2008 Publications from the Metabolism Interest Group
January 2008
Regulation of iron acquisition and storage: consequences for iron-linked disorders.
De Domenico I, McVey Ward D, Kaplan J.
Nat Rev Mol Cell Biol. 2008 Jan;9(1):72-81. Review.
Renal and vascular mechanisms of thiazolidinedione-induced fluid retention.
Yang T, Soodvilai S.
PPAR Res. 2008;2008:943614.
Epigenetic inhibition of nuclear receptor SHP is associated with and regulates hepatocellular carcinoma growth.
He N, Park KT, Zhang YX, Huang JS, Lu S and Wang L Gastroenterology 134, 793-802.
Orphan receptor SHP suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation.
Zhang YX, Xu P, Park KT, Choi YH, Moore DD and Wang L (2008) Hepatology 48, 289-98.
February 2008
Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome.
Bugger H, Abel ED.
Clin Sci (Lond). 2008 Feb;114(3):195-210. Review.
Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor.
Reinke H, Saini C, Fleury-Olela F, Dibner C, Benjamin IJ, Schibler U.
Genes Dev. 2008 Feb 1;22(3):331-45.
Yap5 is an iron-responsive transcriptional activator that regulates vacuolar iron storage in yeast.
Li L, Bagley D, Ward DM, Kaplan J.
Mol Cell Biol. 2008 Feb;28(4):1326-37. Epub 2007 Dec 10.
Multiple pathways influence mitochondrial inheritance in budding yeast.
Frederick RL, Okamoto K, Shaw JM.
Genetics. 2008 Feb;178(2):825-37. Epub 2008 Feb 1.
March 2008
Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis.
Jouihan HA, Cobine PA, Cooksey RC, Hoagland EA, Boudina S, Abel ED, Winge DR, McClain DA.
Mol Med. 2008 Mar-Apr;14(3-4):98-108.
Some vertebrates go with the GLO.
Troadec MB, Kaplan J.
Cell. 2008 Mar 21;132(6):921-2.
Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase.
Taylor RP, Parker GJ, Hazel MW, Soesanto Y, Fuller W, Yazzie MJ, McClain DA.
J Biol Chem. 2008 Mar 7;283(10):6050-7. Epub 2008 Jan 3.
April 2008
Cardiac remodeling in obesity.
Abel ED, Litwin SE, Sweeney G.
Physiol Rev. 2008 Apr;88(2):389-419. Review.
Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis.
Kumánovics A, Chen OS, Li L, Bagley D, Adkins EM, Lin H, Dingra NN, Outten CE, Keller G, Winge D, Ward DM, Kaplan J.
J Biol Chem. 2008 Apr 18;283(16):10276-86. Epub 2008 Feb 15.
Protein modification by O-linked GlcNAc reduces angiogenesis by inhibiting Akt activity in endothelial cells.
Luo B, Soesanto Y, McClain DA.
Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):651-7. Epub 2008 Jan 3.
The role of PAS kinase in regulating energy metabolism.
Hao HX, Rutter J.
IUBMB Life. 2008 Apr;60(4):204-9. Review.
The what, where, when and how of Wnt/beta-catenin signaling in pancreas development.
Murtaugh LC.
Organogenesis. 2008;4(2):81-86
High-throughput biochemical analysis of in vivo location data reveals novel distinct classes of POU5F1(Oct4)/DNA complexes.
Tantin D, Gemberling M, Callister C, Fairbrother W.
Genome Res. 2008 Apr;18(4):631-9. Epub 2008 Jan 22.
May 2008
Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations.
Amiott EA, Lott P, Soto J, Kang PB, McCaffery JM, DiMauro S, Abel ED, Flanigan KM, Lawson VH, Shaw JM.
Exp Neurol. 2008 May;211(1):115-27. Epub 2008 Jan 26.
Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression.
Stoltzman CA, Peterson CW, Breen KT, Muoio DM, Billin AN, Ayer DE.
Proc Natl Acad Sci U S A. 2008 May 13;105(19):6912-7. Epub 2008 May 5.
Mapping the functional interaction of Sco1 and Cox2 in cytochrome oxidase biogenesis.
Rigby K, Cobine PA, Khalimonchuk O, Winge DR.
J Biol Chem. 2008 May 30;283(22):15015-22. Epub 2008 Apr 7.
July 2008
The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.
Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP.
Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H185-96. Epub 2008 May 16.
Serotonin and insulin signaling team up to control growth in Drosophila.
Ruaud AF, Thummel CS.
Genes Dev. 2008 Jul 15;22(14):1851-5.
August 2008
Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts.
Tabbi-Anneni I, Buchanan J, Cooksey RC, Abel ED.
Endocrinology. 2008 Aug;149(8):4043-50. Epub 2008 May 1.
The hepcidin-binding site on ferroportin is evolutionarily conserved.
De Domenico I, Nemeth E, Nelson JM, Phillips JD, Ajioka RS, Kay MS, Kushner JP, Ganz T, Ward DM, Kaplan J.
Cell Metab. 2008 Aug;8(2):146-56.
Iron depletion limits intracellular bacterial growth in macrophages.
Paradkar PN, De Domenico I, Durchfort N, Zohn I, Kaplan J, Ward DM.
Blood. 2008 Aug 1;112(3):866-74. Epub 2008 Mar 27
Iron-independent phosphorylation of iron regulatory protein 2 regulates ferritin during the cell cycle.
Wallander ML, Zumbrennen KB, Rodansky ES, Romney SJ, Leibold EA.
J Biol Chem. 2008 Aug 29;283(35):23589-98. Epub 2008 Jun 23.
Developmental timing: let-7 function conserved through evolution.
Tennessen JM, Thummel CS.
Curr Biol. 2008 Aug 26;18(16):R707-8.
Differential control of Zap1-regulated genes in response to zinc deficiency in Saccharomyces cerevisiae.
Wu CY, Bird AJ, Chung LM, Newton MA, Winge DR, Eide DJ.
BMC Genomics. 2008 Aug 1;9:370.
Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis that facilitates the maturation of Cox1.
Pierrel F, Khalimonchuk O, Cobine PA, Bestwick M, Winge DR.
Mol Cell Biol. 2008 Aug;28(16):4927-39. Epub 2008 Jun 9.
Pet191 is a cytochrome c oxidase assembly factor in Saccharomyces cerevisiae.
Khalimonchuk O, Rigby K, Bestwick M, Pierrel F, Cobine PA, Winge DR.
Eukaryot Cell. 2008 Aug;7(8):1427-31. Epub 2008 May 23.
September 2008
The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging.
Sheaffer KL, Updike DL, Mango SE.
Curr Biol. 2008 Sep 23;18(18):1355-64.
Wormnet: a crystal ball for Caenorhabditis elegans.
Von Stetina SE, Mango SE.
Genome Biol. 2008;9(6):226. Epub 2008 Jun 2. Review.
A genetic screen identifies new regulators of steroid-triggered programmed cell death in Drosophila.
Wang L, Evans J, Andrews HK, Beckstead RB, Thummel CS, Bashirullah A.
Genetics. 2008 Sep;180(1):269-81. Epub 2008 Aug 30.
October 2008
Ceramide is a cardiotoxin in lipotoxic cardiomyopathy.
Park TS, Hu Y, Noh HL, Drosatos K, Okajima K, Buchanan J, Tuinei J, Homma S, Jiang XC, Abel ED, Goldberg IJ.
J Lipid Res. 2008 Oct;49(10):2101-12. Epub 2008 May 30.
Global expression profiling identifies a novel biosignature for protein aggregation R120GCryAB cardiomyopathy in mice.
Rajasekaran NS, Firpo MA, Milash BA, Weiss RB, Benjamin IJ.
Physiol Genomics. 2008 Oct 8;35(2):165-72. Epub 2008 Jul 15.
Clinical, pathological, and molecular correlates in ferroportin disease: a study of two novel mutations.
Girelli D, De Domenico I, Bozzini C, Campostrini N, Busti F, Castagna A, Soriani N, Cremonesi L, Ferrari M, Colombari R, McVey Ward D, Kaplan J, Corrocher R.
J Hepatol. 2008 Oct;49(4):664-71. Epub 2008 Jul 17.
Regulation of Akt signaling by O-GlcNAc in euglycemia.
Soesanto YA, Luo B, Jones D, Taylor R, Gabrielsen JS, Parker G, McClain DA.
Am J Physiol Endocrinol Metab. 2008 Oct;295(4):E974-80. Epub 2008 Aug 26.
Nitro-oleic acid protects the mouse kidney from ischemia and reperfusion injury.
Liu H, Jia Z, Soodvilai S, Guan G, Wang MH, Dong Z, Symons JD, Yang T.
Am J Physiol Renal Physiol. 2008 Oct;295(4):F942-9. Epub 2008 Aug 27.
November 2008
Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy.
Kim J, Wende AR, Sena S, Theobald HA, Soto J, Sloan C, Wayment BE, Litwin SE, Holzenberger M, LeRoith D, Abel ED.
Mol Endocrinol. 2008 Nov;22(11):2531-43. Epub 2008 Sep 18.
Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.
Bugger H, Boudina S, Hu XX, Tuinei J, Zaha VG, Theobald HA, Yun UJ, McQueen AP, Wayment B, Litwin SE, Abel ED.
Diabetes. 2008 Nov;57(11):2924-32. Epub 2008 Aug 4.
December 2008
Regulation of mitochondrial iron import through differential turnover of mitoferrin1 and mitoferrin2.
Paradkar PN, Zumbrennen KB, Paw BH, Ward DM, Kaplan J.
Mol Cell Biol. 2008 Dec 15. [Epub ahead of print]
Upregulation of O-GlcNAc transferase with glucose deprivation in HepG2 cells is mediated by decreased hexosamine pathway flux.
Taylor RP, Geisler TS, Chambers JH, McClain DA.
J Biol Chem. 2008 Dec 10. [Epub ahead of print]
The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin.
Silvestri L, Pagani A, Nai A, De Domenico I, Kaplan J, Camaschella C.
Cell Metab. 2008 Dec;8(6):502-11. Epub 2008 Oct 30.
A single amino acid change in the yeast vacuolar metal transporters ZRC1 and COT1 alters their substrate specificity.
Lin H, Kumánovics A, Nelson JM, Warner DE, Ward DM, Kaplan J.
J Biol Chem. 2008 Dec 5;283(49):33865-73. Epub 2008 Oct 16.
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia.
De La O JP, Emerson LL, Goodman JL, Froebe SC, Illum BE, Curtis AB, Murtaugh LC.
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18907-12. Epub 2008 Nov 21.
Distinct Functions of Vascular Endothelial and Smooth Muscle PPAR{gamma} in Regulation of Blood Pressure and Vascular Tone.
Wang N, Symons JD, Zhang H, Jia Z, Gonzalez FJ, Yang T.
Toxicol Pathol. 2008 Dec 15. [Epub ahead of print]
Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1.
Wang N, Yang G, Jia Z, Zhang H, Aoyagi T, Soodvilai S, Symons JD, Schnermann JB, Gonzalez FJ, Litwin SE, Yang T.
Cell Metab. 2008 Dec;8(6):482-91.
