Internal Medicine Department
Hematology Division

Elizabeth (Betty) A. Leibold, PhD

Email:   betty.leibold@hsc.utah.edu

Education:

1978 – 1985    Ph.D. in Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts

1972 – 1974    B.S. in Biology, State University of New York at Potsdam, Potsdam, New York

1970 – 1972    Hunter College, New York, New York
 

Training:

1985 – 1988    Post-doctoral Fellow in Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts

Bibliography

  1. Wallander ML, Leibold EA, Eisenstein RS. (2006). Molecular control of vertebrate iron homeostasis by iron regulatory proteins. Biochim Biophys Acta, 1763(7), 668-89.
  2. Bradley J, Leibold EA, Harris ZL, Wobken JD, Clarke S, Zumbrennen KB, Eisenstein RS, Georgieff MK. (2004). Influence of gestational age and fetal iron status on IRP activity and iron transporter protein expression in third-trimester human placenta. Am J Physiol Regul Integr Comp Physiol, 287(4), R894-901.
  3. Schneider BD, Leibold EA. (2003). Effects of iron regulatory protein regulation on iron homeostasis during hypoxia. Blood, 102(9), 3404-11.
  4. Hanson ES, Rawlins ML, Leibold EA. (2003). Oxygen and iron regulation of iron regulatory protein 2. J Biol Chem, 278(41), 40337-42.
  5. Siddappa AJ, Rao RB, Wobken JD, Casperson K, Leibold EA, Connor JR, Georgieff MK. (2003). Iron deficiency alters iron regulatory protein and iron transport protein expression in the perinatal rat brain. Pediatr Res, 53(5), 800-7.
  6. Gourley BL, Parker SB, Jones BJ, Zumbrennen KB, Leibold EA. (2003). Cytosolic aconitase and ferritin are regulated by iron in Caenorhabditis elegans. J Biol Chem, 278(5), 3227-34.
  7. Siddappa AJ, Rao RB, Wobken JD, Leibold EA, Connor JR, Georgieff MK. (2002). Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain. J Neurosci Res, 68(6), 761-75.
  8. Leibold EA, Gahring LC, Rogers SW. (2001). Immunolocalization of iron regulatory protein expression in the murine central nervous system. Histochem Cell Biol, 115(3), 195-203.
  9. Schneider BD, Leibold EA. (2000). Regulation of mammalian iron homeostasis. Curr Opin Clin Nutr Metab Care, 3(4), 267-73.
  10. Hanson ES, Leibold EA. (1999). Regulation of the iron regulatory proteins by reactive nitrogen and oxygen species. Gene Expr, 7(4-6), 367-76.
  11. Aisen P, Wessling-Resnick M, Leibold EA. (1999). Iron metabolism. Curr Opin Chem Biol, 3(2), 200-6.
  12. Hanson ES, Foot LM, Leibold EA. (1999). Hypoxia post-translationally activates iron-regulatory protein 2. J Biol Chem, 274(8), 5047-52.
  13. Georgieff MK, Berry SA, Wobken JD, Leibold EA. (1999). Increased placental iron regulatory protein-1 expression in diabetic pregnancies complicated by fetal iron deficiency. Placenta, 20(1), 87-93.
  14. Ke Y, Wu J, Leibold EA, Walden WE, Theil EC. (1998). Loops and bulge/loops in iron-responsive element isoforms influence iron regulatory protein binding. Fine-tuning of mRNA regulation? J Biol Chem, 273(37), 23637-40.
  15. Hanson ES, Leibold EA. (1998). Regulation of iron regulatory protein 1 during hypoxia and hypoxia/reoxygenation. J Biol Chem, 273(13), 7588-93.
  16. Phillips JD, Guo B, Yu Y, Brown FM, Leibold EA. (1996). Expression and biochemical characterization of iron regulatory proteins 1 and 2 in Saccharomyces cerevisiae. Biochemistry, 35(49), 15704-14.
  17. Phillips JD, Kinikini DV, Yu Y, Guo B, Leibold EA. (1996). Differential regulation of IRP1 and IRP2 by nitric oxide in rat hepatoma cells. Blood, 87(7), 2983-92.
  18. Guo B, Phillips JD, Yu Y, Leibold EA. (1995). Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome. J Biol Chem, 270(37), 21645-51.
  19. Guo B, Brown FM, Phillips JD, Yu Y, Leibold EA. (1995). Characterization and expression of iron regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels. J Biol Chem, 270(28), 16529-35.
  20. Guo B, Yu Y, Leibold EA. (1994). Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity. J Biol Chem, 269(39), 24252-60.
  21. Yu Y, Radisky E, Leibold EA. (1992). The iron-responsive element binding protein. Purification, cloning, and regulation in rat liver. J Biol Chem, 267(26), 19005-10.
  22. Leibold EA, Guo B. (1992). Iron-dependent regulation of ferritin and transferrin receptor expression by the iron-responsive element binding protein. Annu Rev Nutr, 12, 345-68.
  23. Leibold EA, Laudano A, Yu Y. (1990). Structural requirements of iron-responsive elements for binding of the protein involved in both transferrin receptor and ferritin mRNA post-transcriptional regulation. Nucleic Acids Res, 18(7), 1819-24.
  24. Leibold EA, Munro HN. (1988). Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs. Proc Natl Acad Sci U S A, 85(7), 2171-5.
  25. Leibold EA, Munro HN. (1987). Characterization and evolution of the expressed rat ferritin light subunit gene and its pseudogene family. Conservation of sequences within noncoding regions of ferritin genes. J Biol Chem, 262(15), 7335-41.
  26. Dorner MH, Salfeld J, Will H, Leibold EA, Vass JK, Munro HN. (1985). Structure of human ferritin light subunit messenger RNA: comparison with heavy subunit message and functional implications. Proc Natl Acad Sci U S A, 82(10), 3139-43.
  27. Leibold EA, Aziz N, Brown AJ, Munro HN. (1984). Conservation in rat liver of light and heavy subunit sequences of mammalian ferritin. Presence of unique octopeptide in the light subunit. J Biol Chem, 259(7), 4327-34.
  28. Brown AJ, Leibold EA, Munro HN. (1983). Isolation of cDNA clones for the light subunit of rat liver ferritin: evidence that the light subunit is encoded by a multigene family. Proc Natl Acad Sci U S A, 80(5), 1265-9.