• Internal Medicine Dept.
• Patients & Visitors
• Research
• Education
• Administration
  

• Physicians
• Researchers
• Education
  • Hematology Laboratory Studies
  • Glossary of Hematology Terms
• Fellowship Program
  • Information for Applicants
  • Fellowship Administration
  • Fellows Directory
• Division of Oncology
• Blood/Marrow Transplant
  • Stem Cell Transplantation
  • Initial Evaluation
  • What to Expect
  • How to Prepare
  • Stem Cell Collection
  • Transplants & Medications
  • After the Transplant
  • Local Support Groups
• Myeloma Program
• Affiliates
• Donations
• Contact Us
• News & Announcements

Gerald J. Spangrude, PhD

Email:   gspangrude@me.com

Web:    http://www.bioscience.utah.edu/mb/mbFaculty/spangrude/spangrude.html

Education:

1980 – 1984    Ph.D. in Experimental Pathology, University of Utah, School of Medicine, Salt Lake City, Utah

1974 – 1979    B.S. in Microbiology, University of Montana, Missoula, Montana

Training:

1988 – 1989    Post-doctoral Fellow, Walter and Eliza Hall Institute of Medical Research, Lymphocyte Differentiation Unit, Melbourne, Australia

1984 – 1988    Post-doctoral Fellow in Pathology, Stanford University, Palo Alto, California

Bibliography

1. Wang H, Pierce LJ, Spangrude GJ. (2006).Distinct roles of IL-7 and stem cell factor in the OP9-DL1 T-cell differentiation culture system. Exp Hematol, 34(12), 1730-40.
2. Spangrude GJ, Cho S, Guedelhoefer O, Vanwoerkom RC, Fleming WH. (2006). Mouse models of hematopoietic engraftment: limitations of transgenic green fluorescent protein strains and a high-performance liquid chromatography approach to analysis of erythroid chimerism. Stem Cells, 24(9), 2045-51.
3. Wang H, Pierce LJ, Spangrude GJ. (2005). Lymphoid potential of primitive bone marrow progenitors evaluated in vitro. Ann N Y Acad Sci, 1044:210-9.
4. Anderson DA, Wu Y, Jiang S, Zhang X, Streeter PR, Spangrude GJ, Archer DR, Fleming WH. (2005). Donor marker infidelity in transgenic hematopoietic stem cells. Stem Cells, 23(5), 638-43.
5. Perry SS, Wang H, Pierce LJ, Yang AM, Tsai S, Spangrude GJ. (2004). L-selectin defines a bone marrow analog to the thymic early T-lineage progenitor. Blood, 103(8), 2990-6.
6. Spangrude GJ. (2003). Future challenges for hematopoietic stem cell research. Biotechniques, 35(6), 1273-9.
7. Migliaccio AR, Lorenzini R, Vannucchi AM, Spangrude GJ, Migliaccio G. (2003). Robust levels of long-term multilineage reconstitution in the absence of stem cell self-replication in W/Wv mice transplanted with purified stem cells. J Hematother Stem Cell Res, 12(4), 409-24.
8. Spangrude GJ. (2003). When is a stem cell really a stem cell? Bone Marrow Transplant, 32 Suppl 1, S7-11.
9. Spangrude GJ, Perry SS, Slayton WB. (2003). Early stages of hematopoietic differentiation. Ann N Y Acad Sci, 996, 186-94.
10. Wang H, Spangrude GJ. (2003). Aspects of early lymphoid commitment. Curr Opin Hematol, 10(3), 203-7.
11. Kim M, Moon HB, Spangrude GJ. (2003). Major age-related changes of mouse hematopoietic stem/progenitor cells. Ann N Y Acad Sci, 996, 195-208.
12. Perry SS, Pierce LJ, Slayton WB, Spangrude GJ. (2003). Characterization of thymic progenitors in adult mouse bone marrow. J Immunol, 170(4), 1877-86.
13. Slayton WB, Georgelas A, Pierce LJ, Elenitoba-Johnson KS, Perry SS, Marx M, Spangrude GJ. (2002). The spleen is a major site of megakaryopoiesis following transplantation of murine hematopoietic stem cells. Blood, 100(12), 3975-82.
14. Spangrude GJ. (2002). Divergent models of lymphoid lineage specification: do clonal assays provide all the answers? Immunol Rev, 187, 40-7.
15. Goldsby RE, Hays LE, Chen X, Olmsted EA, Slayton WB, Spangrude GJ, Preston BD. (2002). High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading. Proc Natl Acad Sci U S A, 99(24), 15560-5.
16. Cai J, Wu Y, Mirua T, Pierce JL, Lucero MT, Albertine KH, Spangrude GJ, Rao MS. (2002). Properties of a fetal multipotent neural stem cell (NEP cell). Dev Biol, 251(2), 221-40.
17. Wiesmann A, Searles AE, Pierce LJ, Spangrude GJ. (2002). Effects of caspase inhibitors on hematopoietic engraftment after short-term culture. Cell Transplant, 11(4), 351-8.
18. Slayton WB, Mojica MP, Pierce LJ, Spangrude GJ. (2001). Observations of residual differentiation potential during lineage commitment. Ann N Y Acad Sci, 938, 157-65; discussion 165-6.
19. Mojica MP, Perry SS, Searles AE, Elenitoba-Johnson KS, Pierce LJ, Wiesmann A, Slayton WB, Spangrude GJ. (2001). Phenotypic distinction and functional characterization of pro-B cells in adult mouse bone marrow. J Immunol, 166(5), 3042-51.
20. Searles AE, Pohlmann SJ, Pierce LJ, Perry SS, Slayton WB, Mojica MP, Spangrude GJ. (2000). Rapid, B lymphoid-restricted engraftment mediated by a primitive bone marrow subpopulation. J Immunol, 165(1), 67-74.
21. Spangrude GJ, Cooper DD. (2000). Paradigm shifts in stem-cell biology. Semin Hematol, 37(1 Suppl 2), 3-10.
22. Wiesmann A, Phillips RL, Mojica M, Pierce LJ, Searles AE, Spangrude GJ, Lemischka I. (2000). Expression of CD27 on murine hematopoietic stem and progenitor cells. Immunity, 12(2), 193-9.
23. Wiesmann A, Kim M, Georgelas A, Searles AE, Cooper DD, Green WF, Spangrude GJ. (2000). Modulation of hematopoietic stem/progenitor cell engraftment by transforming growth factor beta. Exp Hematol, 28(2), 128-39.
24. Perry SS, Kim M, Spangrude GJ. (1999). Direct effects of cyclosporin A on proliferation of hematopoietic stem and progenitor cells. Cell Transplant, 8(4), 339-44.
25. Cooper DD, Spangrude GJ. (1999). (R)evolutionary considerations in hematopoietic development. Ann N Y Acad Sci, 872, 83-93.
26. Wiesmann A, Spangrude GJ. (1999). Marrow engraftment of hematopoietic stem and progenitor cells is independent of Galphai-coupled chemokine receptors. Exp Hematol, 27(5), 946-55.
27. Kim M, Cooper DD, Hayes SF, Spangrude GJ. (1998). Rhodamine-123 staining in hematopoietic stem cells of young mice indicates mitochondrial activation rather than dye efflux. Blood, 91(11), 4106-17.
28. Nibley WE, Spangrude GJ. (1998). Primitive stem cells alone mediate rapid marrow recovery and multilineage engraftment after transplantation. Bone Marrow Transplant, 21(4), 345-54.
29. Nibley WE, Pohlmann SJ, Spangrude GJ. (1997). Patterns of organ-specific engraftment by stem cell subsets and committed progenitors. Stem Cells, 15 Suppl 1, 31-8; discussion 38-9.
30. Tumas DB, Spangrude GJ, Brooks DM, Williams CD, Chesebro B. (1996). High-frequency cell surface expression of a foreign protein in murine hematopoietic stem cells using a new retroviral vector. Blood, 87(2), 509-17.
31. Spangrude GJ, Brooks DM, Tumas DB. (1995). Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function. Blood, 85(4), 1006-16.
32. Portis JL, Spangrude GJ, McAtee FJ. (1994). Identification of a sequence in the unique 5' open reading frame of the gene encoding glycosylated Gag which influences the incubation period of neurodegenerative disease induced by a murine retrovirus. J Virol, 68(6), 3879-87.
33. Lynch WP, Brown WJ, Spangrude GJ, Portis JL. (1994). Microglial infection by a neurovirulent murine retrovirus results in defective processing of envelope protein and intracellular budding of virus particles. J Virol, 68(5), 3401-9.
34. Miyazawa M, Mori S, Spangrude GJ, Wolfinbarger JB, Bloom ME. (1994). Production and characterization of new monoclonal antibodies that distinguish subsets of mink lymphoid cells. Hybridoma, 13(2), 107-14.
35. Spangrude GJ. (1994). Biological and clinical aspects of hematopoietic stem cells. Annu Rev Med, 45, 93-104.
36. Hasenkrug KJ, Spangrude GJ, Nishio J, Brooks DM, Chesebro B. (1994). Recovery from Friend disease in mice with reduced MHC Class I expression. J Virol, 68, 2059-2064.
37. Spangrude GJ, Brooks DM. (1993). Mouse strain variability in the expression of the hematopoietic stem cell antigen Ly-6A/E by bone marrow cells. Blood, 82(11), 3327-32.
38. Fleming WH, Alpern EJ, Uchida N, Ikuta K, Spangrude GJ, Weissman IL. (1993). Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells. J Cell Biol, 122(4), 897-902.
39. Pincus SH, Rosa PA, Spangrude GJ, Heinemann JA. (1992). The interplay of microbes and their hosts. Immunol Today, 13(12), 471-3.
40. Spangrude GJ, Brooks DM. (1992). Phenotypic analysis of mouse hematopoietic stem cells shows a Thy-1-negative subset. Blood, 80(8), 1957-64.
41. Spangrude GJ. (1992). Characteristics of the hematopoietic stem cell compartment in adult mice. Int J Cell Cloning, 10(5), 277-85.
42. Robertson MN, Spangrude GJ, Hasenkrug K, Perry L, Nishio J, Wehrly K, Chesebro B. (1992). Role and specificity of T-cell subsets in spontaneous recovery from Friend virus-induced leukemia in mice. J Virol, 66(6), 3271-7.
43. Sugamata M, Miyazawa M, Mori S, Spangrude GJ, Ewalt LC, Lodmell DL. (1992). Paralysis of street rabies virus-infected mice is dependent on T lymphocytes. J Virol, 66(2), 1252-60.
44. Spangrude GJ. (1992). The pre-spleen colony-forming unit assay: measurement of spleen colony-forming unit regeneration. Curr Top Microbiol Immunol, 177, 31-9.
45. Su H, Spangrude GJ, Caldwell HD. (1991). Expression of Fc gamma RIII on HeLa 229 cells: possible effect on in vitro neutralization of Chlamydia trachomatis. Infect Immun, 59(10), 3811-4.
46. Spangrude GJ, Smith L, Uchida N, Ikuta K, Heimfeld S, Friedman J, Weissman IL. (1991). Mouse hematopoietic stem cells. Blood, 78(6), 1395-402.
47. Spangrude GJ. (1991). Hematopoietic stem-cell differentiation. Curr Opin Immunol, 3(2), 171-8.
48. Wu L, Scollay R, Egerton M, Pearse M, Spangrude GJ, Shortman K. (1991). CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature, 349(6304), 71-4.
49. Spangrude GJ, Scollay R. (1990). Differentiation of hematopoietic stem cells in irradiated mouse thymic lobes. Kinetics and phenotype of progeny. J Immunol, 145(11), 3661-8.
50. Spangrude GJ, Johnson GR. (1990). Resting and activated subsets of mouse multipotent hematopoietic stem cells. Proc Natl Acad Sci U S A, 87(19), 7433-7.
51. Spangrude GJ, Scollay R. (1990). A simplified method for enrichment of mouse hematopoietic stem cells. Exp Hematol, 18(8), 920-6.
52. Shortman K, Egerton M, Spangrude GJ, Scollay R. (1990). The generation and fate of thymocytes. Semin Immunol, 2(1), 3-12.
53. Duhrsen U, Metcalf D, Spangrude GJ, Nicola NA. (1989). PGM-1: a transplantable murine leukemia of granulocyte-macrophage progenitor cells. Leukemia, 3(11), 796-803.
54. Spangrude GJ. (1989). Enrichment of murine haemopoietic stem cells: diverging roads. Immunol Today, 10(10), 344-50.
55. van de Rijn M, Heimfeld S, Spangrude GJ, Weissman IL. (1989). Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family. Proc Natl Acad Sci U S A, 86(12), 4634-8.
56. Spangrude GJ, Klein J, Heimfeld S, Aihara Y, Weissman IL. (1989). Two monoclonal antibodies identify thymic-repopulating cells in mouse bone marrow. J Immunol, 142(2), 425-30.
57. Muller-Sieburg CE, Tidmarsh GF, Weissman IL, Spangrude GJ. (1989). Maturation of hematolymphoid cells that express Thy-1. Immunol Ser, 45, 289-316.
58. Spangrude GJ, Aihara Y, Weissman IL, Klein J. (1988). The stem cell antigens Sca-1 and Sca-2 subdivide thymic and peripheral T lymphocytes into unique subsets. J Immunol, 141(11), 3697-707.
59. Spangrude GJ, Weissman IL. (1988). Mature T cells generated from single thymic clones are phenotypically and functionally heterogeneous. J Immunol, 141(6), 1877-90.
60. Spangrude GJ, Heimfeld S, Weissman IL. (1988). Purification and characterization of mouse hematopoietic stem cells. Science, 241(4861), 58-62.
61. Spangrude GJ, Muller-Sieburg CE, Heimfeld S, Weissman IL. (1988). Two rare populations of mouse Thy-1lo bone marrow cells repopulate the thymus. J Exp Med, 167(5), 1671-83.
62. Adkins B, Mueller C, Okada CY, Reichert RA, Weissman IL, Spangrude GJ. (1987). Early events in T-cell maturation. Annu Rev Immunol, 5, 325-65.
63. Gilhar A, Wojciechowski ZJ, Piepkorn MW, Spangrude GJ, Roberts LK, Krueger GG. (1986). Description of and treatment to inhibit the rejection of human split-thickness skin grafts by congenitally athymic (nude) rats. Exp Cell Biol, 54(5-6), 263-74.
64. Spangrude GJ, Sacchi F, Hill HR, Van Epps DE, Daynes RA. (1985). Inhibition of lymphocyte and neutrophil chemotaxis by pertussis toxin. J Immunol, 135(6), 4135-43.
65. Roberts LK, Spangrude GJ, Daynes RA, Krueger GG. (1985). Correlation between keratinocyte expression of Ia and the intensity and duration of contact hypersensitivity responses in mice. J Immunol, 135(5), 2929-36.
66. Daynes RA, Spangrude GJ, Roberts LK, Krueger GG. (1985). Regulation by the skin of lymphoid cell recirculation and localization properties. J Invest Dermatol, 85(1 Suppl), 14s-20s.
67. Spangrude GJ, Araneo BA, Daynes RA. (1985). Site-selective homing of antigen-primed lymphocyte populations can play a crucial role in the efferent limb of cell-mediated immune responses in vivo. J Immunol, 134(5), 2900-7.
68. Samlowski WE, Spangrude GJ, Daynes RA. (1984). Studies on the liver sequestration of lymphocytes bearing membrane-associated galactose-terminal glycoconjugates: reversal with agents that effectively compete for the asialoglycoprotein receptor. Cell Immunol, 88(2), 309-22.
69. Braaten BA, Spangrude GJ, Daynes RA. (1984). Molecular mechanisms of lymphocyte extravasation. II. Studies of in vitro lymphocyte adherence to high endothelial venules. J Immunol, 133(1), 117-22.
70. Spangrude GJ, Braaten BA, Daynes RA. (1984). Molecular mechanisms of lymphocyte extravasation. I. Studies of two selective inhibitors of lymphocyte recirculation. J Immunol, 132(1), 354-62.
71. Daynes RA, Sholly SP, Gahring LC, Spangrude GJ. (1984). What is the relationship between the status of a patient's host defense mechanisms, his metabolic response, and his ability to respond to injury? J Trauma, 24, S84-S93.
72. Spangrude GJ, Bernhard EJ, Ajioka RS, Daynes RA. (1983). Alterations in lymphocyte homing patterns within mice exposed to ultraviolet radiation. J Immunol, 130(6), 2974-81.
73. Spangrude GJ, Sherris D, Daynes RA. (1982). Inhibitory effects of various oxygenated sterols on the differentiation and function of tumor-specific cytotoxic T lymphocytes. Transplantation, 33(5), 482-91.