Alex Shcheglovitov, PhD

Labs

Lab Website

Languages

  • English
  • Russian
  • Ukrainian

Academic Information

  • Departments: Neurobiology and Anatomy - Assistant Professor, Psychiatry - Adjunct Assistant Professor
  • Divisions: Adult Psychiatry

Academic Office Information

  • 801-581-5606
  • Biomedical Polymers Research Bldg
    Neurobiology and Anatomy
    20 S 2030 E, Room: 408C
    Salt Lake City, UT 84112

Email: alexsh@neuro.utah.edu

Education History

Type School Degree
Postdoctoral Training Stanford University
Neuroscience/Stem Cell Biology
Postdoctoral Training
Postdoctoral Training University of Virginia
Biophysics/Molecular Biology
Postdoctoral Training
Doctoral Training Bogomoletz Institute of Physiology
Biophysics
Ph.D.
Graduate Training National Technical University of Ukraine
Biophysics
M.S.
Undergraduate National Technical University of Ukraine
Applied Physics
B.S.

Global Impact

Education History

Type School Degree Country
Doctoral Training Bogomoletz Institute of Physiology
Biophysics
Ph.D. Ukraine
Graduate Training National Technical University of Ukraine
Biophysics
M.S. Ukraine
Undergraduate National Technical University of Ukraine
Applied Physics
B.S. Ukraine

Career

Institution Description Country
Department of General Physiology of Nervous System, Bogomoletz Institute of Physiology Junior Research Associate Ukraine
Department of General Physiology of Nervous System, Bogomoletz Institute of Physiology Research Assistant Ukraine

Selected Publications

Journal Article

  1. Eckle VS, Shcheglovitov A, Vitko I, Dey D, Yap CC, Winckler B, Perez-Reyes E (2014). Mechanisms by which a CACNA1H mutation in epilepsy patients increases seizure susceptibility. J Physiol, 592(Pt 4), 795-809.
  2. Krey JF, Pasca SP, Shcheglovitov A, Yazawa M, Schwemberger R, Rasmusson R, Dolmetsch RE (2013). Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons. Nat Neurosci, 16(2), 201-9.
  3. Shcheglovitov A, Shcheglovitova O, Yazawa M, Portmann T, Shu R, Sebastiano V, Krawisz A, Froehlich W, Bernstein JA, Hallmayer JF, Dolmetsch RE (2013). SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients. Nature, 503(7475), 267-71.
  4. Shcheglovitov A, Vitko I, Lazarenko RM, Orestes P, Todorovic SM, Perez-Reyes E (2012). Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels. J Gen Physiol, 139(3), 219-34.
  5. Nguyen HN, Byers B, Cord B, Shcheglovitov A, Byrne J, Gujar P, Kee K, Schule B, Dolmetsch RE, Langston W, Palmer TD, Pera RR (2011). LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. Cell Stem Cell, 8(3), 267-80.
  6. Yoo AS, Sun AX, Li L, Shcheglovitov A, Portmann T, Li Y, Lee-Messer C, Dolmetsch RE, Tsien RW, Crabtree GR (2011). MicroRNA-mediated conversion of human fibroblasts to neurons. Nature, 476(7359), 228-31.
  7. Pasca SP, Portmann T, Voineagu I, Yazawa M, Shcheglovitov A, Pasca AM, Cord B, Palmer TD, Chikahisa S, Nishino S, Bernstein JA, Hallmayer J, Geschwind DH, Dolmetsch RE (2011). Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome. Nat Med, 17(12), 1657-62.
  8. Park CY, Shcheglovitov A, Dolmetsch R (2010). The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels. Science, 330(6000), 101-5.
  9. Shcheglovitov A, Vitko I, Bidaud I, Baumgart JP, Navarro-Gonzalez MF, Grayson TH, Lory P, Hill CE, Perez-Reyes E (2008). Alternative splicing within the I-II loop controls surface expression of T-type Ca(v)3.1 calcium channels. FEBS Lett, 582(27), 3765-70.
  10. Vitko I, Shcheglovitov A, Baumgart JP, Arias-Olguin II, Murbartian J, Arias JM, Perez-Reyes E (2008). Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity. PLoS One, 3(10), e3560.
  11. Shcheglovitov A, Kostyuk P, Shuba Y (2007). Selectivity signatures of three isoforms of recombinant T-type Ca2+ channels. Biochim Biophys Acta, 1768(6), 1406-19.
  12. Shcheglovitov A, Zhelay T, Vitko Y, Osipenko V, Perez-Reyes E, Kostyuk P, Shuba Y (2005). Contrasting the effects of nifedipine on subtypes of endogenous and recombinant T-type Ca2+ channels. Biochem Pharmacol, 69(5), 841-54.

Video