Internal Medicine Department
Hematology Division

Dennis R. Winge, PhD

Email:    dennis.winge@hsc.utah.edu

Web:    http://www.biochem.utah.edu/~winge

Education:

1969 ¿ 1975    Ph.D. in Biochemistry, Duke University, Durham, North Carolina

1965 ¿ 1969    B.S., Concordia College, Morehead, Minnesota

Training:

1976 ¿ 1979    Post-doctoral Fellow in Biochemisty. Duke University, Durham, North Carolina

1975                Post-doctoral Fellow. University of Geneva, Geneva, Switzerland

Research Interests:   

Genetics and biochemistry of copper, iron, and zinc utilization in metalloprotein formation

Bibliography

  1. Leary SC, Cobine PA, Kaufman BA, Guercin GH, Mattman A, Palaty J, Lockitch G, Winge DR, Rustin P, Horvath R, Shoubridge EA. (2007). The Human Cytochrome c Oxidase Assembly Factors SCO1 and SCO2 Have Regulatory Roles in the Maintenance of Cellular Copper Homeostasis. Cell Metab, 5(1), 9-20.
  2. Bird AJ, Gordon M, Eide DJ, Winge DR. (2006). Repression of ADH1 and ADH3 during zinc deficiency by Zap1-induced intergenic RNA transcripts. EMBO J, 25(24), 5726-34.
  3. Cobine PA, Pierrel F, Bestwick ML, Winge DR. (2006). Mitochondrial matrix copper complex used in metallation of cytochrome oxidase and superoxide dismutase. J Biol Chem, 281(48), 36552-9.
  4. Bird AJ, Swierczek S, Qiao W, Eide DJ, Winge DR. (2006). Zinc metalloregulation of the zinc finger pair domain. J Biol Chem, 281(35), 25326-35.
  5. Cobine PA, Winge DR. (2006). Visualizing tricoordinate copper transfer. Nat Chem Biol, 2(7), 352-3.
  6. Qiao W, Mooney M, Bird AJ, Winge DR, Eide DJ. (2006). Zinc binding to a regulatory zinc-sensing domain monitored in vivo by using FRET. Proc Natl Acad Sci U S A, 103(23), 8674-9.
  7. Ojeda L, Keller G, Muhlenhoff U, Rutherford JC, Lill R, Winge DR. (2006). Role of glutaredoxin-3 and glutaredoxin-4 in the iron regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiae. J Biol Chem, 281(26), 17661-9.
  8. Cobine PA, Pierrel F, Winge DR. (2006). Copper trafficking to the mitochondrion and assembly of copper metalloenzymes. Biochim Biophys Acta, 1763(7), 759-72.
  9. Yang M, Cobine PA, Molik S, Naranuntarat A, Lill R, Winge DR, Culotta VC. (2006). The effects of mitochondrial iron homeostasis on cofactor specificity of superoxide dismutase 2. EMBO J, 25(8), 1775-83.
  10. Cobine PA, Pierrel F, Leary SC, Sasarman F, Horng YC, Shoubridge EA, Winge DR. (2006). The P174L mutation in human Sco1 severely compromises Cox17-dependent metallation but does not impair copper binding. J Biol Chem, 281(18), 12270-6.
  11. Keller G, Bird A, Winge DR. (2005). Independent metalloregulation of Ace1 and Mac1 in Saccharomyces cerevisiae. Eukaryot Cell, 4(11), 1863-71.
  12. Horng YC, Leary SC, Cobine PA, Young FB, George GN, Shoubridge EA, Winge DR. (2005). Human Sco1 and Sco2 function as copper-binding proteins. J Biol Chem, 280(40), 34113-22. Erratum in: J Biol Chem, 280(49), 41122.
  13. Herbig A, Bird AJ, Swierczek S, McCall K, Mooney M, Wu CY, Winge DR, Eide DJ. (2005). Zap1 activation domain 1 and its role in controlling gene expression in response to cellular zinc status. Mol Microbiol, 57(3), 834-46.
  14. Arnesano F, Balatri E, Banci L, Bertini I, Winge DR. (2005). Folding studies of Cox17 reveal an important interplay of cysteine oxidation and copper binding. Structure, 13(5), 713-22.
  15. Carr HS, Maxfield AB, Horng YC, Winge DR. (2005). Functional analysis of the domains in Cox11. J Biol Chem, 280(24), 22664-9.
  16. Rutherford JC, Ojeda L, Balk J, Muhlenhoff U, Lill R, Winge DR. (2005). Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis. J Biol Chem, 280(11), 10135-40.
  17. Horng YC, Cobine PA, Maxfield AB, Carr HS, Winge DR. (2004). Specific copper transfer from the Cox17 metallochaperone to both Sco1 and Cox11 in the assembly of yeast cytochrome C oxidase. J Biol Chem, 279(34), 35334-40.
  18. Chen OS, Crisp RJ, Valachovic M, Bard M, Winge DR, Kaplan J. (2004). Transcription of the yeast iron regulon does not respond directly to iron but rather to iron-sulfur cluster biosynthesis. J Biol Chem, 279(28), 29513-8.
  19. Bird AJ, Blankman E, Stillman DJ, Eide DJ, Winge DR.  (2004). The Zap1 transcriptional activator also acts as a repressor by binding downstream of the TATA box in ZRT2. EMBO J, 23(5), 1123-32.
  20. Cobine PA, Ojeda LD, Rigby KM, Winge DR.  (2004). Yeast contain a non-proteinaceous pool of copper in the mitochondrial matrix. J Biol Chem, 279(14), 14447-55.
  21. Maxfield AB, Heaton DN, Winge DR. (2004). Cox17 is functional when tethered to the mitochondrial inner membrane. J Biol Chem, 279(7), 5072-80.
  22. Winge DR. (2003). Let's Sco1, Oxidase! Let's Sco! Structure, 11(11), 1313-4.
  23. Bird AJ, McCall K, Kramer M, Blankman E, Winge DR, Eide DJ. (2003). Zinc fingers can act as Zn2+ sensors to regulate transcriptional activation domain function. EMBO J, 22(19), 5137-46.
  24. Rutherford JC, Jaron S, Winge DR. (2003). Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements. J Biol Chem, 278(30), 27636-43.
  25. Carr HS, Winge DR. (2003). Assembly of cytochrome c oxidase within the mitochondrion. Acc Chem Res, 36(5), 309-16.
  26. Evans-Galea MV, Blankman E, Myszka DG, Bird AJ, Eide DJ, Winge DR. (2003). Two of the five zinc fingers in the Zap1 transcription factor DNA binding domain dominate site-specific DNA binding. Biochemistry, 42(4), 1053-61.
  27. Winge DR. (2002). Copper metalloregulation of gene expression. Adv Protein Chem, 60, 51-92.
  28. Daniels PJ, Bittel D, Smirnova IV, Winge DR, Andrews GK. (2002). Mammalian metal response element-binding transcription factor-1 functions as a zinc sensor in yeast, but not as a sensor of cadmium or oxidative stress. Nucleic Acids Res, 30(14), 3130-40.
  29. Romero-Isart N, Jensen LT, Zerbe O, Winge DR, Vasak M. (2002). Engineering of metallothionein-3 neuroinhibitory activity into the inactive isoform metallothionein-1. J Biol Chem, 277(40), 37023-8.
  30. Carr HS, George GN, Winge DR. (2002). Yeast Cox11, a protein essential for cytochrome c oxidase assembly, is a Cu(I)-binding protein. J Biol Chem, 277(34), 31237-42.
  31. Brown KR, Keller GL, Pickering IJ, Harris HH, George GN, Winge DR. (2002). Structures of the cuprous-thiolate clusters of the Mac1 and Ace1 transcriptional activators. Biochemistry, 41(20), 6469-76.
  32. Rutherford JC, Jaron S, Ray E, Brown PO, Winge DR. (2001). A second iron-regulatory system in yeast independent of Aft1p. Proc Natl Acad Sci U S A, 98(25), 14322-7.
  33. Nittis T, George GN, Winge DR. (2001). Yeast Sco1, a protein essential for cytochrome c oxidase function is a Cu(I)-binding protein. J Biol Chem, 276(45), 42520-6.
  34. Keller G, Ray E, Brown PO, Winge DR. (2001). Haa1, a protein homologous to the copper-regulated transcription factor Ace1, is a novel transcriptional activator. J Biol Chem, 276(42), 38697-702.
  35. Heaton DN, George GN, Garrison G, Winge DR. (2001). The mitochondrial copper metallochaperone Cox17 exists as an oligomeric, polycopper complex. Biochemistry, 40(3), 743-51.
  36. Hasler DW, Jensen LT, Zerbe O, Winge DR, Vasak M. (2000). Effect of the two conserved prolines of human growth inhibitory factor (metallothionein-3) on its biological activity and structure fluctuation: comparison with a mutant protein. Biochemistry, 39(47), 14567-75.
  37. Heaton D, Nittis T, Srinivasan C, Winge DR. (2000). Mutational analysis of the mitochondrial copper metallochaperone Cox17. J Biol Chem, 275(48), 37582-7.
  38. Gross C, Kelleher M, Iyer VR, Brown PO, Winge DR. (2000). Identification of the copper regulon in Saccharomyces cerevisiae by DNA microarrays. J Biol Chem, 275(41), 32310-6.
  39. Bird AJ, Zhao H, Luo H, Jensen LT, Srinivasan C, Evans-Galea M, Winge DR, Eide DJ. (2000). A dual role for zinc fingers in both DNA binding and zinc sensing by the Zap1 transcriptional activator. EMBO J, 19(14), 3704-13.
  40. Keller G, Gross C, Kelleher M, Winge DR. (2000). Functional independence of the two cysteine-rich activation domains in the yeast Mac1 transcription factor. J Biol Chem, 275(38), 29193-9.
  41. Bird A, Evans-Galea MV, Blankman E, Zhao H, Luo H, Winge DR, Eide DJ. (2000). Mapping the DNA binding domain of the Zap1 zinc-responsive transcriptional activator. J Biol Chem, 275(21), 16160-6.
  42. Jamison McDaniels CP, Jensen LT, Srinivasan C, Winge DR, Tullius TD. (1999). The yeast transcription factor Mac1 binds to DNA in a modular fashion. J Biol Chem, 274(38), 26962-7.
  43. Faller P, Hasler DW, Zerbe O, Klauser S, Winge DR, Vasak M. (1999). Evidence for a dynamic structure of human neuronal growth inhibitory factor and for major rearrangements of its metal-thiolate clusters. Biochemistry, 38(31), 10158-67.
  44. Winge DR. (1999). Copper-regulatory domain involved in gene expression. Adv Exp Med Biol, 448, 237-46.
  45. Jensen LT, Winge DR. (1998). Identification of a copper-induced intramolecular interaction in the transcription factor Mac1 from Saccharomyces cerevisiae. EMBO J, 17(18), 5400-8.
  46. Jensen LT, Posewitz MC, Srinivasan C, Winge DR. (1998). Mapping of the DNA binding domain of the copper-responsive transcription factor Mac1 from Saccharomyces cerevisiae. J Biol Chem, 273(37), 23805-11.
  47. Martins LJ, Jensen LT, Simon JR, Keller GL, Winge DR. (1998). Metalloregulation of FRE1 and FRE2 homologs in Saccharomyces cerevisiae. J Biol Chem, 273(37), 23716-21. Erratum in: J Biol Chem, 273(45), 30056.
  48. Winge DR, Jensen LT, Srinivasan C. (1998). Metal-ion regulation of gene expression in yeast. Curr Opin Chem Biol, 2(2), 216-21.
  49. Turner RB, Smith DL, Zawrotny ME, Summers MF, Posewitz MC, Winge DR. (1998). Solution structure of a zinc domain conserved in yeast copper-regulated transcription factors. Nat Struct Biol, 5(7), 551-5.
  50. Srinivasan C, Posewitz MC, George GN, Winge DR. (1998). Characterization of the copper chaperone Cox17 of Saccharomyces cerevisiae. Biochemistry, 37(20), 7572-7.
  51. Winge DR. (1998). Copper-regulatory domain involved in gene expression. Prog Nucleic Acid Res Mol Biol, 58, 165-95.
  52. Graden JA, Winge DR. (1997). Copper-mediated repression of the activation domain in the yeast Mac1p transcription factor. Proc Natl Acad Sci U S A, 94(11), 5550-5.
  53. Graden JA, Posewitz MC, Simon JR, George GN, Pickering IJ, Winge DR. (1996). Presence of a copper(I)-thiolate regulatory domain in the copper-activated transcription factor Amt1. Biochemistry, 35(46), 14583-9.
  54. Jensen LT, Howard WR, Strain JJ, Winge DR, Culotta VC. (1996). Enhanced effectiveness of copper ion buffering by CUP1 metallothionein compared with CRS5 metallothionein in Saccharomyces cerevisiae. J Biol Chem, 271(31), 18514-9.
  55. Yu W, Farrell RA, Stillman DJ, Winge DR. (1996). Identification of SLF1 as a new copper homeostasis gene involved in copper sulfide mineralization in Saccharomyces cerevisiae. Mol Cell Biol, 16(5), 2464-72.
  56. Perez-Alvarado GC, Kosa JL, Louis HA, Beckerle MC, Winge DR, Summers MF. (1996). Structure of the cysteine-rich intestinal protein, CRIP. J Mol Biol, 257(1), 153-74.
  57. Farrell RA, Thorvaldsen JL, Winge DR. (1996). Identification of the Zn(II) site in the copper-responsive yeast transcription factor, AMT1: a conserved Zn module. Biochemistry, 35(5), 1571-80.
  58. Richards MP, Andrews GK, Winge DR, Beattie JH. (1996). Separation of three mouse metallothionein isoforms by free-solution capillary electrophoresis. J Chromatogr B Biomed Appl, 675(2), 327-31.
  59. Thorvaldsen JL, Mehra RK, Yu W, Sewell AK, Winge DR. (1995). Analysis of copper-induced metallothionein expression using autonomously replicating plasmids in Candida glabrata. Yeast, 11(15), 1501-11.
  60. Sewell AK, Yokoya F, Yu W, Miyagawa T, Murayama T, Winge DR. (1995). Mutated yeast heat shock transcription factor exhibits elevated basal transcriptional activation and confers metal resistance. J Biol Chem, 270(42), 25079-86.
  61. Dobi A, Dameron CT, Hu S, Hamer D, Winge DR. (1995). Distinct regions of Cu(I).ACE1 contact two spatially resolved DNA major groove sites. J Biol Chem, 270(17), 10171-8.
  62. Sewell AK, Jensen LT, Erickson JC, Palmiter RD, Winge DR. (1995). Bioactivity of metallothionein-3 correlates with its novel beta domain sequence rather than metal binding properties. Biochemistry, 34(14), 4740-7.
  63. Yu W, Santhanagopalan V, Sewell AK, Jensen LT, Winge DR. (1994). Dominance of metallothionein in metal ion buffering in yeast capable of synthesis of (gamma EC)nG isopeptides. J Biol Chem, 269(33), 21010-5.
  64. Thorvaldsen JL, Sewell AK, Tanner AM, Peltier JM, Pickering IJ, George GN, Winge DR. (1994). Mixed Cu+ and Zn2+ coordination in the DNA-binding domain of the AMT1 transcription factor from Candida glabrata. Biochemistry, 33(32), 9566-77.
  65. Erickson JC, Sewell AK, Jensen LT, Winge DR, Palmiter RD. (1994). Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF). Brain Res, 649(1-2), 297-304.
  66. Macreadie IG, Castelli LA, Mehra RK, Thorvaldsen JL, Winge DR. (1994). Heterologous gene expression and protein secretion from Candida glabrata. Biotechnol Appl Biochem, 19(Pt 3), 265-9.
  67. Perez-Alvarado GC, Miles C, Michelsen JW, Louis HA, Winge DR, Beckerle MC, Summers MF. (1994). Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP. Nat Struct Biol, 1(6), 388-98.
  68. Michelsen JW, Sewell AK, Louis HA, Olsen JI, Davis DR, Winge DR, Beckerle MC. (1994). Mutational analysis of the metal sites in an LIM domain. J Biol Chem, 269(15), 11108-13.
  69. Kosa JL, Michelsen JW, Louis HA, Olsen JI, Davis DR, Beckerle MC, Winge DR. (1994). Common metal ion coordination in LIM domain proteins. Biochemistry, 33(2), 468-77.
  70. Winge DR, Dameron CT, George GN. (1994). The metallothionein structural motif in gene expression. Adv Inorg Biochem, 10, 1-48.
  71. Dameron CT, George GN, Arnold P, Santhanagopalan V, Winge DR. (1993). Distinct metal binding configurations in ACE1. Biochemistry, 32(28), 7294-301.
  72. Narula SS, Winge DR, Armitage IM. (1993). Copper- and silver-substituted yeast metallothioneins: sequential 1H NMR assignments reflecting conformational heterogeneity at the C terminus. Biochemistry, 32(26), 6773-87.
  73. Thorvaldsen JL, Sewell AK, McCowen CL, Winge DR. (1993). Regulation of metallothionein genes by the ACE1 and AMT1 transcription factors. J Biol Chem, 268(17), 12512-8.
  74. Michelsen JW, Schmeichel KL, Beckerle MC, Winge DR. (1993). The LIM motif defines a specific zinc-binding protein domain. Proc Natl Acad Sci U S A, 90(10), 4404-8.
  75. Barbas J, Santhanagopalan V, Blaszczynski M, Ellis WR Jr, Winge DR. (1992). Conversion in the peptides coating cadmium:sulfide crystallites in Candida glabrata. J Inorg Biochem, 48(2), 95-105.
  76. Roth EJ, Kurz B, Liang L, Hansen CL, Dameron CT, Winge DR, Smotkin D. (1992). Metal thiolate coordination in the E7 proteins of human papilloma virus 16 and cottontail rabbit papilloma virus as expressed in Escherichia coli. J Biol Chem, 267(23), 16390-5.
  77. Mehra RK, Thorvaldsen JL, Macreadie IG, Winge DR. (1992). Disruption analysis of metallothionein-encoding genes in Candida glabrata. Gene, 114(1), 75-80.
  78. Kille P, Lees WE, Darke BM, Winge DR, Dameron CT, Stephens PE, Kay J. (1992). Sequestration of cadmium and copper by recombinant rainbow trout and human metallothioneins and by chimeric (mermaid and fishman) proteins with interchanged domains. J Biol Chem, 267(12), 8042-9.
  79. Mehra RK, Thorvaldsen JL, Macreadie IG, Winge DR. (1992). Cloning system for Candida glabrata using elements from the metallothionein-IIa-encoding gene that confer autonomous replication. Gene, 113(1), 119-24.
  80. Reese RN, White CA, Winge DR. (1992). Cadmium-Sulfide Crystallites in Cd-(gammaEC)(n)G Peptide Complexes from Tomato. Plant Physiol, 98(1), 225-229.
  81. Kille P, Winge DR, Harwood JL, Kay J. (1991). A plant metallothionein produced in E. coli. FEBS Lett, 295(1-3), 171-5.
  82. Yu W, Macreadie IG, Winge DR. (1991). Protection against cadmium toxicity in yeast by alcohol dehydrogenase. J Inorg Biochem, 44(3), 155-61. 
  83. Dameron CT, Winge DR, George GN, Sansone M, Hu S, Hamer D. (1991). A copper-thiolate polynuclear cluster in the ACE1 transcription factor. Proc Natl Acad Sci U S A, 88(14), 6127-31.
  84. Mehra RK, Winge DR. (1991). Metal ion resistance in fungi: molecular mechanisms and their regulated expression. J Cell Biochem, 45(1), 30-40.
  85. Winge DR. (1991). Copper coordination in metallothionein. Methods Enzymol, 205, 458-69.
  86. Winge DR. (1991). Limited proteolysis of metallothioneins. Methods Enzymol, 205, 438-47.     
  87. Mehra RK, Garey JR, Winge DR. (1990). Selective and tandem amplification of a member of the metallothionein gene family in Candida glabrata. J Biol Chem, 265(11), 6369-75. 
  88. Winge DR, Mehra RK. (1990). Host defenses against copper toxicity. Int Rev Exp Pathol, 31, 47-83.
  89. Dameron CT, Winge DR. (1990). Peptide-mediated formation of quantum semiconductors. Trends Biotechnol, 8(1), 3-6.     
  90. Mehra RK, Garey JR, Butt TR, Gray WR, Winge DR. (1989). Candida glabrata metallothioneins. Cloning and sequence of the genes and characterization of proteins. J Biol Chem, 264(33), 19747-53.
  91. Dameron CT, Smith BR, Winge DR. (1989). Glutathione-coated cadmium-sulfide crystallites in Candida glabrata. J Biol Chem, 264(29), 17355-60.
  92. Brouwer M, Winge DR, Gray WR. (1989). Structural and functional diversity of copper-metallothioneins from the American lobster Homarus americanus. J Inorg Biochem, 35(4), 289-303.
  93. Mehra RK, Tarbet EB, Gray WR, Winge DR. (1988). Metal-specific synthesis of two metallothioneins and gamma-glutamyl peptides in Candida glabrata. Proc Natl Acad Sci U S A, 85(23), 8815-9.
  94. Reese RN, Winge DR. (1988). Sulfide stabilization of the cadmium-gamma-glutamyl peptide complex of Schizosaccharomyces pombe. J Biol Chem, 263(26), 12832-5.
  95. Mehra RK, Winge DR. (1988). Cu(I) binding to the Schizosaccharomyces pombe gamma-glutamyl peptides varying in chain lengths. Arch Biochem Biophys, 265(2), 381-9.
  96. George GN, Byrd J, Winge DR. (1988). X-ray absorption studies of yeast copper metallothionein. J Biol Chem, 263(17), 8199-203.
  97. Thrower AR, Byrd J, Tarbet EB, Mehra RK, Hamer DH, Winge DR. (1988). Effect of mutation of cysteinyl residues in yeast Cu-metallothionein. J Biol Chem, 263(15), 7037-42. 
  98. Byrd J, Berger RM, McMillin DR, Wright CF, Hamer D, Winge DR. (1988). Characterization of the copper-thiolate cluster in yeast metallothionein and two truncated mutants. J Biol Chem, 263(14), 6688-94.
  99. Reese RN, Mehra RK, Tarbet EB, Winge DR. (1988). Studies on the gamma-glutamyl Cu-binding peptide from Schizosaccharomyces pombe. J Biol Chem, 263(9), 4186-92.
  100. Wright CF, McKenney K, Hamer DH, Byrd J, Winge DR. (1987). Structural and functional studies of the amino terminus of yeast metallothionein. J Biol Chem, 262(27), 12912-9.
  101. Winge DR. (1987). Copper coordination in metallothionein. Experientia Suppl, 52, 213-8.
  102. Furey WF, Robbins AH, Clancy LL, Winge DR, Wang BC, Stout CD. (1987). Crystal structure of Cd,Zn metallothionein. Experientia Suppl, 52, 139-48.
  103. Byrd J, Winge DR. (1986). Cooperative cluster formation in metallothionein. Arch Biochem Biophys, 250(1), 233-7.
  104. Winge DR, Brouwer M. (1986). Techniques and problems in metal-binding protein chemistry and implications for proteins in nonmammalian organisms. Environ Health Perspect, 65, 211-4.
  105. Winge DR, Gray WR, Zelazowski A, Garvey JS. (1986). Sequence and antigenicity of calf metallothionein II. Arch Biochem Biophys, 245(1), 254-62.
  106. Furey WF, Robbins AH, Clancy LL, Winge DR, Wang BC, Stout CD. (1986). Crystal structure of Cd,Zn metallothionein. Science, 231(4739), 704-10.
  107. Winge DR, Nielson KB, Gray WR, Hamer DH. (1985). Yeast metallothionein. Sequence and metal-binding properties. J Biol Chem, 260(27), 14464-70.
  108. Nielson KB, Winge DR. (1985). Independence of the domains of metallothionein in metal binding. J Biol Chem, 260(15), 8698-701.
  109. Nielson KB, Atkin CL, Winge DR. (1985). Distinct metal-binding configurations in metallothionein. J Biol Chem, 260(9), 5342-50.
  110. Winge DR, Nielson KB, Zeikus RD, Gray WR. (1984). Structural characterization of the isoforms of neonatal and adult rat liver metallothionein. J Biol Chem, 259(18), 11419-25.
  111. Winge DR. (1984). Normal physiology of copper metabolism. Semin Liver Dis, 4(3), 239-51.
  112. Nielson KB, Winge DR. (1984). Preferential binding of copper to the beta domain of metallothionein. J Biol Chem, 259(8), 4941-6.
  113. Winge DR, Nielson KB. (1984). Formation of the metal-thiolate clusters of rat liver metallothionein. Environ Health Perspect, 54, 129-33.
  114. Melis KA, Carter DC, Stout CD, Winge DR. (1984). Crystals of cadmium, zinc metallothionein. Environ Health Perspect, 54, 105-9.
  115. Geller BL, Winge DR. (1984). Subcellular distribution of superoxide dismutases in rat liver. Methods Enzymol, 105, 105-14.
  116. Nielson KB, Winge DR. (1983). Order of metal binding in metallothionein. J Biol Chem, 258(21), 13063-9.
  117. Melis KA, Carter DC, Stout CD, Winge DR. (1983). Single crystals of cadmium, zinc metallothionein. J Biol Chem, 258(10), 6255-7.
  118. Winge DR, Garvey JS. (1983). Antigenicity of metallothionein. Proc Natl Acad Sci U S A, 80(9), 2472-6.
  119. Geller BL, Winge DR. (1983). A method for distinguishing Cu,Zn- and Mn-containing superoxide dismutases. Anal Biochem, 128(1), 86-92.
  120. Boulanger Y, Armitage IM, Miklossy KA, Winge DR. (1982). 113Cd NMR study of a metallothionein fragment. Evidence for a two-domain structure. J Biol Chem, 257(22), 13717-9.
  121. Geller BL, Winge DR. (1982). Rat liver Cu,Zn-superoxide dismutase. Subcellular location in lysosomes. J Biol Chem, 257(15), 8945-52.
  122. Winge DR, Miklossy KA. (1982). Domain nature of metallothionein. J Biol Chem, 257(7), 3471-6.
  123. Winge DR, Miklossy KA. (1982). Differences in the polymorphic forms of metallothionein. Arch Biochem Biophys, 214(1), 80-8.
  124. Geller BL, Winge DR. (1982). Metal binding sites of rat liver Cu-thionein. Arch Biochem Biophys, 213(1), 109-17.
  125. Winge DR, Geller BL, Garvey J. (1981). Isolation of copper thionein from rat liver. Arch Biochem Biophys, 208(1), 160-6.
  126. Ridlington JW, Winge DR, Fowler BA. (1981). Long-term turnover of cadmium metallothionein in liver and kidney following a single low dose of cadmium in rats. Biochim Biophys Acta, 673(2), 177-83.
  127. Cox JA, Winge DR, Stein EA. (1979). Calcium, magnesium and the conformation of parvalbumin during muscular activity. Biochimie, 61(5-6), 601-5.
  128. Southerland WM, Winge DR, Rajagopalan KV. (1978). The domains of rat liver sulfite oxidase. Proteolytic separation and characterization. J Biol Chem, 253(24), 8747-52.
  129. Winge DR, Premakumar R, Rajagopalan KV. (1978). Studies on the zinc content of Cd-induced thionein. Arch Biochem Biophys, 188(2), 466-75.
  130. Winge DR, Southerland WM, Rajagopalan KV. (1978). Structural studies of the heme domain of sulfite oxidase: CNBr fragments. Biochemistry, 17(10), 1846-53.
  131. Rajagopalan KV, Winge DR, Premakumar R. (1976). Chemistry and biology of copper-chelatin. Adv Exp Med Biol, 74, 565-74.
  132. Premakumar R, Winge DR, Wiley RD, Rajagopalan KV. (1975). Copper-induced synthesis of copper-chelatin in rat liver. Arch Biochem Biophys, 170(1), 267-77.
  133. Winge DR, Premakumar R, Rajagopalan KV. (1975). Metal-induced formation of metallothionein in rat liver. Arch Biochem Biophys, 170(1), 242-52.
  134. Premakumar R, Winge DR, Wiley RD, Rajagopalan KV. (1975). Copper-chelatin: isolation from various eucaryotic sources. Arch Biochem Biophys, 170(1), 278-88.
  135. Winge DR, Premakumar R, Wiley RD, Rajagopalan KV. (1975). Copper-chelatin: purification and properties of a copper-binding protein from rat liver. Arch Biochem Biophys, 170(1), 253-66.

Winge DR, Rajagopalan KV. (1972). Purification and some properties of Cd-binding protein from rat liver. Arch Biochem Biophys, 153(2), 755-62.