Srividya Bhaskara, PhD

Research Interests

  • Chromatin
  • Histone Deacetylases
  • Immunology
  • DNA Repair
  • DNA Replication
  • Cancer Biology
  • Cancer Therapeutics
  • Mouse Models of Cancer

Labs

Lab Website

Languages

  • English

Academic Information

  • Departments: Oncological Sciences - Adjunct Assistant Professor, Radiation Oncology - Assistant Professor
  • Cancer Center Programs: Nuclear Control of Cell Growth & Differentiation

Academic Office Information

  • 801-213-4219
  • Huntsman Cancer Institute
    2000 Circle of Hope, Room: 5243
    Salt Lake City, UT 84112

Academic Bio

Dr. Bhaskara’s research goal is to understand the functions for histone deacetylases (HDACs) in genome maintenance, with the ultimate objective of using the knowledge to improve the therapeutic benefits of HDAC inhibition as a treatment for cancer. In Dr. Bhaskara’s post-doctoral research, she made the discovery that HDAC inhibitors induce cancer cell death by directly targeting genome stability independent of their effect of on transcription. She showed HDAC inhibitors trigger genotoxic stress and death only in cycling cells, and thereby, providing a mechanistic explanation for how HDAC inhibitors selectively kill rapidly cycling cancer cells and not the quiescent normal cells. Using genetic deletion systems, she further found novel functions for Hdac3 in DNA repair, DNA replication and chromatin structure maintenance. Collectively, these findings provide a new paradigm for the mode-of-action of HDAC inhibitors, which are FDA-approved drugs for the treatment of cutaneous T-cell lymphomas. As an independent investigator, Dr. Bhaskara’s lab goal is to investigate cellular functions of Hdacs in maintaining genome stability. Dr. Bhaskara did her PhD in Dr. Ranjan Ganguly’s lab in University of Tennessee, Knoxville and performed her post-doctoral training at Vanderbilt University, Nashville in Dr. Scott Hiebert’s lab. Dr. Bhaskara received Vanderbilt Ingram Cancer Center post-doc of the year 2010 award and NIH Ruth Kirschstein National Research service F32 grant award during her post-doc study.

Education History

Type School Degree
Research Fellow Vanderbilt University Medical Center
Biochemistry
Postdoctoral Research Fellow
Doctoral Training Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee
Biochemistry
Ph.D.
Graduate Training Department of Biochemistry, Dr. A. L. M. Mudaliar Post-graduate Institute of Basic Medical Sciences,
Medical Biochemistry
M.S.
Undergraduate Department of Biochemistry, Mohammad Sathak College of Arts and Science, University of Madras
Biochemistry
B.S.

Global Impact

Education History

Type School Degree Country
Graduate Training Department of Biochemistry, Dr. A. L. M. Mudaliar Post-graduate Institute of Basic Medical Sciences,
Medical Biochemistry
M.S. India
Undergraduate Department of Biochemistry, Mohammad Sathak College of Arts and Science, University of Madras
Biochemistry
B.S. India

Career

Institution Description Country
Domex Pvt. Ltd. Scientific Editor India
Postgraduate Institute of Medical Education and Research Research Trainee in Molecular Biology India
Tuberculosis Research Center Research Trainee India

Selected Publications

Journal Article

  1. Chan E, Arlinghaus LR, Cardin DB, Goff L, Berlin JD, Parikh A, Abramson RG, Yankeelov TE, Hiebert S, Merchant N, Bhaskara S, Chakravarthy AB (2016). Phase I trial of vorinostat added to chemoradiation with capecitabine in pancreatic cancer. Radiother Oncol, 119(2), 312-8.
  2. Bhaskara S (2016). Examination of Proteins Bound to Nascent DNA in Mammalian Cells Using BrdU-ChIP-Slot-Western Technique. J Vis Exp, (107), e53647.
  3. Ramakrishnan S, Pokhrel S, Palani S, Pflueger C, Parnell TJ, Cairns BR, Bhaskara S, Chandrasekharan MB (2016). Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription. Nat Commun, 7, 11949.
  4. Huang F, Ramakrishnan S, Pokhrel S, Pflueger C, Parnell TJ, Kasten MM, Currie SL, Bhachech N, Horikoshi M, Graves BJ, Cairns BR, Bhaskara S, Chandrasekharan MB (2015). Interaction of the Jhd2 Histone H3 Lys-4 Demethylase with Chromatin Is Controlled by Histone H2A Surfaces and Restricted by H2B Ubiquitination. J Biol Chem, 290(48), 28760-77.
  5. Abegglen LM, Caulin AF, Chan A, Lee K, Robinson R, Campbell MS, Kiso WK, Schmitt DL, Waddell PJ, Bhaskara S, Jensen ST, Maley CC, Schiffman JD (2015). Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans. JAMA, 314(17), 1850-60.
  6. Bhaskara S (2015). Histone deacetylases 1 and 2 regulate DNA replication and DNA repair: potential targets for genome stability-mechanism-based therapeutics for a subset of cancers. Cell Cycle, 14(12), 1779-85.
  7. Johnson DP, Spitz GS, Tharkar S, Quayle SN, Shearstone JR, Jones S, McDowell ME, Wellman H, Tyler JK, Cairns BR, Chandrasekharan MB, Bhaskara S (2015). HDAC1,2 inhibition impairs EZH2- and BBAP-mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma. Oncotarget, 6(7), 4863-87.
  8. Ha K, Fiskus W, Choi DS, Bhaskara S, Cerchietti L, Devaraj SG, Shah B, Sharma S, Chang JC, Melnick AM, Hiebert S, Bhalla KN (2014). Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells. Oncotarget, 5(14), 5637-50.
  9. Wells CE, Bhaskara S, Stengel KR, Zhao Y, Sirbu B, Chagot B, Cortez D, Khabele D, Chazin WJ, Cooper A, Jacques V, Rusche J, Eischen CM, McGirt LY, Hiebert SW (2013). Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS One, 8(7), e68915.
  10. Hatzi K, Jiang Y, Huang C, Garrett-Bakelman F, Gearhart MD, Giannopoulou EG, Zumbo P, Kirouac K, Bhaskara S, Polo JM, Kormaksson M, MacKerell AD Jr, Xue F, Mason CE, Hiebert SW, Prive GG, Cerchietti L, Bardwell VJ, Elemento O, Melnick A (2013). A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters. Cell Rep, 4(3), 578-88.
  11. Summers AR, Fischer MA, Stengel KR, Zhao Y, Kaiser JF, Wells CE, Hunt A, Bhaskara S, Luzwick JW, Sampathi S, Chen X, Thompson MA, Cortez D, Hiebert SW (2013). HDAC3 is essential for DNA replication in hematopoietic progenitor cells. J Clin Invest, 123(7), 3112-23.
  12. Bhaskara S, Jacques V, Rusche JR, Olson EN, Cairns BR, Chandrasekharan MB (2013). Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progression. Epigenetics Chromatin, 6(1), 27.
  13. Ziesche E, Kettner-Buhrow D, Weber A, Wittwer T, Jurida L, Soelch J, Muller H, Newel D, Kronich P, Schneider H, Dittrich-Breiholz O, Bhaskara S, Hiebert SW, Hottiger MO, Li H, Burstein E, Schmitz ML, Kracht M (2013). The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-kappaB. Nucleic Acids Res, 41(1), 90-109.
  14. Sirbu BM, Couch FB, Feigerle JT, Bhaskara S, Hiebert SW, Cortez D (2011). Analysis of protein dynamics at active, stalled, and collapsed replication forks. Genes Dev, 25(12), 1320-7.
  15. Wilson AJ, Holson E, Wagner F, Zhang YL, Fass DM, Haggarty SJ, Bhaskara S, Hiebert SW, Schreiber SL, Khabele D (2011). The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells. Cancer Biol Ther, 12(6), 484-93.
  16. Bhaskara S, Hiebert SW (2011). Role for histone deacetylase 3 in maintenance of genome stability. Cell Cycle, 10(5), 727-8.
  17. Huang F, Chandrasekharan MB, Chen YC, Bhaskara S, Hiebert SW, Sun ZW (2010). The JmjN domain of Jhd2 is important for its protein stability, and the plant homeodomain (PHD) finger mediates its chromatin association independent of H3K4 methylation. J Biol Chem, 285(32), 24548-61.
  18. Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, Xia F, Holson EB, Khabele D, Hiebert SW (2010). Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell, 18(5), 436-47.
  19. Knutson SK, Chyla BJ, Amann JM, Bhaskara S, Huppert SS, Hiebert SW (2008). Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J, 27(7), 1017-28.
  20. Bhaskara S, Chyla BJ, Amann JM, Knutson SK, Cortez D, Sun ZW, Hiebert SW (2008). Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell, 30(1), 61-72.
  21. Chyla BJ, Moreno-Miralles I, Steapleton MA, Thompson MA, Bhaskara S, Engel M, Hiebert SW (2008). Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation. Mol Cell Biol, 28(20), 6234-47.
  22. Bhaskara S, Chandrasekharan MB, Ganguly R (2008). Caffeine induction of Cyp6a2 and Cyp6a8 genes of Drosophila melanogaster is modulated by cAMP and D-JUN protein levels. Gene, 415(1-2), 49-59.
  23. Bhaskara S, Dean ED, Lam V, Ganguly R (2006). Induction of two cytochrome P450 genes, Cyp6a2 and Cyp6a8, of Drosophila melanogaster by caffeine in adult flies and in cell culture. Gene, 377, 56-64.