• Brewer, L, Orr, JA, Johnson, KJ, Ermer, S, Egan, TD (Pending). Detecting Ventilatory Depression using Affordable Sensors and Prompting for Patient Self Rescue. Anesth Analg.
  • McFarlane D, Doig A, Agutter J, Brewer L, Syroid N, and Mittu R (2018). Faster clinical response to the onset of adverse events: A wearable metacognitive attention aid for nurse triage of clinical alarms. PLoS ONE, 13(5), e0197157.
  • Orr, JA, Brewer, L (2018). System and method of identifying breaths based solely on capnographic information. U.S. Patent No. 9907511. Washington, D.C.:U.S. Patent and Trademark Office.
  • Orr J, Brewer L (2017). Determining components of total carbon dioxide excreted by a subject. U.S. Patent No. 9,763,601. Washington, D.C.:U.S. Patent and Trademark Office.
  • Allen SG, Brewer L, Gillis ES, Pace NL, Sakata DJ, Orr JA (2017). A Turbine-Driven Ventilator Improves Adherence to Advanced Cardiac Life Support Guidelines During a Cardiopulmonary Resuscitation Simulation. Respir Care, 62(9), 1166-1170.
  • Orr, JA, Brewer L, Westenskow, DR, Goerges, M (2017). Intuitive Presentation of Ventilation Effectiveness. U.S. Patent No. 9,675,300. Washington, D.C.:U.S. Patent and Trademark Office.
  • Kuck K, Johnson KB (2017). The Three Laws of Autonomous and Closed-Loop Systems in Anesthesia. Anesth Analg, 124(2), 377-380.
  • Brewer L, Orr J (2017). System and method for determining dead space fraction in an ongoing manner from intermittent blood gas samples. U.S. Patent No. 9,549,690. Washington, D.C.:U.S. Patent and Trademark Office.
  • McFarlane, D C, Doig, AK, Agutter, J A, et al (2016). Defeating Information Overload in Health Surveillance using a Metacognitive Aid Innovation from Military Combat Systems. Journal of Defense Modeling and Simulation. Journal of Defense Modeling and Simulation: Applications, Methodology, Technology, 154851291666724.
  • Naguib N, Brewer L, LaPierre C, Kopman A, Johnson KB (2016). The Myth of Rescue Reversal in "Can't Intubate, Can't Ventilate" Scenarios. Anesth Analg, 123(1), 82-92.
  • Kai Kck (April 2016). Das Potenzial der IT ist kaum ausgeschöpft. Health & Care Management, pp. 60-61.
  • Patrick Kolbay, Joseph Orr, Kck K (2016). Using Hot Wire Anemometry to Determine Isoflurane Gas Concentration. American Society of Anesthesiologists 2016 Annual Meeting, Chicago, IL.
  • Patrick Kolbay, Joseph A Orr, Kck K (2016). A New Era of Anesthetic Equipment. 22nd AnnualFellowship Symposium Utah NASA Space Grant Consortium, 2016, Orem, Utah.
  • Kolbay P, Orr J, Kck K (2016). Design and Testing of a Novel Anesthetic Gas Analyzer for use in Low-Resource Areas. October 5-8, 2016. Biomedical Engineering Society (BMES) Annual Meeting, Minneapolis, MN.
  • Kuck K, Pace NL, Parmer A (2015). Noninvasive Blood Pressure Does Not Estimate Invasive Blood Pressure Well in a Retrospective Study of Noncardiac Surgical Cases [Abstract]. ASA 2015 Annual Meeting, San Diego, CA. A-1049.
  • Chandra S, Kuck K (2015). Evaluation of Elastomeric Pumps for Continuous Peripheral Nerve Blocks. ASA 2015 Annual Meeting, San Diego, CA. Scientific and Educational Exhibits ScEdEx03. S28. San Diego, CA.
  • Kai Kck, Cornelia Schrader, Steffen Schmitt, Hans-Ullrich Hansmann (2015). Belt with sensors. U.S. Patent No. US 9039613 B2. Washington, D.C.:U.S. Patent and Trademark Office.
  • Ermer S, Orr J, Kuck K, Brewer, L (2014). Discord in the Definition of Apnea: An Analysis of Apnea Duration in Sedated Volunteers [Abstract]. Society of Technology in Anesthesia 2014 Annual Meeting, Phoenix, AZ.
  • Hansmann HU, Blumenthal T, Tschuncky P, Hengstenberg A, Mett F, Kuhn U, Franz F, Kuck K, Schmitt S (2015). Device and method for determining a respiration rate. U.S. Patent No. US8696588B2. Washington, D.C.:U.S. Patent and Trademark Office.
  • Johnson K, Brewer L, LaPierre C (2014). Consideration for the Induction of Anesthesia. In Ken B Johnson (Ed.), Clinical Pharmacology for Anesthesiology (1, p. 512). New York: McGraw-Hill Education Medical.
  • Hans-Ullrich Hansmann, Tilman von BLUMENTHAL, Peter Tschuncky, Andreas Hengstenberg, Frank Mett, Uwe Khn, Frank Franz, Kai Kck, Steffen SCHMITT (2014). Device and method for determining a respiration rate. U.S. Patent No. US8696588 B2. Washington, D.C.:U.S. Patent and Trademark Office.
  • Patwari N, Brewer L, Tate Q, Kaltiokallio O, Bocca M (2013). Breathfinding: A Wireless Network that Monitors and Locates Breathing in a Home. IEEE J Sel Top Signal Process, PP(99).
  • Hans-Ullrich Hansmann, Ryszard Kummerfeld, Michael Riecke, Henryk Schnaars, Kai KCK (2013). Incubator for neonatal care and method for disinfecting same. U.S. Patent No. WO2013124086 A1 (Application). Washington, D.C.:U.S. Patent and Trademark Office.
  • Kck K, Hansmann HU, Ott D, Mohrmann A, Trllsch A (2013). Gas measurement system. U.S. Patent No. US20150168307 A1 (Application). Washington, D.C.:U.S. Patent and Trademark Office.
  • Kuck K, Orr J, Brewer L (2013). Methods and apparatus for improving time domain relationships between signals obtained from respiration. U.S. Patent No. 8,398,559. Washington, D.C.:U.S. Patent and Trademark Office.
  • Yu L, Ting CK, Hill B, Orr JA, Brewer L, Johnson K, Egan T, Westenskow D (2013). Using the Entropy of Tracheal Sounds to Detect Apnea during Sedation. Anesthesiology, 118(6), 1341-1349.
  • Baas J, Brauer U, Dannhorn DR, Hoffmann W, Kuhn M, Kck K, Pfhler W, Porzsolt F, Schmitz-Rode T, Schweins T, Scriba PC, Sthler CF, Wildau HJ, Wrobel WG (Eds.) (Nov 2012). Schlussbericht Nationaler Strategieprozess Innovationen in der Medizintechnik. Berlin, Germany: Lenkungskreis für den Nationalen Strategieprozess»nnovationen für die Medizintechnik.
  • Kuck K (2012). Anesthesia and critical care ventilation - The tools of 2020. Technology Time Machine Symposium (TTM), 2012 IEEE DOI: 10.1109/TTM.2012.6509080, Dresden, Germany.
  • Brewer L, Orr J, Fulcher E, Markewitz B (2011). Evaluation of a CO2 partial rebreathing functional residual capacity measurement method for use during mechanical ventilation. J Clin Monit Comput, 25(6), 397-404.
  • Frank F, Haar M, Manigel J, Kck K, Stahlkopf S, Voigt M, Bouillon T, Luginbhl M, Schumacher P (2011). Process and device for monitoring a patient during anesthesia and for determining the combined effect of a plurality of anesthetics. Also published as DE102007038975A1. U.S. Patent No. US7878982B2;. Washington, D.C.:U.S. Patent and Trademark Office.
  • Brewer LM, Orr JA, Sherman MR, Fulcher EH, Markewitz BA (2011). Measurement of functional residual capacity by modified multiple breath nitrogen washout for spontaneously breathing and mechanically ventilated patients. Br J Anaesth, 107(5), 796-805.
  • Maral Haar, Wilfried Buschke, Frank Franz, Kai Kck, Jrg-Uwe Meyer, Susanne Stahlkopf, Michael Wilkening, Thomas Bouillon, Peter Schumacher, Bela Stetzer (2011). Process and device for monitoring a patient. U.S. Patent No. US7985181 B2, DE102007038915A1, US20080114222. Washington, D.C.:U.S. Patent and Trademark Office.
  • Haar M, Kuck K, et al (2011). Process and device for monitoring a patient. U.S. Patent No. 7,985,181 B2. Washington, D.C.:U.S. Patent and Trademark Office.
  • Frank F, Haar M, Manigel J, Kuck K, Stahlkopf S, Voigt M, Bouillon T, Luginbuhl M, Schumacher P (2011). Process and device for monitoring a patient during anesthesia and for determining the combined effect of a plurality of anesthetics. U.S. Patent No. US7878982B2. Washington, D.C.:U.S. Patent and Trademark Office.
  • Gorges M, Kuck K, Koch SH, Agutter J, Westenskow DR (2011). A far-view intensive care unit monitoring display enables faster triage. Dimens Crit Care Nurs, 30(4), 206-17.
  • Westenskow DR, Orr JA, Syroid N, Snell D, Agutter J, Drews F, Lingutla S, Balakrishnan S, Kuck K, Brewer L (2010). System for providing emergency medical care with real-time instructions and associated methods. U.S. Patent No. 7,774,060. Washington, D.C.:U.S. Patent and Trademark Office.
  • Grges M, Westenskow DR, Kck K, Orr J (2010). Comparison of Nurse and Engineering Student Performance Titrating Sodium-Nitroprusside Using an Advisory System. Proceedings of the 2010 Society for Technology in Anesthesia Annual Meeting, West Palm Beach, FL, West Palm Beach, FL.
  • Kuck K, Orr JA, Brewer L (2010). Noninvasive effective lung volume estimation. U.S. Patent No. 7,699,788. Washington, D.C.:U.S. Patent and Trademark Office.
  • Gorges M, Westenskow DR, Kuck K, Orr JA (2010). A tool predicting future mean arterial blood pressure values improves the titration of vasoactive drugs. J Clin Monit Comput, 24(3), 223-35.
  • Westenskow D, Kuck K, et al (2010). System for Providing Medical Care with real-time instructions and associated methods. U.S. Patent No. 7,774,060 B2. Washington, D.C.:U.S. Patent and Trademark Office.
  • Matthiessen H, Kuck K (2009). Compressed Air Respirator. U.S. Patent No. 7,578,293 B2. Washington, D.C.:U.S. Patent and Trademark Office.
  • Brewer LM, Orr JA, Pace NL (2008). Anatomic dead space cannot be predicted by body weight. Respir Care, 53(7), 885-91.
  • Meyer JU, Kullik G, Wruck N, Kuck K, Manigel J (2008). Advanced technologies and devices for inhalational anesthetic drug dosing. In Schuttler J, Schwilden H (Eds.), Modern Anesthetics, Handbook of Experimental Pharmacology (182). Berlin: Springer.
  • Brewer LM, Haryadi DG, Orr JA (2007). Measurement of functional residual capacity of the lung by partial CO2 rebreathing method during acute lung injury in animals. Respir Care, 52(11), 1480-9.
  • Strahle M, Ehlbeck M, Prapavat V, Kuck K, Franz F, Meyer JU (2007). Towards a Service-Oriented Architecture for Interconnecting Medical Devices and Applications [Abstract]. Joint Workshop on High Confidence Medical Devices, Software, and Systems HCMDSS 2007.
  • Strahle M, Ehlbeck M, Prapavat V, Kuck K, Franz F, Meyer JU (2007). Towards a Service-Oriented Architecture for Interconnecting Medical Devices and Applications. Joint Workshop on High Confidence Medical Devices, Software, and Systems (HCMDSS).
  • Kuck K, Orr JA, Brewer L (2006). Rebreathing methods including oscillating, substantially equal rebreathing and nonrebreathing periods. U.S. Patent No. 7,135,001. Washington, D.C.:U.S. Patent and Trademark Office.
  • Kuck K, Orr JA, Brewer L (2006). Algorithms, systems, and methods for estimating carbon dioxide stores, transforming respiratory gas measurements, and obtaining accurate noninvasive pulmonary capillary blood flow and cardiac output measurements. U.S. Patent No. 7,074,196. Washington, D.C.:U.S. Patent and Trademark Office.
  • Mersmann S, Kuck K (2006). Optimizing Workflow Processes in Critical Care Through Automation [Abstract]. Journal of Clinical Monitoring and Computing, 20(2), 119-120.
  • Kuck K, Orr JA, Brewer L (2005). Algorithms, systems, and methods for estimating carbon doxide stores, transforming respiratory gas measurements, and obtaining accurate noninvasive pulmonary capillary blood flow and cardiac output measurements. U.S. Patent No. 6,955,651. Washington, D.C.:U.S. Patent and Trademark Office.
  • Kck K, Orr JA, Brewer LM (2003). Noninvasive cardiac output performance improved after sufficient stabilization time following decrease of ventilation [Letter to the editor]. Anesthesiology, 99(6), 1460.
  • Orr JA, Kuck K, Brewer LM (2003). Noninvasive cardiac output monitor algorithms are more sophisticated and perform better than indicated in modeling paper [Letter to the editor]. Anesthesiology, 99(6), 1461-2; author reply 1462.
  • Kuck K, Orr JA, Brewer LM (2003). Noninvasive cardiac output performance improved after sufficient stabilization time following decrease of ventilation [Letter to the editor]. Anesthesiology, 99(6), 1460; author reply 1460-1.
  • Orr J, Kuck K (2003). Methods for accurately, substantially non-invasively determining pulmonary capillary blood flow, cardiac output, and mixed venous carbon dioxide content. U.S. Patent No. 6,540,689. Washington, D.C.:U.S. Patent and Trademark Office.
  • Haryadi D, Orr J, Kuck K, Jaffe M (2001). Methods of non-invasively estimating intrapulmonary shunt fraction and measuring cardiac output. U.S. Patent No. 6,258,038. Washington, D.C.:U.S. Patent and Trademark Office.
  • Haryadi D, Orr J, Kuck K, Jaffe M (2001). Methods of measuring cardiac output using a non-invasively estimated intrapulmonary shunt fraction. U.S. Patent No. 6,241,681. Washington, D.C.:U.S. Patent and Trademark Office.
  • Orr J, Jaffe M, Kuck K, Haryadi D (2001). Method for compensating for non-metabolic changes in respiratory or blood gas profile parameters. U.S. Patent No. 6,238,351. Washington, D.C.:U.S. Patent and Trademark Office.
  • Kuck K, Orr J (2001). Bi-directional partial re-breathing method. U.S. Patent No. 6,210,342. Washington, D.C.:U.S. Patent and Trademark Office.
  • Orr J, Jaffe M, Kuck K, Haryadi D (2001). Method of continuously, non-invasively monitoring pulmonary capillary blood flow and cardiac output. U.S. Patent No. 6,217,524. Washington, D.C.:U.S. Patent and Trademark Office.
  • Orr J, Jaffe M, Kuck K, Haryadi D (2000). Iso-volumetric method of measuring carbon dioxide elimination. U.S. Patent No. 6,059,732. Washington, D.C.:U.S. Patent and Trademark Office.
  • Haryadi D, Orr J, Kuck K, Jaffe M (2000). Methods of non-invasively estimating intrapulmonary shunt fraction and measuring cardiac output. U.S. Patent No. 6,042,550. Washington, D.C.:U.S. Patent and Trademark Office.
  • Haryadi DG, Orr JA, Kuck K, McJames S, Westenskow DR (2000). Partial CO2 rebreathing indirect Fick technique for non-invasive measurement of cardiac output. J Clin Monit Comput, 16(5-6), 361-74.
  • Kuck K, Orr JA, Haryadi DG, McJames S, Westenskow DR (1999). CO2 Production is Not a Good Surrogate Cardiac Output Indicator [Abstract]. Anesthesiology, 91(3A), A550.
  • Kuck K, Haryadi DG, Orr J, Bailey PL (1998). Evaluation of partial re-breathing cardiac output measurement during surgery [Abstract]. Anesthesiology, 89(3A), A542.
  • Johnson KB, Haryadi DG, Orr JA, McJames S, Kuck K, Westenskow DR (1998). Influence of pulmonary edema on noninvasive measurements of cardiac output using partial CO2 rebreathing in a canine model [Abstract]. Anesthesiology, 89(3A), A535.
  • Orr JA, Kuck K, Haryadi DG, Jaffe MB (1998). Clinical validation of a new non-invasive breath to breath Fick method for cardiac output estimation [Abstract]. Anesthesiology.
  • Baker PD, Westenskow DR, Kuck K (1997). Theoretical analysis of non-invasive oscillometric maximum amplitude algorithm for estimating mean blood pressure. Med Biol Eng Comput, 35(3), 271-8.
  • Kuck K, Haryadi DG, Westenskow DR (1997). Application of artificial neural networks in anesthesiology. In Lake CL, Sperry RJ (Eds.), Advances in Anesthesia (15). Chicago: Mosby.
  • Lemler J, Kuck K, Haryadi D, Baker PD, Westenskow DR (1996). Variability of the blood-pressure k 'constant' in humans [Abstract]. Journal of Clinical Monitoring and Computing, 12(6), 460-1.
  • Kuck K, Douglas SC, Westenskow DR (1995). Adaptive cancellation of respiratory noise in esophageal heart sounds [Abstract]. Journal of Clinical Monitoring and Computing, 11(4), 272.
  • Haryadi DG, Baker PD, Kuck K, Westenskow DR (1995). Effect of arterial compliance on mean arterial blood pressure estimated from the oscillometric maximum amplitude algorithm [Abstract]. Anesthesiology, 83(3 Suppl. A), A486.
  • Narus SP, Kuck K, Westenskow DR (1995). Intelligent monitor for an anesthesia breathing circuit. Proc Annu Symp Comput Appl Med Care, 96-100.
  • Kuck K, Fine PG, Orr JA, Westenskow DR (1994). Anesthesiologists can detect changes in cardiac output from esophageal heart sounds [Abstract]. Anesthesiology, 81(3A), A1296.
  • Kuck K, Orr JA, Fine PG, Westenskow DR (1993). Neural networks to estimate cardiac output from phonocardiograms [Abstract]. Anesthesiology, 79(3 Suppl. A), A472.
  • Baker PD, Kuck K, Orr JA, Westenskow DR (1992). Improved thermodilution cardiac output using neural networks [Abstract]. Anesthesiology, 77(3A), A476.
  • Farrell RM, Orr JA, Kuck K, Westenskow DR (1992). Differential features for a neural network based anesthesia alarm system. Biomed Sci Instrum, 28, 99-104.
  • Fine PG, Orr JA, Westenskow DR, Kuck K (1991). A neural network for quantification of air embolism. San Francisco, California, October 26-30 [Abstract].
  • Orr J, Kck K, Farrell RM, Westenskow DR (1991). Neural Network Breathing Circuit Alarms in An Anesthesia Workstation [Abstract].
  • Fine PG, Orr JA, Westenskow DR, Kuck K (1991). A neural network for quantification of air embolism. Anesthesiology 1991;75:A465 [Abstract]. Anesthesiology, 75, A465.

Recent News

We recently received funding from the Bill and Melinda Gates Foundation to develop a system which provides supplemental oxygen to pediatric pneumonia patients in low resource countries.

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University of Utah Hospital
Anesthesiology Bioengineering Division:

In the hospital take the B elevators to the 3rd floor. Make a left turn as you exit the elevators. The third door on the left side is the entrance to the bioengineering division. If you get lost in the hospital, ask for the Department of Anesthesiology.