Bradley R. Cairns, Ph.D
Positions:
Professor - Oncological Sciences
Adjunct Professor - Biochemistry
Investigator - Huntsman Cancer Institute
Investigator - Howard Hughes Medical Institute
Phone: (801) 585-1822
Lab Phone: (801) 585-1823
Fax: (801) 585-6410
Email: brad.cairns@hci.utah.edu
Huntsman Cancer Institute
2000 Circle of Hope
Salt Lake City, UT 84112-5550
Links:
Huntsman Cancer Institute Biography
Lab Link
Research Link
Research Description:
We are interested in how chromatin structure helps regulate gene transcription. We address and approach this broad issue in several ways. First, we purify and characterize large protein complexes that remodel and modify chromosome structure. We are also interested in epigenetics, and how chromatin structure and DNA methylation/demethylation dynamics are utilized in germ cells to poise the genome for development, and in embryos to guide developmental processes. We use genetic, biochemical and genomic methods to address these problems, and utilize yeast, zebrafish, and human cells.
Research Keywords:
Chromatin, Genomics, Signaling, Transcription