Clinton C. Mason, PhD

Research Interests

  • Genomic Analysis
  • Cancer Genetics
  • Pediatric Cancers
  • De Novo Mutations
  • Next Generation Sequencing
  • Statistics & Study Design

Languages

  • English

Academic Information

  • Departments: Pediatrics - Assistant Professor
  • Divisions: Pediatric Hematology/Oncology

Academic Office Information

  • 801-587-3633
  • 417 Wakara Way, Room: Room 3117
    Salt Lake City, UT 84108

Academic Bio

Clinton C. Mason, PhD is an Assistant Professor in the Department of Pediatrics, Division of Pediatric Hematology-Oncology, at the University of Utah.

Dr. Mason received his undergraduate training in Physics at Brigham Young University followed by a PhD in Applied Mathematics from Arizona State University in 2006 (emphasis in Differential Equations and Mathematical Biology), with dissertation work modeling the longitudinal development of type 2 diabetes. He then enjoyed a postdoctoral fellowship for 5 years with the National Institutes of Health in the fields of bioinformatics, biostatistics, epidemiology, and diabetes physiology. Following this fellowship, Dr. Mason worked at the Huntsman Cancer Institute as a bioinformatics data analyst for investigators studying leukemia and familial cancers.

Dr. Mason is focused on understanding pediatric cancers as well as other diseases mainly through genome-wide investigations. These genetic queries often require large computational resources to identify potential disease-related variants, mutations, and other genetic factors in comparison to healthy controls. These investigations are crucial steps preceding the era of personalized medicine.

Webpage: home.chpc.utah.edu/~mason

Education History

Type School Degree
Fellowship National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases
Biostatistics, Bioinformatics, Epidemiology
Fellow
Doctoral Training Arizona State University
Differential Equations and Mathematical Biology
Ph.D.
Undergraduate Brigham Young University
Physics, Minor: Mathematics
B.S.

Selected Publications

Journal Article

  1. Grice BA, Nelson RG, Williams DE, Knowler WC, Mason C, Hanson RL, Bullard KM, Pavkov ME (2017). Associations between persistent organic pollutants, type 2 diabetes, diabetic nephropathy and mortality. Occup Environ Med, 74(7), 521-527.
  2. Mason CC (2017). Four study design principles for genetic investigations using next generation sequencing. BMJ, 359, j4069.
  3. Meyer JA, Zhou D, Mason CC, Downie JM, Rodic V, Abromowitch M, Wistinghausen B, Termuhlen AM, Angiolillo AL, Perkins SL, Lones MA, Barnette P, Schiffman JD, Miles RR (2017). Genomic characterization of pediatric B-lymphoblastic lymphoma and B-lymphoblastic leukemia using formalin-fixed tissues.LID - 10.1002/pbc.26363 [doi]. Pediatr Blood Cancer, 64(7).
  4. Patel S, Mason CC, Glenn MJ, Paxton CN, South ST, Cessna MH, Asch J, Cobain EF, Bixby DL, Smith LB, Reshmi S, Gastier-Foster JM, Schiffman JD, Miles RR (2017). Genomic analysis of adult B-ALL identifies potential markers of shorter survival. Leuk Res, 56, 44-51.
  5. Pflieger LT, Mason CC, Facelli JC (2017). Uncertainty quantification in breast cancer risk prediction models using self-reported family health history. J Clin Transl Sci, 1(1), 53-59.
  6. Khorashad JS, Tantravahi SK, Yan D, Mason CC, Qiao Y, Eiring AM, Gligorich K, Hein T, Pomicter AD, Reid AG, Kelley TW, Marth GT, OHare T, Deininger MW (2016). Rapid conversion of chronic myeloid leukemia to chronic myelomonocytic leukemia in a patient on imatinib therapy. Leukemia, 30(11), 2275-2279.
  7. Mason CC, Khorashad JS, Tantravahi SK, Kelley TW, Zabriskie MS, Yan D, Pomicter AD, Reynolds KR, Eiring AM, Kronenberg Z, Sherman RL, Tyner JW, Dalley BK, Dao KH, Yandell M, Druker BJ, Gotlib J, OHare T, Deininger MW (2016). Age-related mutations and chronic myelomonocytic leukemia. Leukemia, 30(4), 906-13.
  8. Cohen A, Sato M, Aldape K, Mason CC, Alfaro-Munoz K, Heathcock L, South ST, Abegglen LM, Schiffman JD, Colman H (2015). DNA copy number analysis of Grade II-III and Grade IV gliomas reveals differences in molecular ontogeny including chromothripsis associated with IDH mutation status. Acta Neuropathol Commun, 3, 34.
  9. Eiring AM, Khorashad JS, Anderson DJ, Yu F, Redwine HM, Mason CC, Reynolds KR, Clair PM, Gantz KC, Zhang TY, Pomicter AD, Kraft IL, Bowler AD, Johnson K, Partlin MM, OHare T, Deininger MW (2015). beta-Catenin is required for intrinsic but not extrinsic BCR-ABL1 kinase-independent resistance to tyrosine kinase inhibitors in chronic myeloid leukemia. Leukemia, 29(12), 2328-37.
  10. Khorashad JS, Eiring AM, Mason CC, Gantz KC, Bowler AD, Redwine HM, Yu F, Kraft IL, Pomicter AD, Reynolds KR, Iovino AJ, Zabriskie MS, Heaton WL, Tantravahi SK, Kauffman M, Shacham S, Chenchik A, Bonneau K, Ullman KS, OHare T, Deininger MW (2015). shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance. Blood, 125(11), 1772-81.
  11. Eiring AM, Page BDG, Kraft IL, Mason CC, Vellore NA, Resetca D, Zabriskie MS, Zhang TY, Khorashad JS, Engar AJ, Reynolds KR, Anderson DJ, Senina A, Pomicter AD, Arpin CC, Ahmad S, Heaton WL, Tantravahi SK, Todic A, Moriggl R, Wilson DJ, Baron R, OHare T, Gunning PT, Deininger MW (2015). Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia. Leukemia, 29(3), 586-597.
  12. Khorashad JS, Kelley TW, Szankasi P, Mason CC, Soverini S, Adrian LT, Eide CA, Zabriskie MS, Lange T, Estrada JC, Pomicter AD, Eiring AM, Kraft IL, Anderson DJ, Gu Z, Alikian M, Reid AG, Foroni L, Marin D, Druker BJ, OHare T, Deininger MW (2013). BCR-ABL1 compound mutations in tyrosine kinase inhibitor-resistant CML: frequency and clonal relationships. Blood, 121(3), 489-98.
  13. Kim NH, Mason CC, Nelson RG, Afton SE, Essader AS, Medlin JE, Levine KE, Hoppin JA, Lin C, Knowler WC, Sandler DP (2013). Arsenic exposure and incidence of type 2 diabetes in Southwestern American Indians. Am J Epidemiol, 177(9), 962-9.
  14. Traurig MT, Orczewska JI, Ortiz DJ, Bian L, Marinelarena AM, Kobes S, Malhotra A, Hanson RL, Mason CC, Knowler WC, Bogardus C, Baier LJ (2013). Evidence for a role of LPGAT1 in influencing BMI and percent body fat in Native Americans. Obesity (Silver Spring), 21(1), 193-202.
  15. Grice BA, Mason CC, Weil EJ, Knowler WC, Pomeroy J (2013). The relationship between insulin sensitivity and maximal oxygen uptake is confounded by method of adjustment for body composition. Diab Vasc Dis Res, 10(6), 530-5.
  16. Pavkov ME, Knowler WC, Lemley KV, Mason CC, Myers BD, Nelson RG (2012). Early renal function decline in type 2 diabetes. Clin J Am Soc Nephrol, 7(1), 78-84.
  17. Weil EJ, Lemley KV, Mason CC, Yee B, Jones LI, Blouch K, Lovato T, Richardson M, Myers BD, Nelson RG (2012). Podocyte detachment and reduced glomerular capillary endothelial fenestration promote kidney disease in type 2 diabetic nephropathy. Kidney Int, 82(9), 1010-7.
  18. Jumpertz R, Guijarro A, Pratley RE, Mason CC, Piomelli D, Krakoff J (2012). Associations of fatty acids in cerebrospinal fluid with peripheral glucose concentrations and energy metabolism. PLoS One, 7(7), e41503.
  19. Florez JC, Jablonski KA, McAteer JB, Franks PW, Mason CC, Mather K, Horton E, Goldberg R, Dabelea D, Kahn SE, Arakaki RF, Shuldiner AR, Knowler WC (2012). Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program. PLoS One, 7(9), e44424.
  20. Dabelea D, DAgostino RB Jr, Mason CC, West N, Hamman RF, Mayer-Davis EJ, Maahs D, Klingensmith G, Knowler WC, Nadeau K (2011). Development, validation and use of an insulin sensitivity score in youths with diabetes: the SEARCH for Diabetes in Youth study. Diabetologia, 54(1), 78-86.
  21. Mason CC, Hanson RL, Ossowski V, Bian L, Baier LJ, Krakoff J, Bogardus C (2011). Bimodal distribution of RNA expression levels in human skeletal muscle tissue. BMC Genomics, 12, 98.
  22. Williams RC, Muller YL, Hanson RL, Knowler WC, Mason CC, Bian L, Ossowski V, Wiedrich K, Chen YF, Marcovina S, Hahnke J, Nelson RG, Baier LJ, Bogardus C (2011). HLA-DRB1 reduces the risk of type 2 diabetes mellitus by increased insulin secretion. Diabetologia, 54(7), 1684-92.
  23. Dong Y, Guo T, Traurig M, Mason CC, Kobes S, Perez J, Knowler WC, Bogardus C, Hanson RL, Baier LJ (2011). SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians. Mol Genet Metab, 104(4), 661-5.
  24. Bian L, Hanson RL, Ossowski V, Wiedrich K, Mason CC, Traurig M, Muller YL, Kobes S, Knowler WC, Baier LJ, Bogardus C (2010). Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians. Diabetes, 59(5), 1276-82.
  25. Moore AF, Jablonski KA, Mason CC, McAteer JB, Arakaki RF, Goldstein BJ, Kahn SE, Kitabchi AE, Hanson RL, Knowler WC, Florez JC (2009). The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program. J Clin Endocrinol Metab, 94(2), 449-55.
  26. Pavkov ME, Mason CC, Bennett PH, Curtis JM, Knowler WC, Nelson RG (2009). Change in the distribution of albuminuria according to estimated glomerular filtration rate in Pima Indians with type 2 diabetes. Diabetes Care, 32(10), 1845-50.
  27. Mason CC, Hanson RL, Knowler WC (2007). Progression to type 2 diabetes characterized by moderate then rapid glucose increases. Diabetes, 56(8), 2054-61.
  28. Li J, Kuang Y, Mason CC (2006). Modeling the glucose-insulin regulatory system and ultradian insulin secretory oscillations with two explicit time delays. J Theor Biol, 242(3), 722-35.

Letter

  1. Mangum DS, Downie J, Mason CC, Jahromi MS, Joshi D, Rodic V, Muschen M, Meeker N, Trede N, Frazer JK, Zhou Y, Cheng C, Jeha S, Pui CH, Willman CL, Harvey RC, Hunger SP, Yang JJ, Barnette P, Mullighan CG, Miles RR, Schiffman JD (2014). VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia [Letter to the editor]. Leukemia, 28(1), 216-20.