Clinical Studies

Current or completed studies include:

  • Refractive Division Studies bullet
    • Comparison of LASIK and PRK technologies
  • Comparing AMO 5.5 round versus SI30 intraocular lenses in a single masked randomized study.
  • Evaluating the ocular safety and efficacy of ofloxacin solution in the treatment of acute bacterial corneal ulcers.
  • Adjunctive therapy with a metallo-proteinase inhibitor in patients with corneal ulcers caused by infection or rheumatoid arthritis.
  • Efficacy and safety of a quinoline verses tobramycin solution for the treatment of bacterial conjunctivitis in children.
  • A comparative study of two high-refractive index, three-piece silicone intraocular lenses.
  • An evaluation of a trabeculsuprachoroidal shunt for the control of intraocular pressure in glaucoma patients.
  • A comparison of the efficacy and tolerability of Timolol and Levobunolol for the control of intraocular pressure in glaucoma patients.
  • A study of carboxymethylcellulose-based artificial tear solutions for the relief of dry eye.
  • The effect of carbachol as an additive to preparations for the relief of dry eye.
  • A study of the effect of pentoxifylline on retinal blood flow in patients with ischemic maculopathy as a result of diabetes.
  • A comparative study of topical steroids in the treatment of anterior uveitis.

Epidemiology Studies

  • The Moran Eye Center is addressing public health issues through several outcome studies and multicenter clinical trials.
  • Studying the effects of a number of nutrients in the prevention and treatment of age related macular degeneration and cataracts.
  • Comparing the effects of "careful follow-up" vs. optic nerve sheath decompression surgery in the treatment of anterior ischemic optic neuropathy.
  • A study to identify behavioral and activity-related risk factors for the prevention of penetrating ocular injuries caused by airguns.

Members of the ophthalmic and research community are encouraged to contact the Moran Eye Center to participate in our research efforts. In addition, we can provide ophthalmic support where needed for other clinical studies.

Clinical studies at the University of Utah John A. Moran Eye Center are conducted to determine the effectiveness of new drugs or of new procedures for the treatment of ocular disease.

Clinical Trials

AGE-RELATED MACULAR DEGENERATION


Title: A Phase 3, randomized, double-masked, parallel-assign-ment study of intravitreal bevasiranib sodium, administered every 8 or 12 weeks as maintenance therapy following three injections of Lucentis® compared with Lucentis® monotherapy every 4 weeks in patients with Exudative Age-Related Macular Degeneration (AMD)
Sponsor: Opko Health, Inc.
Principal Investigator: Paul S. Bernstein, M.D., Ph.D.

Title: The Natural History of Geographic Atrophy Progression (GAP) Study
Sponsor: Alcon Research, Ltd.
Principal Investigator: Michael P. Teske, M.D.

Title: A double-masked, randomized, parallel-group study to investigate the pharmacodynamics, safety, and systemic pharmacokinetics of pazopanib eye drops, administered for 28 days to adult subjects with neovascular age-related macular degeneration
Sponsor: GlaxoSmithKlinePrincipal Investigator: Paul S. Bernstein, M.D., Ph.D.

Title: An open-label, multicenter extension study to evaluate the safety and tolerability of ranibizumab in subjects with choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) who have completed the treatment phase of a Genentech-sponsored ranibizumab study
Sponsor: Genentech, Inc.
Principal Investigator: Kang Zhang, M.D., Ph.D.

Title: A Phase II Study of Encapsulated Human NTC-201 Cell Implants Releasing Ciliary Neurotrophic Factor (CNTF) in Participants with Visual Acuity Impairment Associated with Atrophic Macular Degeneration (CNTF2)
Sponsor: Neurotech USA, Inc.
Principal Investigator: Kang Zhang, M.D., Ph.D.

Title: A Randomized, Double Masked, Active Controlled Phase III Study of the Effcacy, Safety, and Tolerability of Repeated Doses of Intravitreal VEGF Trap in Subjects with Neovascular Age-Related Macular Degeneration Clinical Evaluation of Anti-angiogenesis in the Retina-Intravitreal Trial 3 (VIEW-1)
Sponsor: Regeneron Pharmaceuticals, Inc.
Principal Investigator: Michael P. Teske, M.D.

Title: Study: Evaluating Genotypes while Using Lucentis (SEAGUL)
Sponsor: Genentech, Inc.
Principal Investigator: Kang Zhang, M.D., Ph.D.

CATARACT

Title: Contactless Biometric Measurements Using a New Prototype
Sponsor: Haag-Streit, Ltd.
Principal Investigator: Nick Mamalis, M.D.

Title: Clinical investigation of the Rayner foldable hydrophilic acrylic Copolymer intraocular lens (IOL) for cataract replacement
Sponsor: Rayner Surgical Inc.
Principal Investigator: Nick Mamalis, M.D.

Title: A Prospective multicenter clinical study to evaluate the safety and effectiveness of the Synchrony® Dual-Optic Intraocular Lens in patients undergoing cataract extraction
Sponsor: Visiogen, Inc
Principal Investigator: Alan Crandall, M.D.

CORNEA

Title: Cornea Donor Study
Sponsor: JAEB Center for Health Research, with support from the National Eye Institute
Principal Investigator: Mark Mifflin, M.D.

Title: Surveillance of Resistance to Formulations of Antimicrobials in Cultures of the Eye (SURFACE)
Sponsor: Allergan, Inc.
Principal Investigator: Randall J Olson, M.D.

RETINITIS PIGMENTOSA

Title: A Phase II/III Study of Encapsulated Human NTC-201 Cell Implants Releasing Ciliary Neurotrophic Factor (CNTF) for Partici-pants with Retinitis Pigmentosa Using Visual Field Sensitivity as the Primary Outcome (CNTF4)
Sponsor: Neurotech USA, Inc.
Principal Investigator: Kang Zhang, M.D., Ph.D.

UVEITIS

Title: A double-masked, placebo-controlled, multi-center, parallel group, dose-ranging study with optional extension to assess the effcacy and safety of LX211 as therapy in subjects with clinically quiescent sight threatening, non-infectious, intermediate, anterior and intermediate, posterior, or pan-uveitis
Sponsor: Lux Biosciences, Inc.
Principal Investigator: Albert T. Vitale, M.D.

Title: Clinical Interventions Against Stargardt Macular Dystrophy: DHA Supplementation in Patients with STGD3
Principal Investigator: Paul S. Bernstein, M.D., Ph.D.

Title: A Retrospective Study of 50 Children with After-cataracts after Pediatric Cataract Surgery at the Pediatric Ophthalmology Clinic, University of Utah
Principal Investigator: Robert O. Hoffman, M.D.

Title: Two Year Results of Clinicopathologic Evaluation of the Endothelial Keratoplasty Specimens in an Ophthalmic Pathology Laboratory
Principal Investigator: Nick Mamalis, M.D.

Title: A Prospective Evaluation of the Safety and Ef?cacy of Two Forms of Corneal Stromal Hydration
Principal Investigator: Mark Mifflin, M.D.

Title: IIH Without Papilledema Exists
Principal Investigator: Kathleen B. Digre, M.D.

Title: Arachnoid Granulations and Idiopathic Intracranial Hypertension
Principal Investigator: Kathleen B. Digre, M.D.

Title: Assessment of Photophobia in Moran Eye Center Patients
Principal Investigator: Kathleen B. Digre, M.D.

Title: Evaluation of a Diagnostic Clinical Evaluation Tool for Progressive Supranuclear Palsy
Principal Investigator: Kathleen B. Digre, M.D.

Title: Effect of Systemic Anticoagulant and Antiplatelet Therapy on Outcomes of Trabeculectomy
Principal Investigator: Jason Goldsmith, M.D.

Title: Long-term Outcome of Pediatric Tear Duct Surgery
Principal Investigator: Scott Larson, M.D.

Title: Utah Childhood Vision Screening Survey
Principal Investigator: Scott Larson, M.D.

CLINICAL TRIAL GRANTS

Title: Age-Related Eye Disease Study 2 (AREDS2): A Multi-center, Randomized Trial of Lutein, Zeaxanthin, and Omega-3 Long-Chain Polyunsaturated Fatty Acids (Docosahexaenoic Acid [DHA] and Eicosapentaenoic Acid [EPA]) in Age-Related Macular Degeneration
Sponsor: National Eye Institute/National Institutes of Health (NIH/NEI)
Principal Investigator: Paul S. Bernstein, M.D., Ph.D.

Title: Early Treatment for Retinopathy of Prematurity (ETROP)
Sponsor: NIH/NEI
Principal Investigator: Robert O. Hoffman, M.D.

Title: Multicenter Uveitis Steroid Treatment (MUST) Trial
Sponsor: NIH/NEI
Principal Investigator: Albert T. Vitale, M.D.

Title: A Multicenter Study to Map Novel Genes for Fuchs’ Endothelial Corneal Dystrophy
Sponsor: NIH/NEI
Principal Investigator: Mark Mifflin, M.D.

CLINICAL RESEARCH AWARDS

Title: National Eye Evaluation Research Network (NEER) clinical treatment and evaluation centers (CTEC) for the study of orphan inherited retinal degenerative diseases and dry age-related macular degeneration
Sponsor: National Neurovision Research Institute
Principal Investigator: Paul Bernstein, M.D., Ph.D.

Title: Measurement of Critical Flicker Fusion Frequency
Funding: University of Utah Technology Commercialization grant
Principal Investigator: Bradley Katz, M.D., Ph.D.

Title: Proteomics and Genomics of Giant Cell Arteritis
Funding: American Geriatrics Society
Principal Investigator: Bradley Katz, M.D., Ph.D.

Title: Raman Measurement of Macular Carotenoid Pigments in the Human Retina
Sponsor: NIH/NEI
Principal Investigator: Paul S. Bernstein, M.D., Ph.D.

INVESTIGATOR-INITIATED CLINICAL RESEARCH PROJECTS

Title: A comparison of conventional and custom with iris registration PRK ablations: assessment of visual function and patient satisfaction
Principal Investigator: Mark D. Mifflin, M.D.

Title: A comparison of photorefractive keratectomy (PRK) versus sub-bowman’s keratomileusis (SBK): assessment of visual function and patient satisfaction
Principal Investigator: Majid Moshirfar, M.D., F.A.C.S.

Title: A comparison of laser-assisted in situ keratomileusis (Lasik) versus sub-Bowman’s keratomileusis (SBK): assessment of visual function and patient satisfaction
Principal Investigator: Majid Moshirfar, M.D., F.A.C.S.

Title: Use of Black Diaphragm Intraocular Lens for Aniridia
Principal Investigator: Alan Crandall, M.D.

Members of the ophthalmic and research community are encouraged to contact the Moran Eye Center to participate in our research efforts. In addition, we can provide ophthalmic support where needed for other clinical studies.