- Blaschke Lab
The overall research goal for work in the Molecular Microbiology Laboratory is to develop PCR-based molecular testing that will aid us in understanding the pathogen-based epidemiology of invasive bacterial and viral disease in children. By developing and using molecular-based methods for detection of pathogens, we have the opportunity to expand our knowledge to include both culture-positive and culture-negative manifestations of many disease entities, such as pneumonia, meningitis and sepsis. Our laboratory has a collaborative relationship with a University of Utah-founded biotechnology company, BioFire Diagnostics, Inc., and we work both independently and in cooperation with BioFire to investigate both proposed and novel applications of their diagnostic technologies. In addition to exploring new ways to detect infectious pathogens, we also aim to develop molecular assays that evaluate well-known as well as proposed virulence factors in bacterial pathogens such as Streptococcus pneumoniae and Staphylococcus aureus, and determine if routine testing for these factors can be used to improve clinical management. Finally, we would like to use molecular methods to improve our understanding of pathogen epidemiology not only at the level of the infectious pathogen, but at the population level by characterizing strains or serotypes that are prevalent in populations.
- Bonkowsky Lab
The Bonkowsky lab studies mechanisms and diseases in neurodevelopment. Our focus is on understanding the genetics and logic of brain connectivity; and on studies of diseases of development, particularly prematurity, hypoxia, and leukodystrophies.
- Engel Lab
Michael Engel's research lab at HCI focuses on the molecular pathogenesis of acute myeloid leukemia. His team studies the myeloid translocation gene (MTG) family and the signaling systems that govern normal and abnormal blood cell formation.
- Jorde Lab
Led by Dr. Lynn B. Jorde, a Professor of Human Genetics and Pediatrics, the Lab is involved in two major areas of research: gene mapping and evolutionary genetics. They are analyzing variation in genes in the renin-angiotensin pathway in a series of Utah families and in a cohort of hypertensive subjects to better understand the role of these genes in hypertension susceptibility. The lab is also involved in studies of the genetics of schizophrenia, polycythemia, juvenile idiopathic arthritis, and inflammatory bowel disease. Their evolutionary genetic research involves the analysis of worldwide genetic variation in human mitochondrial and nuclear DNA (including the Y chromosome).
- Joss-Moore Lab
The Joss-Moore Lab studies the effects of poor fetal growth on the molecular mechanisms predisposing to neonatal lung disease and adult-onset obesity. Neonatal lung disease and obesity are both consequences of poor fetal growth. Our primary focus is the interaction between the epigenetic regulation of gene expression and lipid metabolism. We seek to understand: 1. the contribution of the PPARγ-Setd8-H4K20Me axis to the epigenetic program of the lung and adipose tissue during development 2. how the PPARγ-Setd8-H4K20Me axis is altered by fetal growth restriction 3. the therapeutic potential of PPARγ-Setd8-H4K20Me activation by the omega-3 fatty acid, DHA Our studies involve molecular, morphometric, physiologic and genomic approaches.
- Schiffman Lab
The Schiffman Lab studies pediatric hereditary cancer syndromes with a special interest in genetic susceptibility to childhood cancers. The lab also investigates molecular changes in leukemia and Ewing's sarcoma, and the germline genetic variation that gives rise to childhood tumors.
- Schoenwolf Lab
Led by Dr. Gary Schoenwolf, a Professor of Neurobiology and Anatomy and Pediatrics, the Lab addresses the general question of how intercellular and intracellular signaling results in the generation of pattern during vertebrate embryogenesis. Although they work on a number of diverse organ rudiments and developmental events using multiple experimental organisms, their current work is focused on normal and abnormal development of the inner ear. The lab's research combines molecular, cellular, embryological, transgenic, imaging, and in vitro and in vivo approaches. This work is relevant for understanding birth defects, cancer, and aging.
- Yost Lab
Led by Dr. H. Joseph Yost, PhD, a Professor of Neurobiology and Anatomy and Pediatrics, the lab's long-term research goal is to understand the genes, molecules and developmental mechanisms that regulate the assignment of different cell identities in functionally appropriate positions in the developing vertebrate embryo, and to utilize this knowledge for the advancement of human medicine.