Welcome to the Tantin Laboratory

Sequence-specific DNA binding transcription factors are potent controllers of gene expression, as demonstrated by their central role in development and in lineage reprogramming. Transcription factors are used to achieve specific gene expression patterns. Because these patterns are critical for successful development and signal response, aberrations in transcription factor function lead to myriad human disorders such as immune dysfunction and cancer. Our lab is studying mammalian transcription factors, their cofactors and the chromatin marks they control, to identify gene regulatory mechanisms underlying lymphocyte development and function, stem cells, pluripotency and malignancy.

To investigate these problems, we use engineered mouse models along with biochemical, molecular biological and genomic approaches. Our work spans the spectrum from basic molecular mechanisms to normal and disease state physiologies. Some specific current areas of investigation:

  • Role of the transcription factor Oct1 in stem cells and regeneration of the gut epithelium
  • Control of Oct1 protein stability by the tumor suppressor BRCA1
  • Role of the transcriptional cofactor OCA-B in promoting T cell memory and autoimmunity
  • Roles of OCA-B and Oct1 in leukemia
  • Roles of OCA-B and Oct1 in immune memory and autoimmunity
  • Oct1/4 interplay in pluripotent cells and developmental gene poising

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Contact Us

Dean Tantin
Associate Professor
Department of Pathology
University of Utah School of Medicine
15 N. Medical Drive East
5200K JMRB (1100 for courier service)
Salt Lake City, UT 84112

Lab Phone: 801-587-3802
Office Phone: 801-587-3035
Email Address: dean.tantin@path.utah.edu