Hyperinsulinemia

Insulin resistance and hyperinsulinemia (elevated insulin levels) are found in approximately 50% of obese (defined as 20% over ideal body weight) PCOS women. Hyperinsulinemia promotes hyperandrogenism (elevated male hormone levels) in PCOS by increasing circulating ovarian androgens and reducing serum sex hormone binding globulin (a protein which binds circulating male hormones). These actions result in increased circulating free testosterone (male hormone) levels.

This condition often results in chronic anovulation (lack of ovulation) and subsequently infertility. Although insulin resistance and hyperinsulinemia correlate with body mass index (BMI), they may also be found in non-obese PCOS patients. Your reproductive endocrinologist will determine if hyperinsuinemia may play a role in your anovulation.