Dean Tantin, PhD

Research Interests

  • Transcriptional Control of Malignant State
  • Development and Regulation of Immune Responses
  • Stem Cells
  • Gene Regulation

Labs

Lab Website

Languages

  • English

Academic Information

  • Departments: Pathology - Associate Professor
  • Divisions: Microbiology and Immunology
  • Cancer Center Programs: Nuclear Control of Cell Growth & Differentiation

Academic Office Information

  • 801-587-3035
  • Emma Eccles Jones Research Building
    Pathology
    15 North Medical Drive East, Room: 5200K
    Salt Lake City, UT 84112

Email: dean.tantin@path.utah.edu

Academic Bio

Dean Tantin is an Associate Professor in the Department of Pathology at the University of Utah and a member of the Nuclear Control of Cell Growth and Differentiation Program at Huntsman Cancer Institute.

Tantin studies gene expression and its relationship to immune and stem cell function, and malignancy. He focuses on a class of transcription factors that have been tied to cellular reprogramming and immune function. The proteins are called Oct1, Oct2, and Oct4. These proteins affect cellular physiology and differentiation state through control of metabolism and through control of poised (silent but readily inducible) gene expression states. They interact with multiple cofactors that control local chromatin and gene expression.

Tantin received a B.S. in Molecular Biology from the University of California, San Diego and a Ph.D. from the UCLA Molecular Biology Interdepartmental Ph.D. program. He was a Postdoctoral Fellow at the Massachusetts Institute of Technology Center for Cancer Reseach and Department of Biology under Nobel Laureate Phil Sharp.

Education History

Type School Degree
Postdoctoral Fellowship Massachusetts Institute of Technology, Center for Cancer Research and Department of Biology
Postdoctoral Fellow
Doctoral Training University of California, Los Angeles, Molecular Biology Institute Interdepartmental Ph.D. Program
Molecular Biology
Ph.D.
Undergraduate University of California, San Diego Division of Biology
Molecular Biology
B.S.

Selected Publications

Journal Article

  1. Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis.LID - 10.7554/eLife.17985 [doi]LID - e17985 [pii]Kikani CK, Wu X, Paul L, Sabic H, Shen Z, Shakya A, Keefe A, Villanueva C, Kardon G, Graves B, Tantin D, Rutter J (2016). Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis.LID - 10.7554/eLife.17985 [doi]LID - e17985 [pii]. Elife, 5.
  2. Oct1 and OCA-B are selectively required for CD4 memory T cell function.Shakya A, Goren A, Shalek A, German CN, Snook J, Kuchroo VK, Yosef N, Chan RC, Regev A, Williams MA, Tantin D (2015). Oct1 and OCA-B are selectively required for CD4 memory T cell function. J Exp Med, 212(12), 2115-31.
  3. Pluripotency transcription factor Oct4 mediates stepwise nucleosome demethylation and depletion.Shakya A, Callister C, Goren A, Yosef N, Garg N, Khoddami V, Nix D, Regev A, Tantin D (2015). Pluripotency transcription factor Oct4 mediates stepwise nucleosome demethylation and depletion. Mol Cell Biol, 35(6), 1014-25.
  4. Vitamin C promotes maturation of T-cells.Manning J, Mitchell B, Appadurai DA, Shakya A, Pierce LJ, Wang H, Nganga V, Swanson PC, May JM, Tantin D, Spangrude GJ (2013). Vitamin C promotes maturation of T-cells. Antioxid Redox Signal, 19(17), 2054-67.
  5. Dynamic regulatory network controlling TH17 cell differentiation.Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, Wu C, Karwacz K, Xiao S, Jorgolli M, Gennert D, Satija R, Shakya A, Lu DY, Trombetta JJ, Pillai MR, Ratcliffe PJ, Coleman ML, Bix M, Tantin D, Park H, Kuchroo VK, Regev A (2013). Dynamic regulatory network controlling TH17 cell differentiation. Nature, 496(7446), 461-8.
  6. Regulation of Oct1/Pou2f1 transcription activity by O-GlcNAcylation.Kang J, Shen Z, Lim JM, Handa H, Wells L, Tantin D (2013). Regulation of Oct1/Pou2f1 transcription activity by O-GlcNAcylation. FASEB J, 27(7), 2807-17.
  7. Efficient chromatin immunoprecipitation using limiting amounts of biomass.Tantin D, Voth WP, Shakya A (2013). Efficient chromatin immunoprecipitation using limiting amounts of biomass. J Vis Exp, (75), e50064.
  8. Constitutive nuclear localization of NFAT in Foxp3+ regulatory T cells independent of calcineurin activity.Li Q, Shakya A, Guo X, Zhang H, Tantin D, Jensen PE, Chen X (2012). Constitutive nuclear localization of NFAT in Foxp3+ regulatory T cells independent of calcineurin activity. J Immunol, 188(9), 4268-77.
  9. Transcription factor Oct1 is a somatic and cancer stem cell determinant.Maddox J, Shakya A, South S, Shelton D, Andersen JN, Chidester S, Kang J, Gligorich KM, Jones DA, Spangrude GJ, Welm BE, Tantin D (2012). Transcription factor Oct1 is a somatic and cancer stem cell determinant. PLoS Genet, 8(11), e1003048.
  10. Oct1 is a switchable, bipotential stabilizer of repressed and inducible transcriptional states.Shakya A, Kang J, Chumley J, Williams MA, Tantin D (2011). Oct1 is a switchable, bipotential stabilizer of repressed and inducible transcriptional states. J Biol Chem, 286(1), 450-9.
  11. Combinatorial binding of transcription factors in the pluripotency control regions of the genome.Ferraris L, Stewart AP, Kang J, DeSimone AM, Gemberling M, Tantin D, Fairbrother WG (2011). Combinatorial binding of transcription factors in the pluripotency control regions of the genome. Genome Res, 21(7), 1055-64.
  12. Dynamic regulation of Oct1 during mitosis by phosphorylation and ubiquitination.Kang J, Goodman B, Zheng Y, Tantin D (2011). Dynamic regulation of Oct1 during mitosis by phosphorylation and ubiquitination. PLoS One, 6(8), e23872.
  13. A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress.Kang J, Gemberling M, Nakamura M, Whitby FG, Handa H, Fairbrother WG, Tantin D (2009). A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. Genes Dev, 23(2), 208-22.
  14. Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity.Shakya A, Cooksey R, Cox JE, Wang V, McClain DA, Tantin D (2009). Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity. Nat Cell Biol, 11(3), 320-7.
  15. An allergy-associated polymorphism in a novel regulatory element enhances IL13 expression.Kiesler P, Shakya A, Tantin D, Vercelli D (2009). An allergy-associated polymorphism in a novel regulatory element enhances IL13 expression. Hum Mol Genet, 18(23), 4513-20.
  16. Vzquez-Arregun K, Tantin D (In Press). The Oct1 transcription factor and epithelial malignancies: Old protein leans new tricks. Biochim Biophys Acta.

Review

  1. The Oct1 transcription factor and epithelial malignancies: Old protein learns new tricks.Vazquez-Arreguin K, Tantin D (2016). The Oct1 transcription factor and epithelial malignancies: Old protein learns new tricks. [Review]. Biochim Biophys Acta, 1859(6), 792-804.
  2. Oct transcription factors in development and stem cells: insights and mechanisms.Tantin D (2013). Oct transcription factors in development and stem cells: insights and mechanisms. [Review]. Development, 140(14), 2857-66.
  3. Stem cells, stress, metabolism and cancer: a drama in two Octs.Kang J, Shakya A, Tantin D (2009). Stem cells, stress, metabolism and cancer: a drama in two Octs. [Review]. Trends Biochem Sci, 34(10), 491-9.

Editorial

  1. Good times for Oct proteins.Tantin D (2016). Good times for Oct proteins. Biochim Biophys Acta, 1859(6), 769.