Michelle C. Mendoza, Ph.D.

Research Interests

  • Metastasis
  • Cell Signaling
  • Cancer Biology
  • Cell Migration
  • Actin Cytoskeleton Dynamics

Languages

  • English

Academic Information

  • Departments: Oncological Sciences - Assistant Professor

Academic Office Information

  • (801) 213-5797
  • Huntsman Cancer Institute
    2000 Circle of Hope, Room: 5344
    Salt Lake City, UT 84112

Education History

Type School Degree
Postdoctoral Fellowship Harvard Medical School
Department of Cell Biology
Postdoctoral Fellow
Doctoral Training University of California, San Diego
Biomedical Sciences
Ph.D.
Undergraduate Pennsylvania State University
Animal Bioscience
B.S.

Selected Publications

Journal Article

  1. ERK reinforces actin polymerization to power persistent edge protrusion during motility.Mendoza MC, Vilela M, Juarez JE, Blenis J, Danuser G (2015). ERK reinforces actin polymerization to power persistent edge protrusion during motility. Sci Signal, 8(377), ra47.
  2. AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve.Er EE, Mendoza MC, Mackey AM, Rameh LE, Blenis J (2013). AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve. Sci Signal, 6(279), ra45.
  3. Down-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling.Zhang W, Mendoza MC, Pei X, Ilter D, Mahoney SJ, Zhang Y, Ma D, Blenis J, Wang Y (2012). Down-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling. J Biol Chem, 287(15), 11850-8.
  4. ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex.Mendoza MC, Er EE, Zhang W, Ballif BA, Elliott HL, Danuser G, Blenis J (2011). ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex. Mol Cell, 41(6), 661-71.

Review

  1. Phosphoregulation of the WAVE regulatory complex and signal integration.Mendoza MC (2013). Phosphoregulation of the WAVE regulatory complex and signal integration. [Review]. Semin Cell Dev Biol, 24(4), 272-9.
  2. The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation.Mendoza MC, Er EE, Blenis J (2011). The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. [Review]. Trends Biochem Sci, 36(6), 320-8.

Book Chapter

  1. Quantitative fluorescent speckle microscopy (QFSM) to measure actin dynamics.Mendoza MC, Besson S, Danuser G (2012). Quantitative fluorescent speckle microscopy (QFSM) to measure actin dynamics. In Current Protocols in Cytometry (Chapter 2, pp. Unit2.18). United States.
  2. ERK-MAP Kinase signaling in the cytoplasm.Mendoza MC, Er EE, Blenis J (2010). ERK-MAP Kinase signaling in the cytoplasm. In Methods Mol Biol (661, pp. 185-203). United States.

Video