U-CARS 2017

Once again,  attendees from around the world participated in the 5th Annual Utah Cardiac Recovery Symposium (U-CARS), which was held on January 12-13, 2017 at the University of Utah School of Medicine in scenic Salt Lake City, UT.

The keynote address was delivered by Valentin Fuster, MD, PhD, Physician-in-Chief, Mount Sinai Hospital and Director, Mount Sinai Cardiovascular Institute.  Dr. Fuster is also Editor-in-Chief of JACC.   

The 2017 symposium attracted over 450 attendees, sparked in-depth discussions and featured ground-breaking research from around the globe in the field of cardiac recovery.



Thursday, January 12, 2017

9:00 - 11:00am
Session 1: Defining Myocardial Recovery 
Chairpersons: James Fang, MD,
U of Utah, Salt Lake City and Donald Lappe, MD, Intermountain Medical Center, Salt Lake City



1. What is myocardial recovery: basic, translational and clinical perspective?

Douglas Sawyer, MD, PhD,
Maine Medical Center, Portland, ME

2. NHLBI Working Group: “Advancing the science of myocardial recovery
with Mechanical Unloading”.

Frank Pagani, MD, PhD,
U of Michigan, Ann Arbor, MI        

3. How to leverage registries and big data to advance the field of cardiac recovery.

James K. Kirklin, MD,
U of Alabama, Birmingham, AL

4. “AHA HF Strategically Focused Research Network”: opportunities and challenges.

Craig Selzman, MD,
U of Utah, Salt Lake City, UT

11:00 - 11:45am
The Highlight of the Current Cardiology: A Movement from Disease to Health
Valentin Fuster, MD/PhD
Physician-in-Chief, Mount Sinai Hospital, New York, NY
Director, Mount Sinai Cardiovascular Institute, New York, NY
Editor-in-Chief JACC

LUNCH AND POSTER VIEWING: 11:45am -  12:45pm

12:45 -2:45pm
Session 2:  New Approaches to Achieve Cardiac Recovery
Chairpersons: Dean Li, MD, PhD, U of Utah, Salt Lake City and E. Dale Abel, MD, PhD, U of Iowa, Iowa City



1. Targeting Ca-Cycling in Heart Failure: Promises and Challenges.

Evangelia G. Kranias, PhD, University of Cincinnati, Cincinnati, OH

2. Epigenetic Control of mTOR in Cardiovascular Disease.

Joseph Hill, MD, PhD, UT Southwestern, Dallas, TX

3. Intercalated disc proteins, CAR and Z01, in cardiac function and conduction

Kirk Knowlton, MD, Intermountain Healthcare, Salt Lake City, UT

4. Overcoming challenges to the practical application of precision
cardiovascular medicine.

Martin Tristani-Firouzi, MD, U of Utah/Primary Children’s/CVRTI, Salt Lake City, UT

BREAK -2:45 - 3:00pm

3:00 - 4:30pm
Session 3: Right Heart Failure and Recovery
Chairpersons: Stephen McKellar, MD, U of Utah, Salt Lake City and Joshua Zimmerman, MD, U of Utah, Salt Lake City



1. Right Ventricular Recovery and Other Novel Targets in Pulmonary Hypertension Clinical Trials.

John Ryan, MD, U of Utah, Salt Lake City, UT

2. Role of aldosterone in pulmonary hypertension.

Bradley A. Maron, MD, Brigham and Women's Hospital, Boston, MA

3. RV failure and mechanical circulatory support.

Jonathan Rich, MD, Northwestern University, Chicago, IL

4:30 - 6:00pm
Session 4: Defining the Role of Periphery in Heart Failure and Recovery 
Chairpersons: Lillian L. Khor, M.B.B.Ch., M.Sc., U of Utah, Salt Lake City and Adrianna Torres Navas, MD, Fundacion Cardioinfantil, Bogota, Colombia



1. Skeletal muscle oxygen uptake and utilization in
heart failure.

Tim Musch, PhD, Kansas State University, Manhattan, KS

2. Peripheral vascular function in heart failure and

Walter Wray, PhD, U of Utah, Salt Lake City, UT

3. Peripheral vascular pulsatility and function in
heart failure and mechanical circulatory assist

Russell S. Richardson, PhD, U of Utah & VA Medical Center, Salt Lake City, UT

7:00 - 9:30 pm
Symposium Dinner


Friday, January 13, 2017

7:00 - 7:55am
Sunrise Session: Oral Presentation of Best Abstracts
Chairpersons: Edward Michael Gilbert, MD, U of Utah, Salt Lake City, UT and Jose Nativi-Nicolau, MDU of Utah, Salt Lake City, UT



1. Impella 2.5 and CP Use at a Rural Community Hospital; Experience and Outcomes with 97 Implants 2011-2016

Charles Wilkins, MD, San Juan Regional Hospital, Farmington, NM

2. Profiling plasma caspase activity in heart failure and during LVAD support as biomarkers of cardiac health and recovery.

Frank Jefferson, MD, Duke University, Durham, NC

3. Peripheral vascular pulsatility in heart failure patients with continuous flow centrifuge and axial left ventricular assist devices: the effect of pump speed.

Jay Hydren, MS, University of Utah, Salt Lake City, UT

4. Cerebral autoregulation and brain-tissue oxygenation are preserved in patients with continuous-flow left ventricular assist devices.

William K. Cornwell III, MD, University of Colorado, Aurora, CO

5.Scientific considerations: accuracy, physiology, details (the devil lives here).

Alan Morris, MD, U of Utah/Intermountain Healthcare, Salt Lake City, UT

8:00 - 10:15am
Session 5: Mechanical Unloading and Recovery: Moving Forward
Chairpersons: John Spertus, MD, MPH, University of Missouri, Kansas City and J. Timothy Baldwin, PhD, National Heart, Lung, and Blood Institute, Bethesda, Maryland



1. Mechanical unloading and cardiac recovery 20 years later: opportunities and challenges.

A.G. Kfoury, M.D., Intermountain Healthcare, Salt Lake City, UT

2. Optimal type and degree of mechanical unloading: bioengineering perspective.

Stephen M. Koenig, MD, U of Louisville, Louisville, KY

3. Advanced imaging technologies enlightening our perspectives.

Linda R. Peterson, MD, Washington University, St. Louis, MO

4. Connecting clinical factors and biology to patient health status in recovery. 

Josef Stehlik, MD, MPH, U of Utah, Salt Lake City, UT

5. RESTAGE-HF: A North American multicenter trial reviving the field

Emma Birks, MD, U of Louisville, Louisville, KY

BREAK: 10:15- 10:30am

Session 6: Mechanical Unloading and Recovery: the Utah Cardiac Recovery Program (UCAR) Approach
Chairpersons: Joseph Hill, MD, PhD, UT Southwestern, Dallas and Evangelia G. Kranias, PhD, U of Cincinnati, Cincinnati



1. UCAR: clinical and translational perspective.

Stavros Drakos, MD, PhD, U of Utah, Salt Lake City, UT

2. Investigating recovery: from the tissue harvest, to the echo lab, to the patient.

Omar Wever-Pinzon, MD, U of Utah, Salt Lake City, UT

3. Understanding cellular and microstructural remodeling through UCAR 

Frank Sachse, PhD, U of Utah/CVRTI, Salt Lake City, UT

4. Utilizing UCAR to probe the human proteome.

Sarah Franklin, PhD, U of Utah /CVRTI, Salt Lake City, UT

LUNCH: 12:30 - 1:30pm

1:30 - 3:30pm
Session 7:  Oral presentations of best abstracts
Chairpersons: Alejandro Bertolotti, MD, Fundacion Favaloro, Buenos Aires, Argentina and Josef Stehlik, MD, MPH, U of Utah, Salt Lake City

Featured presentation:
Use of MCS to achieve myocardial recovery after primary graft failure. Juan Mejia, MD, Messejana Hospital, Fortaleza, Brazil



1. Gene expression in Pediatric Myocardium: Pulsatile- vs. Continuous-Flow VAD Support.  Iki Adachi, MD, Baylor College of Medicine, Houston, TX
2. Novel trends in speckle tracking echocardiography in non-ischemic cardiomyopathy patients with heart failure with recovered ejection fraction. 

Stanley Swat, MD, Northwestern University Feinberg School of Medicine, Chicago, IL

3. Coronary vascular function is improved in ischemic cardiomyopathy patients after continuous-flow left ventricular assist device (LVAD) implantation.  John David Symons, PhD, U of Utah, Salt Lake City, UT
4. Evidence that Mesenchymal to Endothelial Transition (MET) occurs Secondary to Cardiac Unloading through LVAD support

Ana Sofia Cruz Solbes, MD, Houston Methodist Hospital, Houston, TX

5. Effects of increased myocardial tissue concentration of myristic, palmitic and palmitoleic acids on the course of cardiac atrophy of the failing heart unloaded by heterotopic transplantation.

Martin Pokorný, MD, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

6. The Effect of Reverse Remodeling on Intraventricular Flow in the LVAD-Supported Heart Studied in a Mock Circulatory Loop. 

Karen May-Newman, PhD, San Diego State University, San Diego, CA
7. Cardiac spinal sensory endings mediate remodeling in the post MI state.

Irving H. Zucker, PhD, Editor In Chief, The American Journal of Physiology- Heart and Circulatory Physiology, University of Nebraska, Omaha, NE

8. Combination Bioelectric Stimulator, Micro Infusion Pump and Multi Protein Composition for Heart Regeneration.

Leslie Miller, MD, 
Leonhardt Ventures,
Salt Lake City, UT

3:30 - 5:30pm
Session 8: Acute Heart Failure and Cardiac Recovery
Chairpersons: Fred Welt, MD, U of Utah, Salt Lake City and Joseph E. Tonna, MD, U of Utah, Salt Lake City



1. Acute in Chronic Heart Failure/INTERMACS 2-3: How to select patients and mechanical support therapeutic strategies?

Valluvan Jeevanandam, MD, U of Chicago, Chicago, IL 

2. Profound Cardiogenic shock/ INTERMACS 1: From percutaneous VAD and ECMO to the exit

Pascal Leprince, MD, Pitié Salpêtrière University, Paris

3. Acute coronary syndromes and shock: focus on salvaging myocardium.

E. Magnus Ohman, MD, Duke University, Durham, NC

4. Debate: Cardiogenic shock therapies: Surgical Versus Percutaneous approach

Christian Bermudez, U Penn, Philadelphia, PA 

Claudius Mahr, DO, FACC, FESC, University of Washington, Seattle, WA

Closing Remarks

Faculty Dinner