John E. Greenlee, MD

Professor and Vice Chair of Neurology

Dr. John E. Greenlee is Professor and Vice Chair of Neurology. He is a member of the Brain Institute at the University of Utah in Salt Lake City and is also Neurologist at the George E. Wahlen Veterans Affairs Medical Center. Dr. Greenlee received his medical training at the University of Rochester School of Medicine and Dentistry and then served as intern in medicine, junior assistant resident in medicine, and resident in neurology at the University of Virginia Hospital, followed by a fellowship in neurovirology at the Johns Hopkins School of Medicine in the laboratory of Dr. Richard T. Johnson. He was a member of the Neurology faculty at the University of Virginia from 1976 to 1986 and then joined the faculty of the University of Utah School of Medicine. He has served as Chief of Neurology at the Veterans Affairs Medical Center, Director of the Neurology Student Clerkship, Director of the Neurology Residency Training Program, and founding member of the University’s Brain Attack program. From 2002-2007 he was Interim Chair of the Department of Neurology.

Dr. Greenlee is Associate Editor of the Journal of Clinical Neurology and Neurosurgery and Associate Editor of Medlink, as well as a member of the Topical Work Group for central nervous system infections for the American Academy of Neurology. He has served on the Experimental Virology Study Section of the National Institutes of Health and on advisory groups for neurology within the United States Department of Veterans Affairs.

Dr. Greenlee’s areas of research have been neurovirology, with particular emphasis on polyomavirus infections, and paraneoplastic neurological syndromes, with particular emphasis on the role of humoral immunity in disease pathogenesis. His work has been supported by research awards from the National Institutes of Health, the United States Department of Veterans Affairs, and the Western Institute for Biomedical Research. His clinical interests are central nervous system infections, remote effects of cancer on the nervous system, and stroke.

Selected Publications

Sakai K, Hirose G, Jaeckle KA, Greenlee JE. Analysis of autoantibody binding to paraneoplastic cerebellar associated antigen expressed in recombinant proteins. Annals of Neurology, 33:373-380, 1993.
Greenlee JE, Parks TN, Jaeckle KA. Type IIA ("Anti-Hu) antibodies, associated with human paraneoplastic syndromes, are taken up by and produce destruction of cultured rat granule cell neurons. Neurology, 43:2049-54, 1993.
Greenlee JE, Steffens JD, Clawson SA, Hill K, Dalmau J. Anti-Hu antibodies in Merkel Cell Carcinoma. Annals of Neurology.52:111-115, 2002.
O’Neill FJ, Greenlee JE, Dörries, K, Clawson SA and Carney H. Propagation of archetype and non-archetype JC virus variants in human fetal brain cultures: Demonstration of interference activity by archetype JCV. J Neurovirol.: 9:567-576, 2003.
Schenkenberg T, Jones CR, Steffens J, Greenlee JE. Assessing the neurology clerkship: the value of student feedback. Neurology 63:1757-1758, 2006.
Greenlee JE. Progressive multifocal leukoencephalopathy in the era of natalizumab. International MS Journal, 13:100-107, 2006.
Berger JR, Greenlee JE. The Neurological Consequences of Autoimmune Polyglandular Syndrome . Neurology 70:2248-51, 2008.

Selected Book Chapters

Greenlee JE and Carroll K. Cerebrospinal fluid in central nervous system infections. Chapter 2 In: Scheld WM, Whitley RJ, Durack DT (eds) Infections of the Central Nervous System. 3rd Edition. Raven Press, New York. 2004 pp 5-30.
Greenlee JE, Hale D. Rickettsia In: Biller J. Neurology of Internal Medicine. Lippincott Williams & Wilkins 2008 pp583-588.
Greenlee JE, O’Neill FJ. Polyomaviruses. Chapter 27 In: Richman DD, Whitley RJ, Hayden FG (eds) Clinical Virology. 3^rd Edition. ASM Press 2009 pp 581-602.
Greenlee JE. Suppurative intracranial thrombophlebitis. Chapter 90 In; Karen L. Roos KL, Tunkel AR (eds) Handbook of Clinical Neurology: Bacterial Infections of the Central Nervous System. In press.