Srividya Bhaskara, Ph.D.

Research Interests

  • Chromatin
  • Cancer Biology
  • Cancer Therapeutics
  • DNA Replication
  • DNA Repair
  • Immunology
  • Histone Deacetylases
  • Mouse Models of Cancer

Labs

Lab Website

Languages

  • English

Academic Information

  • Departments: Oncological Sciences - Adjunct Assistant Professor, Radiation Oncology - Assistant Professor
  • Cancer Center Programs: Nuclear Control of Cell Growth & Differentiation

Academic Office Information

  • (801) 213-4219
  • Huntsman Cancer Institute
    2000 Circle of Hope, Room: 5243
    Salt Lake City, UT 84112

Academic Bio

Dr. Bhaskara’s research goal is to understand the functions for histone deacetylases (HDACs) in genome maintenance, with the ultimate objective of using the knowledge to improve the therapeutic benefits of HDAC inhibition as a treatment for cancer. In Dr. Bhaskara’s post-doctoral research, she made the discovery that HDAC inhibitors induce cancer cell death by directly targeting genome stability independent of their effect of on transcription. She showed HDAC inhibitors trigger genotoxic stress and death only in cycling cells, and thereby, providing a mechanistic explanation for how HDAC inhibitors selectively kill rapidly cycling cancer cells and not the quiescent normal cells. Using genetic deletion systems, she further found novel functions for Hdac3 in DNA repair, DNA replication and chromatin structure maintenance. Collectively, these findings provide a new paradigm for the mode-of-action of HDAC inhibitors, which are FDA-approved drugs for the treatment of cutaneous T-cell lymphomas. As an independent investigator, Dr. Bhaskara’s lab goal is to investigate cellular functions of Hdacs in maintaining genome stability. Dr. Bhaskara did her PhD in Dr. Ranjan Ganguly’s lab in University of Tennessee, Knoxville and performed her post-doctoral training at Vanderbilt University, Nashville in Dr. Scott Hiebert’s lab. Dr. Bhaskara received Vanderbilt Ingram Cancer Center post-doc of the year 2010 award and NIH Ruth Kirschstein National Research service F32 grant award during her post-doc study.

Education History

Type School Degree
Research Fellow Vanderbilt University Medical Center
Biochemistry
Postdoctoral Research Fellow
Doctoral Training Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee
Biochemistry
Ph.D.
Graduate Training Department of Biochemistry, Dr. A. L. M. Mudaliar Post-graduate Institute of Basic Medical Sciences,
Biochemistry
M.S.
Undergraduate Department of Biochemistry, Mohammad Sathak College of Arts and Science, University of Madras
Biochemistry
B.S.

Global Impact

Education History

Type School Degree Country
Graduate Training Department of Biochemistry, Dr. A. L. M. Mudaliar Post-graduate Institute of Basic Medical Sciences,
Biochemistry
M.S. India
Undergraduate Department of Biochemistry, Mohammad Sathak College of Arts and Science, University of Madras
Biochemistry
B.S. India

Career

Institution Description Country
Postgraduate Institute of Medical Education and Research Research Trainee in Molecular Biology India
Tuberculosis Research Center Research Trainee India

Selected Publications

Journal Article

  1. Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma.Wells CE, Bhaskara S, Stengel KR, Zhao Y, Sirbu B, Chagot B, Cortez D, Khabele D, Chazin WJ, Cooper A, Jacques V, Rusche J, Eischen CM, McGirt LY, Hiebert SW (2013). Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS One, 8(7), e68915.
  2. A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.Hatzi K, Jiang Y, Huang C, Garrett-Bakelman F, Gearhart MD, Giannopoulou EG, Zumbo P, Kirouac K, Bhaskara S, Polo JM, Kormaksson M, MacKerell AD Jr, Xue F, Mason CE, Hiebert SW, Prive GG, Cerchietti L, Bardwell VJ, Elemento O, Melnick A (2013). A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters. Cell Rep, 4(3), 578-88.
  3. HDAC3 is essential for DNA replication in hematopoietic progenitor cells.Summers AR, Fischer MA, Stengel KR, Zhao Y, Kaiser JF, Wells CE, Hunt A, Bhaskara S, Luzwick JW, Sampathi S, Chen X, Thompson MA, Cortez D, Hiebert SW (2013). HDAC3 is essential for DNA replication in hematopoietic progenitor cells. J Clin Invest, 123(7), 3112-23.
  4. Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progression.Bhaskara S, Jacques V, Rusche JR, Olson EN, Cairns BR, Chandrasekharan MB (2013). Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progression. Epigenetics Chromatin, 6(1), 27.
  5. The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-kappaB.Ziesche E, Kettner-Buhrow D, Weber A, Wittwer T, Jurida L, Soelch J, Muller H, Newel D, Kronich P, Schneider H, Dittrich-Breiholz O, Bhaskara S, Hiebert SW, Hottiger MO, Li H, Burstein E, Schmitz ML, Kracht M (2013). The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-kappaB. Nucleic Acids Res, 41(1), 90-109.
  6. Analysis of protein dynamics at active, stalled, and collapsed replication forks.Sirbu BM, Couch FB, Feigerle JT, Bhaskara S, Hiebert SW, Cortez D (2011). Analysis of protein dynamics at active, stalled, and collapsed replication forks. Genes Dev, 25(12), 1320-7.
  7. The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells.Wilson AJ, Holson E, Wagner F, Zhang YL, Fass DM, Haggarty SJ, Bhaskara S, Hiebert SW, Schreiber SL, Khabele D (2011). The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells. Cancer Biol Ther, 12(6), 484-93.
  8. The JmjN domain of Jhd2 is important for its protein stability, and the plant homeodomain (PHD) finger mediates its chromatin association independent of H3K4 methylation.Huang F, Chandrasekharan MB, Chen YC, Bhaskara S, Hiebert SW, Sun ZW (2010). The JmjN domain of Jhd2 is important for its protein stability, and the plant homeodomain (PHD) finger mediates its chromatin association independent of H3K4 methylation. J Biol Chem, 285(32), 24548-61.
  9. Hdac3 is essential for the maintenance of chromatin structure and genome stability.Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, Xia F, Holson EB, Khabele D, Hiebert SW (2010). Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell, 18(5), 436-47.
  10. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks.Knutson SK, Chyla BJ, Amann JM, Bhaskara S, Huppert SS, Hiebert SW (2008). Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J, 27(7), 1017-28.
  11. Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control.Bhaskara S, Chyla BJ, Amann JM, Knutson SK, Cortez D, Sun ZW, Hiebert SW (2008). Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell, 30(1), 61-72.
  12. Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation.Chyla BJ, Moreno-Miralles I, Steapleton MA, Thompson MA, Bhaskara S, Engel M, Hiebert SW (2008). Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation. Mol Cell Biol, 28(20), 6234-47.
  13. Caffeine induction of Cyp6a2 and Cyp6a8 genes of Drosophila melanogaster is modulated by cAMP and D-JUN protein levels.Bhaskara S, Chandrasekharan MB, Ganguly R (2008). Caffeine induction of Cyp6a2 and Cyp6a8 genes of Drosophila melanogaster is modulated by cAMP and D-JUN protein levels. Gene, 415(1-2), 49-59.
  14. Induction of two cytochrome P450 genes, Cyp6a2 and Cyp6a8, of Drosophila melanogaster by caffeine in adult flies and in cell culture.Bhaskara S, Dean ED, Lam V, Ganguly R (2006). Induction of two cytochrome P450 genes, Cyp6a2 and Cyp6a8, of Drosophila melanogaster by caffeine in adult flies and in cell culture. Gene, 377, 56-64.

Review

  1. Role for histone deacetylase 3 in maintenance of genome stability.Bhaskara S, Hiebert SW (2011). Role for histone deacetylase 3 in maintenance of genome stability. [Review]. Cell Cycle, 10(5), 727-8.