Recent Publications from the Metabolism Interest Group
January 2009
Assembly of the mitochondrial respiratory chain.
Winge DR, Tzagoloff A.Biochim Biophys Acta. 2009 Jan;1793(1):1
Gene expression profiling reveals a diverse array of pathways inhibited by nuclear receptor SHP during adipogenesis.
Song GS, Park KT and Wang L (2009) Int J Clin Exp Pathol 2, 275-285.
Pulling the plug" on cellular copper: The role of mitochondria in copper export.
Leary SC, Winge DR, Cobine PA.
Biochim Biophys Acta. 2009 Jan;1793(1):146-53. Epub 2008 May 15.
February 2009
Serum ferritin regulates blood vessel formation: a role beyond iron storage.
De Domenico I, Ward DM, Kaplan J.
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1683-4. Epub 2009 Feb 4. No abstract available.
Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction.
Sena S, Hu P, Zhang D, Wang X, Wayment B, Olsen C, Avelar E, Abel ED, Litwin SE.
J Mol Cell Cardiol. 2009 Feb 26.
March 2009
Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.
Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel ED.
Circulation. 2009 Mar 10;119(9):1272-83. Epub 2009 Feb 23.
Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2.
De Domenico I, Lo E, Ward DM, Kaplan J.
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3800-5. Epub 2009 Feb 20
Drosophila HNF4 regulates lipid mobilization and beta-oxidation.
Palanker L, Tennessen JM, Lam G, Thummel CS.
Cell Metab. 2009 Mar;9(3):228-39.
Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity.
Shakya A, Cooksey R, Cox JE, Wang V, McClain DA, Tantin D.
Nat Cell Biol. 2009 Mar;11(3):320-7. Epub 2009 Feb 15.
April 2009
Cysteine oxidation regulates the RNA-binding activity of iron regulatory protein 2.
Zumbrennen KB, Wallander ML, Romney SJ, Leibold EA.
Mol Cell Biol. 2009 Apr;29(8):2219-29. Epub 2009 Feb 17.
May 2009
Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure.
Symons JD, McMillin SL, Riehle C, Tanner J, Palionyte M, Hillas E, Jones D, Cooksey RC, Birnbaum MJ, McClain DA, Zhang QJ, Gale D, Wilson LJ, Abel ED.
Circ Res. 2009 May 8;104(9):1085-94. Epub 2009 Apr 2.
Notch signaling: where pancreatic cancer and differentiation meet?
De La O JP, Murtaugh LC.
Gastroenterology. 2009 May;136(5):1499-502. Epub 2009 Mar 25. No abstract available.
The polycomb complex protein mes-2/E(z) promotes the transition from developmental plasticity to differentiation in C. elegans embryos.
Yuzyuk T, Fakhouri TH, Kiefer J, Mango SE.
Dev Cell. 2009 May;16(5):699-710.
June 2009
Involvement of PAS Kinase and ERK1/2 in Palmitate Inhibition of Insulin Gene Expression In Pancreatic Beta-Cells.
Fontés G, Semache M, Hagman DK, Tremblay C, Shah R, Rhodes CJ, Rutter J, Poitout V.
Diabetes. 2009 Jun 5. [Epub ahead of print]
Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: Role of vascular signaling kinases.
Zhang QJ, McMillin SL, Tanner JM, Palionyte M, Abel ED, Symons JD.
J Physiol. 2009 Aug 1;587(Pt 15):3911-20. Epub 2009 Jun 8.
Reductive stress on life span extension in C. elegans.
Ralser M, Benjamin IJ.
BMC Res Notes. 2008 Jun 4;1:19.
Notch and Kras in pancreatic cancer: at the crossroads of mutation, differentiation and signaling.
De La O JP, Murtaugh LC.
Cell Cycle. 2009 Jun 15;8(12):1860-4. Epub 2009 Jun 15.
Regulation and function of yeast PAS kinase: a role in the maintenance of cellular integrity.
Grose JH, Sundwall E, Rutter J.
Cell Cycle. 2009 Jun 15;8(12):1824-32. Epub 2009 Jun 20.
July 2009
SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma.
Hao HX, Khalimonchuk O, Schraders M, Dephoure N, Bayley JP, Kunst H, Devilee P, Cremers CW, Schiffman JD, Bentz BG, Gygi SP, Winge DR, Kremer H, Rutter J.
Science. 2009 Aug 28;325(5944):1139-42. Epub 2009 Jul 23.
Y-Box Protein 1 Stimulates Mesangial Cell Proliferation via Activation of ERK1/2.
Feng Q, Huang S, Zhang A, Chen Q, Guo X, Chen R, Yang T.
Nephron Exp Nephrol. 2009 Jul 9;113(1):e16-e25. Epub 2009 Jul 9.
August 2009
Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases.
Zhang QJ, McMillin SL, Tanner JM, Palionyte M, Abel ED, Symons JD.
J Physiol. 2009 Aug 1;587(Pt 15):3911-20. Epub 2009 Jun 8.
SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.
Hao HX, Khalimonchuk O, Schraders M, Dephoure N, Bayley JP, Kunst H, Devilee P, Cremers CW, Schiffman JD, Bentz BG, Gygi SP, Winge DR, Kremer H, Rutter J.Science. 2009 Aug 28;325(5944):1139-42. Epub 2009 Jul 23.
September 2009
Rodent models of diabetic cardiomyopathy. Bugger H. Abel ED.
Disease Models and Mechanisms. 2009: 2, 454-466.
Nuclear receptor SHP activates miR-206 expression via a cascade dual inhibitory mechanism.
Song G, Wang L. PLoS One. 2009 Sep 1;4(9):e6880.
MICRORNA-206 targets NOTCH3, activates apoptosis, inhibits tumor cell migration and foci formation. Song G, Zhang Y, Wang L. J Biol Chem. 2009 Sep 1. [Epub ahead of print]
Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy. Ikeda H, Shiojima I, Ozasa Y, Yoshida M, Holzenberger M, Kahn CR, Walsh K, Igarashi T, Abel ED, Komuro I. J Mol Cell Cardiol. 2009 Nov;47(5):664-75. Epub 2009 Sep 8
mTOR is a critical regulator of cardiac hypertrophy in Spontaneously Hypertensive Rats. Soesanto W, Lin H, Hu E, Lefler S, Litwin SE, Sena S, Abel ED, Symons JD, Jalili T. Hypertension. 2009. In Press.
Tissue-Specific Remodeling of the Mitochondrial Proteome in Type 1 Diabetic Akita Mice.
Bugger H, Chen D, Riehle C, Soto J, Theobald HA, Hu XX, Ganesan B, Weimer BC, Abel ED.
Diabetes. 2009 Sep;58(9):1986-97. Epub 2009 Jun 19.
October 2009
Lipotoxicity in the heart. Wende AR, Abel ED. Biochim Biophys Acta. 2009 Oct 8.
[Epub ahead of print]
A new wrinkle in the fold: hepcidin links inflammation to the unfolded protein response. De Domenico I, Kaplan J.
Cell Metab. 2009 Oct;10(4):245-6.
The Ferroportin Metal Efflux Proteins Function in Iron and Cobalt Homeostasis in Arabidopsis.
Morrissey J, Baxter IR, Lee J, Li L, Lahner B, Grotz N, Kaplan J, Salt DE, Guerinot ML.
Plant Cell. 2009 Oct 27. [Epub ahead of print]
Control of iron homeostasis by an iron-regulated ubiquitin ligase.
Vashisht AA, Zumbrennen KB, Huang X, Powers DN, Durazo A, Sun D, Bhaskaran N, Persson A, Uhlen M, Sangfelt O, Spruck C, Leibold EA, Wohlschlegel JA.
Science. 2009 Oct 30;326(5953):718-21. Epub 2009 Sep 17.
Stem cells, stress, metabolism and cancer: a drama in two Octs.
Kang J, Shakya A, Tantin D.
Trends Biochem Sci. 2009 Oct;34(10):491-9. Epub 2009 Sep 4.
Repression of sulfate assimilation is an adaptive response of yeast to the oxidative stress of zinc deficiency.
Wu CY, Roje S, Sandoval FJ, Bird AJ, Winge DR, Eide DJ.
J Biol Chem. 2009 Oct 2;284(40):27544-56. Epub 2009 Aug 5.
The Role of Coa2 in Hemylation of Yeast Cox1 Revealed by its Genetic Interaction with Cox10.
Bestwick M, Khalimonchuk O, Pierrel F, Winge DR.
Mol Cell Biol. 2009 Oct 19. [Epub ahead of print]
LONG-TERM FENRETINIDE TREATMENT PREVENTS HIGH FAT DIET-INDUCED OBESITY, INSULIN RESISTANCE AND HEPATIC STEATOSIS.
Preitner F, Mody N, Graham TE, Peroni OD, Kahn B.
Am J Physiol Endocrinol Metab. 2009 Oct 13. [Epub ahead of print]
Metal Acquisition and Availability in the Mitochondria.
Atkinson A, Winge DR.
Chem Rev. Oct;109(10):4708-21. No abstract available.
Link to 2008 Publications
