Our laboratory is focused on understanding the inflammatory cascade for better care and treatment of those suffering from interstitial cystitis/painful bladder syndrome (IC/PBS). This debilitating chronic condition, affecting over three million women above the age of 18 in the US, causes unrelenting bladder pain, frequent urination and discomfort. Currently, there are no effective treatments for this chronic, life altering condition.
Our lab is committed to understanding the disease physiologically, finding a powerful treatment through our proven murine model, and changing the lives of millions affected. Currently examining the cathelicidin, LL-37, its antimicrobial properties, and its potential to initiate the inflammatory cascade, we are determined to find its mechanistic role in IC/PBS and learn how to inhibit the inflammatory cascade by limiting LL-37 mediated bladder inflammation, fibrosis, and pain.