Department of Radiation Oncology

Research

The Department participates in clinical trials with several national cooperative groups including the Radiation Therapy Oncology Group (RTOG), the Southwest Oncology Group (SWOG), and Children's Oncology Group (COG) and others. Drs. Gaffney, Hazard, Hitchcock, Shrieve and Tward are all Principle Investigators for RTOG and Dr. Shrieve is also a co-investigator for COG.

Faculty members have authored a significant number of peer-reviewed articles, and residents have been involved in many of these.  All of our residents either have recently or will soon present their research at national conferences.  Currently the faculty and residents are conducting over 10 investigational studies involving various disease sites.  

In addition, a study published in the Red Journal found that between 2002 and 2007 our residents had more first author publications per capita than those of any other Radiation Oncology residency program.  

In the list below of publications over the last two calendar years, our faculty are listed in bold and our residents are listed in italics. 

 

Recent Publications

2009

Macdonald OK, Chen J, Dodson M, Lee CM, Gaffney DK. (2009). Prognostic significance of histology and positive lymph node involvement following radical hysterectomy in carcinoma of the cervix. Am J Clin Oncol, 32(4), 411-6.

Warters RL, Packard AT, Kramer GF, Gaffney DK, Moos PJ. (2009). Differential gene expression in primary human skin keratinocytes and fibroblasts in response to ionizing radiation. Radiat Res, 172(1), 82-95.

Su FC, Shi C, Mavroidis P, Goytia V, Crownover R, Rassiah-Szegedi P, Papanikolaou N.. Assessing four-dimensional radiotherapy planning and respiratory motion-induced dose difference based on biologically effective uniform dose. Technol Cancer Res Treat, 8(3), 187-200.

Warters RL, Gaffney DK, Kramer GF, Martinez JD, Cress AE. (2009). Transient dephosphorylation of p53 serine 376 as an early response to ionizing radiation. Radiat Res, 171(6), 725-34.

Anker CJ, Cachoeira CV, Boucher KM, Rankin J, Gaffney DK. (2009). Does the Entire Uterus Need to Be Treated in Cancer of the Cervix? Role of Adaptive Brachytherapy. Int J Radiat Oncol Biol Phys.

Montejo M, Werner TL, Gaffney DK. Current challenges in clinical management of endometrial cancer. Adv Drug Deliv Rev, 61, 883-889.

Hitchcock YJ, Tward JD, Szabo A, Bentz BG, Shrieve DC. (2009). Relative contributions of radiation and cisplatin-based chemotherapy to sensorineural hearing loss in head-and-neck cancer patients. Int J Radiat Oncol Biol Phys, 73(3), 779-88.

Sarkar V, Shi C, Rassiah-Szegedi P, Eng T, Diaz A, Papanikolaou N.  A feasibility study on the use of digital tomosynthesis with individually-acquired megavoltage portal images for target localization. J BUON, 14(1), 103-8.

Kwon AK, Dibiase SJ, Wang B, Hughes SL, Milcarek B, Zhu Y. (2009). Hypofractionated stereotactic radiotherapy for the treatment of brain metastases. Cancer, 115(4), 890-8.

Trimble EL, Davis J, DiSaia P, Fujiwara K, Gaffney DK, Kristensen G, Ledermann J, Pfisterer J, Quinn M, Redd N, Schoenfeldt M, Thigpen JT. Gynecologic Cancer Intergroup. Clinical trials in Gynecological Cancer. Int J Gynecol Cancer, 17(3), 547-56.

Salter BJ, Fuss M, Sarkar V, Wang B, Rassiah-Szegedi P, Papanikolaou N, Hollingshaus S, Shrieve DC. (2009). Optimization of isocenter location for intensity modulated stereotactic treatment of small intracranial targets. Int J Radiat Oncol Biol Phys, 73(2), 546-55.

Hazard LJ, Wang B, Skidmore TB, Chern SS, Salter BJ, Jensen RL, Shrieve DC. (2009). Conformity of LINAC-based stereotactic radiosurgery using dynamic conformal arcs and micro-multileaf collimator. Int J Radiat Oncol Biol Phys, 73(2), 562-70.

2008

Tward JD, Cachoeira CV, Salama ME, Lee RJ, Bowen G, Perkins SL, Glenn M, Confer M, Gaffney DK.. Survival and Recurrence in Non-Mycosis Fungoides Primary Cutaneous Lymphoma. Cancer J, 15(1), 87-92.

Petru E, Luck H, Sutart G, Gaffney DK, Millan D, Vergote I. Gynecologic Cancer Intergroup proposals for changes of the current FIGO staging system. Eur J Obstet Gynecol Reprod Biol, 143, 69-74.

Monk BJ, Shamshad A, Gaffney DK. When is being in a hurry going too fast? Lessons learned from clinical trials in cervical cancer. Gynecol Oncol, 113(1), 1-3.

Gaffney DK, Du Bois A, Narayan K, Reed N, Toita T, Pignata S, Blake P, Portelance L, Sadoyze A, Potter R, Colombo A, Randall M, Mirza MR, Trimble EL. (2009). Patterns of care for radiotherapy in vulvar cancer: a Gynecologic Cancer Intergroup study. Int J Gynecol Cancer, 19(1), 163-7.

Small W, Dubois A, Narayan K, Reed N, Toita T, Pignata S, Blake P, Portelance L, Sadoyze A, Potter R, Colombo A, Randall M, Mirza MR, Trimble EL, Gaffney DK. Practice Patterns of Radiotherapy in Endometrial Cancer Among Member Groups of the Gynecologic Cancer Intergroup (GCIG). Int J Gynecol Cancer, 19(3), 395-9.

Warters R, Gaffney DK, Kramer GF, Martinez JD, Cress AE. Transient Dephosphorylation of p53 Serine 376 as an Early Response to Ionizing Radiation. Radiat Res, 171, 725-34.

Moos P, Warters R, Gaffney DK. Differential gene expression in primary human skin keratinocytes and fibroblasts in response to ionizing radiation. Radiat Res, 172, 82-95.

Salter BJ, Wang B, Szegedi MW, Rassiah-Szegedi P, Shrieve DC, Cheng R, Fuss M. (2008). Evaluation of alignment error due to a speed artifact in stereotactic ultrasound image guidance. Phys Med Biol, 53(23), N437-45.

Chen J, Tward JD, Shrieve DC, Hitchcock YJ. (2008). Surgery and radiotherapy improves survival in patients with anaplastic thyroid carcinoma: analysis of the surveillance, epidemiology, and end results 1983-2002. Am J Clin Oncol, 31(5), 460-4.

Morgan RJ Jr, Alvarez RD, Armstrong DK, Boston B, Chen LM, Copeland L, Fowler J, Gaffney DK, Gershenson D, Greer BE, Grigsby PW, Havrilesky LJ, Johnston C, Lancaster JM, Lele S, Matulonis U, O'Malley D, Ozols RF, Remmenga SW, Sabbatini P, Schink J, Teng N. (2008). Ovarian cancer. Clinical practice guidelines in oncology. J Natl Compr Canc Netw, 6(8), 766-94.

Hazard LJ, Tward JD, Shrieve DC. (2008). Adjuvant EBRT improves survival in patients with lymph-node-negative pancreatic cancer. Nat Clin Pract Oncol, 5(8), 438-9.

Smith DC, Macdonald OK, Gaffney DK. (2008). The impact of adjuvant radiation therapy on survival in women with uterine carcinosarcoma. Radiother Oncol, 88(2), 227-32.

Skidmore T, Lee C, Abbott T, Wiggins R, Anderson G, Hitchcock Y. Progressive Bone Loss Gorhma's Disease. Ear Nose Throat J, 87(6), E4-7.

Chen J, Macdonald OK, Gaffney DK. (2008). Incidence, mortality, and prognostic factors of small cell carcinoma of the cervix. Obstet Gynecol, 111(6), 1394-402.

Zempolich K, Fuhrman C, Milash B, Flinner R, Greven K, Ryu J, Forbes A, Kerlin K, Nichols RC, Gaffney DK. (2008). Changes in gene expression induced by chemoradiation in advanced cervical carcinoma: a microarray study of RTOG C-0128. Gynecol Oncol, 109(2), 275-9.

Brem SS, Bierman PJ, Black P, Brem H, Chamberlain MC, Chiocca EA, Deangelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Glass J, Grossman SA, Heimberger AB, Junck L, Linette GP, Loeffler JJ, Maor MH, Moots P, Mrugala M, Nabors LB, Newton HB, Olivi A, Portnow J, Prados M, Raizer JJ, Shrieve DC, Sills AK Jr. (2008). Central nervous system cancers. J Natl Compr Canc Netw, 6(5), 456-504.

Jensen RL, Wendland MM, Chern SS, Shrieve DC. (2008). Novalis intensity-modulated radiosurgery: methods for pretreatment planning. Neurosurgery, 62(5 Suppl), A2-9; discussion A9-10.

Chen J, Shrieve DC, Hitchcock YJ. (2008). Comparison of cervical esophagus dose-volumes for three radiotherapy techniques for head and neck cancer. Radiother Oncol, 87(2), 274-80.

Macdonald OK, D'Amico AV, Sadetsky N, Shrieve DC, Carroll PR. (2008). Predicting PSA failure following salvage radiotherapy for a rising PSA post-prostatectomy: from the CaPSURE database. Urol Oncol, 26(3), 271-5.

Wallace S, Pilon A, Kwok P, Messner LV, Hitchcock Y. Ophthalmic manifestations of an undifferentiated sinonasal carcinoma. Optom Vis Sci, 85(4), 226-9.

Smith DC, Macdonald OK, Lee CM, Gaffney DK. (2008). Survival impact of lymph node dissection in endometrial adenocarcinoma: a surveillance, epidemiology, and end results analysis. Int J Gynecol Cancer, 18(2), 255-61.

Anker CJ, Dechet C, Isaac JC, Akerley W, Shrieve DC. (2008). Small-cell carcinoma of the prostate. J Clin Oncol, 26(7), 1168-71.

Lancaster LT, Hazard LC, Clobert J, Sinervo BR. (2008). Corticosterone manipulation reveals differences in hierarchical organization of multidimensional reproductive trade-offs in r-strategist and K-strategist females. J Evol Biol, 21(2), 556-65.

Brown AP, Chen J, Hitchcock YJ, Szabo A, Shrieve DC, Tward JD. (2008). The risk of second primary malignancies up to three decades after the treatment of differentiated thyroid cancer. J Clin Endocrinol Metab, 93(2), 504-15.

Almony A, Breit S, Zhao H, Ramirez J, Mansur D, Harbour JW. (2008). Tilting of radioactive plaques after initial accurate placement for treatment of uveal melanoma. Archives of Ophthalmology, 126(1), 65-70.

Weidhaas JB, Li S, Winter K, Ruy J, Jhingra A, Miller B, Dicker A, Gaffney DK. Changes in Gene Expression Predicting Local Control in Cervical Cancer: Results from RTOG 0128. Clin Cancer Res, 15(12), 4199-4206.

Wolfson AH, Winter K, Crook W, Krishan A, Grigsby PW, Markoe AM, Morris M, Gaffney DK, Eifel PJ, Lucci JA 3rd. (2008). Are increased tumor aneuploidy and heightened cell proliferation along with heterogeneity associated with patient outcome for carcinomas of the uterine cervix? A combined analysis of subjects treated in RTOG 9001 and a single-institution trial. Int J Radiat Oncol Biol Phys, 70(1), 111-7.

Small W Jr., Mell LK, Anderson P, Creutzberg C, De Los Santos J, Gaffney DK, Jhingran A, Portelance L, Schefter T, Iyer R, Varia M, Winter K, Mundt AJ. Consensus Guidelines for Deliniation of Clinical Target Volume for Intesnsity-=Modulated Pelvic Radiotherapy in Postoperative Treatment of Endometrial and Cervical Cancer. Int J Radiat Oncol Biol Phys, 71(2), 428-34.

Morgan RJ Jr., Alvarez RD, Armstrong DK, Boston B, Chen LM, Copeland L, Fowler J, Gaffney DK, Gershenson D, Greer BE, Gigsby PW, Havrilesky LJ, Johnston C, Lancaster JM, Lele S, Matulonis U, Oxols RF, O'Malley D, Remmenga SW, Sabbatini P, Schink J, Teng N, National Comprehensive Cancer Network. Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw, 6(8), 766-94.

Tanyi JA, Krafft SP, Hagio T, Fuss M, Salter BJ. (2008). MOSFET sensitivity dependence on integrated dose from high energy photon beams. Journal of Medical Physics(35), 39-47.

Zhao H, Cuneo B, Strasburger J, Huhta J, Gotteiner N, Wakai R. (2008). Electrophysiologic characteristics of fetal AV block. Journal of the American College of Cardiology, 51, 77-84.

Wang B, Xu XG. (2008). Measurements of non-target organ doses using MOSFET dosemeters for selected IMRT and 3D CRT radiation treatment procedures. Radiat Prot Dosimetry, 128(3), 336-42.