Nassir F. Marrouche, MD

Education and Training:

Medical School: University of Heidelberg, Germany
Residency: 1997-1998 - Internal Medicine and Cardiology at the University of Heidelberg/Germany; 1998/2000 - Internal Medicine and Cardiology at the University of Wurzburg, Klinikum Coburg, Coburg/Germany
Clinical Fellowships:  3/00-9/00 Section of Cardiac Electrophysiology, Department of Cardiology, University of California, San Francisco; 9/00-2/03 Section of Pacing and Electrophysiology, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation

Clinical Specialties:

• Electrophysiology

Research Interests:

• Atrial Fibrillation: Pathophysiology and Novel Treatment Modalities
• Defining new imaging modalities for treatment of atrial and ventricular arrhythmias

Recent Publications:

• Ablation of Atrial fibrillation: The Cleveland Clinic Experience: 2nd Virtual Meeting of Cardiology, "Argentine Federation of Cardiology" International Congress of Cardiology on the Internet, Nassier F. Marrouche, Andrea Natale
• Pulmonary Veins Isolation for treatment of Atrial Fibrillation: Different Catheter Techniologies for Pulmonary veins isolation. J Am Coll Cardiol 2002 Aug 7;40(3):464-74 Nassir F Marrouche, Christopher Cole, Robert Schweikert, Walid Saliba, Stephen Pavia, Dianna Bash, Andrea Natale, Ahmad Abdul-Karim, Krzysztof Balaban
• Left Septal Atrial Tachycardia: Clinical and Electrophysiologic Characteristics J Am Coll Cardiol 2002 Sep 18;40(6):1133-9 Nassir F Marrouche, Arne SippensGroenewegen, Samer Dibs, Iqwal Mangat, Paul Steiner, Melvin M. Scheinman
• Circular mapping and ablation of the pulmonary vein for treatment of atrial fibrillation. Impact of different catheter technologies. J Am Coll Cardiol. 2002 Aug 7;40(3):464-74.Marrouche NF, Dresing T, Cole C, Bash D, Saad E, Balaban K, Pavia SV, Schweikert R, Saliba W, Abdul-Karim A, Pisano E, Fanelli R, Tchou P, Natale A.
• Simultaneous epicardial and endocardial mapping of a left-sided posteroseptal accessory pathway associated with a large coronary sinus diverticulum: successful ablation by transection of the diverticulum's neck. Pacing Clin Electrophysiol 2002 Oct;25(10):1524-6 Saad EB, Marrouche NF, Cole CR, Natale A
• Circumferential ultrasound ablation for pulmonary vein isolation: analysis of acute and chronic failures. J Cardiovasc Electrophysiol 2002 Oct;13(10):957-61 Saliba W, Wilber D, Packer D, Marrouche N, Schweikert R, Pisano E, Shewchik J, Bash D, Fanelli R, Potenza D, Santarelli P, Tchou P, Natale A.
• Evaluation and management of ventricular outflow tract tachycardias Card Electrophysiol Rev 2002 Dec;6(4):442-7 Cole CR, Marrouche NF, Natale A
• Phased Array Intracardiac Echocardiography Monitoring during Pulmonary Vein Isolation in Patients with Atrial Fibrillation: Impact on outcome and complications Circulation 2003;107:2710-2716 Nassir F. Marrouche, David O. Martin MD MPH, Oussama Wazni MD, A. Marc Gillinov MD, Allan Klein MD, Mandeep Bhargava MD, Eduardo Saad MD, Dianna Bash RN, Hirotsugu Yamada, MD PhD, Wael Jaber MD, Robert Schweikert MD, Patrick Tchou MD, Ahmad Abdul-Karim MD, Walid Saliba MD and Andrea Natale MD
• Percutaneous pericardial instrumentation for endo-epicardial mapping of previously failed ablations.
• Circulation. 2003 Sep 16;108(11):1329-35.
• Schweikert RA, Saliba WI, Tomassoni G, Marrouche NF, Cole CR, Dresing TJ, Tchou PJ, Bash D, Beheiry S, Lam C, Kanagaratnam L, Natale A.
• Randomized study comparing combined pulmonary vein-left atrial junction disconnection and cavotricuspid isthmus ablation versus pulmonary vein-left atrial junction disconnection alone in patients presenting with typical atrial flutter and atrial fibrillation.
• Circulation. 2003 Nov 18;108(20):2479-83.
• Wazni O, Marrouche NF, Martin DO, Gillinov AM, Saliba W, Saad E, Klein A, Bhargava M, Bash D, Schweikert R, Erciyes D, Abdul-Karim A, Brachman J, Gunther J, Pisano E, Potenza D, Fanelli R, Natale A
• Pulmonary vein isolation for the treatment of atrial fibrillation in patients with impaired systolic function. J Am Coll Cardiol. 2004 Mar 17;43(6):100Â Â Chen MS, Marrouche NF, Khaykin Y, Gillinov AM, Wazni O, Martin DO, Rossillo A, Verma A, Cummings J, Erciyes D, Saad E, Bhargava M, Bash D, Schweikert R, Burkhardt D, Williams-Andrews M, Perez-Lugones A, Abdul-Karim A, Saliba W, Natale A
• Mode of initiation and ablation of ventricular fibrillation storms in patients with ischemic cardiomyopathy. J AM Coll Cardiol. 2004 May 5;43(9):1715-20 Marrouche NF, Verma A, Wazni I, Schweikert R, Martin DO, Saliba W, Kilicaslan F, Cummings J, Burkhardt JD, Bhargava M, Bash D, Brachmann J, Guenther J, Hao S, Beheiry S, Rossillo A, Raviele A, Themistoclakis S, Natale A.
• Left septal atrial flutter: electrophysiology, anatomy, and results of ablation. Circulation. 2004 May 25;109(20):2440-7 Marrouche NF, Natale A, Wazni OM, Cheng J, Yang Y, Pollack H. Verma A, Ursell P, Scheinman NM
• Novel method to integrate three-dimensional computed tomographic images of the left atrium with real-time electroanatomic mapping. Journal of Cardiovascular Electrophysiology. 2004 Aug;15(8) Verma A, Marrouche N, Natale A.
• Importance of ablating all potential right atrial flutter circuits in postcardiac surgery patients. JACC 2004 Jul 21;44(2):409--414. Verma A, Marrouche NF, Seshadri N, Schweikert RA, Bharagava M, Burkhardt JD, Kilicaslan F, Cummings J, Saliba W, Natale A.
• Pulmonary vein isolation for atrial fibrillation in patients with symptomatic sinus bradycardia or pauses. Journal of Cardiovascular Electrophysiology. 2004 Jul;15(7):784-789. Khaykin Y, Marrouche NF, Martin DO, Saliba W, Schweikert R, Wexman M, Strucnk b, Beheiry S, Saad E, Bhargava M, Burkhardt JD, Joseph G, Tchou P, Natale A.
• Plasma B-type natriuretic peptide levels predict postoperative atrial fibrillation in patients undergoing cardiac surgery. Circulation 2004 Jul 13;110(2):124-7.Wazni OM, Martin Do, Marrouche NF, Latif AA, Ziada K, Shaaraoui M, Almahameed S, Schweikert RA, Saliba WI, Gillinov AM, Tang WH, Mills RM, Francis GS, Young JB, Natale A
• Asymptomatic acute inferior ST elevation myocardial infarction from thermal injury complicating radiofreuency ablation for atrioventricular re-entrant tachycardia. J Invasive Cardiol. 2004 Sep;16(9):504-5. Chacko M, Marrouche NF, Bhatt DL
• Usefulness of intracardiac Doppler assessment of left atrial function immediately post-pulmonary vein antrum isolation to predict short-term recurrence of atrial fibrillation. Am J Cardiol. 2004 Oct 1;94(7):951-4. Verma A, Marrouche NF, Yamada H, Grimm RA, Cummings J, Burkhardt JD, Kilicaslan F, Bhargava M, Karim AA, Thomas JD, Natale A.
• Impact of coronary sinus lead postion on biventricular pacing: mortality and echocardiographic evaluation during long-term follow-up. J Cardiovasc Electroophsiol. 2004 Oct;15(10):1120-5 Rossillo A, Verma A, Saad EB, Corrado A, Gasparini G, Marrouche NF, Golshayan AR, McCurdy R, Bhargava M, Khaykin Y, Burkhardt JD, Martin DO, Wilkoff BL, Saliba WI, Schweikert RA, Raviele A, Natale A.
• Potential rold of body surface ECG mapping for localization of atrial fibrillation trigger sites. Electrocardiol. 2004;37Suppl:47-52. Sippensroenewegen A, Natale A, Marrouche NF, Bash D, Cheng J.
• Prevalence, predictors, and mortality significance of the causative arrhythmia in patients with electiral storm. J Cardiovasc Electrophysiol. 2004 Nov;15(11):1265-70. Verma A, Kilicaslan F, Marrouche NF, Minor S, Shan M, Wazni O, Burkhardt
• Pulmonary vein antrum isolatin: intracardiac echocardiography-guided technique. J Cardiovasc Electrophysiol. 2004 Nov;15(11):1335-40. Verma A, Marrouche NF, Natale A.
• Pre-existent left atrial scarring in patients undergoing pulmonary vein antrum isolation: an independent predictor of procedural failure. J Am Coll Cardiol. 2005 Jan 18;45(2):285-92. Verma A, Wazni OM, Marrouche NF, Martin DO, Kilicaslan F, Minor S, Schweikert RA, Saliba W, Cummings J, Burkhardt JD, Bhargava M, Belden WA, Abdul-Karim A, Natale A.
• Response to pharmacological challenge of dissociated pulmonary vein rhythm. J Cardiovasc Electrophsiol. 2005 Feb;16(2):122-6. Marrouche N, Wazni OM, Martin DO, Rossillo A, Saliba W, Erciyes D, Schweikert R, Khaykin Y, Burkhardt D, Bhargava M, Verma A, Abdul-Karim A, Natale A.
• Relationship between successful ablation sites and the scar border zone defined by substrate mapping for ventricular tachycardia post-myocardial infarction. J Cardiovasc Electrophysiol. 2005 May;16(5):465-71. Verma A, Marrouche N, Schweikert RA, Saliba W, Wazni O, Cummings, Abdul-Karim A, Bhargava M, Burkhardt JD, Kilicaslan F, Martin DO, Verma A, Natale A.
• C-Reactive protein level and recurrence of atrial fibrillation after electrical cardioversion. Heart. 2005 May 12. Wani O, Martin DO, Marrouche NF, Shaaraoui M, Chung M, Almahameed S, Schweikert R, Saliba W, Natale A.
• Radiofrequency ablation vs antiarrhythmic drugs as first-line treatment of symptomatic atrial fibrillation: a randomized trial. JAMA. 2005 Jun 1;293(21):2634-40. Wazni OM, Marrouche NF, Martin Do, Verma A, Bhargava M, Saliba W, Bash D, Schweikert R, Brachmann J, Gunther J, Gutleben K, Pisano E, Potenza D, Fanelli R, Raviele A, Themistoclakis S, Rossillo A, Bonso A, Natale A.
• Surgical ablation of atrial fibrillation with bipolar radiofrequency as the primary modality. J Thorac Cardiovasc Surg. 2005 Jun;129(6):1322-9. Gillinov AM, McCarthy PM, Blackstone EH, Rajeswaran J, Pettersson G, Sabik J, Svensson LG, Cosgrove DM, Hill KM, Gonzalez-Stawinski G, Marrouche N, Natale A.
• Novel applications in catheter ablation. J Interv Card Electrophysiol. 2005 Aug;13 Suppl 1:17-21. Thal SG, Marrouche NF.
• Avoiding microbubbles formation during radiofrequency left atrial ablation versus continuous microbubbles formation and standard radiofrequency ablation protocols: comparison of energy profiles and chronic lesion characteristics. J Cardiovasc Electrophsiol. 2006 Jan;17(1):72-7.26. Oh S, Kilicaslan F, Zhang Y, Wazni O, Mazgalev TN, Natale A, Marrouche NF.
• Ablation of Atrial Fibrillation. Curr Probl Cardiol. 2006 May;31(5):361-90. Riley M, Marrouche NF.

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