John H. B. Bridge, Ph.D.

Education and Training:

College: London University, BS; University of California, Los Angeles, PhD
Training:  University of California, Los Angeles; University of Washington
Faculty Positions:   University of Utah, 1982

Research Interests:

• Excitation contraction coupling in the heart
• Na-Ca exchange and the regulation of contraction in heart.

Recent Publications:

• Inoue M, Bridge JH. Ca2+ sparks in rabbit ventricular myocytes evoked by action potentials: involvement of clusters of L-type Ca2+ channels. Circ Res. 2003 Mar 21; 92(5): 532-8.
• Cordeiro JM, Spitzer KW, Giles WR, Ershler PE, Cannell MB, Bridge JH. Location of the initiation site of calcium transients and sparks in rabbit heart Purkinje cells. J Physiol. 2001 Mar 1; 531(Pt 2): 301-14.
• Cordeiro JM, Bridge JH, Spitzer KW. Early and delayed afterdepolarizations in rabbit heart Purkinje cells viewed by confocal microscopy. Cell Calcium. 2001 May; 29(5): 289-97.
• Litwin SE, Zhang D, Bridge JH. Dyssynchronous Ca(2+) sparks in myocytes from infarcted hearts. Circ Res. 2000 Nov 24; 87(11): 1040-7.
• Bridge JH, Ershler PR, Cannell MB. Properties of Ca2+ sparks evoked by action potentials in mouse ventricular myocytes. J Physiol. 1999 Jul 15; 518 ( Pt 2): 469-78.
• Su Z, Bridge JH, Philipson KD, Spitzer KW, Barry WH. Quantitation of Na/Ca exchanger function in single ventricular myocytes. J Mol Cell Cardiol. 1999 May; 31(5): 1125-35.
• Yao A, Su Z, Nonaka A, Zubair I, Spitzer KW, Bridge JH, Muelheims G, Ross J Jr, Barry WH. Abnormal myocyte Ca2+ homeostasis in rabbits with pacing-induced heart failure. Am J Physiol. 1998 Oct; 275(4 Pt 2): H1441-8.
• Litwin SE, Li J, Bridge JH. Na-Ca exchange and the trigger for sarcoplasmic reticulum Ca release: studies in adult rabbit ventricular myocytes. Biophys J. 1998 Jul; 75(1): 359-71.
• Yao A, Su Z, Nonaka A, Zubair I, Lu L, Philipson KD, Bridge JH, Barry WH. Effects of overexpression of the Na+-Ca2+ exchanger on [Ca2+]i transients in murine ventricular myocytes. Circ Res. 1998 Apr 6; 82(6): 657-65.
• Yao A, Matsui H, Spitzer KW, Bridge JH, Barry WH. Sarcoplasmic reticulum and Na+/Ca2+ exchanger function during early and late relaxation in ventricular myocytes. Am J Physiol. 1997 Dec; 273(6 Pt 2): H2765-73.
• Litwin SE, Bridge JH. Enhanced Na(+)-Ca2+ exchange in the infarcted heart. Implications for excitation-contraction coupling. Circ Res. 1997 Dec; 81(6): 1083-93.
• Levi AJ, Li J, Spitzer KW, Bridge JH. Effect on the indo-1 transient of applying Ca2+ channel blocker for a single beat in voltage-clamped guinea-pig cardiac myocytes. J Physiol. 1996 Aug 1; 494 ( Pt 3): 653-73.
• Litwin S, Kohmoto O, Levi AJ, Spitzer KW, Bridge JH. Evidence that reverse Na-Ca exchange can trigger SR calcium release. Ann N Y Acad Sci. 1996 Apr 15; 779: 451-63. Review.
• Barry WH, Matsui H, Bridge JH, Spitzer KW. Excitation-contraction coupling in ventricular myocytes: effects of angiotensin II. Adv Exp Med Biol. 1995; 382: 31-9.
• Ikenouchi H, Barry WH, Bridge JH, Weinberg EO, Apstein CS, Lorell BH. Effects of angiotensin II on intracellular Ca2+ and pH in isolated beating rabbit hearts and myocytes loaded with the indicator indo-1. J Physiol. 1994 Oct 15; 480 ( Pt 2): 203-15.
• Levi AJ, Spitzer KW, Kohmoto O, Bridge JH. Depolarization-induced Ca entry via Na-Ca exchange triggers SR release in guinea pig cardiac myocytes. Am J Physiol. 1994 Apr; 266(4 Pt 2): H1422-33.
• Kohomoto O, Levi AJ, Bridge JH. Relation between reverse sodium-calcium exchange and sarcoplasmic reticulum calcium release in guinea pig ventricular cells. Circ Res. 1994 Mar; 74(3): 550-4.
• Barry WH, Bridge JH. Intracellular calcium homeostasis in cardiac myocytes. Circulation. 1993 Jun; 87(6): 1806-15. Review.
• Chin TK, Spitzer KW, Philipson KD, Bridge JH. The effect of exchanger inhibitory peptide (XIP) on sodium-calcium exchange current in guinea pig ventricular cells. Circ Res. 1993 Mar; 72(3): 497-503.

Hide complete profile.