• Adam Barker Lab

    We are interested in MHC class II presentation and how it relates to peptide presentation during infection. We also study virulence factors of Pseudomonas aeruginosa in cystic fibrosis patients using next generation sequencing and top down proteomics.

    Adam Barker, PhD

  • Jessica Brown Lab

    Jessica Brown, PhD

  • Sherwood Casjens Lab

    The Casjens laboratory is studying the genetic control of the assembly and function of virus particles, the modular evolution of bacteriophage genomes, and the genome structure, replication and diversity of the Lyme disease causing bacteria, Borrelia burgdorferi.

    Sherwood Casjen, PhD

  • Xinjian Chen Lab

    We study how our immune system discriminate infectious non-self from self so that it can specifically react against invasions of infectious microorganisms but keep non-reactive towards self-components.

    Xinjian Chen, MD

  • Julio Delgado Lab

    The focus of our research is to understand the functional role of the HLA system in the setting of transplantation and susceptibility to disease.

    Julio Delgado, MD

  • Kael Fischer Lab

    My lab uses both experimental approaches and bioinformatics to answer questions about viral pathogenesis. We use two experimental techniques, coupled with a powerful informatics framework that leverages all the viral sequence in GenBank, to directly interrogate interesting specimens that may contain an undetected virus.

    Kael Fischer, PhD

  • Mark Fisher Lab

    We are focused on using microbial genetics to dissect the complex interaction between Yersinia pestis, the bacterial cause of plague, and its arthropod vectors.

    Mark Fisher, PhD

  • Robert Fujinami Lab

    Dr. Fujinami investigates animal models for human disease. Using these models he investigate ways to modulate the disease. The disease he mainly studies is multiple sclerosis. He has genetically engineered a virus that will protect mice from getting a multiple sclerosis-like disease. Recently he expanded his studies to include studying the immune response to various viruses and “self” proteins in individuals with autism. He is also establishing a new virus induced model for epilepsy and examining how the innate immune response to the virus infection contributes to seizures.

    Robert Fujinami

  • Xiao He Lab

    We are interested in identifying and characterizing the genes that regulate the functions of T lymphocytes and ultimately applying the new findings to improve diagnosis and treatment of related human diseases.

    Xiao He, MD, PhD

  • Harry Hill Lab
  • Peter Jensen Lab

    The Jensen laboratory is focused on antigen processing and presentation and the role of classical and nonclassical histocompatibility (MHC) molecules in regulating immune responses.

    Peter Jensen, MD

  • Jerry Kaplan Lab

    Our research focuses on two topics, iron metabolism, specifically compartmentalization and utilization and membrane trafficking, and the regulation of endocytic vesicle size.

    Jerry Kaplan, PhD

  • Tom Lane Research Lab

    Work in my laboratory is divided into two main research areas: 1) chemokines and chemokine receptors in defense and disease following microbial infection and 2) mouse/human neural progenitor cells (NPCs) and remyelination following viral-induced demyelination.

    Thomas Lane, PhD

  • Rodney Miles Lab

    We study lymphoma and leukemia in patient samples and cell lines to try to identify biomarkers associated with different disease outcomes. Biomarkers of more aggressive disease could represent future therapeutic targets.

    Rodney Miles, MD, PhD

  • Matt Mulvey Lab

    We wish to define how strains or uropathogenic Escherichia coli (UPEC) and related bacterial pathogens colonize host tissues and persist in the face of numerous innate and adaptive defenses.

    Matt Mulvey, PhD

  • Ryan O'Connell Lab

    Our laboratory is exploring the function of non-coding RNAs (including microRNAs) during inflammatory responses. Furthermore, we are investigating why disruptions in non-coding RNA expression or function is linked to human diseases such as autoimmunity and cancer.

    Ryan O'Connell, PhD

  • Vicente Planelles Lab

    Pathogenesis by the human immunodeficiency virus: how HIV induces alterations in the cell cycle of the host cells, leading to programmed cell death.

    Vicente Planelles, PhD

  • June Round Lab

    Interests in the lab include 1) understanding how T cell intrinsic Toll like receptor (TLRs) signaling governs T cell responses and how this impacts host tolerance toward the microbiota, 2) identification and characterization of novel host genes within mucosal T cells regulated by the microbiota, and 3) understand how specific commensal organisms are able to regulate the host adaptive immune system and impact disease states.

    June Round, PhD

  • David Stillman Research Lab

    We study molecular mechanisms controlling eukaryotic transcriptional regulation, using the powerful genetic and molecular tools available in Saccharomyces. Findings are universal, as the transcription machinery is conserved between yeast and vertebrates.

    David Stillman, PhD

  • Dean Tantin Research Lab

    Our interests lie in the elucidation of mammalian transcription factor function and in understanding transcription factor circuitries.

    Dean Tantin, PhD

  • Carl Wittwer Lab

    We develop simple techniques to analyze DNA, including methods, instruments and software necessary for rapid-cycle amplification, real-time monitoring, and high-resolution DNA melting analysis.

    Carl Wittwer, MD, PhD

  • Janis Weis Lab

    My laboratory studies the pathogenesis of Lyme disease; an infection caused by the tick borne spirochete Borrelia burgdorferi.

    Janis Weis, PhD

  • Matthew Williams Lab

    The research of my lab is focused on the mechanisms driving the development of long-lived immunological memory following bacterial or viral infection.

    Matthew Williams, PhD

  • Diane Ward Lab

    My laboratory studies membrane trafficking and the regulation of endocytic vesicle size and iron metabolism specifically compartmentalization and utilization.

    Diane Ward, PhD

  • Histocompatibility and Immunogenetics Laboratory

    The Histocompatibility and Immunogenetics Laboratory provides a complete range of diagnostic testing services used primarily in the field of clinical organ transplantation and for study of associations between certain diseases and several HLA alloantigens.

    Julio Delgado

  • Kimberley Evason Lab

    The overarching goal of the Evason laboratory is to investigate mechanisms involved in liver tumorigenesis in order to develop improved therapies to treat this deadly cancer. A major subset of HCC is defined by mutations in the CTNNB1 gene encoding β-catenin, an integral component of the Wnt signaling pathway [3]. These β-catenin-activated HCC represent 20-40% of human HCC, and our current research focuses primarily on these tumors.

    Kimberley Evason, MD, PhD

  • Ryan O'Connell Lab

    Our overall goal is to determine how the loss of cellular identity and acquisition of alternative differentiation states contributes to cancer progression and alters therapeutic response.

    Eric Snyder, MD, PhD