Mingnan Chen, PhD

Research Interests

  • Immune Tolerance
  • Biomaterials
  • Immune-Tolerant Biomaterials
  • Drug Delivery
  • Metastasis
  • Cancer Vaccines

Languages

  • Chinese
  • English

Academic Information

  • Departments: Pharmaceutics and Pharmaceutical Chemistry - Assistant Professor
  • Cancer Center Programs: Experimental Therapeutics

Academic Office Information

  • 801-581-7616
  • L.S. Skaggs Pharmacy Institute
    30 S 2000 E, Room: 2962
    Salt Lake City, UT 84112

Academic Bio

Mingnan Chen, PhD is an assistant professor in the Department of Pharmaceutics and Pharmaceutical Chemistry at University of Utah and a member of the Utah Nano Institute. He is also a member of the Experimental Therapeutics Program at Huntsman Cancer Institute.Chen is interested in understanding the interplays between peptide materials and the host immune system and applying this understanding to engineer immune tolerant peptide materials. One such material is immune-tolerant elastin-like polypeptide (iTEP). The second research thrust of Chen’s lab concerns medical applications of iTEPs. One such application is to use iTEP-based vaccine carriers to boost the efficacy of cancer peptide vaccines. Another example of the application is to devise iTEP nanoparticles to deliver anti-metastasis drugs to metastasis-initiating cells, which is expected to inhibit tumor metastasis. Chen received a bachelor's degree from the Jimei University, a master’s degree from Peking University, and a PhD from the University of Connecticut.

Education History

Type School Degree
Postdoctoral Training Duke University, Department of Biomedical Engineering
Drug Delivery
Postdoctoral Training
Doctoral Training University of Connecticut, School of Pharmacy
Pharmaceutical Sciences
Ph.D.
Graduate Training Peking University, College of Life Science
Biological Sciences
M.Sc.
Undergraduate Jimei University, College of Aquaculture
Aquaculture
B.Sc.

Global Impact

Education History

Type School Degree Country
Graduate Training Peking University, College of Life Science
Biological Sciences
M.Sc. China
Undergraduate Jimei University, College of Aquaculture
Aquaculture
B.Sc. China

Presentations

Description Country
Immune-tolerant elastin-like polypeptide (iTEP) nanoparticle: a “bilingual” nanocarrier that energizes cancer stem cell-targeted therapy. The Affiliated Hospital of Hainan Medical College and the Exchange Program for High-End Foreign Experts. Haikou, Hainan, China China

Selected Publications

Journal Article

  1. Zhao, P, Dong, S, Bhattacharyya, J, and Chen, M (2014). iTEP Nanoparticle-Delivered Salinomycin Displays an Enhanced Toxicity to Cancer Stem Cells in Orthotopic Breast Tumors. Molecular Pharmaceutics.
  2. MacKay, JA, Chen, M, Liu, W, McDaniel, J, Simnick, A, and Chilkoti, A (2009). Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumors after a single injection. Nature Materials, 8, 993-999.
  3. Sadegh-Nasseri, S, Chen, M, Narayan, K, and Bouvier, M (2008). The convergent roles of tapasin and HLA-DM in antigen presentation. Trends in Immunology, 29, 141-147.
  4. Chen, M, Bouvier, M (2007). Analysis of interactions in a tapasin/class I complex provides a mechanism for peptide selection. Recommended as a “Must Read” paper by Faculty of 1000 Biology. The EMBO Journal, 26, 1681-1690.

Video