(7), 2824-8.
  24. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.Gu Y, Rosenblatt J, Morgan DO (1992). Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J, 11(11), 3995-4005.
  25. Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins.Weiner AJ, Brauer MJ, Rosenblatt J, Richman KH, Tung J, Crawford K, Bonino F, Saracco G, Choo QL, Houghton M, et al (1991). Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins. Virology, 180(2), 842-8.
  26. Detection of hepatitis C viral sequences in non-A, non-B hepatitis.Weiner AJ, Kuo G, Bradley DW, Bonino F, Saracco G, Lee C, Rosenblatt J, Choo QL, Houghton M (1990). Detection of hepatitis C viral sequences in non-A, non-B hepatitis. Lancet, 335(8680), 1-3.
  27. Early events in hepatitis C virus infection of chimpanzees.Shimizu YK, Weiner AJ, Rosenblatt J, Wong DC, Shapiro M, Popkin T, Houghton M, Alter HJ, Purcell RH (1990). Early events in hepatitis C virus infection of chimpanzees. Proc Natl Acad Sci U S A, 87(16), 6441-4.

Review

  1. Epithelial cell extrusion: Pathways and pathologies.LID - S1084-9521(16)30136-7 [pii]LID - 10.1016/j.semcdb.2016.05.010 [doi]Gudipaty SA, Rosenblatt J (2016). Epithelial cell extrusion: Pathways and pathologies.LID - S1084-9521(16)30136-7 [pii]LID - 10.1016/j.semcdb.2016.05.010 [doi]. [Review]. Semin Cell Dev Biol.
  2. Cells: Shaping tissues and organs.Rosenblatt J, Gartner Z (2014). Cells: Shaping tissues and organs. [Review]. Mol Biol Cell, 25(6), 730.
  3. Bringing balance by force: live cell extrusion controls epithelial cell numbers.Eisenhoffer GT, Rosenblatt J (2013). Bringing balance by force: live cell extrusion controls epithelial cell numbers. [Review]. Trends Cell Biol, 23(4), 185-92.
  4. Programmed cell death: a new way worms get rid of unwanted cells.Rosenblatt J (2012). Programmed cell death: a new way worms get rid of unwanted cells. [Review]. Curr Biol, 22(19), R844-6.
  5. New emerging roles for epithelial cell extrusion.Gu Y, Rosenblatt J (2012). New emerging roles for epithelial cell extrusion. [Review]. Curr Opin Cell Biol, 24(6), 865-70.
  6. Rosenblatt J (2005). Spindle assembly: asters part their separate ways. [Review]. Nature Cell Biology, 7((3)), 219-22.
  7. Actin, cofilin and cognition.Rosenblatt J, Mitchison TJ (1998). Actin, cofilin and cognition. [Review]. Nature, 393(6687), 739-40.
  8. Actin dynamics in vivo.Welch MD, Mallavarapu A, Rosenblatt J, Mitchison TJ (1997). Actin dynamics in vivo. [Review]. Curr Opin Cell Biol, 9(1), 54-61.

Letter

  1. HCV testing in low-risk population.Weiner AJ, Truett MA, Rosenblatt J, Han J, Quan S, Polito AJ, Kuo G, Choo QL, Houghton M, Agius C, et al (1990). HCV testing in low-risk population [Letter to the editor]. Lancet, 336(8716), 695.

Other

  1. Jody Rosenblatt: to extrude apically or basally, that is the question. Interview by Caitlin Sedwick.Rosenblatt J (2013). Jody Rosenblatt: to extrude apically or basally, that is the question. Interview by Caitlin Sedwick. J Cell Biol (202(4), pp. 602-3). United States.