Skip to main content
Fei Wang

Fei Wang, PhD

Academic Information

Departments Primary - Internal Medicine

Divisions: Nephrology

Academic Office Information

Education History

Postdoctoral Fellowship University of Utah School of Medicine
Postdoctoral Fellow
Sun Yat-sen University School of Medicine
Undergraduate Guangzhou Medical University

Selected Publications

Journal Article

  1. Cho JM, Park SK, Kwon OS, La Salle DT, Cerbie J, Fermoyle CC, Morgan D, Nelson A, Bledsoe A, Bharath LP, Tandar M, Kunapuli SP, Richardson RS, Anandh Babu PV, Mookherjee S, Kishore BK, Wang F, Yang T, Boudina S, Trinity JD, Symons JD (2022). Activating P2Y1 receptors improves function in arteries with repressed autophagy. Cardiovasc Res.
  2. Xu C, Yang G, Fu Z, Chen Y, Xie S, Wang F, Yang T (2022). Na+-Retaining Action of COX-2 (Cyclooxygenase-2)/EP1 Pathway in the Collecting Duct via Activation of Intrarenal Renin-Angiotensin-Aldosterone System and Epithelial Sodium Channel. Hypertension, HYPERTENSIONAHA12117245.
  3. Xu C, Chen Y, Wang F, Xie S, Yang T (2021). Soluble (Pro)Renin Receptor as a Negative Regulator of NCC (Na+-Cl- Cotransporter) Activity. Hypertension, 78(4), 1027-1038.
  4. Wang F, Chen Y, Zou CJ, Luo R, Yang T (2021). Mutagenesis of the Cleavage Site of Pro Renin Receptor Abrogates Angiotensin II-Induced Hypertension in Mice. Hypertension, 78(1), 115-127.
  5. Fu Z, Wang F, Liu X, Hu J, Su J, Lu X, Lu A, Cho JM, Symons JD, Zou CJ, Yang T (2020). Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor. Clin Sci (Lond), 135(6), 793-810.
  6. Feng Y, Peng K, Luo R, Wang F, Yang T (2020). Site-1 Protease-Derived Soluble (Pro)Renin Receptor Contributes to Angiotensin II-Induced Hypertension in Mice. Hypertension, 77(2), 405-416.
  7. Luo R, Yang K, Wang F, Xu C, Yang T (2020). (Pro)renin receptor decoy peptide PRO20 protects against adriamycin-induced nephropathy by targeting the intrarenal renin-angiotensin system. Am J Physiol Renal Physiol, 319(5), F930-F940.
  8. Wang F, Sun Y, Luo R, Lu X, Yang B, Yang T (2020). COX-2-independent activation of renal (pro)renin receptor contributes to DOCA-salt hypertension in rats. Am J Physiol Renal Physiol, 319(4), F647-F653.
  9. Xu C, Wang F, Chen Y, Xie S, Sng D, Reversade B, Yang T (2020). ELABELA antagonizes intrarenal renin-angiotensin system to lower blood pressure and protects against renal injury. Am J Physiol Renal Physiol, 318(5), F1122-F1135.
  10. Wang F, Luo R, Zou CJ, Xie S, Peng K, Zhao L, Yang KT, Xu C, Yang T (2020). Soluble (pro)renin receptor treats metabolic syndrome in mice with diet-induced obesity via interaction with PPARγ. JCI Insight, 5(7).
  11. Wang F, Luo R, Peng K, Liu X, Xu C, Lu X, Soodvilai S, Yang T (2019). Soluble (pro)renin receptor regulation of ENaC involved in aldosterone signaling in cultured collecting duct cells. Am J Physiol Renal Physiol, 318(3), F817-F825.
  12. Wang F, Xu C, Luo R, Peng K, Ramkumar N, Xie S, Lu X, Zhao L, Zuo CJ, Kohan DE, Yang T (2019). Site-1 protease-derived soluble (pro)renin receptor targets vasopressin receptor 2 to enhance urine concentrating capability. JCI Insight, 4(7).
  13. Liu M, Deng M, Su J, Lin Y, Jia Z, Peng K, Wang F, Yang T (2017). Specific downregulation of cystathionine β-synthase expression in the kidney during obesity. Physiol Rep, 6(13), e13630.
  14. Su J, Liu X, Xu C, Lu X, Wang F, Fang H, Lu A, Qiu Q, Li C, Yang T (2017). NF-κB-dependent upregulation of (pro)renin receptor mediates high-NaCl-induced apoptosis in mouse inner medullary collecting duct cells. Am J Physiol Cell Physiol, 313(6), C612-C620.
  15. Yang KT, Wang F, Lu X, Peng K, Yang T, David Symons J (2017). The soluble (Pro) renin receptor does not influence lithium-induced diabetes insipidus but does provoke beiging of white adipose tissue in mice. Physiol Rep, 5(21).
  16. Peng K, Lu X, Wang F, Nau A, Chen R, Zhou SF, Yang T (2016). Collecting duct (pro)renin receptor targets ENaC to mediate angiotensin II-induced hypertension. Am J Physiol Renal Physiol, 312(2), F245-F253.
  17. Zhao L, Zhao J, Wang X, Chen Z, Peng K, Lu X, Meng L, Liu G, Guan G, Wang F (2016). Serum response factor induces endothelial-mesenchymal transition in glomerular endothelial cells to aggravate proteinuria in diabetic nephropathy. Physiol Genomics, 48(10), 711-718.
  18. Wang F, Lu X, Peng K, Fang H, Zhou L, Su J, Nau A, Yang KT, Ichihara A, Lu A, Zhou SF, Yang T (2016). Antidiuretic Action of Collecting Duct (Pro)Renin Receptor Downstream of Vasopressin and PGE2 Receptor EP4. J Am Soc Nephrol, 27(10), 3022-3034.
  19. Zhao L, Chi L, Zhao J, Wang X, Chen Z, Meng L, Liu G, Guan G, Wang F (2016). Serum response factor provokes epithelial-mesenchymal transition in renal tubular epithelial cells of diabetic nephropathy. Physiol Genomics, 48(8), 580-8.
  20. Song K, Stuart D, Abraham N, Wang F, Wang S, Yang T, Sigmund CD, Kohan DE, Ramkumar N (2016). Collecting Duct Renin Does Not Mediate DOCA-Salt Hypertension or Renal Injury. PLoS One, 11(7), e0159872.
  21. Lu X, Wang F, Liu M, Yang KT, Nau A, Kohan DE, Reese V, Richardson RS, Yang T (2015). Activation of ENaC in collecting duct cells by prorenin and its receptor PRR: involvement of Nox4-derived hydrogen peroxide. Am J Physiol Renal Physiol, 310(11), F1243-50.
  22. Lu X, Wang F, Xu C, Soodvilai S, Peng K, Su J, Zhao L, Yang KT, Feng Y, Zhou SF, Gustafsson J, Yang T (2016). Soluble (pro)renin receptor via β-catenin enhances urine concentration capability as a target of liver X receptor. Proc Natl Acad Sci U S A, 113(13), E1898-906.
  23. Wang F, Lu X, Liu M, Feng Y, Zhou SF, Yang T (2015). Renal medullary (pro)renin receptor contributes to angiotensin II-induced hypertension in rats via activation of the local renin-angiotensin system. BMC Med, 13, 278.
  24. Wang F, Lu X, Peng K, Du Y, Zhou SF, Zhang A, Yang T (2014). Prostaglandin E-prostanoid4 receptor mediates angiotensin II-induced (pro)renin receptor expression in the rat renal medulla. Hypertension, 64(2), 369-77.
  25. Wang F, Lu X, Peng K, Zhou L, Li C, Wang W, Yu X, Kohan DE, Zhu SF, Yang T (2014). COX-2 mediates angiotensin II-induced (pro)renin receptor expression in the rat renal medulla. Am J Physiol Renal Physiol, 307(1), F25-32.

Podcasts & News