J. Michael McIntosh, M.D.
Title: Professor, tenure track
Current Position: Director of Research
Education/Training
- B.S. University of Utah, 1983
- M.D. U.C.L.A., 1987
- Psychiatry Residency , University of Colorado School of Medicine, 1987-1991
- University of Utah, 1991-1992
Certifications
- American Board of Psychiatry & Neurology (Psychiatry), 1994 - does not expire
Honors
- Undergraduate: Presidential Scholarship; Elk's National Scholarship; Phi Beta Kappa
- Medical School: UCLA Medical Auxiliary Scholarship; Eldridge Scholar;, 1982-1987
- Residency Training: National Institute of Mental Health Outstanding Resident Award, 1990
- Faculty: American College of Neuropsychopharmacology/Mead Johnson Travel Awardee; 1996-2000
- Listed among top 20 psychiatrists in U.S. in Men's Health, 2007 to present
Publications
- Vincler M and McIntosh JM (2007) Targeting the alpha9alpha10 nicotinic acetylcholine receptor to treat severe pain. Expert Opinion on Therapeutic Targets 2007 11:891-7
- Vincler, M., Wittenauer, S., Parker, R., Ellison, M., Olivera, B.M., and McIntosh, J.M. (2006) Molecular mechanism for analgesia involving specific antagonism of a9a10 nicotinic acetylcholine receptors. Proc Natl Acad Sci U S A, Nov 21;103(47):17880-17884.
- Quik, M., and McIntosh, J. M. (2006) Striatal alpha6* nicotinic acetylcholine receptors: potential targets for Parkinson's disease therapy. J Pharmacol Exp Ther, Feb; 316(2):481-489.
- Shiembob, D.L., Roberts, R.L., Luetje, C.W., and McIntosh JM. (2006) Determinants of alpha-conotoxin BuIA selectivity on the nicotinic acetylcholine receptor beta subunit. Biochemistry, Sep 19;45(37):11200-11207.
- Azam, L., and McIntosh, J. M. (2005) Effect of novel alpha-conotoxins on nicotine-stimulated [3H]dopamine release from rat striatal synaptosomes. J Pharmacol Exp Ther., Jan;312(1):231-237.
Academic Activities
- Molecular Pharmacology of CNS receptors and ion channels. We are interested in the neurobiology of CNS disorders. Our work is focused on the study of receptor and ion channel pharmacology. At present the research is divided into two main areas: 1) Isolation and characterization of novel conopeptide ligands which can discriminate between closely related receptors and ion channels. These complexes are felt to play a key role in illnesses such as, Parkinson's Disease, mood disorders, chronic pain and epilepsy; 2) The role of receptors and ion channels in neurotransmitter release. Using electrophysiological and neurochemical techniques, we are examining the modulation of neurotransmitter release by particular receptor subtypes. Development of novel therapeutic agents is one ultimate end point.
