Agency: NHGRI 1RM1HG009037-01 Role: PI 4.32 calendar Duration: 4/1/16-03/31/20 Funding: $3,882,490 Utah Center for Excellence in Ethical, Legal and Social Implication Research (UCEER) The University of Utah Center for Excellence in ELSI Research (UCEER) focuses primarily on issues relevant to population screening for genetic conditions in the healthcare of women and children. The specific focus is ELSI issues in prenatal screening, carrier screening and newborn screening.
Agency: NCATS 3U24TR001597-01S1 Dean (PI) .12 calendar Duration: 4/20/16-6/30/18 Funding: $14,999,940 Utah Trial Innovation Center The NIH established the Clinical and Translational Science Award (CTSA) program in 2006 to enhance translation of biomedical discoveries into therapeutic, diagnostic and preventive interventions to beneﬁt patients and communities. In 2011, the CTSA Program became part of the National Center for Advancing Translational Sciences (NCATS). Assessment by the Institute of Medicine (IOM) in 2013, and recommendations from the NCATS Advisory Council Working Group in May 2014, have contributed to the vision that the consortium of CTSA Programs should evolve into a collaborative national network to enable more efﬁcient planning and implementation of high-quality multi-center research. NCATS began this evolution by requiring each CTSAHub to actively participate in a developing national CTSA network (RFA-TR-14-009). NCATS is continuing the process by establishing Trial Innovation Centers (TICs) to accelerate implementation of multi-center studies by adding innovative network capacity to the existing strengths at the ctsa Hubs. The University of Utah proposes to be a TIC for the CTSA Network, with a focus on pediatrics, but capability across the lifespan.
Agency: NIH/NCATS 4UL1TR001067-04 Dere (PI) 1.8 calendar Duration: 5/1/16-06/30/18 Funding: $4,187,697 University of Utah Center for Clinical and Translational Science Precision Medicine The Utah CCTS serves as the major infrastructure and home for clinical and translational research in the state of Utah and aims to: 1) establish an academic home, located in a dedicated space, to support clinical and translational research by consolidating resources, promoting interdepartmental and interdisciplinary research and facilitating increased interactions between basic scientists and clinical investigators; 2) develop new and innovative health services and research programs in the community and provide the infrastructure required to elevate the disciplines of clinical and translational research to the highest possible level; 3) develop services to support the broadest possible spectrum of clinical and translational investigators; 4) provide seed funds to new investigators and established interdisciplinary teams to initiate clinical and translational research projects that have a high likelihood of achieving extramural funding; and 5) promote the development of a new generation of clinical and translational investigators through a variety of educational programs and, most importantly, through a mentoring program to provide support and promote recognition of these investigators.
Agency: NIH NICHD 1R01 HD082148-01 Rothwell/Botkin (Mulitple PI) 1.08 calendar Duration: 7/1/2015-5/312019 Funding: $2,403,087 The Effect of Electronic Informed Consent Information on Residual Newborn Specimen Research The purpose of this study is to 1) Identify the key information items necessary to make an informed decision about broad consent for the retention and future research use of residual DBS; 2) create a state-of-the-art electronic informed consent information (EICI) presentation for use in the clinical setting; 3) Evaluate the EICI consent approach by comparing it to traditional consent delivered on an electronic tablet and the current paper-based consent approach; and 4) Assess feasibility of the EICI through focus groups and interviews before and after the intervention.
- Agency NIH Title: R21 Improved Prenatal Genetic Screening Decision Making through Game Technology (Rothwell PI) Description: This project will develop and conduct a preliminary evaluation of a game application for pregnant couples to enhance education and clarify values regarding prenatal screening Role : Co-Investigator Proposed funding: $272,000
- Agency: NIH Title: UL1RR025764-01 University of Utah Center for Clinical and Translational Science Role: Director of Ethics and Regulator Core (PI McClain D) Duration: 10/2013 – 9/2018 Funding: $4,513,700 annual direct costs
- Agency NIH 1P20HG007249-01 Title: The Utah Center for Excellence in the Ethical, Legal, and Social Implications of Genetics Description: This is a P20 funded grant to fund a center of excellence that will focus on prenatal screening and newborn screening issues Role: PI Proposed funding: $525,000 (3 years)
- Agency NIH #HG005691 Title: Advancing Collaborative Genetic Research: Ethical and Policy Challenges Description: This CWRU project will evaluate policies and practices of informed consent for tissue banking at CTSA institutions and develop recommendations for uniform policies Role: Investigator (Rivera, PI) Proposed amount: $1.9 million Duration: 3 years
- Agency: NIH 1R01HD062762 Title: R01 the efficacy and impact of prenatal education about newborn screening Description: This project will design and evaluate new educational tools for parents regarding newborn screening Role: PI Proposed Amount: $2.8 million direct and indirect Duration: 4 years
- Agency NIH Title: Pilot newborn screening project for identification and prospective follow-up of infants with spinal muscular atrophy Description: The project will design and implement a pilot study of SMA newborn screening, including an assessment of ethical, regulatory, and psychosocial issues Role: Co-investigator at 0.10 FTE (Swoboda, PI) Proposed amount: $1.66 million direct and indirect Duration: 5 years
- Agency: D1BRH20425-01-00 Title: Congressionally-Mandated Health Information Technology Grant: The Utah Biobank Initiative Role: Director, Governance and Community Engagement Cores (Mitchell PI) Duration: 9/10 – 8/12 Funding: $1.6 million
- Agency: NIH/NHGRI 1 R01 HD058854-01 Title: Methods for promoting public dialogue on the use of residual newborn screening samples for research. Role: PI Duration: 9/08 – 6/11 Funding: $1.2 million direct costs
- Agency: NIH Title: UL1RR025764-01 University of Utah Center for Clinical and Translational Science Role: Director of Ethics and Regulator Core (PI McClain D) Duration: 05/19/2008 – 4/30/13 Funding: $4,513,700 annual direct costs
- 06/01/13 - 06/01/16 Improving Personalized Prognostication in Critical Illness. This project develops a novel method for automated calculation of APACHE IV and tests it against gold-standard APACHE IV as well as a Bayesian classifier. Principal Investigator: Samuel M. Brown Direct Costs: $39,854 Total Costs: $39,854 Intermountain Research and Medical Foundation Role: Principal Investigator
- 06/26/13 - Present Optimizing ICU Safety through Patient Engagement, System Science and Information Technology. This represents the BIDMC work within the Libretto Consortium; I work primarily on the electronic communication portal and measurement work. Principal Investigator(s): Ken Sands; Daniel Talmor Direct Costs: $4,500,000 Total Costs: $5,000,000 Gordon and Betty Moore Foundation Role: Co-investigator
- 09/18/13 - Present Value Personas and Decision-making Strategies in Life-threatening Illness: Methodological Studies. This project explores individual differences relevant to how individuals might experience the stresses of an ICU admission, using surveys, simulated decision making, and focus groups. I am senior investigator on this project. Principal Investigator: Eliotte L. Hirshberg Direct Costs: $60,000 Total Costs: $60,000 Intermountain Research and Medical Foundation Role: Co-investigator
- 07/01/14 - 07/01/16 R21HL123433 Discovery and Prediction of Novel Functional Outcome Phenotypes for ARDS. I am contact PI on this project employing "big data" clustering techniques to identify and develop prediction rules for long-term outcome phenotypes among survivors of ARDS. Principal Investigator(s): Samuel M. Brown; Dale Needham Direct Costs: $197,652 Total Costs: $218,434 National Heart, Lung, and Blood Institute Role: Principal Investigator
- 12/01/14 - 12/01/17 Physiology of Acute Stress among Family Members of ICU Patients (CORT-LT). A prospective observational study of autonomic nervous system function and salivary cortisol among family members of patients admitted to the ICU. Investigating the association between markers of acute stress and psychological distress 3 months after ICU admission. I am the senior investigator on this project. Principal Investigator: Eliotte L. Hirshberg Direct Costs: $60,000 Total Costs: $60,000 Intermountain Research and Medical Foundation Role: Co-investigator
- 10/01/14 - 04/30/21 1U01HL123018 The NHLBI Clinical Trials Network for the Prevention and Early Treatment of Acute Lung Injury (PETAL Network). I serve on the Long Term Outcome committee for PETAL, including writing standards and protocols. In addition I have led an effort in oxygenation imputation for overall protocols.Principal Investigator(s): Todd L. Allen; Colin K. Grissom; Alan H. Morris Direct Costs: $1,486,807 Total Costs: $2,052,071 National Heart, Lung, and Blood Institute Role: Co-investigator
- 11/01/14 - 12/01/17 Systems Biology of Cognitive function After Septic Shock (CASS). I lead this prospective observational study of septic patients, which employs deep RNA sequencing to interrogate the physiology of cognitive impairement after sepsis. This study is to generate preliminary data for an R01 submission to NIH. Principal Investigator: Samuel M. Brown Direct Costs: $60,000 Total Costs: $60,000 Intermountain Research and Medical Foundation Role: Principal Investigator
- 11/01/14 - 03/31/19 R01AG048022 Platelet Immune Responses in Aging and Influenza. This research explores aging related changes in immune and platelet responses to influenzavirues infection. I lead the long-term outcomes assessment and provide clinical methodological insight for this research.Principal Investigator: Matthew T. Rondina National Institute on Aging Role: Coinvestigator
09/01/16 - Present Translational Approaches to the Mechanisms of Septic Cardiomyopathy The major goal of this project is to define the intersections between dysadrenergia, dysregulated inflammation, and individual susceptibility, using a prospective observational echocardiography-based cohort of patients with and without septic cardiomyopathy, from whom cardiomyocytes will be derived from inducible pluripotent stem cells. I am co-PI, responsible for the CCC and echocardiographic analyses. Principal Investigator(s): Euan Ashley; Samuel M. Brown Direct Costs: $75,000 Total Costs: $85,000 Stanford University/Intermountain Healthcare Role: Principal Investigator
- Agency: NHGRI 1RM1HG009037-01 Duration: 4/1/16-03/31/20 Funding: $3,882,490 Utah Center for Excellence in Ethical, Legal and Social Implication Research (UCEER) The University of Utah Center for Excellence in ELSI Research (UCEER) focuses primarily on issues relevant to population screening for genetic conditions in the healthcare of women and children. The specific focus is ELSI issues in prenatal screening, carrier screening and newborn screening.
- National Science Foundation, Law & Social Sciences Program, postdoctoral fellowship to study legal issues facing adults with autism ($200,000; 2013-2015) NSF SES-1228503
- Office of the National Coordinator for Health Information Technology, “Non HIPAA Covered Entities,” principal investigator on subcontract for study, 2010.
- University of Utah Seed Grant (co-principal investigator with Margaret P. Battin), “Ethics and Infectious Disease,” 2005, $40,000.
- Young Investigator Grant, 01/15/17 - 01/14/19, Creatine and 5-HTP for antidepressant-resistant depression in women National Alliance for Research on Schizophrenia and Depression, Direct Costs: $70,000 Total Costs: $70,000, Role: Principle Investigator
- Research Grant, 08/01/2012-01/01/16, Pilot study of sertraline for the prevention of PTSD in burn victims,R. Harold Burton Foundation, Role: Principal Investigator
- 7/1/2015-6/30/2019 25% FTE$2,403,087 Pending Funding (9%)The Effect of Video Informed Consent Information on Residual Newborn Specimen Research Co-PI (Co-PI Botkin)
- 4/1/2015 to 3/31/17 20% FTE $409,750 Funded Improving Parental Decision Making about Prenatal Screening through Interactive Technology PI
- 4/1/13 to 3/31/16 10% FTE Funded Utah Center for Excellence in (Ethical, Legal and Social Implication) Research (UCEER) NIH (HG007249 )Co-I (Botkin, PI)
- 11/01/2012-02/28/2016 15% FTE *Subcontract Funded Advancing Collaborative Genetic Research: Ethical and Policy Challenges NIH (R01HG005691) Co-I (Rivera, PI)
- 7/1/2011-6/30/2016 20% FTE Yr 01, 10% FTE Yrs 02-04 ($2,869,598) Funded Parent Education and Choice on Retention and Use of Newborn Screening Samples NIH (R01HD062762)