Sheldon E. Litwin, M.D.

Education and Training:

Medical School: Washington University (St Louis)
Residency: University of Arizona
Fellowships:  Beth Israel Hospital/Harvard Medical School

Clinical Specialties:

• Noninvasive/Echo
• Cellular mechanisms of heart failure
• Diabetes/obesity and heart failure

Research Interests:

• Noninvasive/Echo
• Cellular mechanisms of heart failure
• Diabetes/obesity and heart failure

Recent Publications:

• Skaluba S, Litwin SE. Mechanisms of exercise intolerance: insights from tissue Doppler imaging. Circulation 2004; 109:972.
• Skaluba, S, Litwin SE: Doppler-derived LV filling pressures and heart rate recovery after exercise in patients with suspected coronary artery disease. AM J Cardiol 2005;95:832-837
• Avelar E, Jalili T, Dong L, Arvizo J, Hu P, Litwin SE Mattson JP:PKC translocation and ERK 1/2 activation in compensated right ventricular hypertrophy secondary to chronic emphysema. BMC Physiology 2005;5:6
• Skaluba S, Bray B, Litwin SE,: Close coupling of systolic and diastolic function: Combined assessment provides superior prediction of exercise capacity. J Card Failure 2005; In Press
• Malan Ak, Avelar E, Litwin SE,Hill HR, Litwin CM: Serologic Diagnosis of Trypanosoma cruzi: Evaluation of Three Enzyme Immunoassays and an Immunoglobulin G (IgG) Indirect Immunofluorescesnt Assay. J Med Microbiol 2005; In Press.
• McQueen AP, HU P, Zhang D, Swenson L, Yang Y, Zaha VG, Hoffman JL, Yun Uj, Chakrabarti G, Wang Z, Albertine K, Abel ED, Litwin SE: Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: Possible role of reduced capillary density. J Molec Cell Cardiol 2005: In Press
• Adams TD, Avelar E, Cloward T, Crosby RD, Gress R, Halveson RC, Hopkins P, Kolotkin RL, LaMonte MJ, Litwin SE, Nutall RT, Pendelton R, Rosamond W, Simper SC, Smith SC, Strong M, Walker J, Wiebke G, Yanowitz FG, Hunt SC: Design and rationale of the Utah obesity study. A study to assess morbidity following gastric bypass surgery. Contemp Clin Trials 2005; In Press
• Buchanan J, Mazumder PK, Hu P, Chakrabarti G, Roberts MW, Yun UJ, Cooksey RC, Litwin SE Abel ED: Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity. Endocrinology 2005;In Press
• Litwin SE: The growing problem of obesity and the heart: The plot "thickens" J Am Coll Cardiol 2005; In Press
• Avelar E, Cloward TV, Walker JM, Farney RJ, Strong M, Pendleton R, Adams TD, Gress RE, Hunt SC, Litwin SE:Left ventricular hypertrophy in severe obesity: Influences of body mass index, hypertension, diabetes and obstructive sleep apenea. Submitted
• Valencik ML, Zhang D, Hunter C, Hu P, Yang Y, Punske B, McDonald JA, Litwin SE: Conditional expression of an unregulated a5 integrin in the heart rapidly leads to profound electrical and contractile cardiac dysfunction. Submitted

Research Awards:    

• 2000-2005 Dept. of Veterans Affairs, Merit Review; Principal Investigator "Mechanisms of impaired excitation-contraction coupling in the infarcted heart" Annual Direct Costs $120,000
• 2001-2006 NIDDK U01 HL70525 (P.I. Don McClain) "Mouse Models of Diabetic Cardiovascular Complications" Annual Direct Costs $500,000
• 2003-2008 NHLBI R01 HL73167 (P.I. Dale Able) "Insulin resistance and cardiac dysfunction in obesity" Annual Direct costs $250,0000
• 2004-2008 NHLBI R01 HL070070-01 (P.I. Dale Abel) "Insulin Signaling and the Heart in Diabetes" Annual Direct costs $250,000
• 2001-2005 NHLBI R01 7R01HL070511-04 (P.I. John McDonald, University of Nevada) "Role of integrins in Cardiac Myocytes" Annual Direct Costs $250,000

Hide complete profile.