Ashley E. Walker, Ph.D.

Labs

Lab Website

Languages

  • English

Academic Information

  • Departments: Internal Medicine - Research Assistant Professor
  • Divisions: Geriatrics

Academic Office Information

  • (801) 582-1565 Ext 4334
  • Veterans Administration Medical Center
    500 S Foothill Blvd
    Salt Lake City, UT 84149

Academic Bio

Dr. Walker's primary research interest is to identify the mechanisms leading to impaired vascular function with advancing age. Specifically, she focuses on vascular impairments related to reduced endothelial function, increased arterial stiffness, increased arterial permeability, and increased susceptibility to damage following hemodynamic changes. In addition, Dr. Walker is interested in determining the functional consequences of these vascular impairments.

Education History

Type School Degree
Postdoctoral Fellowship University of Utah
Geriatrics
Postdoctoral Fellow
Postdoctoral Fellowship Cedars-Sinai Medical Institute
Vascular Biology
Postdoctoral Fellow
Doctoral Training University of Colorado
Integrative Physiology
Ph.D.
Undergraduate Oregon State University
Exercise and Sport Science
B.S.

Selected Publications

Journal Article

  1. Age-related arterial telomere uncapping and senescence is greater in women compared with men.Walker AE, Morgan RG, Ives SJ, Cawthon RM, Andtbacka RH, Noyes D, Lesniewski LA, Richardson RS, Donato AJ (2016). Age-related arterial telomere uncapping and senescence is greater in women compared with men. Exp Gerontol, 73, 65-71.
  2. Reduced large elastic artery stiffness with regular aerobic exercise in middle-aged and older adults: potential role of suppressed nuclear factor kappa B signalling.Jablonski KL, Donato AJ, Fleenor BS, Nowlan MJ, Walker AE, Kaplon RE, Ballak DB, Seals DR (2015). Reduced large elastic artery stiffness with regular aerobic exercise in middle-aged and older adults: potential role of suppressed nuclear factor kappa B signalling. J Hypertens, 33(12), 2477-82.
  3. Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium.Gibson CC, Davis CT, Zhu W, Bowman-Kirigin JA, Walker AE, Tai Z, Thomas KR, Donato AJ, Lesniewski LA, Li DY (2015). Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium. PLoS One, 10(10), e0140370.
  4. Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation.Gibson CC, Zhu W, Davis CT, Bowman-Kirigin JA, Chan AC, Ling J, Walker AE, Goitre L, Delle Monache S, Retta SF, Shiu YT, Grossmann AH, Thomas KR, Donato AJ, Lesniewski LA, Whitehead KJ, Li DY (2015). Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation. Circulation, 131(3), 289-99.
  5. Systemic sclerosis induces pronounced peripheral vascular dysfunction characterized by blunted peripheral vasoreactivity and endothelial dysfunction.Frech T, Walker AE, Barrett-OKeefe Z, Hopkins PN, Richardson RS, Wray DW, Donato AJ (2015). Systemic sclerosis induces pronounced peripheral vascular dysfunction characterized by blunted peripheral vasoreactivity and endothelial dysfunction. Clin Rheumatol, 34(5), 905-13.
  6. Greater impairments in cerebral artery compared with skeletal muscle feed artery endothelial function in a mouse model of increased large artery stiffness.Walker AE, Henson GD, Reihl KD, Morgan RG, Dobson PS, Nielson EI, Ling J, Mecham RP, Li DY, Lesniewski LA, Donato AJ (2015). Greater impairments in cerebral artery compared with skeletal muscle feed artery endothelial function in a mouse model of increased large artery stiffness. J Physiol, 593(8), 1931-43.
  7. Prevention of age-related endothelial dysfunction by habitual aerobic exercise in healthy humans: possible role of nuclear factor kappaB.Walker AE, Kaplon RE, Pierce GL, Nowlan MJ, Seals DR (2014). Prevention of age-related endothelial dysfunction by habitual aerobic exercise in healthy humans: possible role of nuclear factor kappaB. Clin Sci (Lond), 127(11), 645-54.
  8. Beneficial effects of lifelong caloric restriction on endothelial function are greater in conduit arteries compared to cerebral resistance arteries.Walker AE, Henson GD, Reihl KD, Nielson EI, Morgan RG, Lesniewski LA, Donato AJ (2014). Beneficial effects of lifelong caloric restriction on endothelial function are greater in conduit arteries compared to cerebral resistance arteries. Age (Dordr), 36(2), 559-69.
  9. Smooth muscle specific disruption of the endothelin-A receptor in mice reduces arterial pressure, and vascular reactivity and affects vascular development.Donato AJ, Lesniewski LA, Stuart D, Walker AE, Henson G, Sorensen L, Li D, Kohan DE (2014). Smooth muscle specific disruption of the endothelin-A receptor in mice reduces arterial pressure, and vascular reactivity and affects vascular development. Life Sci, 118(2), 238-43.
  10. Role of arterial telomere dysfunction in hypertension: relative contributions of telomere shortening and telomere uncapping.Morgan RG, Ives SJ, Walker AE, Cawthon RM, Andtbacka RH, Noyes D, Lesniewski LA, Richardson RS, Donato AJ (2014). Role of arterial telomere dysfunction in hypertension: relative contributions of telomere shortening and telomere uncapping. J Hypertens, 32(6), 1293-9.
  11. Dichotomous mechanisms of aortic stiffening in high-fat diet fed young and old B6D2F1 mice.Henson GD, Walker AE, Reihl KD, Donato AJ, Lesniewski LA (2014). Dichotomous mechanisms of aortic stiffening in high-fat diet fed young and old B6D2F1 mice. Physiol Rep, 2(3), e00268.
  12. Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging.DeVan AE, Eskurza I, Pierce GL, Walker AE, Jablonski KL, Kaplon RE, Seals DR (2013). Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging. Clin Sci (Lond), 124(5), 325-31.
  13. Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice.Donato AJ, Walker AE, Magerko KA, Bramwell RC, Black AD, Henson GD, Lawson BR, Lesniewski LA, Seals DR (2013). Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice. Aging Cell, 12(5), 772-83.
  14. Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: a pilot study.Pierce GL, Jablonski KL, Walker AE, Seibert SM, DeVan AE, Black SM, Sharma S, Seals DR (2012). Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: a pilot study. Am J Hypertens, 25(10), 1050-4.
  15. Vascular smooth muscle responsiveness to nitric oxide is reduced in healthy adults with increased adiposity.Christou DD, Pierce GL, Walker AE, Hwang MH, Yoo JK, Luttrell M, Meade TH, English M, Seals DR (2012). Vascular smooth muscle responsiveness to nitric oxide is reduced in healthy adults with increased adiposity. Am J Physiol Heart Circ Physiol, 303(6), H743-50.
  16. TNF-alpha impairs endothelial function in adipose tissue resistance arteries of mice with diet-induced obesity.Donato AJ, Henson GD, Morgan RG, Enz RA, Walker AE, Lesniewski LA (2012). TNF-alpha impairs endothelial function in adipose tissue resistance arteries of mice with diet-induced obesity. Am J Physiol Heart Circ Physiol, 303(6), H672-9.
  17. Fenofibrate improves vascular endothelial function by reducing oxidative stress while increasing endothelial nitric oxide synthase in healthy normolipidemic older adults.Walker AE, Kaplon RE, Lucking SM, Russell-Nowlan MJ, Eckel RH, Seals DR (2012). Fenofibrate improves vascular endothelial function by reducing oxidative stress while increasing endothelial nitric oxide synthase in healthy normolipidemic older adults. Hypertension, 60(6), 1517-23.
  18. Tadalafil alleviates muscle ischemia in patients with Becker muscular dystrophy.Martin EA, Barresi R, Byrne BJ, Tsimerinov EI, Scott BL, Walker AE, Gurudevan SV, Anene F, Elashoff RM, Thomas GD, Victor RG (2012). Tadalafil alleviates muscle ischemia in patients with Becker muscular dystrophy. Sci Transl Med, 4(162), 162ra155.
  19. Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults.Pierce GL, Eskurza I, Walker AE, Fay TN, Seals DR (2011). Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults. Clin Sci (Lond), 120(1), 13-23.
  20. 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults.Jablonski KL, Chonchol M, Pierce GL, Walker AE, Seals DR (2011). 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults. Hypertension, 57(1), 63-9.
  21. Plasma norepinephrine is an independent predictor of vascular endothelial function with aging in healthy women.Kaplon RE, Walker AE, Seals DR (2011). Plasma norepinephrine is an independent predictor of vascular endothelial function with aging in healthy women. J Appl Physiol (1985), 111(5), 1416-21.
  22. Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults.Walker AE, Seibert SM, Donato AJ, Pierce GL, Seals DR (2010). Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults. Hypertension, 55(2), 363-9.
  23. Modulation of vascular endothelial function by low-density lipoprotein cholesterol with aging: influence of habitual exercise.Walker AE, Eskurza I, Pierce GL, Gates PE, Seals DR (2009). Modulation of vascular endothelial function by low-density lipoprotein cholesterol with aging: influence of habitual exercise. Am J Hypertens, 22(3), 250-6.

Review

  1. Cellular and molecular biology of aging endothelial cells.Donato AJ, Morgan RG, Walker AE, Lesniewski LA (2015). Cellular and molecular biology of aging endothelial cells. [Review]. J Mol Cell Cardiol, 89(Pt B), 122-35.

Abstract

  1. Walker AE, Breevoort SR, Durrant JR, Machin DR, Dobson PS, Nielson EI, Donato AJ, Lesniewski LA (2016). Effect of Age and High Fat Diet on the Pro-Atherogenic Response to Oscillatory Blood Flow [Abstract]. FASEB J, 30(730.4).
  2. Reihl KD, Walker AE, Donato AJ, Lesniewski LA (2015). Partial carotid ligation impairs middle cerebral artery endothelial function in old mice [Abstract]. FASEB J, 29(949.1).
  3. Machin DR, Dobson PS, Ghaffari S, Walker AE, Lesniewski LA, Donato AJ (2015). Age-related telomere uncapping occurs independent of telomere shortening in mouse endothelial cells [Abstract]. FASEB J, 29, 642.1.
  4. Reihl K, Walker A, Henson G, Donato A, Lesniewski A (2014). Effects of aging and high fat diet on endothelial function in middle cerebral arteries is not additive [Abstract]. FASEB J, 28(1070), 11.
  5. Walker AE, Henson GD, Reihl KD, Lesniewski LA, Donato AJ (2014). SIRT1 overexpression protects against high fat diet-induced cerebral artery endothelial dysfunction [Abstract]. FASEB J, 28(1070), 10.
  6. Walker AE, McCullagh JP, Lesniewski LA, Donato AJ (2013). Smaller cerebrovascular arteries have a greater age- related endothelial dysfunction and a blunted response to life-long caloric restriction [Abstract]. FASEB J, 26(685), 31.
  7. Walker AE, Henson GD, Reihl KD, Bramwell RC, Li DY, Lesniewski LA, Donato AJ (2013). Aortic stiffening as a result of reduced elastin content leads to cerebral artery dysfunction [Abstract]. FASEB J, 27(1194), 3.
  8. Henson GD, Reihl KD, Walker AE, Bramwell RC, Donato AJ, Lesniewski LA (2013). Morphological Changes Underlying High Fat Diet-Associated Arterial Stiffening Differ with Advancing Age [Abstract]. FASEB J, 27(1194), 16.
  9. Frech TM, Walker A, Barrett-Okeefe Z, Richardson R, Wray, DW, Donato, A (2013). áThe Clinical Utility Of Flow- Mediated Dilation In Systemic Sclerosis. Presented at American College of Rheumatology Meeting, San Diego, CA [Abstract].
  10. Walker AE, Henson GD, Reihl KD, Bramwell RC, Li DY, Lesniewski LA, Donato AJ (2013). Augmented large artery stiffness suppresses cerebral artery endothelial function via oxidative stress mediated impairments in nitric oxide. Presented at Australian Vascular Biology Meeting, Barossa Valley, South Australia [Abstract].