Maurine R. Hobbs, PhD
The Hobbs lab in the Department of Internal Medicine investigates genetic risk factors in severe malaria infection, cancer, and diabetes with collaborators in the Division of Infectious Diseases, the Division Endocrinology, Eccles Institute of Human Genetics, the Center on Aging, and the Huntsman Cancer Institute.
Hobbs lab has discovered an association between malaria disease severity and single nucleotide polymorphisms (SNPs) in genes important in the redox state of the cell (redox genes). SNPs in some of these redox genes are also associated with susceptibility to diabetes, infection, longevity and other age-related diseases (including cancer, Parkinson’s disease, atherosclerosis, and cardiomyopathy).
The immune system plays a central role in many of these processes. The lab seeks to understand the effect of redox genotypes on the generation of reactive oxygen species (ROS), mitochondrial function, and the immune response in aging, metabolism, and infection.
Maurine R. Hobbs, PhD
Research Assistant Professor
Department of Internal Medicine
Adjunct Assistant Professor,
Department of Human Genetics
Member Investigator
Center on Aging
Member Investigator
Huntsman Cancer Institute
