Internal Medicine Department
Hematology Division

Kirk R. Thomas, PhD

Email:    kthomas@hmbg.utah.edu

Education:

1973 – 1981    Ph.D. in Biology, University of Utah, Salt Lake City, Utah

1969 – 1973    M.B. in Biology, University of California – Santa Cruz, Santa Cruz, California
 

Training:

1983 – 1988    Post-doctoral Fellow, University of Utah, Salt Lake City, Utah

1981 – 1983    Post-doctoral Fellow, University of California – San Francisco, San Francisco, California

Research Interests:     

Hox and wn genes in mammalian development
targeted mutagenesis

Bibliography

  1. Wilson BD, Ii M, Park KW, Suli A, Sorensen LK, Larrieu-Lahargue F, Urness LD, Suh W, Asai J, Kock GA, Thorne T, Silver M, Thomas KR, Chien CB, Losordo DW, Li DY (2006). Netrins promote developmental and therapeutic angiogenesis. Science, 313(5787), 640-4.
  2. Jarvis M, Iyer RK, Williams LO, Noll WW, Thomas K, Telatar M, Grody WW. (2005). A novel method for creating artificial mutant samples for performance evaluation and quality control in clinical molecular genetics. J Mol Diagn, 7(2), 247-51.
  3. Gaufo GO, Thomas KR, Capecchi MR. (2003). Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons. Development, 130(21), 5191-201.
  4. Barrow JR, Thomas KR, Boussadia-Zahui O, Moore R, Kemler R, Capecchi MR, McMahon AP. (2003). Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev, 17(3), 394-409.
  5. Phillips JD, Jackson LK, Bunting M, Franklin MR, Thomas KR, Levy JE, Andrews NC, Kushner JP. (2001). A mouse model of familial porphyria cutanea tarda. Proc Natl Acad Sci U S A, 98(1), 259-64.
  6. Greer JM, Puetz J, Thomas KR, Capecchi MR. (2000). Maintenance of functional equivalence during paralogous Hox gene evolution. Nature, 403(6770), 661-5.
  7. Bunting M, Bernstein KE, Greer JM, Capecchi MR, Thomas KR. (1999). Targeting genes for self-excision in the germ line. Genes Dev, 13(12), 1524-8.
  8. Kelley TJ, Thomas K, Milgram LJH, Drumm ML. (1997). In vivo activation of the cystic fibrosis transmembrane conductance regulator mutant DeltaF508 in murine nasal epithelium. PNAS, 94, 2604-2608.
  9. Zeiher BG, Eichwald E, Zabner J, Smith JJ, Puga AP, McCray PB Jr, Capecchi MR, Welsh MJ, Thomas KR. (1995). A mouse model for the delta F508 allele of cystic fibrosis. J Clin Invest, 96(4), 2051-64.
  10. Thomas KR. (1995). The knockout mouse: six years old and growing stronger. Am J Respir Cell Mol Biol, 12, 461-463.
  11. Thomas KR. (1994). Targeted mutagenesis of mouse developmental genes. J Anim Sci, 72(Suppl 3), 1-8.
  12. Thomas KR. (1994). Impact of gene targeting on medicine. Mol Genet Med, 4, 153-78.
  13. Deng C, Thomas KR, Capecchi MR. (1993). Location of crossovers during gene targeting with insertion and replacement vectors. Mol Cell Biol, 13(4), 2134-40.
  14. Thomas KR, Deng C, Capecchi MR. (1992). High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors. Mol Cell Biol, 12(7), 2919-23.
  15. Thomas KR, Musci TS, Neumann PE, Capecchi MR. (1991). Swaying is a mutant allele of the proto-oncogene Wnt-1. Cell, 67(5), 969-76.
  16. Mansour SL, Thomas KR, Deng CX, Capecchi MR. (1990). Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination. Proc Natl Acad Sci U S A, 87(19), 7688-92.
  17. Thomas KR, Capecchi MR. (1990). Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature, 346(6287), 847-50.
  18. Mansour SL, Thomas KR, Capecchi MR. (1988). Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature, 336(6197), 348-52.
  19. Thomas KR, Capecchi MR. (1987). Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell, 51(3), 503-12.
  20. Thomas KR, Capecchi MR. (1986). Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene. Nature, 324(6092), 34-8.
  21. Thomas KR, Folger KR, Capecchi MR. (1986). High frequency targeting of genes to specific sites in the mammalian genome. Cell, 44(3), 419-28.
  22. Thomas KR, Capecchi MR. (1986). Targeting of genes to specific sites in the mammalian genome. Cold Spring Harb Symp Quant Biol, 51 Pt 2, 1101-13.
  23. Folger K, Thomas K, Capecchi MR. (1984). Analysis of homologous recombination in cultured mammalian cells. Cold Spring Harb Symp Quant Biol, 49, 123-38.
  24. Folger K, Thomas K, Capecchi MR. (1984). Efficient correction of mismatched bases in plasmid heteroduplexes injected into cultured mammalian cell nuclei. Mol Cell Biol, 5, 70-74.
  25. Folger K, Thomas K, Capecchi MR. (1984). Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian cell nuclei. Mol Cell Biol, 5, 59-69.
  26. Thomas KR, Olivera BM. (1983). Flexibility in RNA priming of Okazaki pieces at the E. coli replication fork. Nucleic Acids Res, 11(18), 6531-9.
  27. Thomas KR, Manlapaz-Ramos P, Lundquist R, Olivera BM. (1979). Formation of Okazaki pieces at the Escherichia coli replication fork in vitro. Cold Spring Harb Symp Quant Biol, 43 Pt 1, 231-7.
  28. Thomas KR, Olivera BM. (1978). Processivity of DNA exonucleases. J Biol Chem, 253(2), 424-9.