U-CARS 2016

More than 450 attendees from around the world participated in the 4th Utah Cardiac Recovery Symposium (U-CARS), which was held on January 14-15, 2016 at the University of Utah School of Medicine in Salt Lake City, UT.
Keynote addresses were delivered by Jay Cohn, MD, and Philippe Menasche, MD, with Jeroen J Bax, MD, PhD as a featured guest.  The 2016 U-CARS symposium topics expanded across the basic, translational, and clinical sciences to provide a unique forum to push the field of heart recovery forward.

cohn menasche bax


Thursday, January 14, 2016

9:00 - 10:00am

Session 1: What is myocardial recovery? Chairpersons: Dean Y Li, MD, PhD, University of Utah; Donald Lappe, MD, Intermountain Medical Center

Topic  Speaker

1. Understanding myocardial recovery: translational perspective

Lorrie Kirshenbaum, PhD, University of Manitoba, Manitoba, Canada

2. Understanding mycardial recoverey: insights from biomarker clinical research

Wilson Tang, MD, Cleveland Clinic, Cleveland, OH

10:00 - 10:45am

Keynote Address: Jay Cohn

Cardiac and vascular remodeling: mechanisms of progression and recovery Jay N. Cohn, M.D, University of Minnesota, Minneapolis, MN

10:45 -  11:00am

11:00 -1:00pm

Session 2: Paradigms of cardiac recovery Chairpersons: John Doty, MD, Intermountain Medical Center; Roger A. Freedman, MD, University of Utah

Topic Speaker
1. Revascularization leading to myocardial recovery: do we understand it? Jeroen J. Bax, MD/PhD, Leiden University, The Netherlands/ President European Society of Cardiology (ESC)
2. Pacing the failing heart; the good, the bad, the ugly, and the confused? John Cleland, MD, Harefield/Imperial College, London, UK
3. Through the lens of calcific aortic stenosis

Brian Lindman, MD, Washington University, St. Louis, MO

4. Peripartum cardiomyopathy lessons for the cardiac recovery field

Uri Elkayam, MD, University of Southern California, Los Angeles, CA

1:00 - 2:00pm

LUNCH - Poster Viewing

2:00 - 3:30pm

Session 3: Right heart failure and recovery Chairpersons: John J. Ryan MD, University of Utah; David E. Morgan, MD, University of Utah

Topic Speaker
1. Right heart diastology: prognostic and therapeutic implications

Marielle van de Veerdonk, MD, VU University, Amsterdam, The Netherlands

2. Recovering the failing heart: insights from clinical and experimental studies Stephen Mckellar, MD, University of Utah, Salt Lake City, UT
3. Recovering and restoring RV function in PAH: Is it possible? Vinicio de Jesus Perez, MD, Stanford University, Palo Alto, CA

3:30 - 3:45pm



Session 4: ORAL PRESENTATIONS OF BEST SUBMITTED ABSTRACTS Chairpersons: Josef Stehlik, MD, University of Utah; Sarah Franklin, PhD, University of Utah

Topic Speaker
1. HeartMate PHP initial clinical experience in INTERMACS 1 patients Jiri Maly, MD, IKEM, Prague, Czech Republic

6:30 - 9:00 pm

Symposium Dinner

Friday, January 15, 2016


Session 5: Before the heart is burnt-out and VAD/Tx is necessary Chairpersons: Stephan Schueler, MD, PhD, Newcastle, UK; Edward M. Gilbert, MD, University of Utah

Topic  Speaker

1. The case for VAD therapy in earlier HF stages: pros and cons

Keith Aaronson, MD, University of Michigan, Ann Arbor, MI

2. Innovative strategies for the refractory HFpEF patient: Devices, unloading, and beyond

Dan Burkhoff, MD, PhD, Columbia University, New York, NY

9:00 - 9:15am



Session 6: Mechanical unloading and cardiac recovery Chairpersons: James W. Long, MD, Integris Baptist;  Jean-Bernard Durand, MD, University of Texas MD Anderson

Topic Speaker
1. Type of unloading, degree of unloading, and other new concepts

Nader Moazami, MD, Cleveland Clinic, Cleveland, OH

2. Optimizing mechanical unloading: what can we do with the current technology and what is my wish list for the future. Nir Uriel, MD, University of Chicago, Chicago, IL
3. Unloading and Recovery: From heterotopic transplant model and VAD registries to prospective studies and beyond Stavros G. Drakos, MD, University of Utah, Salt Lake City, UT
4. NIH RFA for the mechanical unloading and cardiac recovery field: Is it required? J. Timothy Baldwin, PhD, National Heart, Lung, and Blood Institute/NIH, Bethesda, Maryland


Panel Discussion: How can the unloading/cardiac recovery field advance?

Dean Y Li, MD/PhD (University of Utah); James C. Fang, MD (University of Utah); Abdallah G. Kfoury, MD (Intermountain Medical Center); James W. Long, MD (Integris Baptist); Emma Birks, MD (University of Louisville); Josef Stehlik, MD (University of Utah)


LUNCH - Poster Viewing


Keynote Address: Philippe Menasche, Paris

Cardiac recovery: When will stem cells be standard-of-care Philippe Menasché, MD, University Paris Descartes, Paris, France


Session 7: New therapeutic approaches for myocardial recovery Chairpersons: Kirk U. Knowlton, MD, Intermountain Medical Center, Salt Lake City; Simon Maltais, MD, PhD, Mayo Clinic Rochester

Topic Speaker
1. VAD-induced unloading and stem cells: Why combine them?

Joseph Woo, MD, Stanford, Palo Alto, CA

2. VAD-induced unloading and modulation of inflammatory resonse: Why combine them?

Craig H. Selzman, MD, University of Utah, Salt Lake City, UT

3. Immune response in cardiac remodeling and recovery: therapeutic opportunities

Sumanth D. Prabhu, MD, UAB, Birmingham, Alabama

3:45 - 4:00pm


4:00-5:45 pm

Session 8: Acute heart failure and cardiac recovery Chairpersons: Frederick G. Welt, MD, University of Utah; Joseph Tonna, MD, University of Utah

Topic Speaker

1. SHOCK Case Presentations: 

  • Acute RV infarction and shock requiring extended RP Impella/MCS to recovery
  • Cardiogenic shock in severe aortic stenosis: The role of emergency BAV and TAVR
  • Emergency Room ECMO

Omar Wever-Pinzon, MD, University of Utah, Salt Lake City, UT Anwar Tandar, MD, University of Utah, Salt Lake City, UT Joseph E. Tonna, MD, FAAEM, University of Utah, Salt Lake City, UT

2. INTERMACS 1: How to select patients and mechanical support therapeutic strategies? Brad Rasmusson, MD, Intermountain Medical Center, Salt Lake
3. Cardiogenic shock: From percutaneous VAD and ECMO to the exit strategy. Ulrich Jorde, MD, Einstein College of Medicine/Montefiore, Bronx, New York
4. Debate: Cardiogenic shock therapies: Surgical approach vs. percutaneous approach Ivan Netuka MD/PhD, IKEM, Prague, Czech Republic Jeff Teuteberg, MD, UPMC, Pittsburgh

6:30 - 9:00pm

Faculty Dinner