Jason Gertz, PhD
- Breast Cancer
- Gene Expression Regulation
- Transcription Factors
- Endometrial Cancer
- Estrogen Receptors
- Departments: Oncological Sciences - Assistant Professor
- Cancer Center Programs: Nuclear Control of Cell Growth & Differentiation
Academic Office Information
Huntsman Cancer Institute
2000 Circle of Hope, Room: 4364
Salt Lake City, UT 84112
Jason Gertz, PhD, is an investigator at Huntsman Cancer Institute (HCI) and an assistant professor in the Department of Oncological Sciences at the University of Utah. He is also a member of the Nuclear Control of Cell Growth and Differentiation Program. Dr. Gertz studies the role of transcription factors in cancer.The inappropriate expression of genes is a common defect across different types of cancer. Transcription factors, which orchestrate gene expression patterns by interacting with specific loci throughout the genome, play a key role in the growth and development of tumors. Dr. Gertz’s research goal is to understand how transcription factors choose their genomic binding sites, how binding events lead to gene expression changes, and how the actions of transcription factors are altered in cancer. To determine the roles that transcription factors play in gene regulation, his lab uses and develops experimental methods that take advantage of next-generation sequencing to create high-resolution maps of gene regulatory networks. The Gertz lab also utilizes cutting edge computational approaches to take full advantage of these rich genomic datasets. The study of transcription factors in cancer promises to lead to new therapeutic targets and an understanding of key events that occur during tumorigenesis.Dr. Gertz received a BA in Mathematics with concentrations in Computer Science and Economics from Cornell University in 2003. In 2008, he received a PhD in Computational Biology from Washington University School of Medicine. He was a postdoctoral fellow in Richard M. Myers’ laboratory at the HudsonAlpha Institute for Biotechnology, where he was funded in part by the American Cancer Society. To learn more about the Gertz lab, please visit http://www.huntsmancancer.org/gertzlab.
|Postdoctoral Fellowship||HudsonAlpha Institute for Biotechnology
|Doctoral Training||Washington University School of Medicine
- Gertz J, Savic D, Varley KE, Partridge EC, Safi A, Jain P, Cooper GM, Reddy TE, Crawford GE, Myers RM (2013). Distinct properties of cell-type-specific and shared transcription factor binding sites. Mol Cell, 52(1), 25-36.
- Gertz J, Reddy TE, Varley KE, Garabedian MJ, Myers RM (2012). Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res, 22(11), 2153-62.
- Gertz J, Varley KE, Reddy TE, Bowling KM, Pauli F, Parker SL, Kucera KS, Willard HF, Myers RM (2011). Analysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation. PLoS Genet, 7(8), e1002228.
- Gertz J, Siggia ED, Cohen BA (2009). Analysis of combinatorial cis-regulation in synthetic and genomic promoters. Nature, 457(7226), 215-8.