- Adam Barker Lab
We are interested in MHC class II presentation and how it relates to peptide presentation during infection. We also study virulence factors of Pseudomonas aeruginosa in cystic fibrosis patients using next generation sequencing and top down proteomics.
- Sherwood Casjens Lab
The Casjens laboratory is studying the genetic control of the assembly and function of virus particles, the modular evolution of bacteriophage genomes, and the genome structure, replication and diversity of the Lyme disease causing bacteria, Borrelia burgdorferi.
- Xinjian Chen Lab
We study how our immune system discriminate infectious non-self from self so that it can specifically react against invasions of infectious microorganisms but keep non-reactive towards self-components.
- Julio Delgado Lab
The focus of our research is to understand the functional role of the HLA system in the setting of transplantation and susceptibility to disease.
- Kael Fischer Lab
My lab uses both experimental approaches and bioinformatics to answer questions about viral pathogenesis. We use two experimental techniques, coupled with a powerful informatics framework that leverages all the viral sequence in GenBank, to directly interrogate interesting specimens that may contain an undetected virus.
- Mark Fisher Lab
We are focused on using microbial genetics to dissect the complex interaction between Yersinia pestis, the bacterial cause of plague, and its arthropod vectors.
- Robert Fujinami Lab
Dr. Fujinami investigates animal models for human disease. Using these models he investigate ways to modulate the disease. The disease he mainly studies is multiple sclerosis. He has genetically engineered a virus that will protect mice from getting a multiple sclerosis-like disease. Recently he expanded his studies to include studying the immune response to various viruses and “self” proteins in individuals with autism. He is also establishing a new virus induced model for epilepsy and examining how the innate immune response to the virus infection contributes to seizures.
- Xiao He Lab
We are interested in identifying and characterizing the genes that regulate the functions of T lymphocytes and ultimately applying the new findings to improve diagnosis and treatment of related human diseases.
- Harry Hill Lab
- Peter Jensen Lab
The Jensen laboratory is focused on antigen processing and presentation and the role of classical and nonclassical histocompatibility (MHC) molecules in regulating immune responses.
- Jerry Kaplan Lab
Our research focuses on two topics, iron metabolism, specifically compartmentalization and utilization and membrane trafficking, and the regulation of endocytic vesicle size.
- Tom Lane Research Lab
Work in my laboratory is divided into two main research areas: 1) chemokines and chemokine receptors in defense and disease following microbial infection and 2) mouse/human neural progenitor cells (NPCs) and remyelination following viral-induced demyelination.
- Rodney Miles Lab
We study lymphoma and leukemia in patient samples and cell lines to try to identify biomarkers associated with different disease outcomes. Biomarkers of more aggressive disease could represent future therapeutic targets.
- Matt Mulvey Lab
We wish to define how strains or uropathogenic Escherichia coli (UPEC) and related bacterial pathogens colonize host tissues and persist in the face of numerous innate and adaptive defenses.
- Ryan O'Connell Lab
Our laboratory is exploring the function of non-coding RNAs (including microRNAs) during inflammatory responses. Furthermore, we are investigating why disruptions in non-coding RNA expression or function is linked to human diseases such as autoimmunity and cancer.
- Vicente Planelles Lab
Pathogenesis by the human immunodeficiency virus: how HIV induces alterations in the cell cycle of the host cells, leading to programmed cell death.
- June Round Lab
Interests in the lab include 1) understanding how T cell intrinsic Toll like receptor (TLRs) signaling governs T cell responses and how this impacts host tolerance toward the microbiota, 2) identification and characterization of novel host genes within mucosal T cells regulated by the microbiota, and 3) understand how specific commensal organisms are able to regulate the host adaptive immune system and impact disease states.
- David Stillman Research Lab
We study molecular mechanisms controlling eukaryotic transcriptional regulation, using the powerful genetic and molecular tools available in Saccharomyces. Findings are universal, as the transcription machinery is conserved between yeast and vertebrates.
- Dean Tantin Research Lab
Our interests lie in the elucidation of mammalian transcription factor function and in understanding transcription factor circuitries.
- Carl Wittwer Lab
We develop simple techniques to analyze DNA, including methods, instruments and software necessary for rapid-cycle amplification, real-time monitoring, and high-resolution DNA melting analysis.
- Janis Weis Lab
My laboratory studies the pathogenesis of Lyme disease; an infection caused by the tick borne spirochete Borrelia burgdorferi.
- Matthew Williams Lab
The research of my lab is focused on the mechanisms driving the development of long-lived immunological memory following bacterial or viral infection.
- Diane Ward Lab
My laboratory studies membrane trafficking and the regulation of endocytic vesicle size and iron metabolism specifically compartmentalization and utilization.
- Histocompatibility and Immunogenetics Laboratory
The Histocompatibility and Immunogenetics Laboratory provides a complete range of diagnostic testing services used primarily in the field of clinical organ transplantation and for study of associations between certain diseases and several HLA alloantigens.
- Kimberley Evason Lab
The overarching goal of the Evason laboratory is to investigate mechanisms involved in liver tumorigenesis in order to develop improved therapies to treat this deadly cancer. A major subset of HCC is defined by mutations in the CTNNB1 gene encoding β-catenin, an integral component of the Wnt signaling pathway . These β-catenin-activated HCC represent 20-40% of human HCC, and our current research focuses primarily on these tumors.
- Ryan O'Connell Lab
Our overall goal is to determine how the loss of cellular identity and acquisition of alternative differentiation states contributes to cancer progression and alters therapeutic response.