Clinical Studies
Current or completed studies include:
- Refractive Division Studies bullet
- Comparison of LASIK and PRK technologies
- Comparing AMO 5.5 round versus SI30 intraocular lenses in a single masked randomized study.
- Evaluating the ocular safety and efficacy of ofloxacin solution in the treatment of acute bacterial corneal ulcers.
- Adjunctive therapy with a metallo-proteinase inhibitor in patients with corneal ulcers caused by infection or rheumatoid arthritis.
- Efficacy and safety of a quinoline verses tobramycin solution for the treatment of bacterial conjunctivitis in children.
- A comparative study of two high-refractive index, three-piece silicone intraocular lenses.
- An evaluation of a trabeculsuprachoroidal shunt for the control of intraocular pressure in glaucoma patients.
- A comparison of the efficacy and tolerability of Timolol and Levobunolol for the control of intraocular pressure in glaucoma patients.
- A study of carboxymethylcellulose-based artificial tear solutions for the relief of dry eye.
- The effect of carbachol as an additive to preparations for the relief of dry eye.
- A study of the effect of pentoxifylline on retinal blood flow in patients with ischemic maculopathy as a result of diabetes.
- A comparative study of topical steroids in the treatment of anterior uveitis.
Epidemiology Studies
- The Moran Eye Center is addressing public health issues through several outcome studies and multicenter clinical trials.
- Studying the effects of a number of nutrients in the prevention and treatment of age related macular degeneration and cataracts.
- Comparing the effects of "careful follow-up" vs. optic nerve sheath decompression surgery in the treatment of anterior ischemic optic neuropathy.
- A study to identify behavioral and activity-related risk factors for the prevention of penetrating ocular injuries caused by airguns.
Members of the ophthalmic and research community are encouraged to contact the Moran Eye Center to participate in our research efforts. In addition, we can provide ophthalmic support where needed for other clinical studies.
Clinical studies at the University of Utah John A. Moran Eye Center are conducted to determine the effectiveness of new drugs or of new procedures for the treatment of ocular disease.
Clinical Trials
AGE-RELATED MACULAR DEGENERATION
|
|
|
Title: The Natural History of Geographic Atrophy Progression (GAP) Study |
|
Title: A double-masked, randomized, parallel-group study to investigate the pharmacodynamics, safety, and systemic pharmacokinetics of pazopanib eye drops, administered for 28 days to adult subjects with neovascular age-related macular degeneration |
|
Title: An open-label, multicenter extension study to evaluate the safety and tolerability of ranibizumab in subjects with choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) who have completed the treatment phase of a Genentech-sponsored ranibizumab study |
|
Title: A Phase II Study of Encapsulated Human NTC-201 Cell Implants Releasing Ciliary Neurotrophic Factor (CNTF) in Participants with Visual Acuity Impairment Associated with Atrophic Macular Degeneration (CNTF2) |
|
Title: A Randomized, Double Masked, Active Controlled Phase III Study of the Effcacy, Safety, and Tolerability of Repeated Doses of Intravitreal VEGF Trap in Subjects with Neovascular Age-Related Macular Degeneration Clinical Evaluation of Anti-angiogenesis in the Retina-Intravitreal Trial 3 (VIEW-1) |
|
Title: Study: Evaluating Genotypes while Using Lucentis (SEAGUL) |
CATARACT
|
Title: Contactless Biometric Measurements Using a New Prototype |
|
Title: Clinical investigation of the Rayner foldable hydrophilic acrylic Copolymer intraocular lens (IOL) for cataract replacement |
|
Title: A Prospective multicenter clinical study to evaluate the safety and effectiveness of the Synchrony® Dual-Optic Intraocular Lens in patients undergoing cataract extraction |
CORNEA
|
Title: Cornea Donor Study |
|
Title: Surveillance of Resistance to Formulations of Antimicrobials in Cultures of the Eye (SURFACE) |
RETINITIS PIGMENTOSA
|
Title: A Phase II/III Study of Encapsulated Human NTC-201 Cell Implants Releasing Ciliary Neurotrophic Factor (CNTF) for Partici-pants with Retinitis Pigmentosa Using Visual Field Sensitivity as the Primary Outcome (CNTF4) |
UVEITIS
|
Title: A double-masked, placebo-controlled, multi-center, parallel group, dose-ranging study with optional extension to assess the effcacy and safety of LX211 as therapy in subjects with clinically quiescent sight threatening, non-infectious, intermediate, anterior and intermediate, posterior, or pan-uveitis |
|
Title: Clinical Interventions Against Stargardt Macular Dystrophy: DHA Supplementation in Patients with STGD3 |
|
Title: A Retrospective Study of 50 Children with After-cataracts after Pediatric Cataract Surgery at the Pediatric Ophthalmology Clinic, University of Utah |
|
Title: Two Year Results of Clinicopathologic Evaluation of the Endothelial Keratoplasty Specimens in an Ophthalmic Pathology Laboratory |
|
Title: A Prospective Evaluation of the Safety and Ef?cacy of Two Forms of Corneal Stromal Hydration |
|
Title: IIH Without Papilledema Exists |
|
Title: Arachnoid Granulations and Idiopathic Intracranial Hypertension |
|
Title: Assessment of Photophobia in Moran Eye Center Patients |
|
Title: Evaluation of a Diagnostic Clinical Evaluation Tool for Progressive Supranuclear Palsy |
|
Title: Effect of Systemic Anticoagulant and Antiplatelet Therapy on Outcomes of Trabeculectomy |
|
Title: Long-term Outcome of Pediatric Tear Duct Surgery |
|
Title: Utah Childhood Vision Screening Survey |
CLINICAL TRIAL GRANTS
|
Title: Age-Related Eye Disease Study 2 (AREDS2): A Multi-center, Randomized Trial of Lutein, Zeaxanthin, and Omega-3 Long-Chain Polyunsaturated Fatty Acids (Docosahexaenoic Acid [DHA] and Eicosapentaenoic Acid [EPA]) in Age-Related Macular Degeneration |
|
Title: Early Treatment for Retinopathy of Prematurity (ETROP) |
|
Title: Multicenter Uveitis Steroid Treatment (MUST) Trial |
|
Title: A Multicenter Study to Map Novel Genes for Fuchs’ Endothelial Corneal Dystrophy |
CLINICAL RESEARCH AWARDS
|
Title: National Eye Evaluation Research Network (NEER) clinical treatment and evaluation centers (CTEC) for the study of orphan inherited retinal degenerative diseases and dry age-related macular degeneration |
|
Title: Measurement of Critical Flicker Fusion Frequency |
|
Title: Proteomics and Genomics of Giant Cell Arteritis |
|
Title: Raman Measurement of Macular Carotenoid Pigments in the Human Retina |
INVESTIGATOR-INITIATED CLINICAL RESEARCH PROJECTS
|
Title: A comparison of conventional and custom with iris registration PRK ablations: assessment of visual function and patient satisfaction |
|
Title: A comparison of photorefractive keratectomy (PRK) versus sub-bowman’s keratomileusis (SBK): assessment of visual function and patient satisfaction |
|
Title: A comparison of laser-assisted in situ keratomileusis (Lasik) versus sub-Bowman’s keratomileusis (SBK): assessment of visual function and patient satisfaction |
|
Title: Use of Black Diaphragm Intraocular Lens for Aniridia |
Members of the ophthalmic and research community are encouraged to contact the Moran Eye Center to participate in our research efforts. In addition, we can provide ophthalmic support where needed for other clinical studies.
