David M. Belnap

David M. Belnap, PhD

Languages spoken: English

Academic Information

Departments Primary - Biochemistry

Academic Office Information

David.Belnap@utah.edu

Research Interests

  • Cryogenic Electron Microscopy and Three-Dimensional Reconstruction (cryo-EM)
  • Structural Biology
  • Virology
  • Virus Assembly
  • Bacteriophages
  • Poliovirus
  • Polyomavirus
  • Papillomavirus
  • Tobacco mosaic satellite virus

Research Statement

I am interested in the structure, function, assembly, and disassembly of viruses and cellular macromolecules. I am particularly interested in using structural techniques to understand virus cell-entry, assembly, and evolution. My primary research tool is cryogenic electron microscopy and three-dimensional reconstruction (cryo-EM). I am also interested in improving cryo-EM techniques. I currently serve as the director of the Electron Microscopy Core Laboratory at the University of Utah, where I work with many to help them image their samples. I am happy to be of service to them.

Education History

Postdoctoral Fellowship National Institutes of Health
 Postdoctoral Fellow
Purdue University
 PhD
Undergraduate Brigham Young University
 BS

Selected Publications

Journal Article

  1. Lempp FA, Volz T, Cameroni E, Benigni F, Zhou J, Rosen LE, Noack J, Zatta F, Kaiser H, Bianchi S, Lombardo G, Jaconi S, Vincenzetti L, Imam H, Soriaga LB, Passini N, Belnap DM, Schulze A, Ltgehetmann M, Telenti A, Cathcart AL, Snell G, Purcell LA, Hebner CM, Urban S, Dandri M, Corti D, Schmid MA (2023). Potent broadly neutralizing antibody VIR-3434 controls hepatitis B and D virus infection and reduces HBsAg in humanized mice. J Hepatol, 79(5), 1129-1138.
  2. Momont C, Dang HV, Zatta F, Hauser K, Wang C, di Iulio J, Minola A, Czudnochowski N, De Marco A, Branch K, Donermeyer D, Vyas S, Chen A, Ferri E, Guarino B, Powell AE, Spreafico R, Yim SS, Balce DR, Bartha I, Meury M, Croll TI, Belnap DM, Schmid MA, Schaiff WT, Miller JL, Cameroni E, Telenti A, Virgin HW, Rosen LE, Purcell LA, Lanzavecchia A, Snell G, Corti D, Pizzuto MS (2023). A pan-influenza antibody inhibiting neuraminidase via receptor mimicry. Nature, 618(7965), 590-597.
  3. Barnard DL, Belnap DM, Azadi P, Heiss C, Snyder DS, Bock SC, Konowalchuk TW (2022). Examining the interactions of Galahad™ compound with viruses to develop a novel inactivated influenza A virus vaccine. Heliyon, 8(7), e09887.
  4. Wardzala CL, Wood AM, Belnap DM, Kramer JR (2022). Mucins Inhibit Coronavirus Infection in a Glycan-Dependent Manner. ACS Cent Sci, 8(3), 351-360.

Other

  1. Momont C, Dang HV, Zatta F, Hauser K, Wang C, di Iulio J, Minola A, Czudnochowski N, De Marco A, Branch K, Donermeyer D, Vyas S, Chen A, Ferri E, Guarino B, Powell AE, Spreafico R, Yim SS, Balce DR, Bartha I, Meury M, Croll TI, Belnap DM, Schmid MA, Schaiff WT, Miller JL, Cameroni E, Telenti A, Virgin HW, Rosen LE, Purcell LA, Lanzavecchia A, Snell G, Corti D, Pizzuto MS (2023). Author Correction: A pan-influenza antibody inhibiting neuraminidase via receptor mimicry. Nature (619(7970), pp. E50). England.

Patent

  1. Masner MT, Garrett T, Wood AK, Croshaw J, Sanz-Garcia E, Belnap DM (2009). "Mechanically Mounted Tweezers, Cryogenic-Atmosphere Extender, and Tweezers-Transfer Device for the FEI™ Vitrobot™ Vitrification Robot".