Ivor J. Benjamin, M.D., FAHA, FACC

Education and Training:

College: Hunter (CUNY)
Medical School: Johns Hopkins University School of Medicine
Residency: Yale - New Haven Hospital
Clinical Fellowship:  Michael Reese Hospital (University of Chicago)
Post-Doctoral Research:  Duke University Medical Center
Fellowships: University of Texas Southwestern Medical Center at Dallas

Clinical Specialties:

• General Cardiology
• Genetics of heart disease

Research Interests:

• Screening for Novel Genetic Pathways in Cardioprotection
• Molecular & Genetic Analysis of Heat Shock Factor (HSF) Transcriptional Networks in Murine Development
• Molecular Mechanisms of Alpha-B CrystallinR120G Familial Cardiomyopathy

Recent Publications:

• Rajasekaran NS, Connell P, Christians ES, Yan L-J, Taylor RP, Orosz A, Zhang XQ, Stevenson TJ, Peshock RM, Leopold JA, Barry WH, Loscalzo J, Odelberg SJ, and Benjamin IJ: Human alphaB-Crystallin Mutation Causes Oxido-reductive Stress and Protein Aggregation Cardiomyopathy in Mice. Cell, 2007 130: 427-439.
• Benjamin IJ, Guo Y, Srinivasan S, Boudina S, Taylor RP, Rajasekaran NS, Gottlieb R, Wawrousek EF, Abel ED, Bolli R: CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice. Am J Physiol, 2007, published online 9/14/2007.
• Benjamin IJ and Patel J. (2007). Heart Failure in the Era of Genomic Medicine. In: Handbook of Genomic Medicine. H. Willard and G. Ginsburg, Editors. Elsevier. In press.
• Orosz A, Benjamin IJ. (2007). Genetic Models of HSF Function. In M. Zouhair Atassi and Stuart K. Calderwood (Eds.), Cell Stress Proteins (7), Protein Reviews. New York: Springer.
• Pinz I, Robbins J, Rajasekaran NS, Benjamin IJ, Ingwall JS. (2007). Unmasking different mechanical and energetic roles for the small heat shock proteins CryAB and HSPb2 using genetically modified mouse hearts. FASEB J, 2007, published online 9/10/2007.
• Chrisitans ES, Benjamin IJ: Heat shock response: lessons from mouse knockouts . Handb Exp Pharmacol. (172):139-52, 2006.
• Kadono T, Zhang XQ, Srinivasan S, Ishida H, Barry WH, Benjamin IJ. CRYAB and HSPB2 deficiency increases myocyte mitochondrial permeability transition and mitochondrial calcium uptake . J Mol Cell Cardiol. 2006 Jun; 40(6): 783-9. Epub 2006 May 5.
• Taylor RP, Benjamin, IJ: Small heat shock proteins: a new classifcation scheme in mammals. Journal Molecular & Cell Cardio. Mar:38(3):433-44, 2005.
• Yan LJ, Rajasekaran NS, Sathyanarayanan S, Benjamin IJ (2005) Mouse HSF1 disruption perturbs redox state and increases mitochondrial oxidative stress in kidney . Antioxid Redox Signal, 7(3-4):465-71.
• Benjamin IJ, Schneider MD. Learning from failure: congestive heart failure in the postgenomic age. J Clin Invest. 2005 Mar; 115(3):495-9.

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