U-CARS 2019

On January 17-18, 2019, thought leaders and participants from around the world gathered for the 7th Annual Utah Cardiac Recovery Symposium (U-CARS).  The two day symposium was held in a stunning new venue at the University of Utah Cleone Peterson Eccles Alumni House in scenic Salt Lake City, Utah.

Thursday, January 17th's keynote address was delivered by Gary H. Gibbons, MD, Director of the National Heart, Lung and Blood Institute at the National Institutes of Health (NIH).  Friday, January 18th's keynote address was delivered by Jeroen J. Bax, MD, PhD, Immediate Past President of the European Society of Cardiology and Professor at Leiden University, The Netherlands.

The 2019 symposium attracted over 600 attendees once again and featured the clinical and translational impact of the impressive results of the multi-center LVAD Bridge-To-Recovery RESTAGE-HF Trial.

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Thursday, January 17, 2019

8:00 - 8:15am
Opening Remarks

8:15 - 9:15am
Session 1:
What is Myocardial Recovery and How to Manipulate it?

Chairpersons: James C. Fang, MD – U of U Health & Donald L. Lappe, MD – Intermountain Healthcare



1. Clinical view. 

Mandeep R. Mehra, MD, FACC, FESC, FRCP
Brigham & Women’s/ Harvard, Boston, MA

2. Basic and translational science view.

Joseph Wu, MD, PhD
- Stanford University, Stanford, CA

9:15 - 10:00am


Advancing Discovery Science for Public Health Impact
Gary H. Gibbons, MD
 Director, National Heart, Lung and Blood Institute (NHLBI) at the National Institutes of Health (NIH)

10:00 - 11:45am
Session 2: Advancing the Science of Cardiac Recovery with Mechanical Circulatory Support (MCS)

Chairpersons: Emma J Birks, MD, PhD U of Louisville Craig Selzman, MDU of U Health 



1. State of the field

Stavros G. Drakos, MD, PhD, FACCU of U Health, Salt Lake City, UT

2. MCS and Regenerative Therapies

Terrence Yau, MDU of Toronto, Canada

3. NHLBI Strategic Vision and the Myocardial Recovery Field

Renee Wong, PhD - NHLBI, NIH, Bethesda, MD

Panel Discussion - Post-RESTAGE Trial era: what are the next steps?
Panelists: Chairs and Speakers

11:45 - 12:45pm
Lunch - Moderated Poster Session 
(*NON CME accredited)
Moderators: Rami Alharethi, MD – Intermountain Healthcare; Anna Catino, MD – U of U Health; Rashmee Shah, MD – U of U Health 

12:45 - 2:45pm
Session 3: Myocardial recovery innovation
Chairpersons: Jared P. Rutter, PhDU of U Health & Dipayan Chaudhuri, MD, PhDU of U Health



1. Door to Unloading to Limit Injury and Promote Cardiac Recovery in Acute MI: Bench to Bedside

Navin K. Kapur, MDTufts Medical Center, Boston, MA

2. Epitranscriptomic Mechanisms of Cardiac Recovery.

Konstantinos Stellos MDU of Newcastle, England, UK

3. Combining Proteomics and Transcriptomics To Predict Cardiac Recovery in Advanced HF Patients

Sarah Franklin, PhD – U of U Health, Salt Lake City, UT

4. Myocardial and Peripheral Vasculature during Mechanical Circulatory Support

Amrut Ambardekar, MD, U of Colorado, Aurora, CO

5. Targeting myocardial recovery in cardiac amyloidosis…!

Jose N. Nativi-Nicolau, MD – U of U Health, Salt Lake City, UT

2:45 - 3:10pm

3:10 - 4:30pm
Session 4: Bioengineering and HF Intersection: Building ‘S
mart Pump’ to Recover Both the Heart and the Patient

Chairpersons: John Watson, PhDUCSD & A.G. Kfoury, MD – Intermountain Healthcare



1. ‘Smart pump’: what does the heart need?

Dan Burkhoff, MD, PhD – Columbia/ CRF, New York, NY

2. ‘Smart pump’: what does the periphery need?

Ulrich P. Jorde, MD – Montefiore/ Albert Einstein, Bronx, NY

3. 'Smart pump': what does the patient need?

Nir Uriel, MD – U of Chicago, Chicago, IL

4. ‘Smart pump’: bioengineering perspective. (*Non-CME accredited)

David J. Farrar, PhD - Abbott, Pleasanton, CA

4:30 - 5:30pm
'How to...' practical break out sessions:


How to treat patients during LVAD support, ii) How to serially screen for cardiac recovery iii) Weaning criteria. INTERACTIVE CASES - Emma J Birks, MD, PhD U of Louisville & Omar Wever-Pinzon, MD – U of U Health


How to stop the VAD: surgical and percutaneous approaches - INTERACTIVE CASES - Manreet Kanwar, MD -Allegheny MC & Craig H. Selzman, MD - U of U Health


Patient-centered decision-making: provider and patient perspectives – PATIENTS LIVE PARTICIPATION – Rebecca J. Cogswell, MD – U of Minnesota & Josef Stehlik, MD – U of Utah 

6:30 - 10:00 pm
Symposium Dinner

Rice Eccles Stadium, University of Utah

Friday, January 18, 2019

8:00 - 9:30am
Session 5: Oral Presentation of Best Abstracts 
(*Non-CME accredited)
Chairpersons: Amanda Vest, MBBS, MPH – Tufts Medical Center, Jack Morshedzadeh, MDU of U Health, & Anthony Donato, PhD - U of U Health



1.  Krüppel-like factor 5 Regulates the miR-30 Family and Promotes Cardiac Dysfunction in Ischemic Cardiomyopathy

Matthew Hoffman ,MD/ PhD Student, Temple University, Philadelphia, PA

2. Novel Redox Mechanism for Pathological Cardiac Remodeling and Diastolic Dysfunction

Rajasekaran Namakkal-Soorappan, MD, U of Alabama at Birmingham, AL

3. Systolic left ventricular energy loss assessed by ultrasonic vector flow mapping

Lixue Yin, MD, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China

4.  Reverse Remodeling Effects of Sacubitril/Valsartan: Structural, Functional and Neurohormonal Optimization in Stage C Heart Failure

Sara Kalantari, MD, U of Chicago, Chicago, IL

5. Clinical implication of volume loading test in patients undergoing left ventricular assist devise support

Fusako Sera, MD Osaka University, Japan

6. Centrifugal-Flow Ventricular Assist Device Support in Children:
A Single Center Experience

Iki Adachi, MD, Texas Children's Hospital, Houston, TX 

7. Mechanical Unloading-induced Reversal of Myocardial Fibrosis in Advanced Heart Failure Patients

Rachit Badolia, PhD, 
U of U, Salt Lake City, UT 

8. Three Year Outcomes of 3 DT-LVAD patients Bridged to Recovery and Explanted

Esther S. Shao MD, PhD, 
Maine Medical Center, Portland, ME

9. New Insights into Right Ventricular Function Among Patients with Left Ventricular Assist Devices using High Fidelity Conductance Catheters to Generate Real Time Pressure Volume Loops

William K. Cornwell III, MD, 
U of Colorado, Denver, CO

10. Recovery of Right Ventricular Function with Intraaortic Balloon Pump Counterpulsation

Michael Bonios, MD, PhD, Onassis Cardiac Surgery Center, Athens, Greece

11. Assessment of Hemodynamic Changes during Transcatheter Aortic Valve Replacement with Real-Time Pressure-Volume Loops

Michael Yaoyao Yin MD, U of U, Salt Lake City, UT

9:30 - 10:15am
Cardiac Resynchronization Therapy: How to Predict Recovery and Outcomes?

Jeroen J. Bax, MD, PhD, FESC

Immediate Past President European Society of Cardiology (ESC) 
Leiden University, The Netherlands

10:15 - 11:45am
Session 6:
Should The Recovery Field Pay More Attention to the Role of Arrhythmia/ Electrophysiology (EP)?
Chairperson: Ravi Ranjan, MD, PhD – U of U Health & John Day, MD - Intermountain Healthcare 



1. EP Looking Beyond Electricity: the Atria as a Pump - Old and New Ideas. 

Stavros Stavrakis, MD, PhD - U of Oklahoma, Oklahoma City, OK

2. Is Cardiac Recovery One of the Reasons CASTLE-AF Worked? Challenges and Opportunities. 

Nassir Marrouche, MDU of U Health, Salt Lake City, UT

3. From the Great Success of CRT to AF Ablation: What EP Still Needs to do to Make HF Docs Look Great Again.

Milton Packer, MD- Baylor University Medical Center, Dallas, TX

Panel discussion (chairs & speakers): How to move the needle: practical recommendations.

11:45am - 12:45pm
Lunch - Posters Viewing

12:45 - 2:45pm
Session 7: Cardiogenic Shock and Recovery 

Chairperson: Sean Overton, MD – U of U Health Joseph Tonna, MD - U of U Health 

Cardiogenic shock cases: HF Surgery and HF Cardiology. Antigone Koliopoulou, MD, U of U Health & Line Kemeyou, MD – U of U Health



1. Assessment of Cardiopulmonary Recovery During Short-Term MCS.

Simon Maybaum, MDHofstra/ Northwell Health, Manhasset, NY

2. Advantages and Disadvantages of ECMO and Impella Support Systems.  

Navin K. Kapur, MD - Tufts Medical Center, Boston, MA

3. ECMO, Cardiac Recovery and LV Vent/Unloading: When and How? 

Eduardo Rame, MD – U of Pennsylvania, Philadelphia, PA

2:45 - 3:00pm

3:00 - 5:00pm
Session 8. Targeted Interactive Discussion: What is the SHOCK Trial study design to advance the field.
Chairperson: Mandeep R. Mehra, MDBrigham & Women’s/ Harvard & Fred Welt, MDU of U Health


Introduction & Rationale for Options: Stephen McKellar, MD - U of U Health

   Option 1: “Time for Direct Comparison ECMO vs. Impella?”

   Option 2: “Short-term MCS Efficacy in Shock Has Not Been Proven -- The 
   Design Has to Be: MCS Vs.
   No MCS?”

   Option 3: Other ideas

B. Intensivist’s View re the ideal study design- Alexandre Mebazaa, MD - Hôpital Lariboisière, University of Paris,France
C. HF Cardiologist’s view re the ideal study design- Shelley Hall, MD - Baylor University Medical Center, Dallas, TX

Interventional Cardiologist’s view re the ideal study design - George Dangas, MD - Mount Sinai, New York, NY

E. HF Surgeon’s view re the ideal study design- Carmelo Milano, MD - Duke University, Durham, NC

Panel Discussion - Chairs and Speakers

Closing Remarks