Dean Li, M.D., Ph.D.

Education and Training:

Medical School: Washington University, St. Louis, Missouri
Residency: Barnes Hospital/Washington University, St. Louis, Missouri (Internal Medicine)
Fellowship:  Barnes Hospital/Washington University, St. Louis, Missouri (Cardiology)

Clinical Specialties:

• Vascular Malformations and Guidance

Research Interests:

• Vascular Malformations and Guidance

Recent Publications:

• Jones CA, Nishiya N, London NR, Zhu W, Sorensen LK, Chan A, Lim CJ, Chen H, Zhang Q, Schultz PG, Hayallah AM, Thomas KR, Famulok M, Zhang K, Ginsberg MH, Li DY.  (2009)  Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity.  Nature Cell Biology 11(11):1325-31. Epub 2009 Oct 18.  (PMID: 19855388)
• Whitehead, KJ, Chan, AC, Navankasattusas, S, Koh, W, London, MR, Ling, J, Mayo, AH, Drakos, SG, Marchuk, DA, Davis, GE, Li, DY (2009) The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nature Medicine  Feb;15(2):177-84. Epub 2009 Jan 18.  (PMID: 19151728)
• London NR, Whitehead KJ, Li DY (2009)  Endogenous endothelial cell signaling systems maintain vascular stability. Angiogenesis 12(2):149-58.  Epub 2009 Jan 27.  (PMID: 19172407)
• Jones C, London N, Park K, Chen H, Stockton R, Nishiya N Ginsberg M, Zhang K, and Li DY. (2008)  Robo4 stabilizes the vasculature by inhibiting angiogenesis and endothelial hyperpermeability. Nature Medicine  14(4):448-53  (PMID18345009; 1R01HL084516-01A1, 5R01HL077671-03)
• Navankasattusas S, Whitehead K, Suli A,  Sorensen LK, Lim A, Zhao J, Thomas KR, Chien C, and Li DY. (2008) The netrin receptor, Unc5b, promote angiogenesis in specific vascular beds. Development 135:659-67 
• Wilson B, Park KW, Li M, Suli A, Koch GA, Sorensen L, Urness L, Chien CB, Losordo D, and Li DY. (2006) Netrins promote developmental and theraeutic angiogenesis.  Science 33:640-4  (PMID16809490; 5R01HL077671-03)
• Drakos SG, Kfoury AG, Reid BB, Selzman CH, Stehlik J, Eckels DD, Horne BD, Li DY, Renlund DG. (2009) Prior HLA-allosensitization and left ventricular assist device type affect degree of post-implantation HLA-allosensitization. J Heart Lung Transpl. 28(8):838-42.
• Drakos SG, Janicki L, Horne BD, Kfoury AG, Reid BB, Li DY, Renlund DG. Risk Factors Predictive of Right Ventricular Failure Following Left Ventricular Assist Device Implantation. Am J Cardiol, In press
• Park KW, Morrison CM, Sorenson LK, Chien CB, Wu JY, Li DY. (2003) Robo4 is a vascular-specific receptor that inhibits endothelial migration. Dev Bio 261:251-267.
• Sorenson L, Brooke B, Li, DY*, Urness L. (2003) Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular specific TGF beta co-receptor. Dev Bio 261:235-250 *corresponding author.
• Karnik S, Wythe J, Sorenson L , Li DY. (2003) Elastin hexapeptide activates myofibrillinogenesis in vascular smooth muscle cells. Matrix Biology 22(5):409-425.
• Faury G, Pezet M, Boyle WA, Knutsen R, Hexamer SP, McLean SE, Minkes RK, Blumer KJ, Kelly DP, Starcher B, Li DY, Mecham RP. (2003) Developmental adaptation of the mouse cardiovascular system to elastin haploisufficiency. JCI 112(9):1419-28.
• Whitehead K, Plummer N, Adams J, Marchuk D, Li DY.(2004) Disrupted arterial morphogenesis in mice lacking Ccm1; implications for the etiology of cavernous malformation. Development 131(6):1437-48.

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