Department of Internal Medicine

Sihem Boudina, Ph.D

Boudina

Title:
Post-Doctoral Fellow

Education:
University of Bordeaux, France

E-mail:
Sihem.boudina@hmbg.utah.edu

Positions/Employment

2002 – Present: Post-Doctoral Associate (Mentor: E. Dale Abel), University of Utah, Salt Lake City, UT

Awards and Honors

1997 - 2001: French-Algerian Scholarship « Algerian Ministry of Education and CROUS of Bordeaux

2001 - 2002: Research Award « Groupe de Réflexion pour la Recherche Cardiovasculaire (GRRC), France

2002: Transition Award « Fondation pour la Recherche Médicale, France

2004 - 2006: Postdoctoral Fellowship Juvenile Diabetes Research Foundation (JDRF)

2006 – 2008: Postdoctoral Fellowship « American Heart Association (AHA)

Peer Reviewed Publications
  1. Laclau MN, Boudina S, Thambo JB, Tariosse L, Gouverneur G, Bonoron-Adele S, Saks VA, Garlid KD, Dos Santos P. Cardioprotection by ischemic preconditioning preserves mitochondrial function and functional coupling between adenine nucleotide translocase and creatine kinase. J Mol Cell Cardiol. 2001; 33(5):947-56.
  2. Boudina S, Laclau MN, Tariosse L, Daret D, Gouverneur G, Bonoron-Adele S, Saks VA, Dos Santos P. Alteration of mitochondrial function in a model of chronic ischemia in vivo in rat heart. Am J Physiol Heart Circ Physiol. 2002; 282(3):H821-31.
  3. Ducret T, Boudina S, Sorin B, Vacher AM, Gourdou I, Liguoro D, Guerin J, Bresson-Bepoldin L, Vacher P. Effects of prolactin on intracellular calcium concentration and cell proliferation in human glioma cells. Glia. 2002; 38(3):200-14.
  4. Dos Santos P, Kowaltowski AJ, Laclau MN, Seetharaman S, Paucek P, Boudina S, Thambo JB, Tariosse L, Garlid KD. Machanisms by which opening the mitochondrial ATP-sensitive K (KATP) channel protects the iscmenic heart. Am J Physiol Heart Circ Physiol. 2002;283(1):H284-95.
  5.  Dos Santos P, Laclau MN, Boudina S, Garlid KD. Alterations of the bioenergetics systems of the cell in acute and chronic myocardial ischemia. Mol Cell Biochem. 2004; 256-257(1-2):157-66.
  6. Mazumder PK, O'Neill BT, Roberts MW, Buchanan J, Yun UJ, Cooksey RC, Boudina S, Abel ED. Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. Diabetes. 2004; 53(9):2366-74.
  7. Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP. PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol. 2005; 3(4):e101.
  8. Boudina S, Sena S, O’Neill BT, Tathireddy P, Young ME, Abel ED.  Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. Circulation. 2005; 112(17) :2686-95.
  9. Boudina S, Abel ED. Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes. Physiology (Bethesda). 2006 Aug;21:250-8.
  10. Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Stromstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A. PLoS Biol. 2006 Nov;4(11):e369.
  11. Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Makela TP, Schneider MD. Cell Metab. 2007 Feb;5(2):129-42.
Presented Abstracts
  1.  Boudina S, Laclau MN, Thambo JB, Tariosse L, Gouverneur G, Bonoron-Adèle S, and Dos Santos P. Alteration of contractile and mitochondrial function after chronic ischemia in rat hearts. « V International Meeting On New Perspectives in Ischemic Heart Disease: Heart Failure, Atherosclerosis and Hypertension in Beginning of the New Millennium », Bologna, Italy 2000.
  2. Laclau MN, Boudina S, Thambo JB, Tariosse L, Gouverneur G, Bonoron-Adèle S, and Dos Santos P. Mitochondrial KATP opener mimics reconditioning in the protection against early ischemic damages. « V International Meeting on New Perspectives in Ischemic Heart Disease: Heart Failure, Atherosclerosis and Hypertension in Beginning of the New Millennium », Bologna, Italy 2000.
  3. Boudina S, Laclau MN, Thambo JB, Tariosse L, Gouverneur G, Bonoron-Adèle S, and Dos Santos P. Alteration of contractile and mitochondrial function after chronic ischemia in rat hearts. « 17e Congrès du Groupe de Réflexion sur la Recherche Cardiovasculaire (GRRC) », Saint-Malo, France 2000.
  4. Laclau MN, Boudina S, Thambo JB, Tariosse L, Gouverneur G, Bonoron- Adèle S, and Dos Santos P. Mitochondrial KATP opener mimics reconditioning in the protection against early ischemic damages. « 17e Congrès du Groupe de Réflexion sur la Recherche  Cardiovasculaire (GRRC)», Saint-Malo, France 2000.
  5. Boudina S, Laclau MN, Thambo JB, Tariosse L, Gouverneur G, Bonoron-Adèle S, and Dos Santos P. Preservation of cardiac and mitochondrial function by Diazoxide in an in vivo model of chronic myocardial ischemia in rats. « Congrès annuel du Groupe de Réflexion sur la Recherche  Cardiovasculaire, et de la Société Française d’Athérosclérose » Montpellier, France 2001.
  6. Dos Santos P, Laclau M, Diolez P, Thombo JB, Boudina S, Tariosse L, Bonoron-Adèle S, and Garlid KD. Opening of heart mitochondrial ATP-sensitive potassium channel is mandatory to respond to calcium-induced positive inotropic stress. « Congrès annuel du Groupe de Réflexion sur la Recherche  Cardiovasculaire, et de la Société Française d’Athérosclérose », Montpellier, France 2001.
  7. Boudina S, Laclau MN, Thambo JB, Tariosse L, Gouverneur G, Bonoron-Adèle S, and Dos Santos P. Preservation of cardiac and mitochondrial function by Diazoxide in an in vivo model of chronic myocardial ischemia in rats. « Congrès annuel du Groupe de Réflexion sur la Recherche  Cardiovasculaire, et de la Société Française d’Athérosclérose » Montpellier, France 2001.
  8. Boudina S, Laclau MN, Tariosse L, Gouverneur G, Bonoron-Adèle S and Dos Santos P. Preservation of cardiac and mitochondrial function by diazoxide in an in vivo model of chronic ischemia in rats. « XVII World Congress of the International Society for Heart Research », Winnipeg, Canada 2001.
  9. Laclau MN, Dos Santos P, Boudina S, Diolez P, Tariosse L, and Garlid KD. Opening of Heart mitochondrial ATP-sensitive potassium channel is mandatory to respond to calcium-induced positive inotropic stress. « VI International Meeting On New Perspectives in Ischemic Heart Disease: Heart Failure, Atherosclerosis and Hypertension in the Third Millennium », Bologna, Italy 2002.
  10. Boudina S, Laclau MN, Pasquet S, Tariosse L, Bonoron-Adèle S, Saks VA, and Dos Santos P. Beneficial effects of diazoxide opening of mitochondrial ATP-sensitive potassium channel on mitochondrial creatine kinase activity in chronic ischemic model in rats. « 22nd European Section Meeting of the ISHR », Szeged, Hungary 2002.
  11. Muriel N Laclau, Pierre Dos Santos, Sihem Boudina, Liliane Tariosse, Gerard Raffard, Philippe Diolez, Simone Bonoron-Adele, Keith D Garlid. The Essential Role of the Mitochondrial ATP-Sensitive Potassium Channel in Cardiac Inotropy. «AHA scientific session 2002», Chicago, 2002.
  12. Pierre Dos Santos, Muriel N Laclau, Alicia J Kowaltowski, Subramanian Seetharaman, Peter Paucek, Sihem Boudina, Liliane Tariosse, Keith D Garlid. Mechanisms by Which Opening the Mitochondrial ATP-Sensitive Potassium Channel Protects the Ischemic Heart. «AHA scientific session 2002», Chicago, 2002.
  13. Boudina S, O’Neil BT, Belke DD, Rodnick KJ, Abel ED. Insulin  Resistance leads to multiple mitochondrial defects in the mouse  heart. Diabetes 2003; 52, Suppl. 1 A284.
  14. Mazumder PK, Graveleau C, Boudina S, Belke DD, Abel ED. Metabolic characterization of the insulin resistant mouse heart. Diabetes 2003; 52, Suppl. 1 A300.
  15. Boudina S, Mazumder PK, Cooksey RC, McClain DA, Abel ED. Mitochondrial impairment contributes to cardiac dysfunction in obese leptin-deficient (ob/ob) mice. Circulation 2003; 108 IV-75.
  16. Boudina S, O’Neill B, Belke DD, Rodnick KJ, Abel ED. Insulin resistance leads to progressive mitochondrial dysfunction in the mouse heart. Circulation 2003; 108 IV-1404.
  17. Boudina S, O’Neill BT, Abel ED. Mitochondrial uncoupling and decreased oxidative capacity contributes to cardiac dysfunction in db/db mice. Diabetes 2004; 53, Suppl. 1 A335.
  18. Boudina S, Sena S, Wright J, O’Neill BT, Mazumder PK, Abel ED. Postnatal Deletion of Myocardial Insulin Receptor Augments Myocardial Fatty Acid Utilization and Enhances Mitochondrial Biogenesis. IXth International Symposium on Insulin Receptors and Insulin Action, Nice, France 2004.
  19. Boudina S, Cooksey RC, McClain DA, Abel ED. Mitochondrial Dysfunction Precedes Generalized Insulin resistance in Response to High-Fat Feeding. IXth International Symposium on Insulin Receptors and Insulin Action, Nice, France 2004.
  20. Boudina S, Sena S, O’Neill BT, Abel ED. Lack of Insulin Signaling in Cardiomyocytes Leads to Progressive ROS-mediated Defects in Mitochondrial Function. International Symposium on the Science of Diabetes Complications: Implication for Novel Therapy. Toronto, Canada 2004.
  21. Boudina S, Cooksey RC, Jones D, McClain DA, Abel ED. Insulin Resistance, Mitochondrial Dysfunction and Energy Expenditure Following High Fat Feeding. Diabetes 2005; 54 Suppl. 1 1578-P.
  22. O’Neill BT, Davis DK, Boudina S, Izumo S, Abel ED. PI3-Kinase Regulates Myocardial Mitochondrial Fatty Acid Utilization by Modulating the Expression of PGC-1-beta. Diabetes 2005; 54 Suppl. 1 1476-P.
  23. Sihem Boudina, Sandra Sena, Brian T O’Neill, Vlad Zaha, Pradip Mazumder, Jordan Wright, Heather Theobald, Isaac Rasmussen, E Dale Abel. Insulin Signaling Regulates Mitochondrial Function and Oxidative Phosphorylation Protein Content in the Murine Heart. Bioscience: From Genes to Systems. Glasgow, UK 2005.
  24. Brian T O’Neill, Don K Davis, Sihem Boudina, Mazumder P. PI3-Kinase Regulates Mitochondrial Fatty Acid Utilization via Modulation of PGC-1 Expression. Circulation 2005; 112 (17): II-35.
  25. John J Lehman, Sihem Boudina, Deanna M Young, Teresa C Leone, E Dale Abel, Daniel P Kelly. The Transcriptional Coactivator PGC-1a is Essential for Maximal and Efficient Cardiac Mitochondrial Fatty Acid Oxidation and ATP Synthesis. Circulation 2005; 112 (17): II-157.
  26. Sihem Boudina, Vlad G. Zaha, Pradip K. Mazumder, Brian T. O’Neill, Heather Theobald, E. Dale Abel. Mitochondrial Adaptations to Chronic GLUT4 Deficiency. Diabetes 2006; 55 Suppl. 1 1235-P.
  27. Sihem Boudina Vlad G. Zaha, Pradip K. Mazumder, Brian T. O’Neill, Heather Theobald, and E. Dale Abel. Increased Fatty Acid (FA) Utilization and Preserved Cardiac Function in the Hypertrophied GLUT4-Deficient Heart Despite Reduced FA Expression Machinery. Keystone 2006.
  28. Sihem Boudina, Sandra Sena, Brian T O’Neill, Vlad G. Zaha, E. Dale Abel. Mechanisms Responsible for Mitochondrial Uncoupling in Obesity and Diabetes. SHVM. Semiahmoo 2006.
  29. Jordan Wright, Jonathan Buchanan, Sihem Boudina, E. Dale Abel. Differential Effects of High-Fat Feeding on the Ability of Insulin to Modulate Glucose versus FA Utilization in the Heart. Circulation 2006; 114 (18): II-209.
  30. Sihem Boudina, Sandra Sena, Brian T O’Neill, Salwa Aziz, E. Dale Abel. Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocase (ANT). Circulation. 2006; 114 (18): II-244.