Frederick G. Strathmann, Ph.D., M.S.

Research Interests

  • Neuroglia
  • Inductively Coupled Plasma Mass Spectroscopy (ICP-MS)
  • Tandem Mass Spectrometry (MS/MS)
  • Metabolomics
  • Time-of-Flight Mass Spectrometry
  • Trace and Toxic Elements
  • Alcohol & Drug Abuse
  • Astrocytes
  • Mass Spectrometry
  • Synapses
  • Oligodendroglia
  • Proteomics
  • Microglia

Languages

  • English

Academic Information

  • Departments: Pathology - Assistant Professor
  • Divisions: Clinical Pathology

Board Certification

  • American Board of Clinical Chemistry
  • American Board of Clinical Chemistry (Sub: Toxicological Chemistry)

Academic Office Information

  • (801) 583-2787 Ext 2874
  • Medical Directors
    500 Chipeta Way
    Salt Lake City, UT 84105

Email: frederick.strathmann@utah.edu

Research Statement

My basic research interest is in exploring how astrocytes influence their environment during development, disease and repair of the central nervous system. My clinical focus is in trace and toxic element analysis, chronic pain and drugs of abuse.

Academic Bio

I am a Medical Director in Toxicology and the Associate Scientific Director of Mass Spectrometry at ARUP Laboratories, a tenure-track assistant professor of Pathology at the University of Utah School of Medicine and an associate member of the Interdepartmental Program In Neuroscience.

I received my MS and PhD in Pathology and Laboratory Medicine from the University of Rochester where I studied early glial cell development of the central nervous system, after which I focused on glial cell biology in development and repair paradigms as a postdoctoral fellow in the department of Biomedical Genetics at the University of Rochester. I completed a ComACC accredited clinical chemistry fellowship at the University of Washington in Seattle where I focused on small molecule analysis by mass spectrometry, quantitative multiplexed immunoassays in solid tissue diagnosis and developing automated laboratory quality metrics

I was the recipient of the 2009 AACC Upstate New York Max E. Chilcote Young Investigator Award and a travel award recipient to the 2010 MSACL conference. I was awarded the Strandjord-Clayson Award for Meritorious Research from the Department of Laboratory Medicine at the University of Washington in 2010, the Paul E. Strandjord Young Investigator Award from the Academy of Clinical Physicians and Scientists in 2010 and 2011 and the Young Clinical Scientist Award (Technology Development) from the Association of Clinical Scientists in 2013. I am board certified in clinical chemistry and toxicological chemistry by the American Board of Clinical Chemistry.

Education History

Type School Degree
Fellowship University of Washington
Clinical Chemistry
Fellow
Postdoctoral Fellowship University of Rochester, Laboratory of Dr. Mark Noble
Glial Biology
Postdoctoral Fellow
Doctoral Training University of Rochester, Laboratory of Dr. Margot Mayer-Proschel
Glial Biology
Ph.D.
Graduate Training University of Rochester
Pathology and Laboratory Medicine
M.S.
Undergraduate Harding University
B.S.

Selected Publications

Journal Article

  1. Marin SJ, Metcalf A, Krasowski MD, Linert BS, Clark CJ, Strathmann FG, McMillin GA (Februrary 2014). Detection of Neonatal Drug Exposure Using Umbilical Cord Tissue and Liquid Chromatography Time-of-Flight Mass Spectrometry. Ther Drug Monit, 36(1), 119-124.
  2. Lin CN, Strathmann FG (November 2013). Elevated urine zinc concentration reduces the detection of methamphetamine, cocaine, THC and opiates in urine by EMIT. J Anal Toxicol, 37(9), 665-669.
  3. Primary prevention of pediatric lead exposure requires new approaches to transfusion screening.Gehrie E, Keiser A, Dawling S, Travis J, Strathmann FG, Booth GS (2013). Primary prevention of pediatric lead exposure requires new approaches to transfusion screening. J Pediatr, 163(3), 855-9.
  4. Patient data algorithms.Straseski JA, Strathmann FG (2013). Patient data algorithms. Clin Lab Med, 33(1), 147-60.
  5. Characterizing antibody cross-reactivity for immunoaffinity purification of analytes prior to multiplexed liquid chromatography-tandem mass spectrometry.Laha TJ, Strathmann FG, Wang Z, de Boer IH, Thummel KE, Hoofnagle AN (2012). Characterizing antibody cross-reactivity for immunoaffinity purification of analytes prior to multiplexed liquid chromatography-tandem mass spectrometry. Clin Chem, 58(12), 1711-6.
  6. Iron deficiency disrupts axon maturation of the developing auditory nerve.Lee DL, Strathmann FG, Gelein R, Walton J, Mayer-Proschel M (2012). Iron deficiency disrupts axon maturation of the developing auditory nerve. J Neurosci, 32(14), 5010-5.
  7. Strathmann FG, Sadilkova K, Laha TJ, LeSourd SE, Bornhorst JA, Hoofnagle AN, Jack R (2012). 3-epi-25 hydroxyvitamin D concentrations are not correlated with age in a cohort of infants and adults. Clin Chim Acta, 413(1-2), 203-6.
  8. Strathmann FG, Borlee G, Born DE, Gonzalez-Cuyar LF, Huber BR, Baird GS (2012). Multiplex immunoassays of Peptide hormones extracted from formalin-fixed, paraffin-embedded tissue accurately subclassify pituitary adenomas. Clin Chem, 58(2), 366-74.
  9. Quantification of 1alpha,25-dihydroxy vitamin D by immunoextraction and liquid chromatography-tandem mass spectrometry.Strathmann FG, Laha TJ, Hoofnagle AN (2011). Quantification of 1alpha,25-dihydroxy vitamin D by immunoextraction and liquid chromatography-tandem mass spectrometry. Clin Chem, 57(9), 1279-85.
  10. Simulations of delta check rule performance to detect specimen mislabeling using historical laboratory data.Strathmann FG, Baird GS, Hoffman NG (2011). Simulations of delta check rule performance to detect specimen mislabeling using historical laboratory data. Clin Chim Acta, 412(21-22), 1973-7.
  11. Strathmann FG, Ka MM, Rainey PM, Baird GS (Accepted For Publication). Use of the BD Vacutainer® Rapid Serum Tube Reduces Immunoassay False Positive Results for Select Beckman Coulter Unicel DxI Tests. Am J Clin Pathol.
  12. Identifying a window of vulnerability during fetal development in a maternal iron restriction model.Mihaila C, Schramm J, Strathmann FG, Lee DL, Gelein RM, Luebke AE, Mayer-Proschel M (2011). Identifying a window of vulnerability during fetal development in a maternal iron restriction model. PLoS One, 6(3), e17483.
  13. Neural precursor cell proliferation is disrupted through activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin.Latchney SE, Lioy DT, Henry EC, Gasiewicz TA, Strathmann FG, Mayer-Proschel M, Opanashuk LA (2011). Neural precursor cell proliferation is disrupted through activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Stem Cells Dev, 20(2), 313-26.
  14. Identification of two novel glial-restricted cell populations in the embryonic telencephalon arising from unique origins.Strathmann FG, Wang X, Mayer-Proschel M (2007). Identification of two novel glial-restricted cell populations in the embryonic telencephalon arising from unique origins. BMC Dev Biol, 7, 33.
  15. Infection of murine oligodendroglial precursor cells with Human Herpesvirus 6 (HHV-6)--establishment of a murine in vitro model.Mock DJ, Strathmann F, Blumberg BM, Mayer-Proschel M (2006). Infection of murine oligodendroglial precursor cells with Human Herpesvirus 6 (HHV-6)--establishment of a murine in vitro model. J Clin Virol, 37 Suppl 1, S17-23.

Review

  1. Blood-based biomarkers for traumatic brain injury: evaluation of research approaches, available methods and potential utility from the clinician and clinical laboratory perspectives.Strathmann FG, Schulte S, Goerl K, Petron DJ (2014). Blood-based biomarkers for traumatic brain injury: evaluation of research approaches, available methods and potential utility from the clinician and clinical laboratory perspectives. [Review]. Clin Biochem, 47(10-11), 876-88.

Book Chapter

  1. Gwendolyn A McMillin, Deborah E Keil, Frederick G Strathmann (2013). Lead Testing. In Leslie M. Shaw, Tai C. Kwong (Eds.), The Clinical Toxicology Laboratory: Contemporary Practice of Poisoning Evaluation (2). American Association for Clinical Chemistry.

Video/Film/CD/Web/Podcast

  1. Strathmann FG (March 2014). Fitting Linear Quadrupoles and Round Flight Tubes into the Square Clinical Laboratory: The What, Where and Why of Clinical Mass Spectrometry. IFL Quarterly Webinar Series [Video]. Salt Lake City, UT: ARUP Institute for Learning. Available: arup.utah.edu.