Ivana De Domenico, PhD

Email: ivana.dedomenico@path.utah.edu

Education:

2002 – 2005 Ph.D. in Cellular Biology and Biotechnology, University of Messina, Messina, Italy

1997 – 2002 B.S. in Biology, University of Messina, Messina, Italy

Research Interests:

Bibliography

Kieffer C, Skalicky JJ, Morita E, De Domenico I, Ward DM, Kaplan J, Sundquist WI. Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. Dev Cell 2008;15:62-73.
Paradkar P, De Domenico I, Durchfort N, Zohn I, Kaplan J, Ward DM. Iron-depletion limits intracellular bacterial growth in macrophages. Blood 2008.
Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, De Domenico I, Vaughn MB, Kaplan J, Palis J, Abkowitz JL. A heme export protein is required for red blood cell differentiation and iron homeostasis. Science 2008;319:825-8.
Kaplan J, De Domenico I, Ward DM. Chediak-Higashi syndrome. Curr Opin Hematol 2008;15:22-9.
De Domenico I, McVey Ward D, Kaplan J. Regulation of iron acquisition and storage: consequences for iron-linked disorders. Nat Rev Mol Cell Biol 2008;9:72-81.
De Domenico I, Vaughn MB, Yoon D, Kushner JP, Ward DM, Kaplan J. Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations. Blood 2007;110:3780-3.
De Domenico I, Ward DM, Kaplan J. Hepcidin regulation: ironing out the details. J Clin Invest 2007;117:1755-8.
De Domenico I, Ward DM, di Patti MC, Jeong SY, David S, Musci G, Kaplan J. Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin. EMBO J 2007;26:2823-31.
De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J. The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell 2007;18:2569-78.
Zohn IE, De Domenico I, Pollock A, Ward DM, Goodman JF, Liang X, Sanchez AJ, Niswander L, Kaplan J. The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease. Blood 2007;109:4174-80.
De Domenico I, Vaughn MB, Li L, Bagley D, Musci G, Ward DM, Kaplan J. Ferroportin-mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome. EMBO J 2006;25:5396-404.
De Domenico I, Ward DM, Musci G, Kaplan J. Evidence for the multimeric structure of ferroportin. Blood 2007;109:2205-9.
Langelier C, von Schwedler UK, Fisher RD, De Domenico I, White PL, Hill CP, Kaplan J, Ward D, Sundquist WI. Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. J Virol 2006;80:9465-80.
De Domenico I, McVey Ward D, Nemeth E, Ganz T, Corradini E, Ferrara F, Musci G, Pietrangelo A, Kaplan J. Molecular and clinical correlates in iron overload associated with mutations in ferroportin. Haematologica 2006;91:1092-5.
De Domenico I, Ward DM, Musci G, Kaplan J. Iron overload due to mutations in ferroportin. Haematologica 2006;91:92-5.
De Domenico I, Lania A, Bonaccorsi di Patti MC, Battistoni A, Musci G, Desideri A. Purification and characterization of recombinant Caulobacter crescentus Cu,Zn superoxide dismutase. Biochim Biophys Acta 2006;1764:105-9.
Bonaccorsi di Patti MC, Felice MR, De Domenico I, Lania A, Alaleona F, Musci G. Specific aspartate residues in FET3 control high-affinity iron transport in Saccharomyces cerevisiae. Yeast 2005;22:677-87.
De Domenico I, Ward DM, Nemeth E, Vaughn MB, Musci G, Ganz T, Kaplan J. The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci U S A 2005;102:8955-60.
Felice MR, De Domenico I, Li L, Ward DM, Bartok B, Musci G, Kaplan J. Post-transcriptional regulation of the yeast high affinity iron transport system. J Biol Chem 2005;280:22181-90.