Internal Medicine Department
Hematology Division

Richard S. Ajioka, PhD

Email:    richard.ajioka@hsc.utah.edu

Education:   

1981 – 1987    Ph.D. in Experimental Pathology, University of Utah, School of Medicine, Salt Lake City, Utah 

1977 – 1981    B.S. in Biology, University of Utah, Salt Lake City, Utah
 

Training:    

1987 – 1991    Post-doctoral Fellow, Research Institute at Scripps Clinic under Dr. Magdalene So, La Jolla, California
 

Research Interests:    

Genetics and biochemistry of iron metabolism

Bibliography

  1. Ajioka RS, Phillips JD, Kushner JP. (2006). Biosynthesis of heme in mammals. Biochimica et Biophysica Acta, 1763(7), 723-36.
  2. Rogers J, Brady R, Gault P, Ajioka R, Kushner JP. (2006). High prevalence of abnormal glucose homeostasis secondary to decreased insulin secretion in individuals with hereditary haemochromatosis. Diabetologia, 49(7), 1661-9.
  3. Cooksey RC, Jouihan HA, Ajioka RS, Hazel MW, Jones DL, Kushner JP, McClain DA. (2004). Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis. Endocrinology, 145(11), 5305-12.
  4. Toomajian C, Ajioka RS, Jorde LB, Kushner JP, Kreitman M. (2003). A method for detecting recent selection in the human genome from allele age estimates. Genetics, 165(1), 287-97.
  5. Ajioka RS, Levy JE, Andrews NC, Kushner JP. (2002). Regulation of iron absorption in Hfe mutant mice. Blood, 100(4), 1465-9.
  6. Bulaj ZJ, Franklin MR, Phillips JD, Miller KL, Bergonia HA, Ajioka RS, Griffen LM, Guinee DJ, Edwards CQ, Kushner JP. (2000). Transdermal estrogen replacement therapy in postmenopausal women previously treated for porphyria cutanea tarda. J Lab Clin Med, 136(6), 482-8.
  7. Bulaj ZJ, Ajioka RS, Phillips JD, LaSalle BA, Jorde LB, Griffen LM, Edwards CQ, Kushner JP. (2000). Disease-related conditions in relatives of patients with hemochromatosis. N Engl J Med, 343(21), 1529-35.
  8. Bulaj ZJ, Phillips JD, Ajioka RS, Franklin MR, Griffen LM, Guinee DJ, Edwards CQ, Kushner JP. (2000). Hemochromatosis genes and other factors contributing to the pathogenesis of porphyria cutanea tarda. Blood, 95(5), 1565-71.
  9. Bernard PS, Ajioka RS, Kushner JP, Wittwer CT. (1998). Homogeneous multiplex genotyping of hemochromatosis mutations with fluorescent hybridization probes. Am J Pathol, 153(4), 1055-61.
  10. Lonjou C, Collins A, Ajioka RS, Jorde LB, Kushner JP, Morton NE. (1998). Allelic association under map error and recombinational heterogeneity: a tale of two sites. Proc Natl Acad Sci USA, 95(19), 11366-70.
  11. Ajioka RS, Jorde LB, Gruen JR, Yu P, Dimitrova D, Barrow J, Radisky E, Edwards CQ, Griffen LM, Kushner JP. (1997). Haplotype analysis of hemochromatosis: evaluation of different linkage-disequilibrium approaches and evolution of disease chromosomes. Am J Hum Genet, 60(6), 1439-47.
  12. Ajioka RS, Yu P, Gruen JR, Edwards CQ, Griffen LM, Kushner JP. (1997). Recombinations defining centromeric and telomeric borders for the hereditary haemochromatosis locus. J Med Genet, 34(1), 28-33.
  13. Taraska T, Ward DM, Ajioka RS, Wyrick PB, Davis-Kaplan SR, Davis CH, Kaplan J. (1996). The late chlamydial inclusion membrane is not derived from the endocytic pathway and is relatively deficient in host proteins. Infect Immun, 64(9), 3713-27.
  14. Gruen JR, Nalabolu SR, Chu TW, Bowlus C, Fan WF, Goei VL, Wei H, Sivakamasundari R, Liu Y, Xu HX, Parimoo S, Nallur G, Ajioka R, Shukla H, Bray-Ward P, Pan J, Weissman SM. (1996). A transcription map of the major histocompatibility complex (MHC) class I region. Genomics, 36(1), 70-85.
  15. Waldbeser LS, Ajioka RS, Merz AJ, Puaoi D, Lin L, Thomas M, So M. (1994). The opaH locus of Neisseria gonorrhoeae MS11A is involved in epithelial cell invasion. Mol Microbiol, 13(5), 919-28.
  16. Radisky ES, Ajioka RS, Edwards CQ, Griffen LM, Kushner JP. (1994). Mapping recombinant events with molecular markers in hemochromatosis pedigrees. Cytogenet Cell Genet, 67(2), 126-8.
  17. Paruchuri DK, Seifert HS, Ajioka RS, Karlsson KA, So M. (1990). Identification and characterization of a Neisseria gonorrhoeae gene encoding a glycolipid-binding adhesin. Proc Natl Acad Sci U S A, 87(1), 333-7.
  18. Seifert HS, Ajioka RS, Paruchuri D, Heffron F, So M. (1990). Shuttle mutagenesis of Neisseria gonorrhoeae: pilin null mutations lower DNA transformation competence. J Bacteriol, 172(1), 40-6.
  19. Ward DM, Ajioka R, Kaplan J. (1989). Cohort movement of different ligands and receptors in the intracellular endocytic pathway of alveolar macrophages. J Biol Chem, 264, 8164-8170.
  20. Seifert HS, Ajioka RS, Marchal C, Sparling PF, So M. (1988). DNA transformation leads to pilin antigenic variation in Neisseria gonorrhoeae. Nature, 336(6197), 392-5.
  21. Ajioka RS, Kaplan J. (1987). Characterization of endocytic compartments using the horseradish peroxidase-diaminobenzidine density shift technique. J Cell Biol, 104(1), 77-85.
  22. Ajioka RS, Kaplan J. (1986). Intracellular pools of transferrin receptors result from constitutive internalization of unoccupied receptors. Proc Natl Acad Sci U S A, 83(17), 6445-9.
  23. Carroll D, Wright SH, Ajioka RS, Hussey CE Jr. (1984). Genetic recombination of Xenopus laevis 5 S DNA in bacteria. J Mol Biol, 178(2), 155-72.
  24. Spangrude GJ, Bernhard EJ, Ajioka RS, Daynes RA. (1983). Alterations in lymphocyte homing patterns within mice exposed to ultraviolet radiation. J Immunol, 130(6), 2974-81.
  25. Carroll D, Ajioka RS, Georgopoulos C. (1980). Bacteriophage lambda cloning vehicles for studies of genetic recombination. Gene, 10(3), 261-71.
  26. Carroll D, Ajioka RS. (1980). Recombination of a eukaryotic DNA in bacteria. Gene, 10(3), 273-81.