Internal Medicine Department
Hematology Division

Josef T. Prchal, MD

Email:    josef.prchal@hsc.utah.edu

Education:

1962 – 1968    M.D., Charles University, Hradec Králové, Prague, Czech Republic

Training:

1974 – 1975    Fellow in Laboratory and Clinical Hematology, University of Toronto, Toronto, Ontario

1972 – 1975    Fellow in Hematology/Oncology, University of Toronto, Toronto, Ontario

1972 – 1973    Fellow of Royal Canadian College of Physicians, Ottowa, Ontario

1970 – 1972    Resident in Internal Medicine, University of Toronto, Toronto, Ontario

1968 – 1969    Intern in Medicine, University of Toronto, Toronto, Ontario

Research Interests:    

Polycythemias
Erythorcyte disorders
Hematopoiesis

Recent Publications

  1. Pospisilova D, Mims MP, Nemeth E, Ganz T, Prchal JT.  DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis. Blood. 2006 Jul 1;108(1):404-5.

  2. Yoon D, Pastore YD, Divoky V, Liu E, Mlodnicka AE, Rainey K, Ponka P, Semenza GL, Schumacher A, Prchal JT.  HIF-1alpha -deficiency results in dysregulated EPO signaling and iron homeostasis in mouse development. J Biol Chem. 2006 Sep 1;281(35):25703-11..
  3. Xiong Z, Yan Y, Liu E, Silver RT, Verstovsek S, Yang F, Wang H, Prchal JT, Yang X-F. Novel Tumor Antigens Elicit Anti-Tumor Humoral Immune Reactions In A Subset Of Patients With Polycythemia Vera. Clinical Immunology. 2007; 122, 279–287

  4. Nussenzveig RH, Swierczek SI, JJelinek J, Gaikwad A,  Liu E, Verstovsek S, Prchal JF and Prchal JT. Polycythemia Vera is not Initiated by JAK2(V617F) Mutation. Experimental Hematology. 35: 32-38, 2007.

  5. Yoder MC, Mead LE, Prater D, Krier TR, Mroueh KN, Li F, Krasich R, Temm CJ, Prchal JT, Ingram DA.  Re-defining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood.; 2007 Mar 1;109(5):1801-9.
  6. Gaikwad A, Nussenzveig R, Liu E, Gottshalk S, Chang K, Prchal JT.  In vitro expansion of erythroid progenitors from polycythemia vera patients patients leads to decrease in JAK2 V617F allele. Experimental Hematology. 2007 Apr;35(4):587-95.

  7. Chen GL, Prchal JT.  X linked clonality testing: interpretation and limitations. Blood. 2007 Sep 1;110(5):1411-9.
  8. Agarwal N, Gordeuk VR, Prchal JT.  Are erythropoietin receptors expressed in tumors? Facts and fiction—more careful studies are needed. J Clin Oncol. 2007 May 1;25(13):1813-4.
  9. Gaikwad A, Verstovsek S, Yoon D, Chang KT, Manshouri T, Nussenzveig R, Cortes J, Vainchenker W, Prchal JT. Imatinib effect on growth and signal transduction in polycythemia vera. Exp Hematol. 2007 Jun;35(6):931-8.
  10. Chen ZY, Asavaritikrai P, Prchal JT, Noguchi CM. Endogenous Erythropoietin
 Signaling Is Required For Normal Neural Progenitor Cell Proliferation. J
Biol Chem, Aug 31;282(35):25875-83, 2007.

  11. Percy MJ, Sanchez M, Swierczek S, McMullin MF, Mojica-Henshaw MP, Muckenthaler MU, Prchal JT, Hentze MW. Is congenital secondary erythrocytosis/polycythemia caused by activating mutations within the HIF-2{alpha} iron-responsive element? Blood. 2007 Oct 1;110(7):2776-7. Jelinek J, Li J, Mnjoyan Z, Issa JP, Prchal JT, Afshar-Kharghan V. Epigenetic control of PRV-1 expression on neutrophils. Exp Hematol. 2007 Nov;35(11):1677-83.

  12. Bruchova H, Yoon D, Agarwal AM, Mendell J, Prchal JT. Regulated expression of microRNAs in normal and polycythemia vera erythropoiesis. Exp Hematol. 2007 Nov;35(11):1657-67.

  13. Gaikwad A, Prchal JT. Study of two tyrosine kinase inhibitors on growth and signal transduction in polycythemia vera. Exp Hematol. 2007 Nov;35(11):1647-56.

  14. Yoon D, Kim B, Prchal JT. Cre recombinase expression controlled by the hematopoietic regulatory domain of Gata-1 is erythroid-specific. Blood Cells Mol Dis. 40(3):381-7, 2008.

  15. Agarwal N, Kutlar F, Mojica-Henshaw MP, Ou CN, Gaikwad A, Reading NS, Bailey L, Kutlar A, Prchal JT. Missense mutation of the last nucleotide of exon 1 (G->C) of beta globin gene not only leads to undetectable mutant peptide and transcript but also interferes with the expression of wild allele. Haematologica. 2007 Dec;92(12):1715-6.

  16. Agarwal N, Gordeuk RV, Prchal JT. Genetic mechanisms underlying regulation of hemoglobin mass. Adv Exp Med Biol. 2007;618:195-210.

  17. Sergueeva AI, Miasnikova GY, Okhotin DJ, Levina AA, Debebe Z, Ammosova T, Niu  X, Romanova EA, Nekhai S, DiBello PM, Jacobsen DW, Prchal JT, Gordeuk VR.  Elevated homocysteine, glutathione and cysteinylglycine concentrations in patients homozygous for the Chuvash polycythemia VHL mutation. Haematologica. 2008 Feb;93(2):279-82.
  18. Samuelson SJ, Parker CJ, Prchal JT.  Revised criteria for the myeloproliferative disorders: too much too soon? Blood. 2008 Feb 1;111(3):1741.
  19. Yoon D, Agarwal N, Prchal JT. Does erythropoietin promote tumor growth? Clin Cancer Res. 2008 Mar 15;14(6):1920.

  20. Bruchova H, Merkerova M, Prchal JT.  Aberrant expression of microRNA in polycythemia vera. Haematologica. 2008 Jul;93(7):1009-16. PMID: 18508790

  21. Prchal JT, Gordeuk VR. The HIF2A gene in familial erythrocytosis. N Engl J Med. 2008 May 1;358(18):1966; author reply 1966-7 PMID: 18456917

  22. 22.  Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, Wang J. Essential role for Nix in autophagic maturation of erythroid cells. Nature. 2008 Jul 10;454(7201):232-5. PMID: 18454133

  23. Swierczek SI, Agarwal N, Nussenzveig RH, Rothstein G, Wilson A, Artz A, Prchal JT.  Hematopoiesis is not clonal in healthy elderly women. Blood. 2008 Oct 15;112(8):3186-93. PMID: 18641369.
  24. Agarwal N, Prchal JT. Erythropoietic agents and the elderly. Semin Hematol. 2008 Oct;45(4):267-75. PMID: 18809098
  25. Prchal JT. Philadelphia chromosome-negative myeloproliferative disorders: an historical perspective. Hematology Am Soc Hematol Educ Program. 2008;2008:68.

  26. Bruchova H, Yoon D, Agarwal AM, Swierczek S, Prchal JT.  Erythropoiesis in polycythemia vera is hyper-proliferative and has accelerated maturation. Blood Cells Mol Dis. 2009 Mar 3, (Epub ahead of print)

  27. Olcaydu D, Skoda RC, Looser R, Li S, Cazzola M, Pietra D, Passamonti F, Lippert E, Carillo S, Girodon F, Vannucchi A, Reading NS, Prchal JT, Ay C, Pabinger I, Gisslinger H, Kralovics R. The 'GGCC' haplotype of JAK2 confers susceptibility to JAK2 exon 12 mutation-positive polycythemia vera. Leukemia. 2009 May 14. [Epub ahead of print]

  28. Lorenzo V F, Yang Y, Simonson TS, Nussenzveig R, Jorde LB, Ge RL, Prchal JT. Genetic adaptation to extreme hypoxia: Study of high-altitude pulmonary edema in a three-generation Han Chinese family. Blood Cells Mol Dis. 2009 May 27.
  29. Usenko T, Li YJ, Haeri M, Li Y, Vecchiarelli-Federico LM, Zhao X, Prchal JT, Ben-David Y. Enrichment of SCA1 positive hematopoietic progenitors in polycythemic mice inhibits leukemogenesis. Blood. 2009 Jul 7. [Epub ahead of print]

  30. Salama ME, Swierczek SI, Hickman K, Wilson A, Prchal JT. Plasma quantitation of JAK2 mutation is not suitable as a clinical test: an artifact of storage. Blood. 2009 Jul 2;114(1):223-4.